PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31099011-4 2019 Flow cytometry displayed that AuNPs-PEI-FA could specifically deliver siRNA into LNCaP cells, a prostate cancer cell line overexpressing prostate-specific membrane antigen (PSMA) that exhibits a hydrolase enzymatic activity with a folate substrate. Folic Acid 231-237 folate hydrolase 1 Homo sapiens 137-171 31492214-6 2020 After folic acid (FA) conjugating to the surface of the PSMA dots, FA-dots were obtained. Folic Acid 6-16 folate hydrolase 1 Homo sapiens 56-60 30844704-3 2019 GCPII has been recognized as a neuropeptidase in the central nervous system, as a folate hydrolase participating in absorption of folates in the jejunum and, most importantly, as a prostate-specific membrane antigen that is highly expressed in prostate adenocarcinoma. Folic Acid 130-137 folate hydrolase 1 Homo sapiens 0-5 31099011-4 2019 Flow cytometry displayed that AuNPs-PEI-FA could specifically deliver siRNA into LNCaP cells, a prostate cancer cell line overexpressing prostate-specific membrane antigen (PSMA) that exhibits a hydrolase enzymatic activity with a folate substrate. Folic Acid 231-237 folate hydrolase 1 Homo sapiens 173-177 29680672-0 2018 Targeting of folate-conjugated liposomes with co-entrapped drugs to prostate cancer cells via prostate-specific membrane antigen (PSMA). Folic Acid 13-19 folate hydrolase 1 Homo sapiens 94-128 30120883-3 2018 This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase (DHFR) and Methylenetetrahydrofolate reductase (MTHFR) and neural tube defects from eastern India. Folic Acid 71-77 folate hydrolase 1 Homo sapiens 112-130 30120883-3 2018 This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase (DHFR) and Methylenetetrahydrofolate reductase (MTHFR) and neural tube defects from eastern India. Folic Acid 71-77 folate hydrolase 1 Homo sapiens 132-137 29680672-0 2018 Targeting of folate-conjugated liposomes with co-entrapped drugs to prostate cancer cells via prostate-specific membrane antigen (PSMA). Folic Acid 13-19 folate hydrolase 1 Homo sapiens 130-134 27378204-2 2016 Analysis of cellular internalization revealed that folic acid conjugated minicells internalized through receptor mediated endocytosis in folate and PSMA receptor positive KB and LNCaP cells, respectively. Folic Acid 51-61 folate hydrolase 1 Homo sapiens 148-152 27917408-5 2016 The presence of folic acid allowed efficient targeting of the PSMA receptor and subsequent internalization of the polymeric vesicles in cultured LNCaP prostate cancer cell spheroids. Folic Acid 16-26 folate hydrolase 1 Homo sapiens 62-66 27389146-1 2016 In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA). Folic Acid 17-23 folate hydrolase 1 Homo sapiens 189-193 27389146-1 2016 In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA). Folic Acid 132-138 folate hydrolase 1 Homo sapiens 153-187 27389146-3 2016 Competitive uptake studies, using excess folate, significantly reduced uptake of targeted nanoparticles in PSMA positive cell lines (P<0.001). Folic Acid 41-47 folate hydrolase 1 Homo sapiens 107-111 27389146-7 2016 This study highlights the ability of incorporating a folate ligand into CD.siRNA nanoparticles to allow for targeted delivery of siRNA to prostate cancer cells via the PSMA. Folic Acid 53-59 folate hydrolase 1 Homo sapiens 168-172 29141866-0 2018 Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors. Folic Acid 47-57 folate hydrolase 1 Homo sapiens 0-34 29141866-5 2018 PSMA"s carboxypeptidase activity releases glutamate from vitamin B9 and other glutamated substrates, which activate mGluR I. Folic Acid 57-67 folate hydrolase 1 Homo sapiens 0-4 28885600-7 2017 In the largest racial group, synthetic FA and the interaction of FOLH1 genotype with naturally occurring food folate significantly predicted RBC folate, with the overall model accounting for 13.8% of the variance in RBC folate levels. Folic Acid 145-151 folate hydrolase 1 Homo sapiens 65-70 28885600-7 2017 In the largest racial group, synthetic FA and the interaction of FOLH1 genotype with naturally occurring food folate significantly predicted RBC folate, with the overall model accounting for 13.8% of the variance in RBC folate levels. Folic Acid 145-151 folate hydrolase 1 Homo sapiens 65-70 28885600-8 2017 Blood folate levels rely on a complex interaction of natural and synthetic folate intake as well as FOLH1 genotype. Folic Acid 6-12 folate hydrolase 1 Homo sapiens 100-105 27389146-0 2016 Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo. Folic Acid 0-6 folate hydrolase 1 Homo sapiens 97-101 27389146-1 2016 In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA). Folic Acid 17-23 folate hydrolase 1 Homo sapiens 153-187 27183249-3 2016 The computational results showed the bio-degradable linker 2, 4-diaminobutyric acid, DABA as a good candidate allowing flexibility of the folic acid group while maintaining the pH sensitivity of PSMA, used as a trigger for drug release. Folic Acid 138-148 folate hydrolase 1 Homo sapiens 195-199 27387982-2 2016 PSMA participates in various biological functions depending on the substrate available in the particular tissue; in the brain, PSMA cleaves the abundant neuropeptide N-acetyl-aspartyl-glutamate to regulate release of key neurotransmitters, while intestinal PSMA cleaves polyglutamated peptides to supply dietary folate. Folic Acid 312-318 folate hydrolase 1 Homo sapiens 0-4 27387982-2 2016 PSMA participates in various biological functions depending on the substrate available in the particular tissue; in the brain, PSMA cleaves the abundant neuropeptide N-acetyl-aspartyl-glutamate to regulate release of key neurotransmitters, while intestinal PSMA cleaves polyglutamated peptides to supply dietary folate. Folic Acid 312-318 folate hydrolase 1 Homo sapiens 127-131 27387982-2 2016 PSMA participates in various biological functions depending on the substrate available in the particular tissue; in the brain, PSMA cleaves the abundant neuropeptide N-acetyl-aspartyl-glutamate to regulate release of key neurotransmitters, while intestinal PSMA cleaves polyglutamated peptides to supply dietary folate. Folic Acid 312-318 folate hydrolase 1 Homo sapiens 127-131 27188645-7 2016 At the cellular level the AuNPs-PEI-FA specifically delivered siRNA into LNCaP cells, a prostate cancer cell line overexpressing prostate specific membrane antigen (PSMA, exhibits a hydrolase enzymic activity with a folate substrate). Folic Acid 216-222 folate hydrolase 1 Homo sapiens 129-163 27188645-7 2016 At the cellular level the AuNPs-PEI-FA specifically delivered siRNA into LNCaP cells, a prostate cancer cell line overexpressing prostate specific membrane antigen (PSMA, exhibits a hydrolase enzymic activity with a folate substrate). Folic Acid 216-222 folate hydrolase 1 Homo sapiens 165-169 27183249-1 2016 We report the computational analysis, synthesis and characterization of folate functionalized poly(styrene-alt-maleic anhydride), PSMA for drug delivery purpose. Folic Acid 72-78 folate hydrolase 1 Homo sapiens 130-134 26471812-6 2015 This variant exhibited higher affinity toward FPG compared with wild GCPII (-2.06 vs. -1.69); and positive correlation was observed between the P160S variant and circulating folate (r = 0.60). Folic Acid 174-180 folate hydrolase 1 Homo sapiens 69-74 26028103-1 2015 BACKGROUND: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated with perturbations in folate metabolism and disease susceptibility. Folic Acid 136-142 folate hydrolase 1 Homo sapiens 38-67 26028103-1 2015 BACKGROUND: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated with perturbations in folate metabolism and disease susceptibility. Folic Acid 136-142 folate hydrolase 1 Homo sapiens 69-74 26028103-3 2015 Therefore, this study examined whether C1561T-GCPII influences folate metabolism and adenomatous polyp occurrence. Folic Acid 63-69 folate hydrolase 1 Homo sapiens 46-51 23266799-2 2013 To test this hypothesis, breast and prostate cancer cases and controls were subjected to whole gene screening of GCPII and correlated with plasma folate levels and PSMA expression. Folic Acid 146-152 folate hydrolase 1 Homo sapiens 113-118 23777916-4 2013 The folate moiety binds quickly to PSMA-positive tumors, and the PSA-responsive moiety is cleaved by PSA that was enriched in tumor tissues. Folic Acid 4-10 folate hydrolase 1 Homo sapiens 35-39 24863754-1 2014 In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Folic Acid 248-255 folate hydrolase 1 Homo sapiens 80-109 24863754-1 2014 In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Folic Acid 248-255 folate hydrolase 1 Homo sapiens 111-116 24863754-1 2014 In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Folic Acid 322-332 folate hydrolase 1 Homo sapiens 80-109 24863754-1 2014 In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Folic Acid 322-332 folate hydrolase 1 Homo sapiens 111-116 24863754-1 2014 In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Folic Acid 348-358 folate hydrolase 1 Homo sapiens 80-109 24863754-1 2014 In addition to its well-characterized role in the central nervous system, human glutamate carboxypeptidase II (GCPII; Uniprot ID Q04609) acts as a folate hydrolase in the small intestine, participating in the absorption of dietary polyglutamylated folates (folyl-n-gamma-l-glutamic acid), which are the provitamin form of folic acid (also known as vitamin B9 ). Folic Acid 348-358 folate hydrolase 1 Homo sapiens 111-116 24863754-5 2014 As a result, the crystallographic data reveal considerable details about the binding mode of polyglutamylated folates to GCPII, especially the engagement of the arene binding site in recognizing the folic acid moiety. Folic Acid 110-117 folate hydrolase 1 Homo sapiens 121-126 24863754-5 2014 As a result, the crystallographic data reveal considerable details about the binding mode of polyglutamylated folates to GCPII, especially the engagement of the arene binding site in recognizing the folic acid moiety. Folic Acid 199-209 folate hydrolase 1 Homo sapiens 121-126 23586109-11 2004 PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (9). Folic Acid 139-145 folate hydrolase 1 Homo sapiens 0-4 22918695-1 2013 Folate hydrolase 1 (FOLH1) gene encodes intestinal folate hydrolase, which regulates intestinal absorption of dietary folate. Folic Acid 51-57 folate hydrolase 1 Homo sapiens 0-18 22918695-1 2013 Folate hydrolase 1 (FOLH1) gene encodes intestinal folate hydrolase, which regulates intestinal absorption of dietary folate. Folic Acid 51-57 folate hydrolase 1 Homo sapiens 20-25 23256225-3 2004 Two site-specific carboxypeptidase activities have been assigned to PSMA: N-acetylated alpha-linked acidic dipeptidase, which hydrolyzes the neuropeptide N-acetyl-aspartyl-glutamate (NAAG) in the brain to regulate release of neurotransmitters, and folate hydrolase activity, which is characterized by the cleavage of terminal glutamates from poly- and gamma-glutamated folates, which play a role in the cellular uptake of dietary folate (2). Folic Acid 248-254 folate hydrolase 1 Homo sapiens 68-72 23256224-3 2004 Two site-specific carboxypeptidase activities have been assigned to PSMA: N-acetylated alpha-linked acidic dipeptidase, which hydrolyzes the neuropeptide N-acetyl-aspartyl-glutamate (NAAG) in the brain to regulate release of neurotransmitters, and folate hydrolase activity, which is characterized by the cleavage of terminal glutamates from poly- and gamma-glutamated folates, which play a role in the cellular uptake of dietary folate (2). Folic Acid 248-254 folate hydrolase 1 Homo sapiens 68-72 20641404-4 2004 PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, and in the absorption of folate (4). Folic Acid 132-138 folate hydrolase 1 Homo sapiens 0-4 22310383-13 2012 However, a positive correlation was seen between plasma folate levels and GCPII expression (r=0.70, p<0.05). Folic Acid 56-62 folate hydrolase 1 Homo sapiens 74-79 22400137-14 2004 PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (10). Folic Acid 139-145 folate hydrolase 1 Homo sapiens 0-4 21634075-19 2004 PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (26). Folic Acid 139-145 folate hydrolase 1 Homo sapiens 0-4 20662139-11 2004 PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (9). Folic Acid 139-145 folate hydrolase 1 Homo sapiens 0-4 22379638-4 2004 PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (4). Folic Acid 139-145 folate hydrolase 1 Homo sapiens 0-4 20641246-20 2004 PSMA may play an important role in the progression of prostate cancer and glutamatergic neurotransmission, as well as in the absorption of folate (4). Folic Acid 139-145 folate hydrolase 1 Homo sapiens 0-4 19830782-0 2010 Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. Folic Acid 72-78 folate hydrolase 1 Homo sapiens 50-54 19830782-0 2010 Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. Folic Acid 179-185 folate hydrolase 1 Homo sapiens 50-54 19830782-0 2010 Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. Folic Acid 179-185 folate hydrolase 1 Homo sapiens 134-138 19830782-0 2010 Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. Folic Acid 187-197 folate hydrolase 1 Homo sapiens 50-54 19830782-0 2010 Expression of prostate-specific membrane antigen (PSMA), increases cell folate uptake and proliferation and suggests a novel role for PSMA in the uptake of the non-polyglutamated folate, folic acid. Folic Acid 187-197 folate hydrolase 1 Homo sapiens 134-138 19830782-3 2010 As PSMA is able to hydrolyze polyglutamated folates, and cancer cells proliferate directly in response to available folate, we examined if expression of human PSMA in PC-3 cells confers a proliferative advantage in a microenvironment with physiologically relevant folate levels. Folic Acid 44-50 folate hydrolase 1 Homo sapiens 3-7 19830782-5 2010 Folic acid was tested for its ability to competitively inhibit the enzymatic activity of PSMA. Folic Acid 0-10 folate hydrolase 1 Homo sapiens 89-93 19830782-7 2010 In media containing physiologic levels of folate, PSMA expression increased folic acid uptake approximately twofold over non-expressing cells. Folic Acid 42-48 folate hydrolase 1 Homo sapiens 50-54 19830782-7 2010 In media containing physiologic levels of folate, PSMA expression increased folic acid uptake approximately twofold over non-expressing cells. Folic Acid 76-86 folate hydrolase 1 Homo sapiens 50-54 19830782-8 2010 Folic acid was able to inhibit hydrolysis of N-[4-(phenylazo)-benzoyl]-glutamyl-gamma-glutamic acid (PABGgG) by PSMA in a competitive inhibition assay. Folic Acid 0-10 folate hydrolase 1 Homo sapiens 112-116 19830782-9 2010 CONCLUSION: These findings implicate PSMA in both the metabolism of polyglutamated folates, and in the uptake of monoglutamated folates. Folic Acid 83-90 folate hydrolase 1 Homo sapiens 37-41 19830782-9 2010 CONCLUSION: These findings implicate PSMA in both the metabolism of polyglutamated folates, and in the uptake of monoglutamated folates. Folic Acid 128-135 folate hydrolase 1 Homo sapiens 37-41 20641595-4 2004 PSMA may play an important role in the progression of prostate cancer, glutamatergic neurotransmission, and in the absorption of folate (4). Folic Acid 129-135 folate hydrolase 1 Homo sapiens 0-4 18974153-8 2008 Ectopic PSMA expression on PC-3 cells increased the invasive capacity of cells in in vitro invasion assays, which could be competed out by folic acid. Folic Acid 139-149 folate hydrolase 1 Homo sapiens 8-12 18974153-9 2008 These results suggest PSMA facilitates the development of prostate cancer, and the invasive ability of these cells may be modulated by folate levels. Folic Acid 135-141 folate hydrolase 1 Homo sapiens 22-26 18974153-10 2008 These findings show a novel mechanism that may contribute to the known role of folate in cancer prevention, and may lead to the use of PSMA inhibitors as novel chemopreventive agents for prostate cancer. Folic Acid 79-85 folate hydrolase 1 Homo sapiens 135-139 18842806-6 2008 DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals. Folic Acid 77-83 folate hydrolase 1 Homo sapiens 135-140 18842806-6 2008 DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals. Folic Acid 117-123 folate hydrolase 1 Homo sapiens 135-140 18842806-9 2008 The FOLH1 1561C>T SNP was associated with altered plasma folate concentrations. Folic Acid 60-66 folate hydrolase 1 Homo sapiens 4-9 18234225-1 2008 Human glutamate carboxypeptidase II (GCPII) is involved in neuronal signal transduction and intestinal folate absorption by means of the hydrolysis of its two natural substrates, N-acetyl-aspartyl-glutamate and folyl-poly-gamma-glutamates, respectively. Folic Acid 103-109 folate hydrolase 1 Homo sapiens 6-35 18234225-1 2008 Human glutamate carboxypeptidase II (GCPII) is involved in neuronal signal transduction and intestinal folate absorption by means of the hydrolysis of its two natural substrates, N-acetyl-aspartyl-glutamate and folyl-poly-gamma-glutamates, respectively. Folic Acid 103-109 folate hydrolase 1 Homo sapiens 37-42 19172696-2 2008 In this nested case-referent study, we related two such polymorphisms, reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T, to the risk of colorectal cancer, taking into account pre-diagnostic plasma folate and total homocysteine concentrations and the MTHFR 677C > T polymorphism, which were analysed in a previous study. Folic Acid 116-122 folate hydrolase 1 Homo sapiens 136-141 19172696-5 2008 In contrast, the FOLH1 1561T-allele was associated with higher plasma folate and reduced plasma total homocysteine concentrations, and the result was statistically significant only for homocysteine. Folic Acid 70-76 folate hydrolase 1 Homo sapiens 17-22 19172696-9 2008 CONCLUSIONS: These findings suggest that although the RFC1 80G > A and FOLH1 1561C > T polymorphisms may influence folate status, they are not likely to have a major independent role in the development of colorectal cancer. Folic Acid 121-127 folate hydrolase 1 Homo sapiens 74-79 20641248-3 2004 It is believed that PSMA plays an important role in the progression of prostate cancer, glutamatergic neurotransmission, and in the absorption of folate (2). Folic Acid 146-152 folate hydrolase 1 Homo sapiens 20-24 12949938-3 2003 PSMA is a folate hydrolase, which cleaves terminal glutamates from poly- and gamma-glutamated folates; and NAALADase, which hydrolyses alpha-glutamate-linked dipeptide, N-acetyl-aspartyl-glutamate (NAAG) and is a glutamate carboxypeptidase. Folic Acid 94-101 folate hydrolase 1 Homo sapiens 0-4 15837926-2 2005 PSMA acts as a glutamate carboxypeptidase (GCPII) on small molecule substrates, including folate, the anticancer drug methotrexate, and the neuropeptide N-acetyl-l-aspartyl-l-glutamate. Folic Acid 90-96 folate hydrolase 1 Homo sapiens 0-4 15837926-2 2005 PSMA acts as a glutamate carboxypeptidase (GCPII) on small molecule substrates, including folate, the anticancer drug methotrexate, and the neuropeptide N-acetyl-l-aspartyl-l-glutamate. Folic Acid 90-96 folate hydrolase 1 Homo sapiens 43-48 15588157-2 2005 We explored whether blood folate concentrations in healthy Czech population are associated with polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), folate hydrolase 1 (FOLH1), reduced folate carrier (RFC), and folate receptor (FOLR1) genes. Folic Acid 26-32 folate hydrolase 1 Homo sapiens 163-181 15588157-2 2005 We explored whether blood folate concentrations in healthy Czech population are associated with polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), folate hydrolase 1 (FOLH1), reduced folate carrier (RFC), and folate receptor (FOLR1) genes. Folic Acid 26-32 folate hydrolase 1 Homo sapiens 183-188 15321811-2 2004 The 1561T allele of the glutamate carboxypeptidase II gene (GCPII), which codes for folylpoly-gamma-glutamyl carboxypeptidase, may impair intestinal absorption of dietary folates. Folic Acid 171-178 folate hydrolase 1 Homo sapiens 24-53 15321811-2 2004 The 1561T allele of the glutamate carboxypeptidase II gene (GCPII), which codes for folylpoly-gamma-glutamyl carboxypeptidase, may impair intestinal absorption of dietary folates. Folic Acid 171-178 folate hydrolase 1 Homo sapiens 60-65 15147814-9 2004 In contrast, LNCaP cells expressed mRNA of prostate-specific membrane antigen (PSMA), which interacts with the folate substrate. Folic Acid 111-117 folate hydrolase 1 Homo sapiens 43-77 15147814-9 2004 In contrast, LNCaP cells expressed mRNA of prostate-specific membrane antigen (PSMA), which interacts with the folate substrate. Folic Acid 111-117 folate hydrolase 1 Homo sapiens 79-83 17684227-0 2007 Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study. Folic Acid 68-74 folate hydrolase 1 Homo sapiens 13-42 17684227-0 2007 Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study. Folic Acid 68-74 folate hydrolase 1 Homo sapiens 44-49 17684227-2 2007 Previous studies provided conflicting results on the effect of the GCPII 1561C-->T polymorphism on folate and total homocysteine (tHcy) concentrations. Folic Acid 102-108 folate hydrolase 1 Homo sapiens 67-72 17684227-3 2007 OBJECTIVE: We aimed to determine the potential effects of 2 polymorphisms of GCPII on plasma folate and tHcy concentrations, cognition, anxiety, and depression in a large aging cohort of Norwegians enrolled in the Hordaland Homocysteine Study. Folic Acid 93-99 folate hydrolase 1 Homo sapiens 77-82 16496414-0 2006 Prostate specific membrane antigen (PSMA) expression gives prostate cancer cells a growth advantage in a physiologically relevant folate environment in vitro. Folic Acid 130-136 folate hydrolase 1 Homo sapiens 0-34 16496414-0 2006 Prostate specific membrane antigen (PSMA) expression gives prostate cancer cells a growth advantage in a physiologically relevant folate environment in vitro. Folic Acid 130-136 folate hydrolase 1 Homo sapiens 36-40 16496414-2 2006 We studied if PSMA folate hydrolase activity provides cells a growth advantage in a low folate (LF) micro-environment by hydrolyzing extracellular poly-gamma-glutamated folate to a form that cells can import. Folic Acid 19-25 folate hydrolase 1 Homo sapiens 14-18 15337665-1 2004 OBJECTIVE: Because glutamate carboxypeptidase II (GCPII) regulates both folate absorption and activation of N-methyl-d-aspartic acid receptors, the authors examined relationships between serum folate concentrations and clinical symptoms in schizophrenia patients. Folic Acid 72-78 folate hydrolase 1 Homo sapiens 19-48 15337665-1 2004 OBJECTIVE: Because glutamate carboxypeptidase II (GCPII) regulates both folate absorption and activation of N-methyl-d-aspartic acid receptors, the authors examined relationships between serum folate concentrations and clinical symptoms in schizophrenia patients. Folic Acid 72-78 folate hydrolase 1 Homo sapiens 50-55 12514270-3 2003 Recently, a H475Y polymorphism in the glutamate carboxypeptidase II (GCPII) gene, encoding the FGCP enzyme, was reported to be associated with decreased plasma folate and increased plasma homocysteine (tHcy) levels. Folic Acid 160-166 folate hydrolase 1 Homo sapiens 38-67 12855225-3 2003 Two recently identified variants are the 1561C-->T (H475Y) mutation in glutamate carboxypeptidase II (GCPII) and the 80A-->G (H27R) change in the reduced folate carrier RFC-1. Folic Acid 160-166 folate hydrolase 1 Homo sapiens 74-103 12855225-3 2003 Two recently identified variants are the 1561C-->T (H475Y) mutation in glutamate carboxypeptidase II (GCPII) and the 80A-->G (H27R) change in the reduced folate carrier RFC-1. Folic Acid 160-166 folate hydrolase 1 Homo sapiens 105-110 12707400-1 2003 This study was designed to examine the effect of two single nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G>A) and the glutamate carboxypeptidase 2 (GCP2 1561C>T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients. Folic Acid 239-245 folate hydrolase 1 Homo sapiens 141-169 12707400-1 2003 This study was designed to examine the effect of two single nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G>A) and the glutamate carboxypeptidase 2 (GCP2 1561C>T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients. Folic Acid 239-245 folate hydrolase 1 Homo sapiens 171-175 12707400-2 2003 Red blood cell folate concentration was higher in patients with the GCP2 CT or TT genotype (ANOVA, P = 0.04). Folic Acid 15-21 folate hydrolase 1 Homo sapiens 68-72 12707400-4 2003 A multivariate analysis confirmed that the GCP2 1561C>T genotype (P = 0.011) had a significant influence on the red blood cell folate concentration. Folic Acid 130-136 folate hydrolase 1 Homo sapiens 43-47 12707400-5 2003 Overall, serum folate, creatinine, and the GCP2 polymorphism explained nearly 50% of the variance of red blood cell folate. Folic Acid 116-122 folate hydrolase 1 Homo sapiens 43-47 12707400-8 2003 In conclusion, GCP2 1561C>T, but not RFC1 80G>A, is a predictor of red blood cell folate level in chronic dialysis patients. Folic Acid 88-94 folate hydrolase 1 Homo sapiens 15-19 12514270-0 2003 The H475Y polymorphism in the glutamate carboxypeptidase II gene increases plasma folate without affecting the risk for neural tube defects in humans. Folic Acid 82-88 folate hydrolase 1 Homo sapiens 30-59 12753319-3 2003 RESULTS: The allele frequency for GCP2 1561C>T was 0.05, and 0.43 for RFC1 80G>A. Heterozygosity or homozygosity for GCP2 1561C>T was associated with higher folate plasma levels compared to patients without mutation (P < 0.0001), while RFC1 80G>A showed no influence. Folic Acid 166-172 folate hydrolase 1 Homo sapiens 123-127 12753319-6 2003 CONCLUSION: We conclude that GCP2 1561C>T is associated with elevated folate levels. Folic Acid 73-79 folate hydrolase 1 Homo sapiens 29-33 12514270-3 2003 Recently, a H475Y polymorphism in the glutamate carboxypeptidase II (GCPII) gene, encoding the FGCP enzyme, was reported to be associated with decreased plasma folate and increased plasma homocysteine (tHcy) levels. Folic Acid 160-166 folate hydrolase 1 Homo sapiens 69-74 12514270-3 2003 Recently, a H475Y polymorphism in the glutamate carboxypeptidase II (GCPII) gene, encoding the FGCP enzyme, was reported to be associated with decreased plasma folate and increased plasma homocysteine (tHcy) levels. Folic Acid 160-166 folate hydrolase 1 Homo sapiens 95-99 12514270-8 2003 The H475Y polymorphism in the GCPII gene may increase the deconjugation activity of the FGCP enzyme, resulting in an increased absorption of folate in the body, as reflected by the increased plasma folate and decreased plasma homocysteine concentrations. Folic Acid 141-147 folate hydrolase 1 Homo sapiens 30-35 12514270-8 2003 The H475Y polymorphism in the GCPII gene may increase the deconjugation activity of the FGCP enzyme, resulting in an increased absorption of folate in the body, as reflected by the increased plasma folate and decreased plasma homocysteine concentrations. Folic Acid 141-147 folate hydrolase 1 Homo sapiens 88-92 12514270-8 2003 The H475Y polymorphism in the GCPII gene may increase the deconjugation activity of the FGCP enzyme, resulting in an increased absorption of folate in the body, as reflected by the increased plasma folate and decreased plasma homocysteine concentrations. Folic Acid 198-204 folate hydrolase 1 Homo sapiens 30-35 12514270-8 2003 The H475Y polymorphism in the GCPII gene may increase the deconjugation activity of the FGCP enzyme, resulting in an increased absorption of folate in the body, as reflected by the increased plasma folate and decreased plasma homocysteine concentrations. Folic Acid 198-204 folate hydrolase 1 Homo sapiens 88-92 12204797-0 2002 Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk. Folic Acid 105-111 folate hydrolase 1 Homo sapiens 15-44 12204797-3 2002 Glutamate carboxypeptidase II (GCPII) regulates the absorption of dietary folates. Folic Acid 74-81 folate hydrolase 1 Homo sapiens 0-29 12204797-3 2002 Glutamate carboxypeptidase II (GCPII) regulates the absorption of dietary folates. Folic Acid 74-81 folate hydrolase 1 Homo sapiens 31-36 10861758-4 2000 PSM is a glutamate exocarboxypeptidase capable of cleaving the terminal alpha-linked glutamate from the dipeptide N-acetyl-aspartyl-glutamate (NAAG) and the gamma-linked glutamates from folate polyglutamate. Folic Acid 186-192 folate hydrolase 1 Homo sapiens 0-3 9123729-19 1997 In the normal prostate where the protein is intracellular, is PSM" antigen keeping folate in nonglutamated forms? Folic Acid 83-89 folate hydrolase 1 Homo sapiens 62-65 9816319-6 1996 Preliminary studies have demonstrated binding of pteroylmonoglutamate (folate) to membrane fractions that also cross-reacted with the PSM monoclonal antibody. Folic Acid 49-69 folate hydrolase 1 Homo sapiens 134-137 9816319-6 1996 Preliminary studies have demonstrated binding of pteroylmonoglutamate (folate) to membrane fractions that also cross-reacted with the PSM monoclonal antibody. Folic Acid 71-77 folate hydrolase 1 Homo sapiens 134-137 34167925-7 2021 PSMA is also expressed by other cancer cell types and is implicated in glutamate and folate metabolism. Folic Acid 85-91 folate hydrolase 1 Homo sapiens 0-4 12042430-2 2002 Recently, a 1561 C>T polymorphism in the GCPII gene was reported to be associated with lower folate and higher homocysteine plasma concentrations in a small (n = 75) selected elderly population. Folic Acid 96-102 folate hydrolase 1 Homo sapiens 44-49 11092759-0 2000 Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. Folic Acid 84-90 folate hydrolase 1 Homo sapiens 0-29 11092759-4 2000 Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene. Folic Acid 8-15 folate hydrolase 1 Homo sapiens 118-160 11092759-4 2000 Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene. Folic Acid 8-15 folate hydrolase 1 Homo sapiens 162-166 11092759-4 2000 Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene. Folic Acid 8-15 folate hydrolase 1 Homo sapiens 260-288 11092759-4 2000 Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene. Folic Acid 8-15 folate hydrolase 1 Homo sapiens 290-295 11092759-4 2000 Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene. Folic Acid 50-57 folate hydrolase 1 Homo sapiens 118-160 11092759-4 2000 Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene. Folic Acid 50-57 folate hydrolase 1 Homo sapiens 162-166 11092759-4 2000 Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene. Folic Acid 50-57 folate hydrolase 1 Homo sapiens 260-288 11092759-4 2000 Dietary folates are a mixture of polyglutamylated folates which are digested to monoglutamyl folates by the action of folylpoly-gamma-glutamate carboxypeptidase (FGCP), an enzyme that is anchored to the intestinal brush border membrane and is expressed by the glutamate carboxypepidase II (GCPII) gene. Folic Acid 50-57 folate hydrolase 1 Homo sapiens 290-295 11092759-8 2000 The presence of the H475Y GCPII allele was significantly associated with lower folate and higher homocysteine levels in this population. Folic Acid 79-85 folate hydrolase 1 Homo sapiens 26-31 11092759-9 2000 These data suggest that the presence of the H475Y GCPII allele impairs the intestinal absorption of dietary folates, resulting in relatively low blood folate levels and consequent hyperhomocysteinemia. Folic Acid 108-115 folate hydrolase 1 Homo sapiens 50-55 11092759-9 2000 These data suggest that the presence of the H475Y GCPII allele impairs the intestinal absorption of dietary folates, resulting in relatively low blood folate levels and consequent hyperhomocysteinemia. Folic Acid 108-114 folate hydrolase 1 Homo sapiens 50-55 9685395-2 1998 Jejunal folylpoly-gamma-glutamate carboxypeptidase hydrolyzes dietary folates prior to their intestinal absorption. Folic Acid 70-77 folate hydrolase 1 Homo sapiens 8-50