PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31163320-6 2019 Mechanistically, exosomes from microglial cells were incorporated into photoreceptors in vitro and inhibited the inositol-requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) cascade, which contributes to hypoxia-induced photoreceptor apoptosis. Inositol 113-121 X-box binding protein 1 Mus musculus 158-181 31846435-1 2020 The induction of endoplasmic reticulum (ER) stress is associated with adipogenesis, during which the inositol-requiring enzyme 1 alpha (IRE1alpha) -X-box binding protein 1 (XBP1) pathway is involved. Inositol 101-109 X-box binding protein 1 Mus musculus 148-171 31846435-1 2020 The induction of endoplasmic reticulum (ER) stress is associated with adipogenesis, during which the inositol-requiring enzyme 1 alpha (IRE1alpha) -X-box binding protein 1 (XBP1) pathway is involved. Inositol 101-109 X-box binding protein 1 Mus musculus 173-177 32926479-5 2021 Here, we investigate the contribution of the inositol-requiring protein-1alpha-X-box binding protein-1 (XBP1)-mediated UPR signaling pathway to the pathogenesis of spinal cord injury (SCI). Inositol 45-53 X-box binding protein 1 Mus musculus 104-108 31123148-6 2019 Liver-specific disruption of the inositol-requiring enzyme 1alpha (IRE1alpha)-XBP1s signaling branch results in diminished COPII vesicle trafficking. Inositol 33-41 X-box binding protein 1 Mus musculus 78-82 31163320-6 2019 Mechanistically, exosomes from microglial cells were incorporated into photoreceptors in vitro and inhibited the inositol-requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) cascade, which contributes to hypoxia-induced photoreceptor apoptosis. Inositol 113-121 X-box binding protein 1 Mus musculus 183-187 30146262-1 2018 As the most conserved branch of the unfolded protein response (UPR), the inositol-requiring enzyme 1a (IRE1a)/X-box binding protein 1 (XBP1) pathway plays crucial roles in cell survival and cell death by upregulating UPR-associated genes involved in protein entry into the endoplasmic reticulum (ER) and ER-associated degradation (ERAD). Inositol 73-81 X-box binding protein 1 Mus musculus 110-133 30943188-7 2019 Cultured murine Xbp1 deficient VSMCs migrated more in response to platelet derived growth factor (PDGF) than control VSMCs, and had an increased level of inositol-requiring enzyme 1alpha (Ire1alpha), a PDGF receptor-binding UPRER transmembrane endonuclease whose substrates include XBP1. Inositol 154-162 X-box binding protein 1 Mus musculus 16-20 30620686-8 2019 Gene array analysis prompted a detailed mechanistic study, which revealed that Pak2 regulation of protective ER function was via the IRE (inositol-requiring enzyme)-1/XBP (X-box-binding protein)-1-dependent pathway. Inositol 138-146 X-box binding protein 1 Mus musculus 172-196 30319453-3 2018 When the ER stress-induced unfolded protein response (UPR) is activated, the X-box binding protein 1 (XBP1) mRNA is spliced by inositol-requiring enzyme-1alpha (IRE1alpha) to produce the spliced form of XBP1 (sXBP1). Inositol 127-135 X-box binding protein 1 Mus musculus 77-100 30319453-3 2018 When the ER stress-induced unfolded protein response (UPR) is activated, the X-box binding protein 1 (XBP1) mRNA is spliced by inositol-requiring enzyme-1alpha (IRE1alpha) to produce the spliced form of XBP1 (sXBP1). Inositol 127-135 X-box binding protein 1 Mus musculus 102-106 30319453-3 2018 When the ER stress-induced unfolded protein response (UPR) is activated, the X-box binding protein 1 (XBP1) mRNA is spliced by inositol-requiring enzyme-1alpha (IRE1alpha) to produce the spliced form of XBP1 (sXBP1). Inositol 127-135 X-box binding protein 1 Mus musculus 203-207 30146262-1 2018 As the most conserved branch of the unfolded protein response (UPR), the inositol-requiring enzyme 1a (IRE1a)/X-box binding protein 1 (XBP1) pathway plays crucial roles in cell survival and cell death by upregulating UPR-associated genes involved in protein entry into the endoplasmic reticulum (ER) and ER-associated degradation (ERAD). Inositol 73-81 X-box binding protein 1 Mus musculus 135-139 29430617-5 2018 In this study, treatment with tunicamycin, an ER stress inducer, enhanced the phosphorylation level of inositol-requiring ER-to-nucleus signal kinase 1 (IRE1) and increased X-box-binding protein 1 (XBP1) mRNA splicing activity in the mouse PFC, whereas inhibition of IRE1/XBP1 pathway in PFC by a viral particle approach attenuated social behavioral deficits caused by tunicamycin treatment. Inositol 103-111 X-box binding protein 1 Mus musculus 272-276 29377207-2 2018 The inositol-requiring enzyme 1alpha/X-box binding protein 1 (IRE1alpha/XBP1) pathway of the unfolded protein response (UPR) is a protective cellular signaling pathway activated in response to endoplasmic reticulum (ER) stress. Inositol 4-12 X-box binding protein 1 Mus musculus 37-60 29377207-2 2018 The inositol-requiring enzyme 1alpha/X-box binding protein 1 (IRE1alpha/XBP1) pathway of the unfolded protein response (UPR) is a protective cellular signaling pathway activated in response to endoplasmic reticulum (ER) stress. Inositol 4-12 X-box binding protein 1 Mus musculus 72-76 28039331-1 2017 The unfolded protein response (UPR) is an adaptive response to endoplasmic reticulum stress and the inositol-requiring enzyme 1alpha/X-box binding protein 1 (IRE1alpha/XBP1) pathway of the UPR is important in lipid metabolism. Inositol 100-108 X-box binding protein 1 Mus musculus 133-156 28039331-1 2017 The unfolded protein response (UPR) is an adaptive response to endoplasmic reticulum stress and the inositol-requiring enzyme 1alpha/X-box binding protein 1 (IRE1alpha/XBP1) pathway of the UPR is important in lipid metabolism. Inositol 100-108 X-box binding protein 1 Mus musculus 168-172 27186946-9 2016 Mechanistic studies revealed that the beneficial effects of GK occurred through enhancement of inositol-requiring enzyme 1alpha (IRE1alpha)/X box-binding protein-1 (XBP1) activity, which in turn led to increased ER-associated degradation-mediated clearance of misfolded proteins and autophagy. Inositol 95-103 X-box binding protein 1 Mus musculus 140-163 27186946-9 2016 Mechanistic studies revealed that the beneficial effects of GK occurred through enhancement of inositol-requiring enzyme 1alpha (IRE1alpha)/X box-binding protein-1 (XBP1) activity, which in turn led to increased ER-associated degradation-mediated clearance of misfolded proteins and autophagy. Inositol 95-103 X-box binding protein 1 Mus musculus 165-169 23493568-6 2013 alphaXBPKD cells exhibited activation of inositol-requiring enzyme 1, an upstream activator of XBP1, leading to phosphorylation of Jun NH2-terminal kinase. Inositol 41-49 X-box binding protein 1 Mus musculus 95-99 26469762-2 2015 Here, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring enzyme 1 alpha (IRE1alpha) to initiate X-box-binding protein 1 (Xbp1) mRNA splicing in adult primary beta cells. Inositol 85-93 X-box binding protein 1 Mus musculus 143-166 26469762-2 2015 Here, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring enzyme 1 alpha (IRE1alpha) to initiate X-box-binding protein 1 (Xbp1) mRNA splicing in adult primary beta cells. Inositol 85-93 X-box binding protein 1 Mus musculus 168-172 34502057-4 2021 In pathogenesis, cereulide exposure activated endoplasmic reticulum stress (ER stress) via the pathways of inositol-requiring enzyme 1alpha (IRE1alpha)/Xbox binding protein (XBP1) and PRKR-like ER kinase (PERK)/eukaryotic translation initiation factor 2alpha (eIF2alpha), and consequently led to the apoptosis and tissue damages in mouse liver and kidney. Inositol 107-115 X-box binding protein 1 Mus musculus 174-178 23529610-4 2013 METHODS AND RESULTS: We found that vascular endothelial cell growth factor induced the kinase insert domain receptor internalization and interaction through C-terminal domain with the unspliced XBP1 and the inositol requiring enzyme 1 alpha in the endoplasmic reticulum, leading to inositol requiring enzyme 1 alpha phosphorylation and XBP1 mRNA splicing, which was abolished by siRNA-mediated knockdown of kinase insert domain receptor. Inositol 207-215 X-box binding protein 1 Mus musculus 336-340 23529610-4 2013 METHODS AND RESULTS: We found that vascular endothelial cell growth factor induced the kinase insert domain receptor internalization and interaction through C-terminal domain with the unspliced XBP1 and the inositol requiring enzyme 1 alpha in the endoplasmic reticulum, leading to inositol requiring enzyme 1 alpha phosphorylation and XBP1 mRNA splicing, which was abolished by siRNA-mediated knockdown of kinase insert domain receptor. Inositol 282-290 X-box binding protein 1 Mus musculus 194-198 23529610-4 2013 METHODS AND RESULTS: We found that vascular endothelial cell growth factor induced the kinase insert domain receptor internalization and interaction through C-terminal domain with the unspliced XBP1 and the inositol requiring enzyme 1 alpha in the endoplasmic reticulum, leading to inositol requiring enzyme 1 alpha phosphorylation and XBP1 mRNA splicing, which was abolished by siRNA-mediated knockdown of kinase insert domain receptor. Inositol 282-290 X-box binding protein 1 Mus musculus 336-340 23184933-3 2013 Endostatin activated autophagic gene expression through XBP1 mRNA splicing in an inositol-requiring enzyme 1alpha (IRE1alpha)-dependent manner. Inositol 81-89 X-box binding protein 1 Mus musculus 56-60