PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11160764-2 2001 Activated cytosolic phospholipase (cPLA2) catalyzes the production of arachidonic acid, which is converted by cyclooxygenases into leukotriene A4 (LTA4) and subsequently into the chemotaxin LTB4, which has no direct bronchoconstrictor activity. Leukotriene A4 131-145 phospholipase A2 group IVA Homo sapiens 35-40 18042000-1 2007 Leukotriene B(4) (LTB(4)) is a lipid inflammatory mediator derived from membrane phospholipids by the sequential actions of cytosolic phospholipase A2 (PLA2), 5-lipoxygenase (5-LO) and leukotriene A(4) (LTA(4)) hydrolase. Leukotriene A4 185-198 phospholipase A2 group IVA Homo sapiens 124-150 9620944-1 1998 Cytosolic phospholipase A2 translocates from the cytoplasm to selectively hydrolyze nuclear envelope phospholipids, releasing free arachidonate. 5-Lipoxygenase-activating protein, an arachidonate transfer protein, then binds arachidonate and presents it to 5-lipoxygenase (5-LO), which catalyzes a two-step reaction to produce leukotriene A4. In resting human and rat peripheral blood neutrophils, 5-LO is localized to the cytoplasm; in rat basophilic leukemia cells and human alveolar macrophages, however, it is found predominantly in the nucleus. Leukotriene A4 328-342 phospholipase A2 group IVA Homo sapiens 1-27 30606731-2 2019 When inflammatory cells are activated, 5-LO translocates to the nuclear membrane to initiate oxygenation of AA released by cytosolic phospholipase A2 (cPLA2) into leukotriene A4 (LTA4). Leukotriene A4 163-177 phospholipase A2 group IVA Homo sapiens 151-156