PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26586196-7	2016	The splenic expression levels of IL-2 and IL-4 were up-regulated, whereas that of IL-6 was down-regulated, in the 100- and 150-microg folic acid treatment groups.	Folic Acid	134-144	interleukin 6	Homo sapiens	82-86	
27904616-8	2016	IL-6 decreased significantly after folic acid use (P < 0.05).	Folic Acid	35-45	interleukin 6	Homo sapiens	0-4	
26586196-9	2016	In contrast, a decrease in H3K4m2 and an increase in H3K9me2 were observed in the IL-6 promoter in folic acid treatments.	Folic Acid	99-109	interleukin 6	Homo sapiens	82-86	
34857394-7	2021	Folic acid supplementation significantly reduced serum levels of C-reactive protein (mean difference (MD), -0.21 mg/L; 95% CI, -0.41 to -0.01; n = 16), TNF-alpha (MD, -14.88 pg/mL; 95% CI, -23.68 to -6.09; n = 10), and IL-6 (MD, -0.93 pg/mL; 95% CI, -1.72 to -0.14; n = 11).	Folic Acid	0-10	interleukin 6	Homo sapiens	219-223	
26263423-7	2015	An inverse association was observed between CSF folate and CSF levels of IL-6 (P <= 0.05).	Folic Acid	48-54	interleukin 6	Homo sapiens	73-77	
19360465-3	2010	Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth.	Folic Acid	245-251	interleukin 6	Homo sapiens	273-276	
31345146-10	2019	RESULTS: Compared with control group, the folic acid plus vitamin B 12 group had significantly greater improvements in serum folate, homocysteine, vitamin B 12 and IL-6, TNF-alpha, MCP-1.	Folic Acid	42-52	interleukin 6	Homo sapiens	164-168	
35429607-5	2022	Pre-treatment with folic acid, which has known neuroprotective and anti-inflammatory properties, ameliorated IL-6 effects on mitochondrial respiration and IFN-gamma effects on dendritic spine density.	Folic Acid	19-29	interleukin 6	Homo sapiens	109-113	
35429607-6	2022	These findings suggest distinct mechanisms for how fetal IL-6 and IFN-gamma exposure influence risk for neuropsychiatric disorders, and how folic acid can mitigate such risk.	Folic Acid	140-150	interleukin 6	Homo sapiens	57-61	
32019627-6	2020	Folate catabolite apABG was positively correlated with IL-6 (r= 0.27, plinear<0.0001) and pABG was positively correlated with IL-8 (r= 0.21, plinear<0.0001), indicating higher folate utilization during inflammation.Our data support the hypothesis of inverse associations between PLP and inflammatory biomarkers among colorectal cancer patients.	Folic Acid	0-6	interleukin 6	Homo sapiens	55-59	
34371837-3	2021	To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).	Folic Acid	143-153	interleukin 6	Homo sapiens	248-261	
34371837-3	2021	To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha).	Folic Acid	143-153	interleukin 6	Homo sapiens	263-267	
35125691-10	2022	In addition, presence of low folate, and hyperhomocysteinemia was observed in the present study, may be the contributing factors for the hypomethylation of IL-6 and TNF-alpha and oxidative stress.	Folic Acid	29-35	interleukin 6	Homo sapiens	156-160	
31296192-9	2019	Serum folate was negatively correlated with hs-CRP, TNF-alpha, and IL-6 (P < 0.05).	Folic Acid	6-12	interleukin 6	Homo sapiens	67-71	
29132841-6	2017	Pg-3-glc and PGA at 0.08 mumol/L increased the concentration of IL-10 (P<.01 and P<.001, respectively), but there was no effect on tumor necrosis factor-alpha, IL-1beta, IL-6, and IL-8, and there were no effects of the other compounds.	Folic Acid	13-16	interleukin 6	Homo sapiens	176-180