PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1314495-4	1992	This was done to assess the degree of inhibition of PI synthase under various degrees of D-myo-inositol depletion and sorbitol accumulation induced by glucose and other metabolic manipulations in cultured human retinal pigment epithelial cells, a new in vitro model for diabetic complications.	Inositol	89-103	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	52-63	
26552689-3	2016	The synthesis of phosphatidylinositol requires the activity of an enzyme called phosphatidylinositol synthase, also known as CDIPT, which catalyzes a reversible headgroup exchange reaction on its substrate liponucleotide CDP-diacylglycerol resulting in the incorporation of inositol to generate phosphatidylinositol and the release of CMP.	Inositol	29-37	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	80-109	
26552689-3	2016	The synthesis of phosphatidylinositol requires the activity of an enzyme called phosphatidylinositol synthase, also known as CDIPT, which catalyzes a reversible headgroup exchange reaction on its substrate liponucleotide CDP-diacylglycerol resulting in the incorporation of inositol to generate phosphatidylinositol and the release of CMP.	Inositol	29-37	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	125-130	
9989274-12	1999	Structural analogs of myo-inositol, epi-inositol and scyllo-inositol and Zn2+ were shown to be more potent inhibitors of mycobacterial PI synthase than of mammalian analogs.	Inositol	22-34	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	135-146	
9989274-12	1999	Structural analogs of myo-inositol, epi-inositol and scyllo-inositol and Zn2+ were shown to be more potent inhibitors of mycobacterial PI synthase than of mammalian analogs.	Inositol	36-48	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	135-146	
7896081-1	1995	The PIS gene for an enzyme phosphatidylinositol synthase having an increased Km for myo-inositol, was isolated from Saccharomyces cerevisiae.	Inositol	84-96	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	4-7	
7915914-4	1994	Human brain PtdIns synthase showed Kmapp values of 0.49 mM and 18 microM for inositol and CMP, respectively.	Inositol	77-85	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	12-27	
8387272-2	1993	Only three of the monodeoxyfluoro-myo-inositols were incorporated into the phospholipids of thymocytes: 1D-3-deoxy-3-fluoro-myo-inositol, 5-deoxy-5-fluoro-myo-inositol and 1D-6-deoxy-6-fluoro-myo-inositol, all of which were weaker substrates for phosphatidylinositol synthase than was myo-inositol.	Inositol	34-46	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	246-275	
9407135-7	1997	Expression of the pis1 gene led to the overproduction of both phosphatidylinositol synthase and phosphatidylinositol:inositol exchange reactions, indicating that the Pis1 polypeptide catalyzed both of these activities.	Inositol	74-82	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	18-22	
9407135-7	1997	Expression of the pis1 gene led to the overproduction of both phosphatidylinositol synthase and phosphatidylinositol:inositol exchange reactions, indicating that the Pis1 polypeptide catalyzed both of these activities.	Inositol	74-82	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	166-170	
7595517-7	1995	Comparison of the effects of agonist +/- Li+ on the concentrations of these cosubstrates for PtdIns synthase suggest that accelerated activity of this enzyme is differentially driven by stimulated increases in the amounts of CMP-phosphatidate or inositol in inositol-replete or depleted cells, respectively.	Inositol	246-254	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	93-108	
7595517-7	1995	Comparison of the effects of agonist +/- Li+ on the concentrations of these cosubstrates for PtdIns synthase suggest that accelerated activity of this enzyme is differentially driven by stimulated increases in the amounts of CMP-phosphatidate or inositol in inositol-replete or depleted cells, respectively.	Inositol	258-266	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	93-108	
1314495-5	1992	The results suggest that sorbitol accumulation limits the PI synthase reaction in these cells by selectively depleting specific intracellular pools of D-myo-inositol and/or by possible independent effects of sorbitol on PI synthase.	Inositol	151-165	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	Homo sapiens	58-69