PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18375715-1 2008 Folic acid (FA) is a member of the B-vitamin family with cardiovascular roles in homocysteine regulation and endothelial nitric oxide synthase (eNOS) activity. Folic Acid 0-10 nitric oxide synthase 3 Homo sapiens 109-142 22116698-10 2012 Folates interact with the endothelial enzyme NO synthase (eNOS) and, exert effects on the cofactor bioavailability of NO and thus, on peroxynitrite formation. Folic Acid 0-7 nitric oxide synthase 3 Homo sapiens 58-62 19409716-1 2009 Reduced folates have been shown to reconstitute the proper activity of "uncoupled" endothelial nitric oxide synthase in inflamed endothlelium. Folic Acid 8-15 nitric oxide synthase 3 Homo sapiens 83-116 17357445-9 2007 The addition of folic acid (100 micromol/L)resulted in partial antagonistic effects against the injury of Hcy on NOS system of endothelial cells, the eNOS protein level and eNOS activity, and NO production increased,and so does the DDAH activity,and the ADMA concentration reduced. Folic Acid 16-26 nitric oxide synthase 3 Homo sapiens 150-154 17420345-7 2007 Low-dose folic acid increased nitric oxide-mediated endothelium-dependent vasomotor responses, reduced vascular superoxide production, and improved enzymatic coupling of endothelial nitric oxide synthase through availability of the cofactor tetrahydrobiopterin. Folic Acid 9-19 nitric oxide synthase 3 Homo sapiens 170-203 17420345-10 2007 CONCLUSIONS: Low-dose folic acid treatment, comparable to daily intake and dietary fortification, improves vascular function through effects on endothelial nitric oxide synthase and vascular oxidative stress. Folic Acid 22-32 nitric oxide synthase 3 Homo sapiens 144-177 17357445-9 2007 The addition of folic acid (100 micromol/L)resulted in partial antagonistic effects against the injury of Hcy on NOS system of endothelial cells, the eNOS protein level and eNOS activity, and NO production increased,and so does the DDAH activity,and the ADMA concentration reduced. Folic Acid 16-26 nitric oxide synthase 3 Homo sapiens 173-177 17357445-13 2007 Folic acid can exert partial protective roles against the Hcy in the level of eNOS protein and eNOS activity,but without impact on the expression of eNOS gene. Folic Acid 0-10 nitric oxide synthase 3 Homo sapiens 78-82 17357445-13 2007 Folic acid can exert partial protective roles against the Hcy in the level of eNOS protein and eNOS activity,but without impact on the expression of eNOS gene. Folic Acid 0-10 nitric oxide synthase 3 Homo sapiens 95-99 17357445-13 2007 Folic acid can exert partial protective roles against the Hcy in the level of eNOS protein and eNOS activity,but without impact on the expression of eNOS gene. Folic Acid 0-10 nitric oxide synthase 3 Homo sapiens 95-99 15134582-8 2004 This folate shuttle facilitates the important recoupling of the uncoupled endothelial nitric oxide synthase enzyme reaction and may restore the synthesis of the omnipotent endothelial nitric oxide to the vasculature. Folic Acid 5-11 nitric oxide synthase 3 Homo sapiens 74-107 16585403-11 2006 In addition, folic acid and infusions of vitamin C are able to restore eNOS functionality, most probably by enhancing BH4 levels as well. Folic Acid 13-23 nitric oxide synthase 3 Homo sapiens 71-75 15136061-8 2004 We propose that hyperhomocysteinemia in MTHFR 677TT homozygote smokers is the consequence of mild intracellular folate deficiency caused by a smoking-related reduction of NOS3 activity that is exacerbated when serum folate is low. Folic Acid 112-118 nitric oxide synthase 3 Homo sapiens 171-175 17117898-1 2006 BACKGROUND: The nitric oxide synthase (NOS3) G894T gene polymorphism seems as a genetic determinant of total homocysteine (tHcy) concentrations through an effect on folate catabolism. Folic Acid 165-171 nitric oxide synthase 3 Homo sapiens 39-43 12689917-9 2003 CONCLUSIONS: These data indicate that the NOS3 894TT genotype is a risk factor for elevated tHcy in healthy nonsmoking adults with low serum folate and supports the hypothesis that nitric oxide modulates homocysteine through an effect on folate catabolism. Folic Acid 141-147 nitric oxide synthase 3 Homo sapiens 42-46 12689917-5 2003 In both populations, NOS3 genotype was significantly associated with tHcy concentrations in nonsmokers with low folate (P=0.03 for each). Folic Acid 112-118 nitric oxide synthase 3 Homo sapiens 21-25 12689917-9 2003 CONCLUSIONS: These data indicate that the NOS3 894TT genotype is a risk factor for elevated tHcy in healthy nonsmoking adults with low serum folate and supports the hypothesis that nitric oxide modulates homocysteine through an effect on folate catabolism. Folic Acid 238-244 nitric oxide synthase 3 Homo sapiens 42-46 32759013-4 2020 Our work has shown that, in the systemic circulation, folic acid in high dose rapidly improves nitric oxide mediated vasodilation, by activating endothelial nitric oxide synthase (eNOS). Folic Acid 54-64 nitric oxide synthase 3 Homo sapiens 145-178 12003352-4 2002 Folate acts directly to produce antioxidant effects, interactions with enzyme endothelial NO synthase (eNOS) and effects on cofactor bioavailability of NO. Folic Acid 0-6 nitric oxide synthase 3 Homo sapiens 103-107 10997917-11 2000 Folates, superoxide ions, and peroxynitrite scavengers restore the NO-generating activity to eNOS, collectively suggesting that cellular redox state plays an important role in HCy-suppressed NO-generating function of this enzyme. Folic Acid 0-7 nitric oxide synthase 3 Homo sapiens 93-97 10850963-0 2000 Folic acid reverts dysfunction of endothelial nitric oxide synthase. Folic Acid 0-10 nitric oxide synthase 3 Homo sapiens 34-67 32759013-4 2020 Our work has shown that, in the systemic circulation, folic acid in high dose rapidly improves nitric oxide mediated vasodilation, by activating endothelial nitric oxide synthase (eNOS). Folic Acid 54-64 nitric oxide synthase 3 Homo sapiens 180-184 28624453-5 2017 Folic acid also decreased cyclooxygenase-2 (COX-2) and hypoxia-inducible factor 1-alpha (HIF-1alpha) expression and altered endothelial nitric oxide synthase (eNOS) signaling by increasing p-eNOS(Ser1177) and decreasing p-eNOS(Thr495) in a dose-dependent manner. Folic Acid 0-10 nitric oxide synthase 3 Homo sapiens 124-157 26414244-0 2015 Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase. Folic Acid 0-10 nitric oxide synthase 3 Homo sapiens 127-160 26906511-9 2016 In addition, folic acid decreased protein expressions of NOX4 and p-ERK1/2, while it increased the protein expression of eNOS in HUVECs. Folic Acid 13-23 nitric oxide synthase 3 Homo sapiens 121-125 25592012-0 2015 Effects of polymorphisms in endothelial nitric oxide synthase and folate metabolizing genes on the concentration of serum nitrate, folate, and plasma total homocysteine after folic acid supplementation: a double-blind crossover study. Folic Acid 131-137 nitric oxide synthase 3 Homo sapiens 28-61 25477161-0 2015 A NOS3 polymorphism determines endothelial response to folate in children with type 1 diabetes or obesity. Folic Acid 55-61 nitric oxide synthase 3 Homo sapiens 2-6 25477161-1 2015 OBJECTIVE: To determine the effect of polymorphisms in NOS3 and folate pathway enzymes on vascular function and folate status and endothelial response to folate in children with diabetes or obesity. Folic Acid 112-118 nitric oxide synthase 3 Homo sapiens 55-59 25477161-1 2015 OBJECTIVE: To determine the effect of polymorphisms in NOS3 and folate pathway enzymes on vascular function and folate status and endothelial response to folate in children with diabetes or obesity. Folic Acid 112-118 nitric oxide synthase 3 Homo sapiens 55-59 25477161-3 2015 The effect of NOS3 genotype on endothelial response to folate (5 mg) was assessed in 85 subjects with diabetes and 28 obese subjects who received active treatment during intervention trials. Folic Acid 55-61 nitric oxide synthase 3 Homo sapiens 14-18 25477161-6 2015 The polymorphism in intron 4 of endothelial nitric oxide synthase altered endothelial response to folate significantly: in subjects with diabetes FMD improved by 6.4 +- 5% (insertion carriers) vs 2.3 +- 6.6% (deletion carriers), P = .01; in obese subjects FMD improved by 1.8 +- 5.4% (insertion carriers) and deteriorated by -3.2 +- 7.2% (deletion carriers), P = .05. Folic Acid 98-104 nitric oxide synthase 3 Homo sapiens 32-65 25477161-8 2015 CONCLUSIONS: A NOS3 polymorphism predicts endothelial response to folate in children with diabetes or obesity, with implications for vascular risk and folate intervention studies. Folic Acid 66-72 nitric oxide synthase 3 Homo sapiens 15-19 25477161-8 2015 CONCLUSIONS: A NOS3 polymorphism predicts endothelial response to folate in children with diabetes or obesity, with implications for vascular risk and folate intervention studies. Folic Acid 151-157 nitric oxide synthase 3 Homo sapiens 15-19 25592012-0 2015 Effects of polymorphisms in endothelial nitric oxide synthase and folate metabolizing genes on the concentration of serum nitrate, folate, and plasma total homocysteine after folic acid supplementation: a double-blind crossover study. Folic Acid 175-185 nitric oxide synthase 3 Homo sapiens 28-61 25592012-4 2015 The aim of this study was to investigate whether genetic polymorphisms in endothelial nitric oxide synthase (eNOS) and genes involved in folate metabolism affect the concentration of serum nitrate, serum folate, and plasma total homocysteine in healthy individuals after folic acid supplementation. Folic Acid 204-210 nitric oxide synthase 3 Homo sapiens 74-107 25592012-4 2015 The aim of this study was to investigate whether genetic polymorphisms in endothelial nitric oxide synthase (eNOS) and genes involved in folate metabolism affect the concentration of serum nitrate, serum folate, and plasma total homocysteine in healthy individuals after folic acid supplementation. Folic Acid 204-210 nitric oxide synthase 3 Homo sapiens 109-113 25592012-10 2015 The individuals with three polymorphisms in eNOS gene had increased concentration of serum folate and decreased concentration of p-tHcy after folic acid supplementation. Folic Acid 91-97 nitric oxide synthase 3 Homo sapiens 44-48 25592012-10 2015 The individuals with three polymorphisms in eNOS gene had increased concentration of serum folate and decreased concentration of p-tHcy after folic acid supplementation. Folic Acid 142-152 nitric oxide synthase 3 Homo sapiens 44-48 25592012-13 2015 CONCLUSIONS: Polymorphisms in eNOS and folate genes affect the concentration of serum folate and p-tHcy but do not have any effect on the concentration of NO3 in healthy individuals after folic acid supplementation. Folic Acid 188-198 nitric oxide synthase 3 Homo sapiens 30-34 21872972-10 2012 In addition, folic acid had a protective effect in the NOS3 786 TT and NOS3 894 GT + TT genotype. Folic Acid 13-23 nitric oxide synthase 3 Homo sapiens 55-59 23796957-0 2013 Folic acid modulates eNOS activity via effects on posttranslational modifications and protein-protein interactions. Folic Acid 0-10 nitric oxide synthase 3 Homo sapiens 21-25 23796957-3 2013 Particular focus was placed on folic acid-induced changes in posttranslational modifications of endothelial nitric oxide synthase (eNOS). Folic Acid 31-41 nitric oxide synthase 3 Homo sapiens 96-129 23796957-3 2013 Particular focus was placed on folic acid-induced changes in posttranslational modifications of endothelial nitric oxide synthase (eNOS). Folic Acid 31-41 nitric oxide synthase 3 Homo sapiens 131-135 23796957-9 2013 Folic acid promoted eNOS dephosphorylation at negative regulatory sites, and increased phosphorylation at positive regulatory sites. Folic Acid 0-10 nitric oxide synthase 3 Homo sapiens 20-24 23796957-11 2013 Inhibition of PI3K/Akt revealed specific roles for this kinase pathway in folic acid-mediated eNOS phosphorylation. Folic Acid 74-84 nitric oxide synthase 3 Homo sapiens 94-98 23796957-13 2013 Folic acid-mediated eNOS activation involves the modulation of eNOS phosphorylation status at multiple residues and positive changes in important protein-protein interactions. Folic Acid 0-10 nitric oxide synthase 3 Homo sapiens 20-24 23796957-13 2013 Folic acid-mediated eNOS activation involves the modulation of eNOS phosphorylation status at multiple residues and positive changes in important protein-protein interactions. Folic Acid 0-10 nitric oxide synthase 3 Homo sapiens 63-67 21872972-10 2012 In addition, folic acid had a protective effect in the NOS3 786 TT and NOS3 894 GT + TT genotype. Folic Acid 13-23 nitric oxide synthase 3 Homo sapiens 71-75 22112349-8 2012 These strategies include targeting NO synthesis by modulation of endothelial nitric oxide synthase (eNOS) coupling, such as folates and tetrahydrobiopterin. Folic Acid 124-131 nitric oxide synthase 3 Homo sapiens 65-98