PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16963249-8 2007 However, pretreatment with chlormethiazole (CMZ), a specific inhibitor of CYP2E1, significantly reduced the levels of LPO, CYP2E1, JNK activity and the rate of cell death. Chlormethiazole 27-42 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 74-80 17963120-7 2007 In addition, CYP2E1 inhibitors chlormethiazole and diallyl dulphide inhibited both ROS generation and cytotoxicity induced by MCLR. Chlormethiazole 31-46 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 13-19 16963249-8 2007 However, pretreatment with chlormethiazole (CMZ), a specific inhibitor of CYP2E1, significantly reduced the levels of LPO, CYP2E1, JNK activity and the rate of cell death. Chlormethiazole 27-42 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 123-129 16963249-8 2007 However, pretreatment with chlormethiazole (CMZ), a specific inhibitor of CYP2E1, significantly reduced the levels of LPO, CYP2E1, JNK activity and the rate of cell death. Chlormethiazole 44-47 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 74-80 16963249-8 2007 However, pretreatment with chlormethiazole (CMZ), a specific inhibitor of CYP2E1, significantly reduced the levels of LPO, CYP2E1, JNK activity and the rate of cell death. Chlormethiazole 44-47 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 123-129 11133247-2 2001 Certain drugs such as the sedative chlormethiazole are effective inhibitors of CYP2E1, and may have clinical potential in the treatment of alcoholics. Chlormethiazole 35-50 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 79-85 10461422-3 1999 Recently, chlormethiazole a sedative drug, is reported to be an efficient inhibitor of CYP2E1 activity in human beings. Chlormethiazole 10-25 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 87-93 33972357-0 2022 Clomethiazole inhibits cytochrome P450 2E1 and improves alcoholic liver disease. Chlormethiazole 0-13 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 23-42 9695719-0 1998 Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers. Chlormethiazole 24-39 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 14-20 9695719-1 1998 BACKGROUND: Chlormethiazole has been shown in in vitro studies, with use of rat and human liver microsomes, to specifically inhibit cytochrome P4502E1 (CYP2E1)-mediated activity by inhibition of the rate of CYP2E1 gene transcription. Chlormethiazole 12-27 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 132-150 9695719-1 1998 BACKGROUND: Chlormethiazole has been shown in in vitro studies, with use of rat and human liver microsomes, to specifically inhibit cytochrome P4502E1 (CYP2E1)-mediated activity by inhibition of the rate of CYP2E1 gene transcription. Chlormethiazole 12-27 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 152-158 9695719-1 1998 BACKGROUND: Chlormethiazole has been shown in in vitro studies, with use of rat and human liver microsomes, to specifically inhibit cytochrome P4502E1 (CYP2E1)-mediated activity by inhibition of the rate of CYP2E1 gene transcription. Chlormethiazole 12-27 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 207-213 9695719-7 1998 CONCLUSION: Chlormethiazole administration seems to result in a marked reduction of CYP2E1 activity in subjects with high CYP2E1 activity and could at least partially explain the claimed hepatoprotective action of this drug. Chlormethiazole 12-27 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 84-90 9695719-7 1998 CONCLUSION: Chlormethiazole administration seems to result in a marked reduction of CYP2E1 activity in subjects with high CYP2E1 activity and could at least partially explain the claimed hepatoprotective action of this drug. Chlormethiazole 12-27 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 122-128 9328319-0 1997 Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans. Chlormethiazole 0-15 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 30-49 9328319-2 1997 Because it had been reported that chlormethiazole inhibits the alcohol-inducible cytochrome P450 2E1 in rat liver, we investigated the in vivo and in vitro effect of this drug on cytochrome P450 2E1 in human beings. Chlormethiazole 34-49 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 81-100 9328319-10 1997 In addition, the effect of chlormethiazole on cytochrome P450 2E1 was studied in vitro using human liver microsomes. Chlormethiazole 27-42 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 46-65 9328319-12 1997 These data clearly show that chlormethiazole is an efficient inhibitor of chlorzoxazone metabolism and thus of cytochrome P450 2E1 activity in human beings. Chlormethiazole 29-44 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 111-130 9328319-13 1997 Because cytochrome P450 2E1 induction after chronic ethanol consumption has detrimental effects on the liver through free radical formation, treatment of alcohol detoxification with chlormethiazole may be beneficial. Chlormethiazole 182-197 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 8-27 30641601-12 2019 First results on the effect of CYP2E1 inhibition by chlormethiazole, a specific CYP2E1 inhibitor on ALD, can be expected soon. Chlormethiazole 52-67 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 31-37 30641601-12 2019 First results on the effect of CYP2E1 inhibition by chlormethiazole, a specific CYP2E1 inhibitor on ALD, can be expected soon. Chlormethiazole 52-67 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 80-86 28336091-5 2017 The CYP2E1 inhibitor chlormethiazole inhibited ROS generation, mitochondrial membrane potential loss, caspase-3 activity, and cytotoxicity caused by MC-LR. Chlormethiazole 21-36 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 4-10 30362092-5 2018 Etheno-DNA adducts are generated in the liver (HepG2) cells over-expressing CYP2E1 when incubated with ethanol;and are inhibited by chlormethiazole. Chlormethiazole 132-147 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 76-82 28987868-6 2018 Ethanol exposure resulted in increased levels of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE)-Akt adducts, which was significantly inhibited by chlormethiazole (CMZ), an efficient CYP2E1 inhibitor. Chlormethiazole 150-165 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 186-192 28987868-6 2018 Ethanol exposure resulted in increased levels of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE)-Akt adducts, which was significantly inhibited by chlormethiazole (CMZ), an efficient CYP2E1 inhibitor. Chlormethiazole 167-170 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 186-192 29404485-7 2017 EV CYP2E1 amounts depended on increased oxidative and endoplasmic reticulum (ER) stress because their levels were decreased by cotreatment with the antioxidant N-acetylcysteine or the CYP2E1 inhibitor chlormethiazole but increased by ER stress-inducer thapsigargin, which was blocked by 4-phenylbutyric acid. Chlormethiazole 201-216 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 3-9 29404485-7 2017 EV CYP2E1 amounts depended on increased oxidative and endoplasmic reticulum (ER) stress because their levels were decreased by cotreatment with the antioxidant N-acetylcysteine or the CYP2E1 inhibitor chlormethiazole but increased by ER stress-inducer thapsigargin, which was blocked by 4-phenylbutyric acid. Chlormethiazole 201-216 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 184-190 26739624-9 2016 In cells pretreated with the CYP2E1 inhibitor chlormethiazole, recovery of ATP was significantly higher in the presence of stearate with low (2.5mM) or high (20mM) concentrations of APAP. Chlormethiazole 46-61 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 29-35 27149898-0 2016 Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole. Chlormethiazole 66-79 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 56-62 25427901-8 2015 ROS production correlates significantly with CYP2E1 in the liver but also in the esophagus, and its generation can be significantly reduced by the specific CYP2E1 inhibitor clomethiazole. Chlormethiazole 173-186 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 45-51 25427901-8 2015 ROS production correlates significantly with CYP2E1 in the liver but also in the esophagus, and its generation can be significantly reduced by the specific CYP2E1 inhibitor clomethiazole. Chlormethiazole 173-186 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 156-162 23400919-11 2013 We have shown that chlormethiazole is a specific CYP2E1 inhibitor in humans. Chlormethiazole 19-34 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 49-55 23400919-12 2013 Chlormethiazole inhibits CYP2E1 activity and thus blocks the formation of DNA adducts in cell cultures, restores retinoic acids in alcohol fed animals and inhibits chemical induced ethanol mediated hepatocarcinogenesis. Chlormethiazole 0-15 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 25-31