PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14578131-6 2003 In addition, an increased risk of colorectal adenoma (OR, 17.1; 95% CI, 2.1-137) was observed for those with the ADH3(2-2) genotype and high alcohol-low folate intake compared with those with low alcohol-high folate intake and the ADH3(1-1) genotype (P for interaction = 0.006). Folic Acid 209-215 alcohol dehydrogenase 1C (class I), gamma polypeptide Homo sapiens 113-117 14578131-8 2003 The findings that alcohol interacts with a folate-related gene (MTHFR) and that the interaction between alcohol and ADH3 is stronger among those with low folate intake support the hypothesis that the carcinogenic influence of alcohol in the large bowel is mediated through folate status. Folic Acid 154-160 alcohol dehydrogenase 1C (class I), gamma polypeptide Homo sapiens 116-120