PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2822525-5 1987 In goldfish, the angiotensin-converting enzyme inhibitor captopril, which inhibits the conversion of AI to AII, was not able to block sAI-stimulated ACTH release. Captopril 57-66 NLR family pyrin domain containing 3 Homo sapiens 107-110 2856549-11 1987 Raising the level of endogenous AII by intravenous administration of its precursor renin has similar effects, and these are prevented if captopril is administered previously (Koller et al, 1979). Captopril 137-146 NLR family pyrin domain containing 3 Homo sapiens 32-35 2856549-12 1987 Also, chronic oral treatment with captopril produces changes of brain renin angiotensin system parameters which suggest inhibition of AII biosyntheses in the brain (Scholkens et al, 1983). Captopril 34-43 NLR family pyrin domain containing 3 Homo sapiens 134-137 2856549-13 1987 It is conceivable therefore, that our findings with prolonged administration of captopril are exerted through reduced formation of AII. Captopril 80-89 NLR family pyrin domain containing 3 Homo sapiens 131-134 7039897-2 1982 A depressor effect of Captopril was observed even in patients with AII-A unresponsive dialysis resistant hypertension. Captopril 22-31 NLR family pyrin domain containing 3 Homo sapiens 67-70 6167515-9 1981 In addition, postjunctional pressor responses to AI, AII, and NE were also significantly inhibited by chronic captopril treatment. Captopril 110-119 NLR family pyrin domain containing 3 Homo sapiens 53-56 6167515-11 1981 However, the combination of pretreatment of indomethacin and infusion of AII completely restored sympathetic function in SHR receiving captopril. Captopril 135-144 NLR family pyrin domain containing 3 Homo sapiens 73-76 6167515-14 1981 Since, under appropriate conditions, the inhibition can be reversed by AII infusion but not nephrectomy, it is suggested that this inhibition occurs at the vascular level by inhibition of local AII formation by captopril, a site not accessible to teprotide or saralasin. Captopril 211-220 NLR family pyrin domain containing 3 Homo sapiens 194-197