PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24597986-1 2014 Abstract Methotrexate (MTX) is a key component of chemotherapeutic regimens for childhood acute lymphoblastic leukemia (ALL), and enters the cell via active transport mediated by the reduced folate carrier (RFC1). Folic Acid 191-197 replication factor C subunit 1 Homo sapiens 207-211 28994615-1 2017 AIM: To investigate the relationships of polymorphisms in genes whose protein products are related in the metabolic pathway of folic acid, particularly MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C, and disease activity in Mexican patients with rheumatoid arthritis (RA) treated with methotrexate (MTX). Folic Acid 127-137 replication factor C subunit 1 Homo sapiens 163-167 25758536-8 2015 The baseline concentration of serum folate in subjects with polymorphism combination, reduced folate carrier protein, RFC1-80 GA and methylenetetrahydrofolate reductase, MTHFR677 CT+TT, was lower than RFC1-80 AA and MTHFR677 CT+TT (p = 0.002). Folic Acid 36-42 replication factor C subunit 1 Homo sapiens 201-205 25758536-9 2015 After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT+TT combination (p < 0.0001). Folic Acid 6-16 replication factor C subunit 1 Homo sapiens 144-148 25758536-9 2015 After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT+TT combination (p < 0.0001). Folic Acid 6-16 replication factor C subunit 1 Homo sapiens 176-180 25758536-9 2015 After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT+TT combination (p < 0.0001). Folic Acid 82-88 replication factor C subunit 1 Homo sapiens 144-148 25758536-9 2015 After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT+TT combination (p < 0.0001). Folic Acid 82-88 replication factor C subunit 1 Homo sapiens 176-180 25758536-12 2015 The combination of RFC1-80 and MTHFR-677 polymorphisms had a profound affect on the concentration of serum folate in healthy subjects before and after folic acid supplementation. Folic Acid 107-113 replication factor C subunit 1 Homo sapiens 19-23 25758536-12 2015 The combination of RFC1-80 and MTHFR-677 polymorphisms had a profound affect on the concentration of serum folate in healthy subjects before and after folic acid supplementation. Folic Acid 151-161 replication factor C subunit 1 Homo sapiens 19-23 25536437-10 2015 CONCLUSION: Our results suggest that mother and child RFC-1 G80A genotypes play a role on the risk of neuroblastoma and nephroblastoma since this polymorphism may impair the intracellular levels of folate, through carrying fewer folate molecules to the cell interior, and thus, the intracellular concentration is not enough to maintain regular DNA synthesis and methylation pathways. Folic Acid 198-204 replication factor C subunit 1 Homo sapiens 54-59 25536437-10 2015 CONCLUSION: Our results suggest that mother and child RFC-1 G80A genotypes play a role on the risk of neuroblastoma and nephroblastoma since this polymorphism may impair the intracellular levels of folate, through carrying fewer folate molecules to the cell interior, and thus, the intracellular concentration is not enough to maintain regular DNA synthesis and methylation pathways. Folic Acid 229-235 replication factor C subunit 1 Homo sapiens 54-59 24554143-3 2014 The reduced folate carrier (RFC1) gene, rs1051266, which encodes the RFC 1, protein was analyzed for polymorphism by polymerase chain reaction-restriction fragment length polymorphism. Folic Acid 12-18 replication factor C subunit 1 Homo sapiens 19-33 24333266-1 2014 The current study was conducted to elucidate the effect of genetic variations in one-carbon metabolism on the epigenetic regulation of major histocompatibility complex II transactivator (MHC2TA), reduced folate carrier 1 (RFC1/SLC19A1) and human leukocyte antigen (HLA)-DR in systemic lupus erythematosus (SLE). Folic Acid 204-210 replication factor C subunit 1 Homo sapiens 222-226 24333266-7 2014 Plasma folate and thymidylate synthase (TYMS) 5"-UTR 28 bp tandem repeat showed an inverse association with methylation of RFC1 and MHC2TA. Folic Acid 7-13 replication factor C subunit 1 Homo sapiens 123-127 24554143-3 2014 The reduced folate carrier (RFC1) gene, rs1051266, which encodes the RFC 1, protein was analyzed for polymorphism by polymerase chain reaction-restriction fragment length polymorphism. Folic Acid 12-18 replication factor C subunit 1 Homo sapiens 69-74 24995314-3 2014 A common c.80G>A polymorphism (rs1051266) in the gene coding for the reduced folate carrier (SLC19A1 gene, commonly known as RFC-1 gene) was investigated as AD risk factor in Asian populations, yielding conflicting results. Folic Acid 77-83 replication factor C subunit 1 Homo sapiens 125-130 22975209-1 2012 The reduced folate carrier (RFC1) plays a crucial role in mediating folate delivery into a variety of cells. Folic Acid 12-18 replication factor C subunit 1 Homo sapiens 28-32 23857226-0 2013 The reduced folate carrier (RFC-1) 80A>G polymorphism and maternal risk of having a child with Down syndrome: a meta-analysis. Folic Acid 12-18 replication factor C subunit 1 Homo sapiens 28-33 23857226-1 2013 A common polymorphism (c.80A>G) in the gene coding for the reduced folate carrier (SLC19A1, commonly known as RFC-1) has been associated with maternal risk of the birth of a child with Down Syndrome (DS), but results are controversial. Folic Acid 70-76 replication factor C subunit 1 Homo sapiens 113-118 22975209-1 2012 The reduced folate carrier (RFC1) plays a crucial role in mediating folate delivery into a variety of cells. Folic Acid 68-74 replication factor C subunit 1 Homo sapiens 28-32 21878957-0 2012 Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population. Folic Acid 112-122 replication factor C subunit 1 Homo sapiens 25-29 19650776-2 2009 As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels. Folic Acid 3-9 replication factor C subunit 1 Homo sapiens 93-97 20468076-7 2010 In case-control analysis, a significant increase in the reduced folate carrier (RFC1) G allele frequency was found among case mothers, but not among fathers or affected children. Folic Acid 64-70 replication factor C subunit 1 Homo sapiens 80-84 20501616-1 2010 PURPOSE: Pralatrexate (10-propargyl-10-deazaaminopterin) is an antifolate with improved cellular uptake and retention due to greater affinity for the reduced folate carrier (RFC-1) and folyl-polyglutamyl synthase. Folic Acid 67-73 replication factor C subunit 1 Homo sapiens 174-179 18258338-1 2009 We examined polymorphisms in reduced folate carrier gene (RFC1) and methylenetetrahydrofolate reductase gene (MTHFR) for association with sporadic AD (SAD) in Chinese population. Folic Acid 37-43 replication factor C subunit 1 Homo sapiens 58-62 19105199-8 2009 Our findings suggest that there is a potential gene-environment interaction on the risk of NTDs between maternal or offspring RFC1 GG genotype and maternal periconceptional intake of folic acid. Folic Acid 183-193 replication factor C subunit 1 Homo sapiens 126-130 19650776-2 2009 As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels. Folic Acid 77-83 replication factor C subunit 1 Homo sapiens 93-97 19650776-2 2009 As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels. Folic Acid 77-83 replication factor C subunit 1 Homo sapiens 147-151 19650776-2 2009 As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels. Folic Acid 3-9 replication factor C subunit 1 Homo sapiens 147-151 19650776-2 2009 As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels. Folic Acid 77-83 replication factor C subunit 1 Homo sapiens 93-97 19650776-2 2009 As folate transport across cell membranes is mediated in part by the reduced folate carrier (RFC1), variants within SLC19A1, the gene that encodes RFC1, may influence disease risk via an effect on folate and/or homocysteine levels. Folic Acid 77-83 replication factor C subunit 1 Homo sapiens 147-151 18823966-1 2008 BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR), glutamate carboxypeptidase II (GCPII) and reduced folate carrier (RFC1) gene polymorphisms were associated with folate status. Folic Acid 111-117 replication factor C subunit 1 Homo sapiens 127-131 18602821-4 2009 Bivariate analysis showed that folate deficiency (0.3 nmol/L of folate vs. 2.27 mumol/L in control medium) displayed rapid and coordinated regulation during the first 2 h with differential expression for hRfc1 (increased by 69%) and Ahcy (decreased by 437%). Folic Acid 31-37 replication factor C subunit 1 Homo sapiens 204-209 18602821-4 2009 Bivariate analysis showed that folate deficiency (0.3 nmol/L of folate vs. 2.27 mumol/L in control medium) displayed rapid and coordinated regulation during the first 2 h with differential expression for hRfc1 (increased by 69%) and Ahcy (decreased by 437%). Folic Acid 64-70 replication factor C subunit 1 Homo sapiens 204-209 18629538-2 2008 We assessed whether the reduced folate carrier [NM_194255.1: c.80A-->G (i.e., p.His27Arg)] (RFC-1) polymorphism was associated with placental abruption, and evaluated if maternal smoking modified the association between plasma folate and abruption. Folic Acid 32-38 replication factor C subunit 1 Homo sapiens 95-100 18842806-6 2008 DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals. Folic Acid 77-83 replication factor C subunit 1 Homo sapiens 356-360 17531458-2 2008 Our group has previously shown that both reduced folate carrier (RFC1) and folate receptor alpha (FRalpha) seem to be involved in the uptake of [3H]folic acid ([3H]FA) by a human trophoblast cell line (BeWo) and by human primary cultured cytotrophoblasts. Folic Acid 49-55 replication factor C subunit 1 Homo sapiens 65-69 18400109-0 2008 Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex. Folic Acid 36-42 replication factor C subunit 1 Homo sapiens 52-56 18400109-6 2008 The identification of alterations in gene expression and signaling pathways involved in the observed dysmorphology following inactivation of RFC1-mediated folate transport are the focus of this investigation. Folic Acid 155-161 replication factor C subunit 1 Homo sapiens 141-145 18400109-12 2008 CONCLUSION: Inactivation of RFC1 impacts the expression of several ligands and interacting proteins in the cubilin-amnionless-megalin complex that are involved in the maternal-fetal transport of folate and other nutrients, lipids and morphogens such as sonic hedgehog (Shh) and retinoids that play critical roles in normal embryogenesis. Folic Acid 195-201 replication factor C subunit 1 Homo sapiens 28-32 17531458-2 2008 Our group has previously shown that both reduced folate carrier (RFC1) and folate receptor alpha (FRalpha) seem to be involved in the uptake of [3H]folic acid ([3H]FA) by a human trophoblast cell line (BeWo) and by human primary cultured cytotrophoblasts. Folic Acid 148-158 replication factor C subunit 1 Homo sapiens 65-69 17615259-2 2007 Two folate transporters (folate receptor, FR, and Reduced Folate Carrier, hRFC1) are involved in the cell uptake of folate. Folic Acid 4-10 replication factor C subunit 1 Homo sapiens 74-79 19172696-4 2008 RESULTS: The RFC1 80A-allele was associated with reduced plasma folate and elevated plasma total homocysteine concentrations, but the result was statistically significant only for folate. Folic Acid 64-70 replication factor C subunit 1 Homo sapiens 13-17 19172696-4 2008 RESULTS: The RFC1 80A-allele was associated with reduced plasma folate and elevated plasma total homocysteine concentrations, but the result was statistically significant only for folate. Folic Acid 180-186 replication factor C subunit 1 Homo sapiens 13-17 19172696-9 2008 CONCLUSIONS: These findings suggest that although the RFC1 80G > A and FOLH1 1561C > T polymorphisms may influence folate status, they are not likely to have a major independent role in the development of colorectal cancer. Folic Acid 121-127 replication factor C subunit 1 Homo sapiens 54-58 18022874-2 2008 The mutations on two genes involved in folate metabolism, the C677 of the MTHFR gene and the RFC-1(A80G) gene are potential risk factors of NTDs. Folic Acid 39-45 replication factor C subunit 1 Homo sapiens 93-97 19172696-0 2008 The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study. Folic Acid 12-18 replication factor C subunit 1 Homo sapiens 28-32 19172696-2 2008 In this nested case-referent study, we related two such polymorphisms, reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T, to the risk of colorectal cancer, taking into account pre-diagnostic plasma folate and total homocysteine concentrations and the MTHFR 677C > T polymorphism, which were analysed in a previous study. Folic Acid 79-85 replication factor C subunit 1 Homo sapiens 95-99 17325736-2 2007 MTX enters the cells through the reduced folate carrier (RFC-1) and is activated to polyglutamates. Folic Acid 41-47 replication factor C subunit 1 Homo sapiens 57-62 17325736-4 2007 The studies suggest that G80A polymorphism in RFC-1 is associated with altered folate/antifolate levels and the subjects carrying homozygous mutant 80AA genotype tend to have higher plasma folate and MTX concentrations and higher erythrocyte polyglutamate levels compared with those with the wild type or heterozygous genotype. Folic Acid 79-85 replication factor C subunit 1 Homo sapiens 46-51 17325736-4 2007 The studies suggest that G80A polymorphism in RFC-1 is associated with altered folate/antifolate levels and the subjects carrying homozygous mutant 80AA genotype tend to have higher plasma folate and MTX concentrations and higher erythrocyte polyglutamate levels compared with those with the wild type or heterozygous genotype. Folic Acid 90-96 replication factor C subunit 1 Homo sapiens 46-51 16596679-2 2006 The 80G>A polymorphism of the reduced folate carrier gene (RFC-1) has been recently demonstrated to affect plasma folate and homocysteine levels, alone or in combination with the 677C>T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene. Folic Acid 41-47 replication factor C subunit 1 Homo sapiens 62-67 17329909-1 2007 Stereoselectivity of the human reduced folate carrier (RFC1) in Caco-2 cells was examined using methotrexate (L-amethopterin, L-MTX) and its antipode (D-amethopterin, D-MTX) as model substrates. Folic Acid 39-45 replication factor C subunit 1 Homo sapiens 55-59 16962770-2 2006 Reduced folate carrier (RFC1, also named SLC19A1) is an essential folate transporter and functions as a bidirectional anion exchanger, taking up folate cofactors and exporting various organic anions. Folic Acid 8-14 replication factor C subunit 1 Homo sapiens 24-28 16962770-2 2006 Reduced folate carrier (RFC1, also named SLC19A1) is an essential folate transporter and functions as a bidirectional anion exchanger, taking up folate cofactors and exporting various organic anions. Folic Acid 66-72 replication factor C subunit 1 Homo sapiens 24-28 16962770-3 2006 A G80A polymorphism in RFC1 gene has been shown to be associated with alterations in folate and homocysteine metabolism in healthy individuals. Folic Acid 85-91 replication factor C subunit 1 Homo sapiens 23-27 16122883-4 2005 The purpose of this study was to analyze if the folate level and the gene expression levels of reduced folate carrier (RFC-1) and folylpolyglutamate synthase (FPGS) had impact on the expression of DCC splice variants. Folic Acid 103-109 replication factor C subunit 1 Homo sapiens 119-124 16086047-10 2005 CONCLUSION: Our findings indicate that the RFC1 genotype (GG) is a possible susceptible gene marker for an increased NTDs risk in this Chinese population, and there is a potential influence on the risk of NTDs in maternal periconceptional folic acid supplementation, and maternal fever during the early pregnancy. Folic Acid 239-249 replication factor C subunit 1 Homo sapiens 43-47 15952116-1 2005 OBJECTIVE: To search the interaction between reduced folate carrier gene (RFC1 A80G) polymorphism of children with neural tube defects (NTDs) and maternal periconceptional no supplementation of folic acid. Folic Acid 194-204 replication factor C subunit 1 Homo sapiens 74-78 15952116-9 2005 CONCLUSION: The above findings indicate that the RFC1 genotype (GG) is a possible susceptible gene marker for an increased NTDs risk in Chinese population, and there is a potential gene-nutrient interaction between offspring RFC1 GG genotype and maternal periconceptional intake of folic acid on the risk of NTDs. Folic Acid 282-292 replication factor C subunit 1 Homo sapiens 49-53 15952116-9 2005 CONCLUSION: The above findings indicate that the RFC1 genotype (GG) is a possible susceptible gene marker for an increased NTDs risk in Chinese population, and there is a potential gene-nutrient interaction between offspring RFC1 GG genotype and maternal periconceptional intake of folic acid on the risk of NTDs. Folic Acid 282-292 replication factor C subunit 1 Homo sapiens 225-229 16096989-1 2005 Stereoselectivity of the human reduced folate carrier (RFC1) was examined in Caco-2 cells using methotrexate (l-amethopterin or l-MTX) and its antipode (d-amethopterin or d-MTX) as model substrates. Folic Acid 39-45 replication factor C subunit 1 Homo sapiens 55-59 15799025-9 2005 CONCLUSIONS: Our findings suggest that the RFC1 G allele is likely to be an important genetic factor in determining folate transport and subsequently may be a risk factor for NTDs in this Chinese population. Folic Acid 116-122 replication factor C subunit 1 Homo sapiens 43-47 15769366-3 2004 We performed a family-based association test and analyzed the interaction between RFC1 A80G genotype and maternal periconceptional supplementation of folic acid. Folic Acid 150-160 replication factor C subunit 1 Homo sapiens 82-86 15639995-4 2004 This paper reviews folate transport carrier, Reduced Folate Carrier (RFC)"s characteristics in biological chemistry, physiological function, the folate transport mechanism, structure, function, regulation and expression of reduced folate carrier gene (RFC1), and the relationship between RFC1 with plasm or erythrocyte folate level and neural tube defects, et al. Folic Acid 19-25 replication factor C subunit 1 Homo sapiens 288-292 15639995-4 2004 This paper reviews folate transport carrier, Reduced Folate Carrier (RFC)"s characteristics in biological chemistry, physiological function, the folate transport mechanism, structure, function, regulation and expression of reduced folate carrier gene (RFC1), and the relationship between RFC1 with plasm or erythrocyte folate level and neural tube defects, et al. Folic Acid 53-59 replication factor C subunit 1 Homo sapiens 252-256 15639995-4 2004 This paper reviews folate transport carrier, Reduced Folate Carrier (RFC)"s characteristics in biological chemistry, physiological function, the folate transport mechanism, structure, function, regulation and expression of reduced folate carrier gene (RFC1), and the relationship between RFC1 with plasm or erythrocyte folate level and neural tube defects, et al. Folic Acid 53-59 replication factor C subunit 1 Homo sapiens 288-292 14676127-2 2003 EXPERIMENTAL DESIGN: Real-time PCR was used to quantify expression levels of folate-associated genes including the reduced folate carrier (RFC-1), folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH),and thymidylate synthase (TS) in tumor tissue and adjacent mucosa of patients with primary colorectal cancer (n=102). Folic Acid 77-83 replication factor C subunit 1 Homo sapiens 139-144 14676127-7 2003 The total reduced folate concentration correlated with the gene expression levels of RFC-1 and FPGS but not with TS or GGH. Folic Acid 18-24 replication factor C subunit 1 Homo sapiens 85-90 12753319-1 2003 BACKGROUND: The effect of the glutamate carboxypeptidase II GCP2 1561C>T and the reduced folate carrier 1 RFC1 80G>A polymorphisms on folate and total homocysteine (tHcy) plasma levels of kidney transplant patients are unknown. Folic Acid 92-98 replication factor C subunit 1 Homo sapiens 109-113 12855225-3 2003 Two recently identified variants are the 1561C-->T (H475Y) mutation in glutamate carboxypeptidase II (GCPII) and the 80A-->G (H27R) change in the reduced folate carrier RFC-1. Folic Acid 160-166 replication factor C subunit 1 Homo sapiens 175-180 12854905-0 2003 Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression. Folic Acid 25-31 replication factor C subunit 1 Homo sapiens 149-154 12854905-10 2003 RT-PCR analysis for the expression of genes involved in folate metabolism demonstrated that increased sensitivity to PDX correlated with higher RFC-1 gene expression with no difference in FPGS or FPGH levels, suggesting that measurement of tumor RFC-1 gene expression level may be a predictor of response to PDX. Folic Acid 56-62 replication factor C subunit 1 Homo sapiens 246-251 12753319-1 2003 BACKGROUND: The effect of the glutamate carboxypeptidase II GCP2 1561C>T and the reduced folate carrier 1 RFC1 80G>A polymorphisms on folate and total homocysteine (tHcy) plasma levels of kidney transplant patients are unknown. Folic Acid 140-146 replication factor C subunit 1 Homo sapiens 109-113 11427193-1 2001 The reduced folate carrier (RFC1) is a major route for the transport of folates in mammalian cells. Folic Acid 12-18 replication factor C subunit 1 Homo sapiens 28-32 12707400-1 2003 This study was designed to examine the effect of two single nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G>A) and the glutamate carboxypeptidase 2 (GCP2 1561C>T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients. Folic Acid 100-106 replication factor C subunit 1 Homo sapiens 118-122 12519783-1 2003 The human reduced folate carrier (hRFC) is the dominant transporter mediating the uptake of reduced folate cofactors and antifolate anticancer drugs. Folic Acid 18-24 replication factor C subunit 1 Homo sapiens 34-38 12519783-1 2003 The human reduced folate carrier (hRFC) is the dominant transporter mediating the uptake of reduced folate cofactors and antifolate anticancer drugs. Folic Acid 100-106 replication factor C subunit 1 Homo sapiens 34-38 11427193-1 2001 The reduced folate carrier (RFC1) is a major route for the transport of folates in mammalian cells. Folic Acid 72-79 replication factor C subunit 1 Homo sapiens 28-32 11266438-1 2001 The reduced folate carrier (RFC1) is an important route by which the major blood folate, 5-methyltetrahydrofolate, is transported into mammalian cells. Folic Acid 12-18 replication factor C subunit 1 Homo sapiens 28-32 11306683-1 2001 The reduced folate carrier (RFC1) plays a major role in the delivery of folates into mammalian cells. Folic Acid 12-18 replication factor C subunit 1 Homo sapiens 28-32 11306683-1 2001 The reduced folate carrier (RFC1) plays a major role in the delivery of folates into mammalian cells. Folic Acid 72-79 replication factor C subunit 1 Homo sapiens 28-32 11266438-1 2001 The reduced folate carrier (RFC1) is an important route by which the major blood folate, 5-methyltetrahydrofolate, is transported into mammalian cells. Folic Acid 81-87 replication factor C subunit 1 Homo sapiens 28-32 10993718-3 2000 We isolated a cDNA for the reduced folate carrier (RFC-1) from human skin fibroblasts. Folic Acid 35-41 replication factor C subunit 1 Homo sapiens 51-56 7641195-9 1995 Finally, MTXR ZR-75-1 cells transfected with an RFC1 gene showed increased MTX uptake, which was more sensitive to competition by folinic acid than by folic acid. Folic Acid 151-161 replication factor C subunit 1 Homo sapiens 48-52 10375617-1 1999 Decreased reduced folate carrier (RFC) activity has been associated with MTX resistance in experimental models of transport-mediated MTX resistance, and has been attributed to changes in the expression of RFC1, the gene that encodes a protein with this activity. Folic Acid 18-24 replication factor C subunit 1 Homo sapiens 205-209 10448518-5 1999 The widely studied one-carbon, reduced-folate transport system is mediated by a transporter encoded by the newly discovered RFC-1 (reduced-folate carrier) gene. Folic Acid 39-45 replication factor C subunit 1 Homo sapiens 124-154 10448518-8 1999 RFC-1 gene expression also appears to regulate luminal epithelial cell folate absorption in small intestine. Folic Acid 71-77 replication factor C subunit 1 Homo sapiens 0-5 10226652-1 1998 The reduced folate carrier (rfc1) gene encodes a protein that is involved in the intracellular accumulation of folates. Folic Acid 111-118 replication factor C subunit 1 Homo sapiens 28-32 9212241-0 1997 Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines. Folic Acid 8-14 replication factor C subunit 1 Homo sapiens 29-33 10648641-1 2000 In previous reports, an E45K mutation in reduced folate carrier (RFC1) resulted in marked substrate-specific changes in folate binding and the induction of an obligatory inorganic anion requirement for carrier function. Folic Acid 49-55 replication factor C subunit 1 Homo sapiens 65-69 10648641-1 2000 In previous reports, an E45K mutation in reduced folate carrier (RFC1) resulted in marked substrate-specific changes in folate binding and the induction of an obligatory inorganic anion requirement for carrier function. Folic Acid 120-126 replication factor C subunit 1 Homo sapiens 65-69 10648641-7 2000 These data further substantiate the important role that glutamate-45 plays in the selectivity of binding of folates to RFC1 and establish that it is the addition of a positive charge at this site and not the loss of a negative charge that results in the induced anion dependence. Folic Acid 108-115 replication factor C subunit 1 Homo sapiens 119-123 10648641-8 2000 These and other studies indicate that mutations in the first transmembrane domain can have a markedly selective impact on the affinity of RFC1 for folate compounds and in particularly a highly salutary effect on binding of the oxidized folate, folic acid. Folic Acid 147-153 replication factor C subunit 1 Homo sapiens 138-142 9634005-0 1998 Concentrating capacity of the human reduced folate carrier (hRFC1) in human ZR-75 breast cancer cell lines. Folic Acid 44-50 replication factor C subunit 1 Homo sapiens 60-65 9634005-8 1998 The changes in the human cells transfected with hRFC1 however, were similar to what has been observed by other investigators when RFC1 expression is increased by low folate selective pressure. Folic Acid 166-172 replication factor C subunit 1 Homo sapiens 48-53 9634005-8 1998 The changes in the human cells transfected with hRFC1 however, were similar to what has been observed by other investigators when RFC1 expression is increased by low folate selective pressure. Folic Acid 166-172 replication factor C subunit 1 Homo sapiens 49-53 31223065-8 2019 A high tumoral expression of the genes SLC46A1/PCFT, SLC19A1/RFC-1, ABCC3/MRP3, GGH, and MTHFD1L, which are involved in folate transport, polyglutamation, or metabolism, was associated with longer disease-free survival of the patients. Folic Acid 120-126 replication factor C subunit 1 Homo sapiens 61-66 34769063-3 2021 In this study, we found that folate antagonists, such as methotrexate (MTX) and pemetrexed, are selectively cytotoxic to GSCs, but not to their differentiated counterparts, normal fibroblasts, or neural stem cells in vitro, and that the high sensitivity of GCSs to anti-folates may be due to the increased expression of RFC-1/SLC19A1, the reduced folate carrier that transports MTX into cells, in GSCs. Folic Acid 29-35 replication factor C subunit 1 Homo sapiens 320-325 34769063-3 2021 In this study, we found that folate antagonists, such as methotrexate (MTX) and pemetrexed, are selectively cytotoxic to GSCs, but not to their differentiated counterparts, normal fibroblasts, or neural stem cells in vitro, and that the high sensitivity of GCSs to anti-folates may be due to the increased expression of RFC-1/SLC19A1, the reduced folate carrier that transports MTX into cells, in GSCs. Folic Acid 270-277 replication factor C subunit 1 Homo sapiens 320-325 33913025-8 2021 Furthermore, maternal folate supplementation may help to offset some of the risks of CHD in offspring due to maternal RFC1 genetic variants. Folic Acid 22-28 replication factor C subunit 1 Homo sapiens 118-122 33913025-10 2021 Studies have assessed the associations of folate metabolism-related genes with CHD, but genes involved in cellular transportation of folate, such as the RFC1 gene, have not garnered enough attention. Folic Acid 133-139 replication factor C subunit 1 Homo sapiens 153-157 33913025-13 2021 Folate supplementation may help to offset some risks of CHD due to RFC1 genetic variants. Folic Acid 0-6 replication factor C subunit 1 Homo sapiens 67-71 32820034-4 2021 Functional analysis indicates that CIC binds to an octameric sequence in the promoter regions of folate transport genes: FOLR1, PCFT and reduced folate carrier (Slc19A1; RFC1). Folic Acid 97-103 replication factor C subunit 1 Homo sapiens 170-174 31482954-1 2019 OBJECTIVE: To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS). Folic Acid 73-79 replication factor C subunit 1 Homo sapiens 151-156