PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22913921-0 2012 In silico modeling of the molecular structure and binding of leukotriene A4 into leukotriene A4 hydrolase. Leukotriene A4 61-75 leukotriene A4 hydrolase Homo sapiens 81-105 11601994-1 2001 Leukotriene A(4) hydrolase in mammals is a bifunctional zinc metalloenzyme that catalyzes the hydrolysis of leukotriene A(4) into the proinflammatory mediator leukotriene B(4), and also possesses an aminopeptidase activity. Leukotriene A4 108-121 leukotriene A4 hydrolase Homo sapiens 0-26 18539590-2 2008 In agreement with their sequence similarity, the overall structure of ColAP displayed a high correspondence with leukotriene A4 hydrolase (LTA4H), a human bifunctional enzyme that converts leukotriene A4 (LTA4) in the potent chemoattractant leukotriene B4. Leukotriene A4 113-127 leukotriene A4 hydrolase Homo sapiens 139-144 18674901-1 2008 We studied the synthetic modification of structurally similar N-mercaptoacyl-L-proline and (4R)-N-mercaptoacylthiazolidine-4-carboxylic acid to obtain potent leukotriene A(4) (LTA(4)) hydrolase inhibitors. Leukotriene A4 158-171 leukotriene A4 hydrolase Homo sapiens 176-193 11601994-8 2001 Exchange of a Phe-424 in S. cerevisiae leukotriene A(4) hydrolase for a Tyr, the corresponding residue in human leukotriene A(4) hydrolase, results in a protein that converts leukotriene A(4) into leukotriene B(4) with an improved efficiency and specificity. Leukotriene A4 39-52 leukotriene A4 hydrolase Homo sapiens 112-138 11601994-9 2001 Hence, by a single point mutation, we could make the active site better suited to bind and turn over the substrate leukotriene A(4), thus mimicking a distinct step in the molecular evolution of S. cerevisiae leukotriene A(4) hydrolase toward its mammalian counterparts. Leukotriene A4 115-128 leukotriene A4 hydrolase Homo sapiens 208-234 8798687-0 1996 Leukotriene A4 hydrolase, mutation of tyrosine 378 allows conversion of leukotriene A4 into an isomer of leukotriene B4. Leukotriene A4 72-86 leukotriene A4 hydrolase Homo sapiens 0-24 10940725-1 2000 BACKGROUND/AIMS: Leukotriene A(4) (LTA(4)) hydrolase catalyzes the final step in the synthesis of leukotriene B(4) (LTB(4)). Leukotriene A4 17-30 leukotriene A4 hydrolase Homo sapiens 35-52 8798687-1 1996 Leukotriene A4 hydrolase catalyzes the final step in the biosynthesis of the proinflammatory compound leukotriene B4, a reaction which is accompanied by suicide inactivation of the enzyme by leukotriene A4. Leukotriene A4 191-205 leukotriene A4 hydrolase Homo sapiens 0-24 8706657-9 1996 Conversion of leukotriene A4 into compound X was due to an enzymatic activity as judged by its protein dependence, heat sensitivity, and resistance to ultrafiltration, and this activity appeared to be linked, directly or indirectly,, to leukotriene A4 hydrolase. Leukotriene A4 14-28 leukotriene A4 hydrolase Homo sapiens 237-261 8555027-1 1995 Leukotriene A4 hydrolase is a bifunctional cytosolic enzyme, which both hydrolyses leukotriene A4 (LTA4) into leukotriene B4 (LTB4) and exerts aminopeptidase activity against opioid peptides. Leukotriene A4 83-97 leukotriene A4 hydrolase Homo sapiens 0-24 2837199-4 1988 Several established cell lines of B and T lymphocytic origin were also found to convert leukotriene A4 into leukotriene B4, showing that monoclonal lymphocytic cells possess leukotriene A4 hydrolase activity. Leukotriene A4 88-102 leukotriene A4 hydrolase Homo sapiens 174-198 7649151-7 1995 Kinetic analysis was performed with the mutant [Y383Q]LTA4 hydrolase, which revealed an approximately 10-fold increase in Km for leukotriene A4 compared to that for the unmutated enzyme. Leukotriene A4 129-143 leukotriene A4 hydrolase Homo sapiens 54-68 7582974-4 1995 Possible LTA4 binding modes in the active site of LTA4 hydrolase, including a possible direct role for the carboxylic acid of LTA4 in the enzyme-catalyzed hydrolysis of leukotriene A4, are discussed. Leukotriene A4 169-183 leukotriene A4 hydrolase Homo sapiens 50-64 8157657-11 1994 Although the primary role of LTA4 hydrolase is widely regarded as the conversion of the lipid substrate leukotriene A4 into the inflammatory lipid mediator leukotriene B4, our data are the first showing that tripeptides are "better" substrates. Leukotriene A4 104-118 leukotriene A4 hydrolase Homo sapiens 29-43 2168394-12 1990 Results conform to criteria for a mechanism-based inactivation, in which leukotriene A4 participates in two parallel processes, one leading to leukotriene B4 formation, the other to "suicide" inactivation of leukotriene A4 hydrolase in intact erythrocytes. Leukotriene A4 73-87 leukotriene A4 hydrolase Homo sapiens 208-232 3006048-6 1986 Biosynthesis of leukotriene B4 within the erythrocyte, from neutrophil-derived leukotriene A4, was established by comparing the effect of normal erythrocytes with erythrocytes containing a leukotriene A4 hydrolase that was inactivated by the substrate. Leukotriene A4 79-93 leukotriene A4 hydrolase Homo sapiens 189-213 2996528-2 1985 Both rat and human LTA4 hydrolase utilized leukotriene A5 less effectively as a substrate than leukotriene A4. Leukotriene A4 95-109 leukotriene A4 hydrolase Homo sapiens 19-33 2996528-6 1985 Leukotriene A5 was an inhibitor of the formation of leukotriene B4 from leukotriene A4 by both the rat and human neutrophil LTA4 hydrolase. Leukotriene A4 72-86 leukotriene A4 hydrolase Homo sapiens 124-138 30058075-4 2018 In particular, leukotriene B4, which is converted from leukotriene A4 by leukotriene A4 hydrolase (LTA4H), has been implicated in several types of cancer. Leukotriene A4 55-69 leukotriene A4 hydrolase Homo sapiens 73-97 6329309-13 1984 Since delta 6-trans-leukotriene B4 represents the nonenzymatic decomposition of leukotriene A4, we suggest that one of the rate-limiting steps in the synthesis of leukotriene B4 is the leukotriene A4 hydrolase. Leukotriene A4 80-94 leukotriene A4 hydrolase Homo sapiens 185-209 33896285-1 2021 Leukotriene A4 hydrolase (LTA4H) is an important anti-inflammatory target which can convert leukotriene A4 (LTA4) into pro-inflammatory substance leukotriene B4 (LTB4). Leukotriene A4 92-106 leukotriene A4 hydrolase Homo sapiens 0-24 33896285-1 2021 Leukotriene A4 hydrolase (LTA4H) is an important anti-inflammatory target which can convert leukotriene A4 (LTA4) into pro-inflammatory substance leukotriene B4 (LTB4). Leukotriene A4 92-106 leukotriene A4 hydrolase Homo sapiens 26-31 33896285-1 2021 Leukotriene A4 hydrolase (LTA4H) is an important anti-inflammatory target which can convert leukotriene A4 (LTA4) into pro-inflammatory substance leukotriene B4 (LTB4). Leukotriene A4 26-30 leukotriene A4 hydrolase Homo sapiens 0-24 30058075-4 2018 In particular, leukotriene B4, which is converted from leukotriene A4 by leukotriene A4 hydrolase (LTA4H), has been implicated in several types of cancer. Leukotriene A4 55-69 leukotriene A4 hydrolase Homo sapiens 99-104 28132911-1 2017 Leukotriene A4 hydrolase is a soluble enzyme with epoxide hydrolase and aminopeptidase activities catalysing the conversion of leukotriene A4 to leukotriene B4 and the hydrolysis of the peptide proline-glycine-proline. Leukotriene A4 127-141 leukotriene A4 hydrolase Homo sapiens 0-24