PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10449919-5 1999 Fluorescence in situ hybridization studies on the first patient placed the two breakpoints near the folate-sensitive fragile sites FRA11A and FRA11B. Folic Acid 100-106 Cbl proto-oncogene Homo sapiens 142-148 12021520-2 2002 methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients. Folic Acid 204-214 Cbl proto-oncogene Homo sapiens 20-23 7881408-2 1994 However, one case report has highlighted a possible relationship between the inheritance of a rare folate-sensitive fragile site in band 11q23.3 (FRA11B) and the chromosome 11q23-->qter deletion in Jacobsen (11q-) syndrome. Folic Acid 99-105 Cbl proto-oncogene Homo sapiens 146-152 9508241-1 1998 Recent studies have identified a (CCG)n repeat in the 5" untranslated region of the CBL2 protooncogene (11q23.3) and have demonstrated that expansion of this repeat causes expression of the folate-sensitive fragile site FRA11B. Folic Acid 190-196 Cbl proto-oncogene Homo sapiens 84-88 9508241-1 1998 Recent studies have identified a (CCG)n repeat in the 5" untranslated region of the CBL2 protooncogene (11q23.3) and have demonstrated that expansion of this repeat causes expression of the folate-sensitive fragile site FRA11B. Folic Acid 190-196 Cbl proto-oncogene Homo sapiens 220-226 8673085-1 1996 Five folate-sensitive fragile sites have been characterized at the molecular level (FRAXA, FRAXE, FRAXF, FRA16A and FRA11B). Folic Acid 5-11 Cbl proto-oncogene Homo sapiens 116-122 31123954-1 2019 PURPOSE: Vitamin B12 (cobalamin, Cbl) plays a role in the recycling of folate, which is important in pregnancy. Folic Acid 71-77 Cbl proto-oncogene Homo sapiens 33-36 963297-6 1976 Folic acid and methyltetrahydrofolate enhanced synthesis of Me-Cbl both in normal and in PA cells, while methotrexate and 5-fluorouracil depressed it. Folic Acid 0-10 Cbl proto-oncogene Homo sapiens 63-66 963297-7 1976 This depression was overcome by 5-formyltetrahydrofolate, suggesting that an uninterrupted folate cycle may play an important role in Me-Cbl synthesis. Folic Acid 50-56 Cbl proto-oncogene Homo sapiens 137-140 27730072-13 2016 DISCUSSION: Even short-term treatment with metformin causes a decrease in serum Cbl folic acid and increase in Hcy, which leads to peripheral neuropathy in Type 2 diabetes patients. Folic Acid 84-94 Cbl proto-oncogene Homo sapiens 80-83 30693532-8 2019 It also provides a description of folate-mediated one-carbon metabolism and its intersection with Cbl at the methionine cycle. Folic Acid 34-40 Cbl proto-oncogene Homo sapiens 98-101 25298785-6 2014 The breakpoint was close to the folate sensitive rare fragile site FRA11B and the aphidicolin inducible common fragile site FRA11G, the co-localization fragile site could have caused instability and constitutional chromosomal breakage. Folic Acid 32-38 Cbl proto-oncogene Homo sapiens 67-73 15203205-2 2004 Expansion of CGG/CCG repeats has been shown to be the molecular basis of all five folate-sensitive fragile sites characterized molecularly so far, i.e., FRAXA, FRAXE, FRAXF, FRA11B, and FRA16A. Folic Acid 82-88 Cbl proto-oncogene Homo sapiens 174-180