PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27164711-0 2016 Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease. Inositol 0-12 apolipoprotein E Homo sapiens 61-65 24850492-3 2014 RESULTS: Frontal white matter myo-inositol was elevated in subjects with HIV across the age span but showed age-dependent increase in seronegative subjects, especially in APOE epsilon4+ carriers. Inositol 30-42 apolipoprotein E Homo sapiens 171-175 26401443-16 2015 There is an association between higher mI/Cr in right hippocampus and worse cognitive function for the non-demented older adults, and the correlation could be modified by APOE status and age. Inositol 39-41 apolipoprotein E Homo sapiens 171-175 24850492-4 2014 In contrast, only seronegative APOE epsilon4+ subjects showed elevated myo-inositol in parietal cortex. Inositol 71-83 apolipoprotein E Homo sapiens 31-35 24850492-7 2014 Higher myo-inositol levels were associated with poorer fine motor function across all subjects, slower speed of information processing in APOE epsilon4+ subjects, and worse fluency in HIV+ APOE epsilon4+ subjects. Inositol 7-19 apolipoprotein E Homo sapiens 138-142 24850492-7 2014 Higher myo-inositol levels were associated with poorer fine motor function across all subjects, slower speed of information processing in APOE epsilon4+ subjects, and worse fluency in HIV+ APOE epsilon4+ subjects. Inositol 7-19 apolipoprotein E Homo sapiens 189-193 23831342-7 2014 RESULTS: General linear model analysis demonstrated that older APOE E4 carriers had significantly higher choline/creatine and myo-inositol/creatine ratios than APOE E3 homozygotes. Inositol 126-138 apolipoprotein E Homo sapiens 63-67 23831342-8 2014 Structural equation modeling resulted in a model with an excellent goodness of fit and in which the APOE x age interaction and APOE status each had a significant effect on (1)H-MRS metabolites (choline/creatine and myo-inositol/creatine). Inositol 215-227 apolipoprotein E Homo sapiens 100-104 23831342-8 2014 Structural equation modeling resulted in a model with an excellent goodness of fit and in which the APOE x age interaction and APOE status each had a significant effect on (1)H-MRS metabolites (choline/creatine and myo-inositol/creatine). Inositol 215-227 apolipoprotein E Homo sapiens 127-131 23831342-10 2014 CONCLUSIONS: In a healthy aging normal population, choline/creatine and myo-inositol/creatine ratios were significantly increased in APOE E4 carriers, suggesting the presence of neuroinflammatory processes and greater membrane turnover in older carriers. Inositol 72-84 apolipoprotein E Homo sapiens 133-137