PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32257815-4	2020	MTRR enzyme is a key regulator of the methionine and folate cycles.	Folic Acid	53-59	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	0-4	
30024025-2	2018	Folate metabolism, which requires the enzyme methionine synthase reductase (MTRR), is necessary for DNA synthesis and the transmission of one-carbon methyl groups for cellular methylation.	Folic Acid	0-6	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	45-74	
30024025-2	2018	Folate metabolism, which requires the enzyme methionine synthase reductase (MTRR), is necessary for DNA synthesis and the transmission of one-carbon methyl groups for cellular methylation.	Folic Acid	0-6	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	76-80	
30024025-9	2018	Methionine synthase reductase (MTRR) is a key enzyme necessary for the progression of folate metabolism since knocking down the Mtrr gene in mice results in hyperhomocysteinaemia and global DNA hypomethylation.	Folic Acid	86-92	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	0-29	
30024025-9	2018	Methionine synthase reductase (MTRR) is a key enzyme necessary for the progression of folate metabolism since knocking down the Mtrr gene in mice results in hyperhomocysteinaemia and global DNA hypomethylation.	Folic Acid	86-92	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	31-35	
30024025-9	2018	Methionine synthase reductase (MTRR) is a key enzyme necessary for the progression of folate metabolism since knocking down the Mtrr gene in mice results in hyperhomocysteinaemia and global DNA hypomethylation.	Folic Acid	86-92	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	128-132	
31537252-2	2019	Knocking down the mouse gene Mtrr impedes the progression of folate and methionine metabolism and results in hyperhomocysteinaemia, dysregulation of DNA methylation and developmental phenotypes (e.g. neural tube, heart and placenta defects).	Folic Acid	61-67	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	29-33	
24074862-2	2013	The enzyme methionine synthase reductase (Mtrr) is necessary for utilization of methyl groups from the folate cycle.	Folic Acid	103-109	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	11-40	
29492317-5	2017	The enzyme methionine synthase reductase (MTRR) is required for the progression of folate metabolism and the utilization of methyl groups from the folate cycle.	Folic Acid	83-89	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	11-40	
29492317-5	2017	The enzyme methionine synthase reductase (MTRR) is required for the progression of folate metabolism and the utilization of methyl groups from the folate cycle.	Folic Acid	83-89	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	42-46	
29492317-5	2017	The enzyme methionine synthase reductase (MTRR) is required for the progression of folate metabolism and the utilization of methyl groups from the folate cycle.	Folic Acid	147-153	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	11-40	
29492317-5	2017	The enzyme methionine synthase reductase (MTRR) is required for the progression of folate metabolism and the utilization of methyl groups from the folate cycle.	Folic Acid	147-153	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	42-46	
24074862-2	2013	The enzyme methionine synthase reductase (Mtrr) is necessary for utilization of methyl groups from the folate cycle.	Folic Acid	103-109	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	42-46	
18413293-2	2008	Methionine synthase reductase (MTRR) is required for activation of methionine synthase, a folate- and vitamin B(12)-dependent enzyme.	Folic Acid	90-96	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	0-29	
18413293-2	2008	Methionine synthase reductase (MTRR) is required for activation of methionine synthase, a folate- and vitamin B(12)-dependent enzyme.	Folic Acid	90-96	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	31-35	
17369066-0	2007	Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.	Folic Acid	40-46	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	79-108	
34957089-3	2021	MTRR is necessary for methyl group utilisation from folate metabolism, and the Mtrr gt allele disrupts this process.	Folic Acid	52-58	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	0-4	
34957089-3	2021	MTRR is necessary for methyl group utilisation from folate metabolism, and the Mtrr gt allele disrupts this process.	Folic Acid	52-58	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	79-83	
34140513-2	2021	We previously showed that disruption of folate metabolism in mice by the Mtrr hypomorphic mutation results in transgenerational epigenetic inheritance of congenital malformations.	Folic Acid	40-46	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Mus musculus	73-77