PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12895593-4	2003	The K(m) and V(max) values of human LTC(4) synthase are 3.6 microM and 1.3 micromol/mg/min for LTA(4) and 1.6 mM and 2.7 micromol/mg/min for GSH, respectively.	Leukotriene A4	95-98	leukotriene C4 synthase	Homo sapiens	36-51	
9988463-6	1998	Leukotriene A4 subsequently becomes a substrate for one of two enzymes, leukotriene A4 epoxide hydrolase or LTC4 synthase.	Leukotriene A4	0-14	leukotriene C4 synthase	Homo sapiens	108-121	
9153254-1	1997	The functional characteristics of leukotriene C4 synthase (LTC4S), which specifically conjugates leukotriene A4 with GSH, were assessed by mutagenic analysis.	Leukotriene A4	97-111	leukotriene C4 synthase	Homo sapiens	34-57	
9554994-0	1998	Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase.	Leukotriene A4	48-62	leukotriene C4 synthase	Homo sapiens	66-89	
9153254-1	1997	The functional characteristics of leukotriene C4 synthase (LTC4S), which specifically conjugates leukotriene A4 with GSH, were assessed by mutagenic analysis.	Leukotriene A4	97-111	leukotriene C4 synthase	Homo sapiens	59-64	
8052639-0	1994	Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4.	Leukotriene A4	128-142	leukotriene C4 synthase	Homo sapiens	39-62	
24974917-2	2014	Leukotriene C4 synthase (LTC4S) is a nuclear-membrane enzyme responsible for the conjugation of leukotriene A4 (LTA4) to glutathione to form LTC4, a cysteinyl leukotriene.	Leukotriene A4	96-110	leukotriene C4 synthase	Homo sapiens	0-23	
8305492-1	1994	Human platelets are devoid of 5-lipoxygenase activity but convert exogenous leukotriene A4 (LTA4) either by a specific LTC4 synthase to leukotriene C4 or via a 12-lipoxygenase mediated reaction to lipoxins.	Leukotriene A4	76-90	leukotriene C4 synthase	Homo sapiens	119-132	
27477678-2	2016	They are formed by 5-lipoxygenase (5-LOX) from arachidonic acid (AA) yielding the unstable leukotriene A4 (LTA4) that is subsequently conjugated with glutathione (GSH) by LTC4 synthase (LTC4S).	Leukotriene A4	91-105	leukotriene C4 synthase	Homo sapiens	171-184	
27477678-2	2016	They are formed by 5-lipoxygenase (5-LOX) from arachidonic acid (AA) yielding the unstable leukotriene A4 (LTA4) that is subsequently conjugated with glutathione (GSH) by LTC4 synthase (LTC4S).	Leukotriene A4	91-105	leukotriene C4 synthase	Homo sapiens	186-191	
7914721-8	1994	These results indicate that human skin contains leukotriene C4 synthase activity capable of producing significant amounts of leukotriene C4 from leukotriene A4, and that the keratinocytes may play a more active role in peptide leukotriene formation in the skin than previously thought.	Leukotriene A4	145-159	leukotriene C4 synthase	Homo sapiens	48-71	
1312812-5	1992	As determined with leukotriene C4 synthase of a crude membrane fraction from human platelets, the Km value was 7 microM and the V value was 0.56 nmol x min-1 x mg-1 with leukotriene A4 as substrate.	Leukotriene A4	170-184	leukotriene C4 synthase	Homo sapiens	19-42	
24974917-2	2014	Leukotriene C4 synthase (LTC4S) is a nuclear-membrane enzyme responsible for the conjugation of leukotriene A4 (LTA4) to glutathione to form LTC4, a cysteinyl leukotriene.	Leukotriene A4	96-110	leukotriene C4 synthase	Homo sapiens	25-30	
17623009-2	2007	The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotriene C4) by LTC4 synthase.	Leukotriene A4	39-53	leukotriene C4 synthase	Homo sapiens	169-182