PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2692455-4	1989	Endothelin showed a slight but significant inhibitory effect on renin release stimulated by isoproterenol or TMB-8 even in the absence of extracellular Ca.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	109-114	renin	Rattus norvegicus	64-69	
2553324-9	1989	8-(N.N-Diethylamino)octyl-3,4,5-trimethoxybenzoate</compound-id> (TMB-8) reduces the release of Ca2+ from intracellular stores and, studied over a range of concentrations, this compound increased renin release.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	66-71	renin	Rattus norvegicus	196-201	
2553324-14	1989	Effects of low [Ca2+], diltiazem and TMB-8 on renin secretion were all shown to be reversible when superfusion with control buffer was resumed.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	37-42	renin	Rattus norvegicus	46-51	
2856063-9	1988	The decrease in renin release was attenuated by calcium-interacting agents, such as nifedipine, TMB-8 and W-7, but these agents were without effect on the stimulation of the release by exposure to calcium.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	96-101	renin	Rattus norvegicus	16-21	
3018407-7	1986	Similarly, TMB-8 (0.6 X 10(-4) M), another agent thought to lower Cai, also resulted in increased renin release (455 to 810 ng X mg-1), p less than .01) which was also unaffected by the addition of the AP.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	11-16	renin	Rattus norvegicus	98-103	
3893987-7	1985	TMB-8, an inhibitor of intracellular calcium release, also caused a dose-related increase in basal renin release.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	0-5	renin	Rattus norvegicus	99-104	
3922379-0	1985	Stimulation of renin secretion by 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8).	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	34-84	renin	Rattus norvegicus	15-20	
3922379-0	1985	Stimulation of renin secretion by 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate (TMB-8).	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	86-91	renin	Rattus norvegicus	15-20	
3922379-3	1985	TMB-8 was a potent stimulant of renin secretion within the concentration range 10(-5)M to 5 X 10(-4)M with an optimum concentration of 2 X 10(-4)M. TMB-8 overcame the inhibition of renin secretion by angiotensin II, ouabain, 60 mM KCl and A23187.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	0-5	renin	Rattus norvegicus	32-37	
3922379-3	1985	TMB-8 was a potent stimulant of renin secretion within the concentration range 10(-5)M to 5 X 10(-4)M with an optimum concentration of 2 X 10(-4)M. TMB-8 overcame the inhibition of renin secretion by angiotensin II, ouabain, 60 mM KCl and A23187.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	0-5	renin	Rattus norvegicus	181-186	
3922379-3	1985	TMB-8 was a potent stimulant of renin secretion within the concentration range 10(-5)M to 5 X 10(-4)M with an optimum concentration of 2 X 10(-4)M. TMB-8 overcame the inhibition of renin secretion by angiotensin II, ouabain, 60 mM KCl and A23187.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	148-153	renin	Rattus norvegicus	32-37	
3922379-3	1985	TMB-8 was a potent stimulant of renin secretion within the concentration range 10(-5)M to 5 X 10(-4)M with an optimum concentration of 2 X 10(-4)M. TMB-8 overcame the inhibition of renin secretion by angiotensin II, ouabain, 60 mM KCl and A23187.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	148-153	renin	Rattus norvegicus	181-186	
1921644-0	1991	Calcium-dependent inhibition of renin secretion: TMB-8 is a non-specific antagonist.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	49-54	renin	Rattus norvegicus	32-37	
1921644-4	1991	Basal renin secretory rate was unaffected by 1 and 10 microM TMB-8, but more than doubled in response to 100 microM TMB-8.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	116-121	renin	Rattus norvegicus	6-11