PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17360897-10 2007 Remarkably, hyperhomocysteinemia induced in wild-type and cystathionine-beta-synthase +/- mice by feeding a high-methionine, low-folate diet is associated with increased brain S-adenosylhomocysteine levels, PPMT downregulation, reduced PP2A methylation levels, and tau and APP phosphorylation. Folic Acid 129-135 cystathionine beta-synthase Mus musculus 58-85 15105297-6 2004 Tg-CBS mice maintained on a high-methionine, low-folate diet also had significantly lower serum homocysteine compared with control animals (179 micromol/L versus 242 micromol/L; P<0.02). Folic Acid 49-55 cystathionine beta-synthase Mus musculus 3-6 10993757-0 2000 Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine beta-synthase-deficient mice. Folic Acid 0-6 cystathionine beta-synthase Mus musculus 70-97 10993757-8 2000 In contrast, in mice fed a low-folate diet, maximal relaxation to acetylcholine was markedly impaired in CBS +/- mice (58 +/- 9%) compared with CBS +/+ mice (84 +/- 4%) (P = 0.01). Folic Acid 31-37 cystathionine beta-synthase Mus musculus 105-108