PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34967850-11 2022 Highest vs. lowest quartiles of aggregated genetic risk scores from SNVs in MTHFR and MTRR were associated with 14.8% to 18.9% lower RBC folate concentrations. Folic Acid 137-143 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 86-90 34397023-0 2021 Individualized Supplement of Folic Acid Based on the Gene Polymorphisms of MTHER/MTRR Reduced the Incidence of Adverse Pregnancy Outcomes and Newborn Defects. Folic Acid 29-39 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 81-85 34917626-16 2021 Moreover, our results provide preliminary evidence for MTRR genetic polymorphisms, involving folate metabolism function, may be related to the susceptibility to agitation. Folic Acid 93-99 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 55-59 34397023-9 2021 Results: Based on the genotype of MTHFR and MTRR, women were identified as five risk levels of folic acid metabolism. Folic Acid 95-105 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 44-48 34169999-13 2021 CONCLUSION: We reported significant association between genetic alterations of folate metabolism (MTHFR, MTRR) and DNA repair mechanism (RAD54L) genes with the histopathological characteristics of the meningioma tumors. Folic Acid 79-85 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 105-109 35434830-2 2022 Methionine synthase reductase (MTRR) is one of the main targets of MTX in the folate metabolic pathways. Folic Acid 78-84 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 0-29 35434830-2 2022 Methionine synthase reductase (MTRR) is one of the main targets of MTX in the folate metabolic pathways. Folic Acid 78-84 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 31-35 33505124-1 2021 Methionine synthase reductase (MTRR) is an important enzyme of the folate/homocysteine pathway. Folic Acid 67-73 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 0-29 35489763-1 2022 BACKGROUND/AIM: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) is responsible for folate metabolism, and we aimed to investigate its genetic role in colorectal cancer (CRC) among Taiwanese. Folic Acid 108-114 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 54-81 35489763-1 2022 BACKGROUND/AIM: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) is responsible for folate metabolism, and we aimed to investigate its genetic role in colorectal cancer (CRC) among Taiwanese. Folic Acid 108-114 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 83-87 33497043-0 2021 A Association of MTHFR C677T and MTRR A66G Gene Polymorphisms with Iranian Male Infertility and Its Effect on Seminal Folate and Vitamin B12. Folic Acid 118-124 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 33-37 33505124-1 2021 Methionine synthase reductase (MTRR) is an important enzyme of the folate/homocysteine pathway. Folic Acid 67-73 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 31-35 32266834-5 2020 Results: The study demonstrates that the genetic variants in folate cycle and methionine cycle genes such as MTHFR, MTRR, MTR, BHMT and DNMT1 are associated with the risk of aneurysm. Folic Acid 61-67 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 116-120 33179601-5 2020 The re-methylation reaction not only involves the enzymes methionine synthase and methionine synthase reductase but also depends on the cofactor cobalamin and on the provision of methyl groups from the folate cycle. Folic Acid 202-208 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 82-111 32353563-1 2020 In eucaryotic cells, methionine synthase reductase (MSR/MTRR) is capable of dominating the folate-homocysteine metabolism as an irreplaceable partner in electron transfer for regeneration of methionine synthase. Folic Acid 91-97 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 52-55 32353563-1 2020 In eucaryotic cells, methionine synthase reductase (MSR/MTRR) is capable of dominating the folate-homocysteine metabolism as an irreplaceable partner in electron transfer for regeneration of methionine synthase. Folic Acid 91-97 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 56-60 33121283-1 2020 Objective: Although genetic variants of key enzymes in the folic acid-methionine metabolic circulation, including methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) were thought to be related to the risk of recurrent pregnancy loss (RPL), the results of recent studies have been inconsistent. Folic Acid 59-69 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 193-197 32238907-8 2020 Four exonic CpG-SNPs of MTHFD1, MTRR, and GGH genes were identified in folate pathway genes. Folic Acid 71-77 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 32-36 32203239-9 2020 RESULTS: MTHFD rs1950902 and MTRR rs162036, rs1801394 was associated with the folate treatment response (P = 0.000, 0.048, and 0.043, respectively). Folic Acid 78-84 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 29-33 32203239-11 2020 DNA methylation of MTHFR, MTR, and MTRR was also significantly associated with folate treatment response (P < 0.001). Folic Acid 79-85 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 35-39 31482954-1 2019 OBJECTIVE: To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS). Folic Acid 73-79 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 137-141 32146711-11 2020 CONCLUSION: MTR 2756A>G and MTRR 66A>G polymorphisms related to folate metabolism might be genetic markers for risk of hypertension in the Korean population. Folic Acid 64-70 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 28-32 31209768-0 2019 Associations of MTRR and TSER polymorphisms related to folate metabolism with susceptibility to metabolic syndrome. Folic Acid 55-61 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 16-20 29159983-5 2018 METHODS: Association between population prevalence of 17 variants in 9 folate-related genes (MTRR, MTR, MTHFR, CBS, SHMT1, MTHFD1, RFC1, BHMT, TYMS) and the Fitzpatrick skin phototype of populations was assessed via collation of genotypic data from ALFRED (Allele Frequency Database) and 1000 Genomes databases. Folic Acid 71-77 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 93-97 30848279-2 2019 A key pathway of this metabolism is the vitamin B-12- and folate-dependent remethylation of homocysteine, which depends on methionine synthase (MS, encoded by MTR), methionine synthase reductase, and methylenetetrahydrofolate reductase. Folic Acid 58-64 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 165-194 31200713-2 2019 The aim of this study is to explore the effects of folate pathway gene polymorphisms (the 5-10-methylenetetrahydrofolate reductase, MTHTR C677T, MTHFR A1298C and the methionine synthase reductase, MTRR A66G) and their interactions with homocysteine on serum lipid levels in patients with RSA. Folic Acid 51-57 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 166-195 31200713-2 2019 The aim of this study is to explore the effects of folate pathway gene polymorphisms (the 5-10-methylenetetrahydrofolate reductase, MTHTR C677T, MTHFR A1298C and the methionine synthase reductase, MTRR A66G) and their interactions with homocysteine on serum lipid levels in patients with RSA. Folic Acid 51-57 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 197-201 29340279-2 2017 Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the two key regulatory enzymes in the folate/homocysteine (Hcy) metabolism. Folic Acid 19-25 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 79-83 29162511-4 2018 METHODS: We investigated if major polymorphisms of folate-related genes, namely MTHFR c.677C>T, MTR c.2756A>G, MTRR c.66A>G and TYMS TSER (a 28-bp tandem repeat in the 5" promoter enhancer region of TYMS) increase the risk of pathological changes of the thymus in AChR+ MG patients. Folic Acid 51-57 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 111-115 28702146-1 2017 BACKGROUND: The 5, 10-methyleneterahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are two essential enzymes involved in folate metabolism. Folic Acid 40-46 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 69-98 28778621-1 2017 Methionine synthase reductase (MTRR) is one of the main regulatory enzymes in the homocysteine/folate pathway. Folic Acid 95-101 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 0-29 28778621-1 2017 Methionine synthase reductase (MTRR) is one of the main regulatory enzymes in the homocysteine/folate pathway. Folic Acid 95-101 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 31-35 28537809-3 2017 Methionine synthase (MTR) and methionine synthase reductase (MTRR) are critical enzymes for the folate cycle. Folic Acid 96-102 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 30-59 28537809-3 2017 Methionine synthase (MTR) and methionine synthase reductase (MTRR) are critical enzymes for the folate cycle. Folic Acid 96-102 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 61-65 28702146-1 2017 BACKGROUND: The 5, 10-methyleneterahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are two essential enzymes involved in folate metabolism. Folic Acid 40-46 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 100-104 28345611-8 2017 Disruption of the genes NUP98 (embryonic stem cell development) and MTRR (folate metabolism) was detected exclusively in RPL placentas, potentially indicative to novel loci implicated in RPL. Folic Acid 74-80 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 68-72 26961134-8 2016 Four DM CpGs identified by SNPs in MTRR, MTHFR, and FTHFD were significantly associated with alcohol consumption and/or breast folate. Folic Acid 127-133 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 35-39 28243331-1 2017 Methionine synthase reductase (MTRR) is a key regulatory enzyme involved in the folate metabolic pathway. Folic Acid 80-86 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 0-29 28243331-1 2017 Methionine synthase reductase (MTRR) is a key regulatory enzyme involved in the folate metabolic pathway. Folic Acid 80-86 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 31-35 28118645-1 2017 Polymorphisms in genes encoding the enzymes involved in the metabolism of homocysteine, such as methionine synthase (MTR) and methionine synthase reductase (MTRR), play an important function in the metabolism of folic acid and vitamin B12. Folic Acid 212-222 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 126-155 28118645-1 2017 Polymorphisms in genes encoding the enzymes involved in the metabolism of homocysteine, such as methionine synthase (MTR) and methionine synthase reductase (MTRR), play an important function in the metabolism of folic acid and vitamin B12. Folic Acid 212-222 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 157-161 25544674-3 2015 We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C>T, MTHFR 1298A>C, methionine synthase (MTR) 2756A>G, methionine synthase reductase (MTRR) 66A>G and reduced folate carrier 1 (RFC-1) 80A>G, and their associations with URPL. Folic Acid 72-78 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 215-244 26337056-11 2015 Each of four gene polymorphisms (MTHTR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) combined with low folate showed higher odds of hypertriglyceridemia (P for trend: 0.049, 0.004, 0.007 and 0.005, respectively). Folic Acid 104-110 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 75-79 25105440-2 2015 The genes MTHFR, MTR, MTRR, and TCN2 play key roles in folate metabolism. Folic Acid 55-61 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 22-26 26334892-2 2015 Besides, methionine synthase (MTR) gene and methionine synthase reductase (MTRR) gene were folate metabolism involved genes and had been investigated in several previous studies with inconsistent results. Folic Acid 91-97 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 44-73 26334892-2 2015 Besides, methionine synthase (MTR) gene and methionine synthase reductase (MTRR) gene were folate metabolism involved genes and had been investigated in several previous studies with inconsistent results. Folic Acid 91-97 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 75-79 25801246-3 2015 The single nucleotide polymorphisms, MTHFR C677T, A1298C, MTR A2756G, and MTRR A66G, alter plasmatic folate and homocysteine concentrations, causing problems during the repairment, synthesis, and methylation of the genetic material. Folic Acid 101-107 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 74-78 26154858-2 2015 The mammalian folic acid cycle is highly complex and the enzymes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR), have crucial roles in this metabolic pathway. Folic Acid 14-24 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 142-171 26154858-2 2015 The mammalian folic acid cycle is highly complex and the enzymes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR), have crucial roles in this metabolic pathway. Folic Acid 14-24 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 173-177 25544674-3 2015 We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C>T, MTHFR 1298A>C, methionine synthase (MTR) 2756A>G, methionine synthase reductase (MTRR) 66A>G and reduced folate carrier 1 (RFC-1) 80A>G, and their associations with URPL. Folic Acid 72-78 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 246-250 24559276-3 2014 The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism. Folic Acid 174-180 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 69-98 25809864-10 2015 Maternal prepregnancy folic acid supplementation showed a stronger negative association with CBT risk where the child, mother, or father had the MTRR 66GG genotype (Pinteraction = 0.07, 0.10, and 0.18, respectively). Folic Acid 22-32 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 145-149 25809864-12 2015 There was possible protection by the MTRR 66GG genotype, particularly when combined with maternal prepregnancy folic acid supplementation; these results are novel and require replication. Folic Acid 111-121 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 37-41 25809864-13 2015 IMPACT: The possible interaction between folic acid supplementation and MTRR 66A>G, if confirmed, would strengthen evidence for prepregnancy folate protection against CBT. Folic Acid 41-51 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 72-76 25809864-13 2015 IMPACT: The possible interaction between folic acid supplementation and MTRR 66A>G, if confirmed, would strengthen evidence for prepregnancy folate protection against CBT. Folic Acid 144-150 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 72-76 25754229-1 2015 INTRODUCTION: Our objective was to investigate the association between gene polymorphisms of folate cycle (MTHFR 677 C>T, MTHFR 1298 A>C, MTR 2756 A>G, and MTRR 66 A>G) and the risk of pulmonary embolism (PE) in a case-control study. Folic Acid 93-99 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 165-169 25140779-0 2014 [Association of folate metabolism genes MTRR and MTHFR with complex congenital abnormalities among Chinese population in Shanxi Province, China]. Folic Acid 16-22 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 40-44 26835343-0 2014 Association of folate metabolism genes MTHFR and MTRR with multiple complex congenital malformation risk in Chinese population of Shanxi. Folic Acid 15-21 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 49-53 26835343-3 2014 In the present study 250 Chinese birth defects cases who suffered 1-8 types of birth defect disease phenotypes were subjected and two genetic variants in two folate metabolism key enzymes, rs1801394 of methionine synthase reductase (MTRR) and rs1801133 of methylenetetrahydrofolate reductase (MTHFR) were genotyped by using SNaPshot method. Folic Acid 158-164 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 202-231 26835343-3 2014 In the present study 250 Chinese birth defects cases who suffered 1-8 types of birth defect disease phenotypes were subjected and two genetic variants in two folate metabolism key enzymes, rs1801394 of methionine synthase reductase (MTRR) and rs1801133 of methylenetetrahydrofolate reductase (MTHFR) were genotyped by using SNaPshot method. Folic Acid 158-164 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 233-237 25634728-0 2015 Individualized supplementation of folic acid according to polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) reduced pregnant complications. Folic Acid 34-44 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 120-149 25634728-0 2015 Individualized supplementation of folic acid according to polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) reduced pregnant complications. Folic Acid 34-44 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 151-155 24559276-3 2014 The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism. Folic Acid 174-180 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 100-104 23459165-2 2013 The single nucleotide polymorphisms, MTHFR C677T, A1298C, MTR A2756G and MTRR A66G, cause alteration in the homocysteine levels and reduced enzymatic activity that generates deficiency in the assimilation of folates associated with DNA damage; that is, why it is important to know if the single nucleotide polymorphisms are associated with the pathological characteristics and development of prostate cancer, through a case-control retrospective study. Folic Acid 208-215 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 73-77 23959833-3 2013 It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma. Folic Acid 80-86 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 175-179 23959833-3 2013 It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma. Folic Acid 80-86 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 186-215 23959833-3 2013 It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma. Folic Acid 80-86 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 175-178 23166529-3 2012 In the folate pathway, several genes are involved, including methylenetetrahydrofolate reductase (MTHFR), methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR), and methyltetrahydrofolate-homocysteine methyltransferase (MTR). Folic Acid 7-13 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 171-175 23094987-3 2013 Methionine synthase reductase (5-methyltetrahydrofolate-homocysteine methyltransferase reductase MTRR) plays an important role in folic acid pathway and a common polymorphism (c.66A>G) has been associated with DS but results were controversial. Folic Acid 130-140 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 0-29 23094987-3 2013 Methionine synthase reductase (5-methyltetrahydrofolate-homocysteine methyltransferase reductase MTRR) plays an important role in folic acid pathway and a common polymorphism (c.66A>G) has been associated with DS but results were controversial. Folic Acid 130-140 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 97-101 23166529-7 2012 To identify the genetic association with gastric cancer, we selected 17 SNPs sites in folate pathway-associated genes of MTHFR, MTR, and MTRR and tested in 1,261 gastric cancer patients and 375 healthy controls. Folic Acid 86-92 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 137-141 22961839-5 2013 However, statistically significant interactions modifying CC risk were observed for DNMT1 I311V with dietary folate, methionine, vitamin B2 , and vitamin B12 intake and for MTRR I22M with dietary folate, a predefined one-carbon dietary pattern, and vitamin B6 intake. Folic Acid 196-202 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 173-177 22864933-6 2012 This SNP is located upstream of the 5 methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) gene, and it is known that the enzyme for MTRR is involved in the methionine-folate biosynthesis and metabolism pathway, which is the primary target of 5-FU-related compounds, although the authors were unable to identify a direct relation between rs4702484 and MTRR expression in a tested subset of cells. Folic Acid 54-60 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 151-155 22864933-6 2012 This SNP is located upstream of the 5 methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) gene, and it is known that the enzyme for MTRR is involved in the methionine-folate biosynthesis and metabolism pathway, which is the primary target of 5-FU-related compounds, although the authors were unable to identify a direct relation between rs4702484 and MTRR expression in a tested subset of cells. Folic Acid 54-60 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 103-107 22864933-6 2012 This SNP is located upstream of the 5 methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) gene, and it is known that the enzyme for MTRR is involved in the methionine-folate biosynthesis and metabolism pathway, which is the primary target of 5-FU-related compounds, although the authors were unable to identify a direct relation between rs4702484 and MTRR expression in a tested subset of cells. Folic Acid 54-60 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 151-155 22097960-1 2011 Human methionine synthase reductase (MSR), a diflavin oxidoreductase, plays a vital role in methionine and folate metabolism by sustaining methionine synthase (MS) activity. Folic Acid 107-113 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 6-35 22706675-2 2012 This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism. Folic Acid 47-57 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 238-242 22236648-0 2012 Polymorphisms in the folate-metabolizing genes MTR, MTRR, and CBS and breast cancer risk. Folic Acid 21-27 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 52-56 22236648-2 2012 The aim of our study was to investigate the association of three single-nucleotide polymorphisms (SNPs) in the folate-metabolizing genes - A2756G MTR, A66G MTRR, and 844ins68 CBS - which have putative functional significance in breast cancer risk. Folic Acid 111-117 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 156-160 22377700-5 2012 The polymorphisms MTHFR c.677C>T and solute carrier family 19 (folate transporter), member 1 (SLC19A1) c.80 A>G modulate folate concentrations, whereas the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) c.66A>G polymorphism affects the MMA concentration. Folic Acid 66-72 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 162-227 22377700-5 2012 The polymorphisms MTHFR c.677C>T and solute carrier family 19 (folate transporter), member 1 (SLC19A1) c.80 A>G modulate folate concentrations, whereas the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) c.66A>G polymorphism affects the MMA concentration. Folic Acid 66-72 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 229-233 22097960-1 2011 Human methionine synthase reductase (MSR), a diflavin oxidoreductase, plays a vital role in methionine and folate metabolism by sustaining methionine synthase (MS) activity. Folic Acid 107-113 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 37-40 21045269-1 2010 This study aimed to investigate the role of maternal polymorphisms, as well as their risk genotypes combinations of MTR A2756G, MTRR A66G, CBS 844ins68, and RFC A80G, involved in folate/homocysteine metabolism, as possible risk factors for Down syndrome (DS) in Southern Brazil. Folic Acid 179-185 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 128-132 21748308-7 2011 Levels of maternal folate intake modified associations with SNPs in CBS, MTRR, and TYMS. Folic Acid 19-25 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 73-77 21070756-7 2011 CONCLUSION: Our findings provide support for the synergistic effects of polymorphisms in the folate metabolic pathway genes in PD susceptibility; the increased PD risk would be more significant in carriers with the polymorphisms of MTHFR, MTR, and MTRR genes. Folic Acid 93-99 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 248-252 20411324-1 2010 Methionine synthase reductase (MTRR) is one of the important enzymes involved in the folate metabolic pathway and its functional genetic polymorphisms may be associated with breast cancer risk. Folic Acid 85-91 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 0-29 20411324-1 2010 Methionine synthase reductase (MTRR) is one of the important enzymes involved in the folate metabolic pathway and its functional genetic polymorphisms may be associated with breast cancer risk. Folic Acid 85-91 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 31-35 20386493-4 2010 RESULTS: RBC folate concentrations were significantly associated with MTHFR 677C>T (P=0.002), MTRR 66A>G (P<0.0001), MTHFD1 1958G>A (P=0.001) and SHMT 1420C>T (P=0.012), whereas no association of these polymorphisms with disease activity was observed. Folic Acid 13-19 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 97-101 20544798-10 2010 In African Americans, folate derivative levels were associated with smoking, B(12), and polymorphisms in MTR, TYMS, methionine synthase reductase (MTRR), and reduced folate carrier1 (RFC1). Folic Acid 22-28 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 116-145 20544798-10 2010 In African Americans, folate derivative levels were associated with smoking, B(12), and polymorphisms in MTR, TYMS, methionine synthase reductase (MTRR), and reduced folate carrier1 (RFC1). Folic Acid 22-28 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 147-151 19852428-5 2009 Molecular analysis of 12 genetic polymorphisms involved in the folate metabolism revealed that the mother is heterozygous for the MTHFR C677T and TC2 A67G polymorphisms, and homozygous for the mutant MTRR A66G polymorphism. Folic Acid 63-69 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 200-204 18602821-10 2009 The study shows a strong influence of folate status on Mtrr transcription in HepG2 cells. Folic Acid 38-44 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 55-59 18174236-9 2008 In addition, interaction between the MTRR A66G polymorphism and folate intake for risk of postmenopausal breast cancer was observed (interaction P = 0.008). Folic Acid 64-70 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 37-41 18515090-9 2008 CONCLUSIONS: Our study suggested a common missense SNP of the MTRR gene as a novel pancreatic cancer susceptibility factor with a functional significance in folate-related metabolism and the genome-wide methylation status. Folic Acid 157-163 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 62-66 17611986-1 2007 OBJECTIVE: To investigate the distribution of the A2756G polymorphism of the methionine synthase reductase (MTR) gene in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) compared with a healthy control group; and to examine the relationships among the A2756G polymorphism, plasma total homocysteine (tHcy), serum folate and vitamin B12 levels, disease activity, and MTX toxicity in patients with RA. Folic Acid 336-342 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 77-106 17892308-12 2007 The biological implications of an attenuated mechanism of MS reactivation by MSR on methionine and folate metabolism are discussed. Folic Acid 99-105 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 77-80 17611986-1 2007 OBJECTIVE: To investigate the distribution of the A2756G polymorphism of the methionine synthase reductase (MTR) gene in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) compared with a healthy control group; and to examine the relationships among the A2756G polymorphism, plasma total homocysteine (tHcy), serum folate and vitamin B12 levels, disease activity, and MTX toxicity in patients with RA. Folic Acid 336-342 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 108-111 16861746-1 2006 BACKGROUND: Three typical folate metabolism enzymes-i.e. methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS) and MS reductase (MTRR) in the folate cycle-play a critical role in DNA synthesis and methylation reactions. Folic Acid 26-32 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 145-149 17113603-3 2007 Methionine synthase reductase (MTRR) is an enzyme that catalyzes the remethylation of homocysteine (Hcy) to methionine via cobalamin and folate dependant reactions. Folic Acid 137-143 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 0-29 17113603-3 2007 Methionine synthase reductase (MTRR) is an enzyme that catalyzes the remethylation of homocysteine (Hcy) to methionine via cobalamin and folate dependant reactions. Folic Acid 137-143 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 31-35 16985020-5 2006 Furthermore, a significant reduction in recurrence risk was seen in MTRR A66G heterozygotes who received folate supplements but not in those who did not receive folate. Folic Acid 105-111 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 68-72 16351505-9 2005 MTRR polymorphism interacted with the association of folate (P for interaction = 0.04) or vitamin (P for interaction = 0.02) with colorectal cancer, although the other polymorphisms did not interact with any nutrient intake. Folic Acid 53-59 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 0-4 16169148-1 2006 Altered maternal folate status and homozygous mutation in the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes can promote chromosomal instability and non-dysjunction resulting in fetal trisomy 21. Folic Acid 17-23 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 141-145 17087642-2 2006 The methionine synthase reductase (MTRR) enzyme restores methionine synthase (MTR) enzyme activity and therefore plays an essential role in the folate- and vitamin B(12)-dependent remethylation of homocysteine to methionine. Folic Acid 144-150 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 4-33 17087642-2 2006 The methionine synthase reductase (MTRR) enzyme restores methionine synthase (MTR) enzyme activity and therefore plays an essential role in the folate- and vitamin B(12)-dependent remethylation of homocysteine to methionine. Folic Acid 144-150 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 35-39 15612980-6 2005 MTRR A66G was also correlated with serum folate. Folic Acid 41-47 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 0-4 15612980-9 2005 Differences in cobalamin and folate levels with the MTRR A66G and MS A2756G polymorphisms were noted. Folic Acid 29-35 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 52-56 14717604-1 2004 Human methionine synthase reductase (MSR) is a key enzyme in folate and methionine metabolism as it reactivates the catalytically inert cob(II)alamin form of methionine synthase (MS). Folic Acid 61-67 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 6-35 15135249-1 2004 The association of variants of the gene encoding methionine synthase reductase (MTRR) with hyperhomocysteinemia, folate and Vitamin B(12) status in kidney graft recipients is unknown. Folic Acid 113-119 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 49-78 15135249-1 2004 The association of variants of the gene encoding methionine synthase reductase (MTRR) with hyperhomocysteinemia, folate and Vitamin B(12) status in kidney graft recipients is unknown. Folic Acid 113-119 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 80-84 14717604-1 2004 Human methionine synthase reductase (MSR) is a key enzyme in folate and methionine metabolism as it reactivates the catalytically inert cob(II)alamin form of methionine synthase (MS). Folic Acid 61-67 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 37-40 12801615-0 2003 Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid. Folic Acid 240-250 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 89-93 12626825-4 2003 Based on evidence that abnormal folate and methyl metabolism can lead to DNA hypomethylation and abnormal chromosomal segregation, researchers have observed that mothers with mutation in MTHFR (C677T) and MTRR (A66G) gene have elevated levels of plasma homocysteine. Folic Acid 32-38 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 205-209 12482398-9 2002 These two loci harbor the methylenetetrahydrofolate dehydrogenase (MTHFD1) and 5"-methyltetrahdrofolate-homocysteine methyltransferase reductase (MTRR) genes, both of which are involved in folate metabolism. Folic Acid 45-51 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 117-144 12810987-5 2002 Ones of those are genes of metabolism of folic acid as MTHFR, MTR, MTRR, CBS, MTHFD, folic acid receptors (FR) regulator genes from PAX family, T, PDGFRA and BRCA1 genes. Folic Acid 41-51 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 67-71 12482398-9 2002 These two loci harbor the methylenetetrahydrofolate dehydrogenase (MTHFD1) and 5"-methyltetrahdrofolate-homocysteine methyltransferase reductase (MTRR) genes, both of which are involved in folate metabolism. Folic Acid 45-51 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 146-150 11807890-1 2002 Polymorphisms in genes encoding the folate metabolizing enzymes methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR A66G) have been linked to the etiology of Down syndrome. Folic Acid 36-42 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 118-147 11807890-1 2002 Polymorphisms in genes encoding the folate metabolizing enzymes methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR A66G) have been linked to the etiology of Down syndrome. Folic Acid 36-42 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 149-153 10930360-6 2000 Methionine synthase reductase (MTRR) is another enzyme essential for normal folate metabolism. Folic Acid 76-82 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 0-29 11443546-2 2001 Thus, recent reports linking Down syndrome to maternal polymorphisms at either of two folate metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), have generated considerable interest. Folic Acid 86-92 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 161-190 11443546-2 2001 Thus, recent reports linking Down syndrome to maternal polymorphisms at either of two folate metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), have generated considerable interest. Folic Acid 86-92 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 192-196 10930360-6 2000 Methionine synthase reductase (MTRR) is another enzyme essential for normal folate metabolism. Folic Acid 76-82 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 31-35 10484769-0 1999 Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism. Folic Acid 133-139 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 90-94 10484769-1 1999 Methionine synthase reductase (MSR) deficiency is an autosomal recessive disorder of folate/cobalamin metabolism leading to hyperhomocysteinemia, hypo- methioninemia and megaloblastic anemia. Folic Acid 85-91 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 0-29 10484769-1 1999 Methionine synthase reductase (MSR) deficiency is an autosomal recessive disorder of folate/cobalamin metabolism leading to hyperhomocysteinemia, hypo- methioninemia and megaloblastic anemia. Folic Acid 85-91 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 31-34