PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10449919-5	1999	Fluorescence in situ hybridization studies on the first patient placed the two breakpoints near the folate-sensitive fragile sites FRA11A and FRA11B.	Folic Acid	100-106	Cbl proto-oncogene	Homo sapiens	142-148	
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	Folic Acid	204-214	Cbl proto-oncogene	Homo sapiens	20-23	
7881408-2	1994	However, one case report has highlighted a possible relationship between the inheritance of a rare folate-sensitive fragile site in band 11q23.3 (FRA11B) and the chromosome 11q23-->qter deletion in Jacobsen (11q-) syndrome.	Folic Acid	99-105	Cbl proto-oncogene	Homo sapiens	146-152	
9508241-1	1998	Recent studies have identified a (CCG)n repeat in the 5" untranslated region of the CBL2 protooncogene (11q23.3) and have demonstrated that expansion of this repeat causes expression of the folate-sensitive fragile site FRA11B.	Folic Acid	190-196	Cbl proto-oncogene	Homo sapiens	84-88	
9508241-1	1998	Recent studies have identified a (CCG)n repeat in the 5" untranslated region of the CBL2 protooncogene (11q23.3) and have demonstrated that expansion of this repeat causes expression of the folate-sensitive fragile site FRA11B.	Folic Acid	190-196	Cbl proto-oncogene	Homo sapiens	220-226	
8673085-1	1996	Five folate-sensitive fragile sites have been characterized at the molecular level (FRAXA, FRAXE, FRAXF, FRA16A and FRA11B).	Folic Acid	5-11	Cbl proto-oncogene	Homo sapiens	116-122	
31123954-1	2019	PURPOSE: Vitamin B12 (cobalamin, Cbl) plays a role in the recycling of folate, which is important in pregnancy.	Folic Acid	71-77	Cbl proto-oncogene	Homo sapiens	33-36	
963297-6	1976	Folic acid and methyltetrahydrofolate enhanced synthesis of Me-Cbl both in normal and in PA cells, while methotrexate and 5-fluorouracil depressed it.	Folic Acid	0-10	Cbl proto-oncogene	Homo sapiens	63-66	
963297-7	1976	This depression was overcome by 5-formyltetrahydrofolate, suggesting that an uninterrupted folate cycle may play an important role in Me-Cbl synthesis.	Folic Acid	50-56	Cbl proto-oncogene	Homo sapiens	137-140	
27730072-13	2016	DISCUSSION: Even short-term treatment with metformin causes a decrease in serum Cbl folic acid and increase in Hcy, which leads to peripheral neuropathy in Type 2 diabetes patients.	Folic Acid	84-94	Cbl proto-oncogene	Homo sapiens	80-83	
30693532-8	2019	It also provides a description of folate-mediated one-carbon metabolism and its intersection with Cbl at the methionine cycle.	Folic Acid	34-40	Cbl proto-oncogene	Homo sapiens	98-101	
25298785-6	2014	The breakpoint was close to the folate sensitive rare fragile site FRA11B and the aphidicolin inducible common fragile site FRA11G, the co-localization fragile site could have caused instability and constitutional chromosomal breakage.	Folic Acid	32-38	Cbl proto-oncogene	Homo sapiens	67-73	
15203205-2	2004	Expansion of CGG/CCG repeats has been shown to be the molecular basis of all five folate-sensitive fragile sites characterized molecularly so far, i.e., FRAXA, FRAXE, FRAXF, FRA11B, and FRA16A.	Folic Acid	82-88	Cbl proto-oncogene	Homo sapiens	174-180