PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26400185-0	2015	Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism.	Folic Acid	0-10	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	65-69	
26804918-5	2016	These data implicate the PGC-1alpha/ERRalpha axis as a core regulatory node of folate cycle metabolism and further suggest that activators of AMPK could be used to modulate this pathway in cancer.	Folic Acid	79-85	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	142-146	
26400185-9	2015	Consistent with in vivo findings, 5-methyltetrahydrofolate (bioactive form of folate) restored phosphorylation (activation) of both AMPK and LKB1 in palmitic acid-treated HepG2 cells.	Folic Acid	52-58	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	132-136	
26400185-10	2015	Activation of AMPK by folic acid might be responsible for AMPK-dependent phosphorylation of HMG-CoA reductase, leading to reduced hepatic cholesterol synthesis during high-fat diet feeding.	Folic Acid	22-32	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	14-18	
26400185-10	2015	Activation of AMPK by folic acid might be responsible for AMPK-dependent phosphorylation of HMG-CoA reductase, leading to reduced hepatic cholesterol synthesis during high-fat diet feeding.	Folic Acid	22-32	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	58-62	
26400185-11	2015	These results suggest that folic acid supplementation may improve cholesterol and glucose metabolism by restoration of AMPK activation in the liver.	Folic Acid	27-37	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	119-123	
26400185-4	2015	The aim of the present study was to investigate the effect of folic acid on hepatic AMPK during high-fat diet feeding and the mechanisms involved.	Folic Acid	62-72	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	84-88	
26400185-7	2015	Folic acid supplementation restored AMPK phosphorylation (activation) and reduced blood glucose and hepatic cholesterol levels.	Folic Acid	0-10	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	36-40	
26400185-8	2015	Activation of AMPK by folic acid was mediated through an elevation of its allosteric activator AMP and activation of its upstream kinase, namely, liver kinase B1 (LKB1) in the liver.	Folic Acid	22-32	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	14-18