PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33947921-5 2021 The screening system to track X-box binding protein 1 (XBP1) splicing activity revealed that the ethanol extract of the Periploca calophylla stem inhibited the inositol-requiring enzyme 1 (IRE1)-XBP1 pathway. Inositol 160-168 X-box binding protein 1 Homo sapiens 55-59 33947921-5 2021 The screening system to track X-box binding protein 1 (XBP1) splicing activity revealed that the ethanol extract of the Periploca calophylla stem inhibited the inositol-requiring enzyme 1 (IRE1)-XBP1 pathway. Inositol 160-168 X-box binding protein 1 Homo sapiens 195-199 33205567-3 2021 A 26-nt-long ncRNA (X26nt) is generated in the process of inositol requiring-enzyme 1 alpha (IRE1alpha) induced unspliced XBP1 splicing. Inositol 58-66 X-box binding protein 1 Homo sapiens 122-126 33254564-5 2020 In addition, myo-inositol has been found able to decrease the levels of IL-6 in several experimental settings, due to an effect on the inositol-requiring enzyme 1 (IRE1)-X-box-binding protein 1 (XBP1) and on the signal transducer and activator of transcription 3 (STAT3) pathways. Inositol 13-25 X-box binding protein 1 Homo sapiens 170-193 33396378-6 2020 In the ER, TNFalpha selectively phosphorylates inositol-requiring enzyme 1 alpha (pIRE1alpha) triggering downstream splicing of the transcription factor X-box binding protein 1 (XBP1s); thus, activating the pIRE1alpha/XBP1s ER stress pathway. Inositol 47-55 X-box binding protein 1 Homo sapiens 153-176 33396378-6 2020 In the ER, TNFalpha selectively phosphorylates inositol-requiring enzyme 1 alpha (pIRE1alpha) triggering downstream splicing of the transcription factor X-box binding protein 1 (XBP1s); thus, activating the pIRE1alpha/XBP1s ER stress pathway. Inositol 47-55 X-box binding protein 1 Homo sapiens 178-182 33254564-5 2020 In addition, myo-inositol has been found able to decrease the levels of IL-6 in several experimental settings, due to an effect on the inositol-requiring enzyme 1 (IRE1)-X-box-binding protein 1 (XBP1) and on the signal transducer and activator of transcription 3 (STAT3) pathways. Inositol 13-25 X-box binding protein 1 Homo sapiens 195-199 31329612-2 2019 Upon accumulation of the UPR-converted XBP1 mRNA splicing from an unspliced (u) XBP1 (inactive) isoform to the spliced (s) XBP1 (active) isoform, inositol-requiring enzyme 1 alpha (IRE1alpha) removes a 26-nucleotide intron from uXBP1 mRNA. Inositol 146-154 X-box binding protein 1 Homo sapiens 39-43 32061752-3 2020 The inositol-requiring enzyme 1alpha (IRE1alpha), an arm of unfolded protein response (UPR), splices XBP1 mRNA to generate an active transcription factor XBP1s. Inositol 4-12 X-box binding protein 1 Homo sapiens 101-105 31285958-6 2019 Activation of inositol-requiring enzyme 1alpha (IRE1alpha)-mRNA X-box binding protein 1 (XBP1) pathway and spliced XBP1 (XBP1s) expression were analyzed by Western blot, Phos-tag gel assay, RT-PCR, qRT-PCR and flow cytometry. Inositol 14-22 X-box binding protein 1 Homo sapiens 64-87 31205564-2 2019 As the most conserved branch among the three un-folded protein response (UPR) pathways, Inositol-requiring enzyme 1alpha (IRE1alpha)-X-box-binding protein 1 (XBP1) signaling has been implicated in cancer development and progression. Inositol 88-96 X-box binding protein 1 Homo sapiens 133-156 31205564-2 2019 As the most conserved branch among the three un-folded protein response (UPR) pathways, Inositol-requiring enzyme 1alpha (IRE1alpha)-X-box-binding protein 1 (XBP1) signaling has been implicated in cancer development and progression. Inositol 88-96 X-box binding protein 1 Homo sapiens 158-162 30214606-1 2018 Of the three unfolded protein response pathways, which are activated by endoplasmic reticulum stress, inositol-requiring enzyme 1alpha (IRE1alpha)-X-box-binding protein 1 (XBP1) signaling is the most conserved. Inositol 102-110 X-box binding protein 1 Homo sapiens 147-170 30214606-1 2018 Of the three unfolded protein response pathways, which are activated by endoplasmic reticulum stress, inositol-requiring enzyme 1alpha (IRE1alpha)-X-box-binding protein 1 (XBP1) signaling is the most conserved. Inositol 102-110 X-box binding protein 1 Homo sapiens 172-176 29534223-2 2018 Glandular dysfunction could be partly the consequence of an altered inositol-requiring enzyme 1alpha (IRE1alpha)/X box-binding protein 1 (XBP-1) signalling pathway of the unfolded protein response, which then regulates genes involved in biogenesis of the secretory machinery. Inositol 68-76 X-box binding protein 1 Homo sapiens 113-136 29534223-2 2018 Glandular dysfunction could be partly the consequence of an altered inositol-requiring enzyme 1alpha (IRE1alpha)/X box-binding protein 1 (XBP-1) signalling pathway of the unfolded protein response, which then regulates genes involved in biogenesis of the secretory machinery. Inositol 68-76 X-box binding protein 1 Homo sapiens 138-143 29381485-2 2018 Here, we show that Myc overexpression induces endoplasmic reticulum (ER) stress and engages the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway through multiple molecular mechanisms in a variety of c-Myc- and N-Myc-dependent cancers. Inositol 96-104 X-box binding protein 1 Homo sapiens 141-164 29381485-2 2018 Here, we show that Myc overexpression induces endoplasmic reticulum (ER) stress and engages the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway through multiple molecular mechanisms in a variety of c-Myc- and N-Myc-dependent cancers. Inositol 96-104 X-box binding protein 1 Homo sapiens 166-170 28835517-5 2017 Further investigation revealed that VCP inhibitors cooperated with M1 virus-suppressed inositol-requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) pathway and triggered irresolvable endoplasmic reticulum (ER) stress, subsequently promoting robust apoptosis in HCC. Inositol 87-95 X-box binding protein 1 Homo sapiens 132-155 30109813-1 2018 Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the sensor inositol-requiring enzyme 1alpha (IRE1), an endoribonuclease that splices the mRNA of the transcription factor XBP1 (X-box-binding protein 1). Inositol 88-96 X-box binding protein 1 Homo sapiens 199-203 30109813-1 2018 Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the sensor inositol-requiring enzyme 1alpha (IRE1), an endoribonuclease that splices the mRNA of the transcription factor XBP1 (X-box-binding protein 1). Inositol 88-96 X-box binding protein 1 Homo sapiens 205-228 28882789-1 2017 A previous study found that inositol-requiring enzyme-1-X-box binding protein 1 (IRE1-XBP1) pathway and the protein kinase RNA (PKR)-like ER kinase-eIF2alpha (PERK-eIF2alpha) pathway of shrimp play roles in the unfolded protein response (UPR). Inositol 28-36 X-box binding protein 1 Homo sapiens 86-90 28847931-3 2017 During ER stress, the inositol requiring enzyme 1alpha (IRE1alpha) endoribonuclease (RNase), a key mediator of the UPR, cleaves Xbp1 mRNA to generate a potent transcription factor adaptive toward ER stress. Inositol 22-30 X-box binding protein 1 Homo sapiens 128-132 28835517-5 2017 Further investigation revealed that VCP inhibitors cooperated with M1 virus-suppressed inositol-requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) pathway and triggered irresolvable endoplasmic reticulum (ER) stress, subsequently promoting robust apoptosis in HCC. Inositol 87-95 X-box binding protein 1 Homo sapiens 157-161 28867746-6 2017 We found that MeHg specifically attenuated inositol-requiring enzyme 1alpha (IRE1alpha)-x-box binding protein 1 (XBP1) branch, but not the protein kinase RNA-like endoplasmic reticulum kinase (PERK) and activating transcriptional factor 6 (ATF6) branches. Inositol 43-51 X-box binding protein 1 Homo sapiens 88-111 28867746-6 2017 We found that MeHg specifically attenuated inositol-requiring enzyme 1alpha (IRE1alpha)-x-box binding protein 1 (XBP1) branch, but not the protein kinase RNA-like endoplasmic reticulum kinase (PERK) and activating transcriptional factor 6 (ATF6) branches. Inositol 43-51 X-box binding protein 1 Homo sapiens 113-117 26621917-8 2016 Because PA activates ER stress, we used KO hepatocytes to demonstrate that PA-induced EV release was mediated by inositol requiring enzyme 1alpha (IRE1alpha)/X-box binding protein-1. Inositol 113-121 X-box binding protein 1 Homo sapiens 158-181 26823555-6 2016 The transcription factors spliced X-box-binding protein 1 and p65, which are activated by inositol-requiring enzyme 1alpha upon ER stress, each bound the angiogenin promoter and controlled the amount of angiogenin secreted. Inositol 90-98 X-box binding protein 1 Homo sapiens 34-57 26331676-3 2015 Recent findings have linked endoplasmic reticulum stress responses mediated by inositol-requiring enzyme 1alpha-dependent messenger RNA splicing (activation) of X-box-binding protein-1 (XBP-1s) to inflammation in peripheral macrophages. Inositol 79-87 X-box binding protein 1 Homo sapiens 161-184 26315405-4 2015 In vitro studies indicated that platelet-derived growth factor-BB triggered XBP1 splicing in SMCs via the interaction between platelet-derived growth factor receptor beta and the inositol-requiring enzyme 1alpha. Inositol 179-187 X-box binding protein 1 Homo sapiens 76-80 24915138-6 2014 The slight increase in the spliced form of X-box binding protein 1 (XBP1s) together with the decrease of the unspliced form (XBP1u) indicated a higher endoribonuclease activity of inositol-requiring 1alpha (IRE1alpha). Inositol 180-188 X-box binding protein 1 Homo sapiens 43-66 26068456-6 2015 Our results reveal the presence of basal unconventional splicing of XBP1 mRNA in the nucleus that also requires inositol-requiring transmembrane kinase and endonuclease 1alpha (IRE1alpha) and can occur independently of acute ER stress. Inositol 112-120 X-box binding protein 1 Homo sapiens 68-72 25821218-4 2015 In this study, we found that ER stress-induced inositol-requiring enzyme (IRE)1alpha activation differentially regulates proinflammatory cytokine gene expression via activation of glycogen synthase kinase (GSK)-3beta and X-box binding protein (XBP)-1. Inositol 47-55 X-box binding protein 1 Homo sapiens 221-250 24356728-2 2015 The inositol-requiring enzyme 1-X-box binding protein-1 (IRE1-XBP-1) arm of the UPR pathway has been shown to play crucial roles not only in relieving the ER stress by up-regulating a series of genes favoring ER-associated protein degradation and protein folding, but in mediating terminal plasmacytic differentiation and maturation. Inositol 4-12 X-box binding protein 1 Homo sapiens 62-67 21723843-2 2011 The endoplasmic reticulum (ER) stress response component inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) axis is essential for MM pathogenesis. Inositol 57-65 X-box binding protein 1 Homo sapiens 102-125 22538852-2 2012 Inositol-requiring enzyme 1alpha (IRE1alpha) is activated to splice X-box binding protein 1 (XBP1) mRNA, thereby increasing XBP1s protein, which in turn regulates genes responsible for protein folding and degradation during the unfolded protein response. Inositol 0-8 X-box binding protein 1 Homo sapiens 68-91 22538852-2 2012 Inositol-requiring enzyme 1alpha (IRE1alpha) is activated to splice X-box binding protein 1 (XBP1) mRNA, thereby increasing XBP1s protein, which in turn regulates genes responsible for protein folding and degradation during the unfolded protein response. Inositol 0-8 X-box binding protein 1 Homo sapiens 93-97 21723843-2 2011 The endoplasmic reticulum (ER) stress response component inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) axis is essential for MM pathogenesis. Inositol 57-65 X-box binding protein 1 Homo sapiens 127-131 21703863-3 2011 Specifically, recent studies indicate a crucial role for the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway, the most conserved branch of the unfolded protein response (UPR), in glucose and lipid metabolism as well as in insulin function. Inositol 61-69 X-box binding protein 1 Homo sapiens 106-129 21757700-1 2011 Inositol-requiring enzyme 1alpha (IRE1alpha), an endoplasmic reticulum-resident sensor for mammalian unfolded protein response, is a bifunctional enzyme containing kinase and RNase domains critical for trans-autophosphorylation and Xbp1 mRNA splicing, respectively, in response to endoplasmic reticulum stress. Inositol 0-8 X-box binding protein 1 Homo sapiens 232-236 21703863-3 2011 Specifically, recent studies indicate a crucial role for the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway, the most conserved branch of the unfolded protein response (UPR), in glucose and lipid metabolism as well as in insulin function. Inositol 61-69 X-box binding protein 1 Homo sapiens 131-135 20146926-1 2010 Inositol requiring enzyme-1alpha (IRE1alpha) is an ER-located transmembrane RNase whose activation leads to the production of the transcription factor X-box binding protein 1 (XBP1). Inositol 0-8 X-box binding protein 1 Homo sapiens 151-174 21233347-1 2011 Upon endoplasmic reticulum (ER) stress, an endoribonuclease, inositol-requiring enzyme-1alpha, splices the precursor unspliced form of X-box-binding protein 1 messenger RNA (XBP1u mRNA) on the ER membrane to yield an active transcription factor (XBP1s), leading to the alleviation of the stress. Inositol 61-69 X-box binding protein 1 Homo sapiens 135-158 20146926-1 2010 Inositol requiring enzyme-1alpha (IRE1alpha) is an ER-located transmembrane RNase whose activation leads to the production of the transcription factor X-box binding protein 1 (XBP1). Inositol 0-8 X-box binding protein 1 Homo sapiens 176-180 35625730-11 2022 In conclusion, PA treatment induced ER stress and activated the inositol-requiring enzyme 1 alpha-spliced XBP1 (IRE1alpha-XBP1s) pathway. Inositol 64-72 X-box binding protein 1 Homo sapiens 106-110 17464326-8 2007 CdCl(2) also triggered activation of the inositol-requiring ER-to-nucleus signal kinase 1 (IRE1)-X-box-binding protein 1 (XBP1) pathway and inhibition of XBP1 attenuated apoptosis independent of GRP78 and CHOP. Inositol 41-49 X-box binding protein 1 Homo sapiens 97-120 17464326-8 2007 CdCl(2) also triggered activation of the inositol-requiring ER-to-nucleus signal kinase 1 (IRE1)-X-box-binding protein 1 (XBP1) pathway and inhibition of XBP1 attenuated apoptosis independent of GRP78 and CHOP. Inositol 41-49 X-box binding protein 1 Homo sapiens 122-126 17380188-4 2007 All four subunits are induced simultaneously by endoplasmic reticulum stresses from the X-box-binding protein 1/inositol-requiring 1alpha pathway. Inositol 112-120 X-box binding protein 1 Homo sapiens 88-111 16461360-1 2006 Upon the accumulation of unfolded proteins in the mammalian endoplasmic reticulum (ER), X-box binding protein 1 (XBP1) premessenger RNA (premRNA) is converted to mature mRNA by unconventional splicing that is mediated by the endonuclease inositol-requiring enzyme 1. Inositol 238-246 X-box binding protein 1 Homo sapiens 88-111 16461360-1 2006 Upon the accumulation of unfolded proteins in the mammalian endoplasmic reticulum (ER), X-box binding protein 1 (XBP1) premessenger RNA (premRNA) is converted to mature mRNA by unconventional splicing that is mediated by the endonuclease inositol-requiring enzyme 1. Inositol 238-246 X-box binding protein 1 Homo sapiens 113-117 35017615-5 2022 Mainly the inositol-requiring enzyme 1alpha branch of the UPR was upregulated as shown by elevated X-box binding-protein 1 (XBP1u) and its spliced isoform (XBP1s) mRNA (p < 0.05, respectively). Inositol 11-19 X-box binding protein 1 Homo sapiens 99-122