PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11023840-6	2000	Finally, the luminal portion of Ire1p (Ire=high inositol-requiring), thought to convey the sensing function of this transmembrane kinase and endoribonuclease, was shown to contain repeats similar to those in beta-propeller proteins.	Inositol	48-56	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	32-37	
8932376-2	1996	We have characterized a yeast gene, IRE2, which was isolated as a suppressor gene that complements the inositol auxotrophic phenotype of the ire1 mutation.	Inositol	103-111	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	141-145	
8932376-6	1996	These results clearly indicate that the IRE2/HAC1 gene product plays a critical role in the induction of KAR2 expression and in the inositol prototrophy mediated by IRE1.	Inositol	132-140	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	165-169	
8513503-6	1993	IRE1 is also required for inositol prototrophy, suggesting that the induction of ER resident proteins is coupled to the biogenesis of new ER membrane.	Inositol	26-34	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	0-4	
30110882-6	2018	However, in yeast species, the only sensor present is the inositol-requiring enzyme Ire1.	Inositol	58-66	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	84-88	
16041130-2	2005	IRE1- and HAC1-disruptants require high concentrations of inositol for its normal growth.	Inositol	58-66	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	0-4	
1625574-0	1992	IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae.	Inositol	97-105	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	0-4	
1625574-1	1992	A novel gene, IRE1, of Saccharomyces cerevisiae was cloned through genetic complementation of a myoinositol auxotrophic mutant.	Inositol	96-107	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	14-18	
1625574-4	1992	Disruption of the IRE1 locus caused myo-inositol auxotrophy.	Inositol	36-48	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	18-22	
1625574-5	1992	The IRE1 product is very likely a protein kinase required for myo-inositol synthesis.	Inositol	62-74	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	4-8	
21775630-4	2011	In contrast, this mutant was activated like wild-type Ire1 by depletion of the membrane lipid component inositol or by deletion of genes involved in lipid homeostasis.	Inositol	104-112	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	54-58	
21775630-5	2011	Another Ire1 mutant lacking the authentic luminal domain was up-regulated by inositol depletion as strongly as wild-type Ire1.	Inositol	77-85	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	8-12