PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30595691-3 2018 Moreover, intracellular glucose is required for de novo biosynthesis of inositol through the inositol-3-phosphate synthase 1 pathway, while a few glucose-related metabolites, like sorbitol, reduce intracellular levels of inositol. Inositol 72-80 inositol-3-phosphate synthase 1 Homo sapiens 93-124 17121275-1 2006 The first and rate-limiting step in the biosynthesis of myo-inositol is the conversion of D-glucose 6-phosphate to 1L-myo-inositol 1-phosphate catalyzed by 1L-myo-inositol 1-phosphate synthase (MIP synthase). Inositol 56-68 inositol-3-phosphate synthase 1 Homo sapiens 194-206 26951199-1 2016 Inositol levels, maintained by the biosynthetic enzyme inositol-3-phosphate synthase (Ino1), are altered in a range of disorders, including bipolar disorder and Alzheimer"s disease. Inositol 0-8 inositol-3-phosphate synthase 1 Homo sapiens 86-90 26951199-4 2016 We show that loss of Ino1 results in an inositol auxotrophy that can be rescued only partially by exogenous inositol. Inositol 40-48 inositol-3-phosphate synthase 1 Homo sapiens 21-25 26951199-4 2016 We show that loss of Ino1 results in an inositol auxotrophy that can be rescued only partially by exogenous inositol. Inositol 108-116 inositol-3-phosphate synthase 1 Homo sapiens 21-25 26951199-5 2016 Removal of inositol supplementation from the ino1(-) mutant resulted in a rapid 56% reduction in inositol levels, triggering the induction of autophagy, reduced cytokinesis, and substrate adhesion. Inositol 11-19 inositol-3-phosphate synthase 1 Homo sapiens 45-49 26951199-5 2016 Removal of inositol supplementation from the ino1(-) mutant resulted in a rapid 56% reduction in inositol levels, triggering the induction of autophagy, reduced cytokinesis, and substrate adhesion. Inositol 97-105 inositol-3-phosphate synthase 1 Homo sapiens 45-49 25345501-6 2015 Interestingly, the inhibition of inositol synthesis by knocking down INO1, which encodes inositol-3-phosphate synthase, the rate-limiting enzyme of inositol synthesis, led to the inactivation of GSK-3alpha by increasing the inhibitory phosphorylation of this kinase. Inositol 33-41 inositol-3-phosphate synthase 1 Homo sapiens 69-73 25345501-6 2015 Interestingly, the inhibition of inositol synthesis by knocking down INO1, which encodes inositol-3-phosphate synthase, the rate-limiting enzyme of inositol synthesis, led to the inactivation of GSK-3alpha by increasing the inhibitory phosphorylation of this kinase. Inositol 89-97 inositol-3-phosphate synthase 1 Homo sapiens 69-73 27035231-0 2016 Regulation of myo-inositol biosynthesis by p53-ISYNA1 pathway. Inositol 14-26 inositol-3-phosphate synthase 1 Homo sapiens 47-53 27035231-6 2016 We also indicated that inositol 3-phosphate synthase (ISYNA1) which encodes an enzyme essential for myo-inositol biosynthesis as a direct target of p53. Inositol 100-112 inositol-3-phosphate synthase 1 Homo sapiens 54-60 27035231-8 2016 Ectopic ISYNA1 expression increased myo-inositol levels in the cells and suppressed tumor cell growth. Inositol 36-48 inositol-3-phosphate synthase 1 Homo sapiens 8-14 19754467-3 2009 Inositol is taken up by neurons from the extracellular fluid, presumably via membrane transporters; it can also be synthesized by the enzyme MIP-synthase (myo-inositol-1-phosphate synthase) and, in addition, it is generated by inositol phospholipid hydrolysis. Inositol 0-8 inositol-3-phosphate synthase 1 Homo sapiens 141-153 15024000-5 2004 Expression of the protein in the yeast ino1Delta mutant lacking MIP synthase (ino1Delta/hINO1) complemented the inositol auxotrophy of the mutant and led to inositol excretion. Inositol 112-120 inositol-3-phosphate synthase 1 Homo sapiens 64-76 15634688-3 2005 The ino1 mutant displayed wild-type growth rates and steady-state levels of PI, PIM, and LAM when grown in the presence of 1 mM inositol. Inositol 128-136 inositol-3-phosphate synthase 1 Homo sapiens 4-8 15634688-4 2005 The non-dividing ino1 mutant was highly resistant to inositol starvation, reflecting the slow turnover of inositol lipids in this stage. Inositol 53-61 inositol-3-phosphate synthase 1 Homo sapiens 17-21 15634688-5 2005 In contrast, dilution of growing or stationary-phase ino1 mutant in inositol-free medium resulted in the rapid depletion of PI and apolar PIMs. Inositol 68-76 inositol-3-phosphate synthase 1 Homo sapiens 53-57 15024000-5 2004 Expression of the protein in the yeast ino1Delta mutant lacking MIP synthase (ino1Delta/hINO1) complemented the inositol auxotrophy of the mutant and led to inositol excretion. Inositol 112-120 inositol-3-phosphate synthase 1 Homo sapiens 88-93 15024000-5 2004 Expression of the protein in the yeast ino1Delta mutant lacking MIP synthase (ino1Delta/hINO1) complemented the inositol auxotrophy of the mutant and led to inositol excretion. Inositol 157-165 inositol-3-phosphate synthase 1 Homo sapiens 64-76 15024000-5 2004 Expression of the protein in the yeast ino1Delta mutant lacking MIP synthase (ino1Delta/hINO1) complemented the inositol auxotrophy of the mutant and led to inositol excretion. Inositol 157-165 inositol-3-phosphate synthase 1 Homo sapiens 88-93 12941308-1 2003 myo-Inositol 1-phosphate synthase (EC 5.5.1.4) (IPS) is a key enzyme in myo-inositol biosynthesis pathway. Inositol 72-84 inositol-3-phosphate synthase 1 Homo sapiens 48-51 10713523-1 2000 The conversion of glucose 6-phosphate to 1-L-myo-inositol 1--phosphate (MIP) by 1-L-myo-inositol 1-phosphate synthase (MIP synthase) is the first committed and rate-limiting step in the de novo biosynthesis of inositol in all eukaryotes. Inositol 49-57 inositol-3-phosphate synthase 1 Homo sapiens 119-131 11840310-6 2002 Epi-inositol affects regulation of expression of the INO1 gene (encoding inositol-1-P synthase), even though it cannot support growth of an inositol auxotroph (suggesting that, as in mammalian cells, it is not incorporated into phosphatidylinositol). Inositol 0-12 inositol-3-phosphate synthase 1 Homo sapiens 53-57 11840310-6 2002 Epi-inositol affects regulation of expression of the INO1 gene (encoding inositol-1-P synthase), even though it cannot support growth of an inositol auxotroph (suggesting that, as in mammalian cells, it is not incorporated into phosphatidylinositol). Inositol 4-12 inositol-3-phosphate synthase 1 Homo sapiens 53-57 34531253-5 2022 We use gain- and loss-of-function experiments to reveal a synthetic lethal genetic interaction between ISYNA1 and SLC5A3 in AML, which function redundantly to sustain intracellular myo-inositol. Inositol 181-193 inositol-3-phosphate synthase 1 Homo sapiens 103-109 35247568-7 2022 Knockout of ISYNA1 (encoding myo-inositol-3-P synthase 1) in HEK293T cells generated a human cell line that is deficient in de novo inositol synthesis. Inositol 132-140 inositol-3-phosphate synthase 1 Homo sapiens 12-18 35247568-7 2022 Knockout of ISYNA1 (encoding myo-inositol-3-P synthase 1) in HEK293T cells generated a human cell line that is deficient in de novo inositol synthesis. Inositol 132-140 inositol-3-phosphate synthase 1 Homo sapiens 29-56 35247568-8 2022 ISYNA1-KO cells exhibited inositol-less death when deprived of inositol. Inositol 26-34 inositol-3-phosphate synthase 1 Homo sapiens 0-6 35247568-8 2022 ISYNA1-KO cells exhibited inositol-less death when deprived of inositol. Inositol 63-71 inositol-3-phosphate synthase 1 Homo sapiens 0-6 35462605-3 2022 Accordingly, many cancers have been documented to silence expression of the ISYNA1 gene, which encodes the rate-limiting enzyme of inositol synthesis. Inositol 131-139 inositol-3-phosphate synthase 1 Homo sapiens 76-82 35073444-6 2022 Myo-inositol, in quantities that is present in FPP, significantly improved macrophage respiratory burst and phagocytosis via de novo synthesis pathway of ISYNA1. Inositol 0-12 inositol-3-phosphate synthase 1 Homo sapiens 154-160