PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11481906-2 2001 Hyperhomocysteinemia may be induced by failure or decreased enzyme activity of the cystathionine-beta-synthase and methylenetetrahydrofolate reductase due to genetic mutation or deficiency of folic acid, vitamin B12 and vitamin B6. Folic Acid 192-202 cystathionine beta-synthase Homo sapiens 83-110 11391481-10 2001 The increased activity of CBS in children with DS significantly alters homocysteine metabolism such that the folate-dependent resynthesis of methionine is compromised. Folic Acid 109-115 cystathionine beta-synthase Homo sapiens 26-29 12186157-3 2002 Our study was aimed at finding the relationship between HCA, folate, vitamins B12 levels, and mutations in the 5,10-methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS) genes. Folic Acid 61-67 cystathionine beta-synthase Homo sapiens 164-191 11204591-9 2001 This interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate. Folic Acid 247-253 cystathionine beta-synthase Homo sapiens 25-28 11204591-9 2001 This interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate. Folic Acid 247-253 cystathionine beta-synthase Homo sapiens 92-95 10894832-2 2000 The four most common functional polymorphisms in genes involved in folate/homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MS) A2756G, and cystathionine beta-synthase (CBS) 844ins68. Folic Acid 67-73 cystathionine beta-synthase Homo sapiens 201-228 11103808-2 2000 The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy. Folic Acid 179-185 cystathionine beta-synthase Homo sapiens 33-36 11103808-2 2000 The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy. Folic Acid 116-122 cystathionine beta-synthase Homo sapiens 4-31 11103808-2 2000 The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy. Folic Acid 116-122 cystathionine beta-synthase Homo sapiens 33-36 11103808-2 2000 The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy. Folic Acid 179-185 cystathionine beta-synthase Homo sapiens 4-31 10894832-2 2000 The four most common functional polymorphisms in genes involved in folate/homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MS) A2756G, and cystathionine beta-synthase (CBS) 844ins68. Folic Acid 67-73 cystathionine beta-synthase Homo sapiens 230-233 10833331-0 2000 Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid. Folic Acid 151-161 cystathionine beta-synthase Homo sapiens 21-24 10833331-4 2000 We found that two single nucleotide polymorphisms in the cystathionine beta synthase (CBS) gene, 699C --> T and 1080T --> C, are associated with decreased risk of CAD and increased responsiveness to the tHcy lowering effects of folic acid. Folic Acid 228-238 cystathionine beta-synthase Homo sapiens 57-84 10833331-4 2000 We found that two single nucleotide polymorphisms in the cystathionine beta synthase (CBS) gene, 699C --> T and 1080T --> C, are associated with decreased risk of CAD and increased responsiveness to the tHcy lowering effects of folic acid. Folic Acid 228-238 cystathionine beta-synthase Homo sapiens 86-89 3091098-5 1986 We also measured the activities of another three enzymes of the folic acid cycle, viz., 5,10-methylene-H4folate dehydrogenase, 10-formyl-H4folate synthetase, and 5,10-methenyl-H4folate cyclohydrolase, as well as the enzyme cystathionine beta-synthase. Folic Acid 64-74 cystathionine beta-synthase Homo sapiens 223-250 9701830-1 1998 Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig. Folic Acid 89-95 cystathionine beta-synthase Homo sapiens 213-240 9701830-1 1998 Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig. Folic Acid 89-95 cystathionine beta-synthase Homo sapiens 242-245 9472972-0 1998 Cystathionine-beta-synthase deficiency: detection of heterozygotes by the ratios of homocysteine to cysteine and folate. Folic Acid 113-119 cystathionine beta-synthase Homo sapiens 0-27 32975579-6 2020 This increase of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the subsequent downregulation of serine biosynthesis and the adaptation of other sulfide linked pathways, such as folate cycle, nucleotides metabolism and glutathione system. Folic Acid 274-280 cystathionine beta-synthase Homo sapiens 56-83 31558761-0 2019 Association between BHMT and CBS gene promoter methylation with the efficacy of folic acid therapy in patients with hyperhomocysteinemia. Folic Acid 80-90 cystathionine beta-synthase Homo sapiens 29-32 31864233-0 2020 CBS gene polymorphism and promoter methylation-mediating effects on the efficacy of folate therapy in patients with hyperhomocysteinemia. Folic Acid 84-90 cystathionine beta-synthase Homo sapiens 0-3 31864233-3 2020 The present study aimed to explore CBS promoter methylation-mediating effects on the efficacy of folate treatment for HHcy. Folic Acid 97-103 cystathionine beta-synthase Homo sapiens 35-38 31864233-10 2020 Additionally, baseline CBS promoter methylation mediated 33.39% of the effect of rs2851391 on the efficacy of folate treatment for HHcy (ACME [average causal mediation effects]: -0.05, 95% CI = -0.11 to 0.00, p = 0.046). Folic Acid 110-116 cystathionine beta-synthase Homo sapiens 23-26 31864233-12 2020 There were potentially causal effects of genetic, epigenetic variations at the CBS rs2851391 locus on the efficacy of HHcy therapy with folate. Folic Acid 136-142 cystathionine beta-synthase Homo sapiens 79-82 31558761-3 2019 The present study is performed to explore the association between the methylation levels in the promoter regions of the BHMT and CBS genes and the efficacy of folic acid therapy in patient with hyperhomocysteinemia (HHcy). Folic Acid 159-169 cystathionine beta-synthase Homo sapiens 129-132 31558761-10 2019 These studies suggest that lower levels of BHMT and CBS methylation are all predictors of failure in folic acid therapy for HHcy. Folic Acid 101-111 cystathionine beta-synthase Homo sapiens 52-55 18565815-16 2008 CONCLUSION: The lower homocysteine, folic acid and B 12 values may be considered as the consequence of an increased cystathionine-beta-synthase activity ("atheroma free model"). Folic Acid 36-46 cystathionine beta-synthase Homo sapiens 116-143 28806886-6 2016 The CBS SNP at rs6586282 may infl uence anthropometric parameters, though only in case of low folate intake. Folic Acid 94-100 cystathionine beta-synthase Homo sapiens 4-7 22946297-1 2012 The work is dedicated to creation of the mathematical model of folate-dependent one-carbon unit metabolism (FOCM) and study of its function in human placenta under homocysteine load and the most common mutations in the genes of methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS). Folic Acid 63-69 cystathionine beta-synthase Homo sapiens 276-303 23152928-3 2012 Cystathionine-beta-synthase (CBS) functions in the folate metabolism pathway, which is intricately linked to methylation of genomic DNA. Folic Acid 51-57 cystathionine beta-synthase Homo sapiens 0-27 23152928-3 2012 Cystathionine-beta-synthase (CBS) functions in the folate metabolism pathway, which is intricately linked to methylation of genomic DNA. Folic Acid 51-57 cystathionine beta-synthase Homo sapiens 29-32 23152928-13 2012 CONCLUSION: A novel finding from this study is that the folate metabolism enzyme CBS mRNA levels are frequently downregulated through CpG methylation of the CBS gene in gastric cancer and CRC, suggesting that CBS functions as a tumor suppressor gene. Folic Acid 56-62 cystathionine beta-synthase Homo sapiens 81-84 23152928-13 2012 CONCLUSION: A novel finding from this study is that the folate metabolism enzyme CBS mRNA levels are frequently downregulated through CpG methylation of the CBS gene in gastric cancer and CRC, suggesting that CBS functions as a tumor suppressor gene. Folic Acid 56-62 cystathionine beta-synthase Homo sapiens 157-160 23152928-13 2012 CONCLUSION: A novel finding from this study is that the folate metabolism enzyme CBS mRNA levels are frequently downregulated through CpG methylation of the CBS gene in gastric cancer and CRC, suggesting that CBS functions as a tumor suppressor gene. Folic Acid 56-62 cystathionine beta-synthase Homo sapiens 157-160 22419938-1 2010 INTRODUCTION: Susceptibility to head and neck squamous cell carcinoma may be modified by functional polymorphisms in genes involved in the folate pathway, such as cystathionine beta-synthase (CBS). Folic Acid 139-145 cystathionine beta-synthase Homo sapiens 163-190 22419938-1 2010 INTRODUCTION: Susceptibility to head and neck squamous cell carcinoma may be modified by functional polymorphisms in genes involved in the folate pathway, such as cystathionine beta-synthase (CBS). Folic Acid 139-145 cystathionine beta-synthase Homo sapiens 192-195 19657138-2 2009 The main regulating enzymes in folate and homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS). Folic Acid 31-37 cystathionine beta-synthase Homo sapiens 118-145 19657138-2 2009 The main regulating enzymes in folate and homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS). Folic Acid 31-37 cystathionine beta-synthase Homo sapiens 147-150 18398434-2 2008 The effect of the cystathionine beta-synthase (CBS) 844ins68 polymorphism on homocysteine and folate concentrations was examined alone and in the context of the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism in a Northwestern European male population. Folic Acid 94-100 cystathionine beta-synthase Homo sapiens 18-45 28881655-5 2017 Then, the correlation analysis between folate level, DNA methylation alteration in promoter and expression of CBS was carried out in vitro and vivo. Folic Acid 39-45 cystathionine beta-synthase Homo sapiens 110-113 24559276-3 2014 The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism. Folic Acid 174-180 cystathionine beta-synthase Homo sapiens 110-137 24559276-3 2014 The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism. Folic Acid 174-180 cystathionine beta-synthase Homo sapiens 139-142 21957013-3 2012 The protective effect provided by FA suggests that the genes involved in folate metabolism, such as cystathionine beta-synthase (CBS), warrant further investigation. Folic Acid 73-79 cystathionine beta-synthase Homo sapiens 100-127 21957013-3 2012 The protective effect provided by FA suggests that the genes involved in folate metabolism, such as cystathionine beta-synthase (CBS), warrant further investigation. Folic Acid 73-79 cystathionine beta-synthase Homo sapiens 129-132 15134582-7 2004 The absence of the cystathionine beta synthase enzyme in human vascular cells contributes to the importance of a dual role of folic acid in lowering tHcy through remethylation, as well as, its action of being an electron and hydrogen donor to the essential cofactor tetrahydrobiopterin. Folic Acid 126-136 cystathionine beta-synthase Homo sapiens 19-46 12670934-1 2003 Vitamins B12, B6, and folic acid converge at the homocysteine metabolic junction where they support the activities of two key enzymes involved in intracellular homocysteine management, methionine synthase (MS) and cystathionine beta-synthase. Folic Acid 22-32 cystathionine beta-synthase Homo sapiens 214-241