PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10075922-3	1999	Sac1p shows no homology to other known solute transporters but displays similarity to the N-terminal non-catalytic domain of a subset of inositol 5"-phosphatases.	Inositol	137-145	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	0-5	
19139096-5	2009	In contrast, sac1Delta dramatically reduced inositol phosphosphingolipids, which result from the addition of a PtdIns-derived phosphoinositol head group to ceramides through Aur1p.	Inositol	44-52	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	13-17	
8314848-0	1993	SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast.	Inositol	126-134	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	0-5	
8314848-5	1993	Finally, we report that sac1 mutants also exhibit a specific inositol auxotrophy that is not exhibited by the other sac mutant strains.	Inositol	61-69	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	24-28	
8314848-6	1993	This sac1-associated inositol auxotrophy is not manifested by measurable defects in de novo inositol biosynthesis, nor is it the result of some obvious defect in the ability of sac1 mutants to utilize inositol for phosphatidylinositol biosynthesis.	Inositol	21-29	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	5-9	
8314848-7	1993	Thus, sac1 mutants represent a novel class of inositol auxotroph in that these mutants appear to require elevated levels of inositol for growth.	Inositol	46-54	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	6-10	
8314848-7	1993	Thus, sac1 mutants represent a novel class of inositol auxotroph in that these mutants appear to require elevated levels of inositol for growth.	Inositol	124-132	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	6-10	
8314848-8	1993	On the basis of the collective data, we suggest that SAC1p dysfunction exerts its pleiotropic effects on yeast Golgi function, the organization of the actin cytoskeleton, and the cellular requirement for inositol, through altered metabolism of inositol glycerophospholipids.	Inositol	204-212	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	53-58	
14527956-2	2003	Yeast SAC1 mutants display a wide array of phenotypes including inositol auxotrophy, cold sensitivity, secretory defects, disturbed ATP transport into the ER, or suppression of actin gene mutations.	Inositol	64-72	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	6-10	
10625610-1	2000	The yeast protein Sac1p is involved in a range of cellular functions, including inositol metabolism, actin cytoskeletal organization, endoplasmic reticulum ATP transport, phosphatidylinositol-phosphatidylcholine transfer protein function, and multiple-drug sensitivity.	Inositol	80-88	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	18-23	
12713536-2	2003	SAC1p has been implicated in multiple cellular functions: actin cytoskeleton organization, secretory functions, inositol metabolism, ATP transport, and multiple-drug sensitivity.	Inositol	112-120	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	0-5	
12713536-4	2003	We demonstrated that the three AtSAC1 proteins are functional homologs of the yeast SAC1p because they can rescue the cold-sensitive and inositol auxotroph yeast sac1-null mutant strain.	Inositol	137-145	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	84-89	
12713536-4	2003	We demonstrated that the three AtSAC1 proteins are functional homologs of the yeast SAC1p because they can rescue the cold-sensitive and inositol auxotroph yeast sac1-null mutant strain.	Inositol	137-145	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	162-166	
10397762-0	1999	Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy.	Inositol	103-111	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	53-57	
10397762-9	1999	Finally, we determine that CDP-choline pathway activity contributes to the inositol auxotrophy of sac1 strains in a novel manner that does not involve obvious defects in transcriptional expression of the INO1 gene.	Inositol	75-83	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	98-102	
10455234-6	1999	SAC1 encodes a protein which has been previously implicated in the correct function of the actin cytoskeleton, in inositol metabolism, in ATP transport in the endoplasmic reticulum and in Sec14p (PI-TP) function.	Inositol	114-122	phosphatidylinositol-3-phosphatase SAC1	Saccharomyces cerevisiae S288C	0-4