PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34502057-4 2021 In pathogenesis, cereulide exposure activated endoplasmic reticulum stress (ER stress) via the pathways of inositol-requiring enzyme 1alpha (IRE1alpha)/Xbox binding protein (XBP1) and PRKR-like ER kinase (PERK)/eukaryotic translation initiation factor 2alpha (eIF2alpha), and consequently led to the apoptosis and tissue damages in mouse liver and kidney. Inositol 107-115 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 141-150 34808241-1 2022 The unfolded protein response is activated by UVB irradiation, but the role of a key mediator, inositol requiring enzyme 1a (IRE1alpha), is not clear. Inositol 95-103 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 125-134 34675883-3 2021 Here, we found that the ER stress sensor inositol-requiring enzyme 1alpha (IRE1alpha) was activated in the Akita mice, a mouse model of mutant insulin gene-induced diabetes of youth (MIDY), a monogenic diabetes. Inositol 41-49 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 75-84 34375928-2 2021 Increased expression of inducible nitric oxide synthase (iNOS) and dysfunction of the unfolded protein response (UPR), especially inositol-requiring enzyme 1alpha-X-box binding protein 1 (IRE1alpha-Xbp1s) signaling in the heart, have been associated with HFpEF. Inositol 130-138 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 188-197 34407601-10 2021 Inhibition of inositol-requiring enzyme 1 alpha (IRE1alpha), the most conserved signaling branch in ER stress, reduced GVHD development in mice. Inositol 14-22 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 49-58 35379745-2 2022 Here we demonstrated that the EP4-mediated activation of AKT by PGE2 was required for the proper control of inositol-requiring transmembrane kinase endoribonuclease-1alpha (IRE1alpha) hyperactivation and hence the endoplasmic reticulum (ER) homeostasis in IgM-producing SLPCs. Inositol 108-116 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 173-182 35304860-2 2022 Inositol-requiring enzyme 1alpha (IRE1alpha) mediates chaperone production and autophagy during ER stress. Inositol 0-8 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 34-43 33298866-3 2020 This study characterizes mechanisms by which inositol requiring enzyme-1alpha (IRE1alpha), a UPR transducer, regulates proteostasis in GECs. Inositol 45-53 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 79-88 34027646-5 2021 Here, we identify a new role of inositol-requiring transmembrane kinase/endoribonuclease 1alpha (IRE1alpha) in the regulation of plasma lipids. Inositol 32-40 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 97-106 33879967-7 2021 Phosphorylation of inositol-requiring transmembrane kinase/endonuclease1alpha (IRE1alpha), a sensor for endoplasmic reticulum stress, and c-Jun N-terminal kinase, a downstream target of IRE1alpha, were significantly enhanced in IECs in DSS-treated Atg5 DeltaIEC mice. Inositol 19-27 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 79-88 33879967-7 2021 Phosphorylation of inositol-requiring transmembrane kinase/endonuclease1alpha (IRE1alpha), a sensor for endoplasmic reticulum stress, and c-Jun N-terminal kinase, a downstream target of IRE1alpha, were significantly enhanced in IECs in DSS-treated Atg5 DeltaIEC mice. Inositol 19-27 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 186-195 32915195-1 2021 BCR-ABL1-positive acute lymphoblastic leukemia (ALL) cell survival is dependent on the inositol requiring enzyme 1 alpha (IRE1alpha) branch of the unfolded protein response. Inositol 87-95 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 122-131 31846435-1 2020 The induction of endoplasmic reticulum (ER) stress is associated with adipogenesis, during which the inositol-requiring enzyme 1 alpha (IRE1alpha) -X-box binding protein 1 (XBP1) pathway is involved. Inositol 101-109 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 136-145 32520957-3 2020 Here we report that the inositol-requiring enzyme 1 (IRE1alpha) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1, as well as surface expression of CD86 and programmed death ligand 1 (PD-L1). Inositol 24-32 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 53-62 31827236-4 2020 SPHK1 deficiency alleviated APAP-induced endoplasmic reticulum (ER) stress by affecting the phosphorylation of inositol-requiring enzyme 1alpha (IRE1alpha) and protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)-eukaryotic translation initiation factor 2alpha (eIF2alpha), levels of activating transcription factor 4 (ATF4), and activation of activating transcription factor 6 (ATF6). Inositol 111-119 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 145-154 31921161-7 2019 Our data show that proteasome impairment by bortezomib is a stimulus that activates all three intracellular ER-stress transducers activation transcription factor 6, protein kinase R-like endoplasmic reticulum kinase and inositol-requiring protein 1 alpha (IRE1alpha), causing a full activation of the UPR. Inositol 220-228 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 256-265 31578081-8 2019 Proinflammatory effects occur late and represent a modified ER stress response, mediated by IRE1a (inositol-requiring enzyme 1a)/ASK1 (apoptosis signal-regulating kinase 1)/p38 MAPK (p38 mitogen-activated protein kinase) signaling, that occurs under conditions of extreme cholesterol depletion. Inositol 99-107 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 92-97 31163320-6 2019 Mechanistically, exosomes from microglial cells were incorporated into photoreceptors in vitro and inhibited the inositol-requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) cascade, which contributes to hypoxia-induced photoreceptor apoptosis. Inositol 113-121 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 147-156 31081266-4 2019 It is reported that the inositol-requiring enzyme 1alpha (IRE1alpha) and its downstream molecules play a central role in the endoplasmic reticulum (ER) stress-induced apoptosis pathway. Inositol 24-32 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 58-67 31123148-6 2019 Liver-specific disruption of the inositol-requiring enzyme 1alpha (IRE1alpha)-XBP1s signaling branch results in diminished COPII vesicle trafficking. Inositol 33-41 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 67-76 30943188-7 2019 Cultured murine Xbp1 deficient VSMCs migrated more in response to platelet derived growth factor (PDGF) than control VSMCs, and had an increased level of inositol-requiring enzyme 1alpha (Ire1alpha), a PDGF receptor-binding UPRER transmembrane endonuclease whose substrates include XBP1. Inositol 154-162 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 188-197 30319453-3 2018 When the ER stress-induced unfolded protein response (UPR) is activated, the X-box binding protein 1 (XBP1) mRNA is spliced by inositol-requiring enzyme-1alpha (IRE1alpha) to produce the spliced form of XBP1 (sXBP1). Inositol 127-135 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 161-170 30559399-2 2018 Here we show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1alpha (IRE1alpha), links key cellular processes required for iNKT cell effector functions in specific iNKT subsets, in which TCR-dependent activation of IRE1alpha is associated with downstream activation of p38 MAPK and the stabilization of preformed cytokine mRNAs. Inositol 58-66 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 92-101 30559399-2 2018 Here we show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1alpha (IRE1alpha), links key cellular processes required for iNKT cell effector functions in specific iNKT subsets, in which TCR-dependent activation of IRE1alpha is associated with downstream activation of p38 MAPK and the stabilization of preformed cytokine mRNAs. Inositol 58-66 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 238-247 30630412-1 2019 BACKGROUND: T cell activation induces ER stress and upregulates Inositol Requiring Enzyme 1 alpha (IRE1alpha), an activator of the unfolded protein response (UPR) pathway. Inositol 64-72 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 99-108 30538632-3 2018 Previous researches reported that ER stress sensor inositol-requiring enzyme 1 alpha (IRE1alpha) was first activated in the process of liver fibrosis. Inositol 51-59 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 86-95 30146262-1 2018 As the most conserved branch of the unfolded protein response (UPR), the inositol-requiring enzyme 1a (IRE1a)/X-box binding protein 1 (XBP1) pathway plays crucial roles in cell survival and cell death by upregulating UPR-associated genes involved in protein entry into the endoplasmic reticulum (ER) and ER-associated degradation (ERAD). Inositol 73-81 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 103-108 29457838-2 2018 B-cell lymphoma 2 (BCL2)-associated X protein (Bax) inhibitor-1 (BI-1), a negative regulator of the ER stress sensor, inositol-requiring enzyme 1 alpha (IRE1alpha), has yet to be explored in NAFLD as a hepatoprotective agent. Inositol 118-126 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 153-162 30135303-6 2018 In vitro studies revealed that CHOP regulates hypoxia-induced apoptosis in AECs via the inositol-requiring enzyme 1alpha (IRE1alpha) and the PKR-like ER kinase (PERK) pathways. Inositol 88-96 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 122-131 29506314-4 2018 Here we report a dual role for inositol-requiring enzyme 1alpha (IRE1alpha), the ER-localized UPR signal transducer, in obesity-promoted HCC development. Inositol 31-39 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 65-74 29377207-2 2018 The inositol-requiring enzyme 1alpha/X-box binding protein 1 (IRE1alpha/XBP1) pathway of the unfolded protein response (UPR) is a protective cellular signaling pathway activated in response to endoplasmic reticulum (ER) stress. Inositol 4-12 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 62-71 28346409-4 2017 Here, we identified inositol-requiring enzyme 1alpha (IRE1alpha) as a critical switch governing M1-M2 macrophage polarization and energy balance. Inositol 20-28 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 54-63 29673059-8 2018 Mechanistic investigations demonstrate that inositol-requiring enzyme 1alpha (IRE1alpha), one of three major signal transduction pathways activated during endoplasmic reticulum (ER) stress, is the downstream target of palmitate-elicited TLR4 activation and mechanistically implicated in TLR4 activation-triggered cell death in response to palmitate exposure. Inositol 44-52 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 78-87 29732320-3 2018 We previously demonstrated that the activity of host unfolded protein response (UPR) sensor IRE1alpha (inositol-requiring enzyme 1) and ER-associated autophagy confer susceptibility to Brucella melitensis and Brucella abortus intracellular replication. Inositol 103-111 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 92-101 29504610-6 2018 Furthermore, inositol-requiring enzyme-1alpha (IRE1alpha)-dependent degradation (RIDD) of IRE1alpha was reduced by IC87114, resulting in a decreased release of proinflammatory cytokines from bronchial epithelial cells. Inositol 13-21 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 47-56 29504610-6 2018 Furthermore, inositol-requiring enzyme-1alpha (IRE1alpha)-dependent degradation (RIDD) of IRE1alpha was reduced by IC87114, resulting in a decreased release of proinflammatory cytokines from bronchial epithelial cells. Inositol 13-21 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 90-99 28428258-1 2017 Inositol-requiring enzyme-1alpha (IRE1alpha) is an endoplasmic reticulum (ER)-transmembrane endoribonuclease kinase that plays an essential function in extraembryonic tissues during normal development and is activated during ER stress. Inositol 0-8 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 34-43 29764990-1 2018 Obesity or a high-fat diet represses the endoribonuclease activity of inositol-requiring enzyme 1alpha (IRE1alpha), a transducer of the unfolded protein response (UPR) in cells under endoplasmic reticulum (ER) stress. Inositol 70-78 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 104-113 28039331-1 2017 The unfolded protein response (UPR) is an adaptive response to endoplasmic reticulum stress and the inositol-requiring enzyme 1alpha/X-box binding protein 1 (IRE1alpha/XBP1) pathway of the UPR is important in lipid metabolism. Inositol 100-108 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 158-167 29098149-2 2017 The most conserved arm of the UPR, inositol-requiring ER-to-nucleus signaling protein (IRE1alpha), has been linked to the regulation of a diverse array of cellular processes including ER-associated degradation, inflammatory signaling, cell proliferation and membrane biogenesis. Inositol 35-43 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 87-96 28098884-7 2017 Phosphorylated inositol-requiring 1alpha (p-IRE1alpha), an ER stress marker protein, was mainly expressed in macrophages in the atherosclerotic lesions. Inositol 15-23 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 44-53 27186946-9 2016 Mechanistic studies revealed that the beneficial effects of GK occurred through enhancement of inositol-requiring enzyme 1alpha (IRE1alpha)/X box-binding protein-1 (XBP1) activity, which in turn led to increased ER-associated degradation-mediated clearance of misfolded proteins and autophagy. Inositol 95-103 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 129-138 27558934-1 2016 Although numerous functions of inositol-requiring enzyme 1alpha (IRE1alpha) have been identified, a role of IRE1alpha in pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus is largely unknown. Inositol 31-39 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 65-74 26484121-3 2014 Our focus was on a specific branch of UPR namely the bi-functional protein kinase/endoribonuclease inositol-requiring element 1alpha (IRE1alpha). Inositol 99-107 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 134-143 26469762-2 2015 Here, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring enzyme 1 alpha (IRE1alpha) to initiate X-box-binding protein 1 (Xbp1) mRNA splicing in adult primary beta cells. Inositol 85-93 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 120-129 25457211-3 2015 Here we investigated the role of inositol-requiring enzyme-1alpha (IRE1alpha), a key signal transducer of the unfolded protein response (UPR), in liver regeneration. Inositol 33-41 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 67-76 22128176-0 2012 Dissociation of inositol-requiring enzyme (IRE1alpha)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. Inositol 16-24 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 43-52 23711292-4 2013 We found that aged macrophages exhibited more apoptosis than young macrophages, which was accompanied by reduced activation of phosphorylated inositol-requiring enzyme-1 (p-IRE1alpha), one of the three key ER stress signal transducers. Inositol 142-150 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 173-182 23184933-3 2013 Endostatin activated autophagic gene expression through XBP1 mRNA splicing in an inositol-requiring enzyme 1alpha (IRE1alpha)-dependent manner. Inositol 81-89 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 115-124 24089213-8 2013 Ileitis is dependent on commensal microbiota and derives from increased intestinal epithelial cell death, inositol requiring enzyme 1alpha (IRE1alpha)-regulated NF-kappaB activation and tumour-necrosis factor signalling, which are synergistically increased when autophagy is deficient. Inositol 106-114 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 140-149 21703174-5 2012 RESULTS: The current model for JNK activation by SFA involves endoplasmic reticulum (ER) stress, which induces JNK activation through an inositol requiring enzyme 1 (IRE1alpha) Apoptosis Regulating Kinase 1 (ASK1)-dependent mechanism. Inositol 137-145 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 166-175 20587749-2 2011 This has been reported to cause insulin resistance in selective tissues through activation of the inositol-requiring enzyme 1alpha (IRE1alpha)-c-Jun NH(2)-terminal kinase (JNK) pathway, which results in the phosphorylation of the insulin receptor substrate-1 (IRS-1) at an inhibitory site and blocks insulin receptor signaling. Inositol 98-106 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 132-141 15690081-3 2005 Two major proximal sensors of the UPR are inositol-requiring enzyme 1alpha (IRE1alpha), an ER transmembrane protein kinase/endoribonuclease, and ER-resident eukaryotic translation initiation factor 2alpha (eIF2alpha) kinase (PERK). Inositol 42-50 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 76-85 21407177-3 2011 In this study, we show that the most conserved UPR sensor inositol-requiring enzyme 1 alpha (IRE1alpha), an ER transmembrane protein kinase/endoribonuclease, is required to maintain hepatic lipid homeostasis under ER stress conditions through repressing hepatic lipid accumulation and maintaining lipoprotein secretion. Inositol 58-66 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 93-102 20103773-1 2010 Autophosphorylation of inositol-requiring enzyme 1alpha (IRE1alpha) is required for its activation, which elicits the cellular unfolded protein response (UPR) and is functionally connected with insulin biosynthesis in pancreatic beta cells. Inositol 23-31 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 57-66 16645094-1 2006 Accumulation of misfolded protein in the endoplasmic reticulum (ER) triggers an adaptive stress response-termed the unfolded protein response (UPR)-mediated by the ER transmembrane protein kinase and endoribonuclease inositol-requiring enzyme-1alpha (IRE1alpha). Inositol 217-225 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 251-260