PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26552689-3 2016 The synthesis of phosphatidylinositol requires the activity of an enzyme called phosphatidylinositol synthase, also known as CDIPT, which catalyzes a reversible headgroup exchange reaction on its substrate liponucleotide CDP-diacylglycerol resulting in the incorporation of inositol to generate phosphatidylinositol and the release of CMP. Inositol 29-37 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 80-109 26552689-3 2016 The synthesis of phosphatidylinositol requires the activity of an enzyme called phosphatidylinositol synthase, also known as CDIPT, which catalyzes a reversible headgroup exchange reaction on its substrate liponucleotide CDP-diacylglycerol resulting in the incorporation of inositol to generate phosphatidylinositol and the release of CMP. Inositol 29-37 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 125-130 9989274-12 1999 Structural analogs of myo-inositol, epi-inositol and scyllo-inositol and Zn2+ were shown to be more potent inhibitors of mycobacterial PI synthase than of mammalian analogs. Inositol 22-34 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 135-146 9989274-12 1999 Structural analogs of myo-inositol, epi-inositol and scyllo-inositol and Zn2+ were shown to be more potent inhibitors of mycobacterial PI synthase than of mammalian analogs. Inositol 36-48 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 135-146 9407135-7 1997 Expression of the pis1 gene led to the overproduction of both phosphatidylinositol synthase and phosphatidylinositol:inositol exchange reactions, indicating that the Pis1 polypeptide catalyzed both of these activities. Inositol 74-82 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 18-22 9407135-7 1997 Expression of the pis1 gene led to the overproduction of both phosphatidylinositol synthase and phosphatidylinositol:inositol exchange reactions, indicating that the Pis1 polypeptide catalyzed both of these activities. Inositol 74-82 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 166-170 7595517-7 1995 Comparison of the effects of agonist +/- Li+ on the concentrations of these cosubstrates for PtdIns synthase suggest that accelerated activity of this enzyme is differentially driven by stimulated increases in the amounts of CMP-phosphatidate or inositol in inositol-replete or depleted cells, respectively. Inositol 246-254 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 93-108 7595517-7 1995 Comparison of the effects of agonist +/- Li+ on the concentrations of these cosubstrates for PtdIns synthase suggest that accelerated activity of this enzyme is differentially driven by stimulated increases in the amounts of CMP-phosphatidate or inositol in inositol-replete or depleted cells, respectively. Inositol 258-266 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 93-108 7896081-1 1995 The PIS gene for an enzyme phosphatidylinositol synthase having an increased Km for myo-inositol, was isolated from Saccharomyces cerevisiae. Inositol 84-96 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 4-7 7915914-4 1994 Human brain PtdIns synthase showed Kmapp values of 0.49 mM and 18 microM for inositol and CMP, respectively. Inositol 77-85 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 12-27 8387272-2 1993 Only three of the monodeoxyfluoro-myo-inositols were incorporated into the phospholipids of thymocytes: 1D-3-deoxy-3-fluoro-myo-inositol, 5-deoxy-5-fluoro-myo-inositol and 1D-6-deoxy-6-fluoro-myo-inositol, all of which were weaker substrates for phosphatidylinositol synthase than was myo-inositol. Inositol 34-46 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 246-275 1314495-4 1992 This was done to assess the degree of inhibition of PI synthase under various degrees of D-myo-inositol depletion and sorbitol accumulation induced by glucose and other metabolic manipulations in cultured human retinal pigment epithelial cells, a new in vitro model for diabetic complications. Inositol 89-103 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 52-63 1314495-5 1992 The results suggest that sorbitol accumulation limits the PI synthase reaction in these cells by selectively depleting specific intracellular pools of D-myo-inositol and/or by possible independent effects of sorbitol on PI synthase. Inositol 151-165 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 58-69