PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19628632-8 2009 Conversely, contractile responses to ET-1 were, compared with PHE, hypersensitive to the relaxing effects of the TRPV1-agonist capsaicin and to exogenous CGRP, but not to acetylcholine, forskolin, pinacidil, or SNP. Capsaicin 127-136 endothelin 1 Rattus norvegicus 37-41 23396520-4 2013 During whole-cell patch-clamp recording, endothelin-1 enhanced an induced current in response to capsaicin, a TRPV1 agonist, in approximately 20% of dissociated neurons. Capsaicin 97-106 endothelin 1 Rattus norvegicus 41-53 23293745-8 2012 Capsaicin treatment restored the gastric resistance and blood flow responses to topical application of ethanol in BDL rats and ET-1 and -3 production to levels observed in controls. Capsaicin 0-9 endothelin 1 Rattus norvegicus 127-138 20532232-4 2010 Stimuli of peri-vascular vasodilator sensory-motor nerves such as capsaicin not only reduced but also terminated long-lasting effects of ET-1. Capsaicin 66-75 endothelin 1 Rattus norvegicus 137-141 20532232-6 2010 Using 2-photon laser scanning microscopy in vital intact arteries, capsaicin and CGRP, but not ET(A)-antagonism, were observed to promote dissociation of pre-existing ET-1/ET(A)-receptor complexes. Capsaicin 67-76 endothelin 1 Rattus norvegicus 167-171 22815806-11 2012 Epicardial application of capsaicin increased superoxide anion level in PVN which was further enhanced by PVN pretreatment with ET-1. Capsaicin 26-35 endothelin 1 Rattus norvegicus 128-132 19429182-0 2009 Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats. Capsaicin 142-151 endothelin 1 Rattus norvegicus 48-60 19559390-8 2009 ET-1 also enhanced the capsaicin-stimulated release of CGRP (up to 2-fold for 0.3 nM ET-1), but did not change capsaicin-stimulated glutamate release. Capsaicin 23-32 endothelin 1 Rattus norvegicus 0-4 19559390-8 2009 ET-1 also enhanced the capsaicin-stimulated release of CGRP (up to 2-fold for 0.3 nM ET-1), but did not change capsaicin-stimulated glutamate release. Capsaicin 23-32 endothelin 1 Rattus norvegicus 85-89 12162579-7 2001 Endothelin-1 (0.1 nM), the putative mediator of the capsaicin effect, significantly decreased heart rate and coronary flow irrespective of the presence or absence of diabetes. Capsaicin 52-61 endothelin 1 Rattus norvegicus 0-12 35228812-11 2022 The sole effect of WAS exposure or ET-1 administration on the micturition reflex could be suppressed by capsaicin pretreatment. Capsaicin 104-113 endothelin 1 Rattus norvegicus 35-39 9600661-16 1998 Moreover, the effects of endothelin-1 were attenuated in capsaicin pretreated rats (125 mg/kg, 10 days earlier) and almost abolished in rats subjected to sympathectomy with 6-hydroxydopamine (100 mg/kg, 24-48 h earlier). Capsaicin 57-66 endothelin 1 Rattus norvegicus 25-37 7513837-0 1994 Endothelin-1 enhances capsaicin-induced peptide release and cGMP accumulation in cultures of rat sensory neurons. Capsaicin 22-31 endothelin 1 Rattus norvegicus 0-12 7513837-2 1994 Although ET-1 had minimal actions on spontaneous neuropeptide release, pretreating cultures with 500 nM resulted in a 50% augmentation of SP and CGRP release evoked by 50 nM capsaicin. Capsaicin 174-183 endothelin 1 Rattus norvegicus 9-13 7513837-3 1994 Moreover, 2000 nM ET-1 enhanced capsaicin-evoked release of CGRP two fold. Capsaicin 32-41 endothelin 1 Rattus norvegicus 18-22 7513837-4 1994 In an analogous manner, ET-1 alone did not alter intracellular cGMP content, but enhanced the increase in cGMP caused by 50 nM capsaicin. Capsaicin 127-136 endothelin 1 Rattus norvegicus 24-28 1315978-5 1992 The relaxing capacity of ET-1 was absent when the tissue was precontracted by potassium yet was resistant to pretreatments with tetrodotoxin, capsaicin, propranolol, indomethacin, NG-methyl-L-arginine or glibenclamide. Capsaicin 142-151 endothelin 1 Rattus norvegicus 25-29 1855123-6 1991 Capsaicin-pretreatment, two weeks earlier to deplete sensory neuropeptides from primary afferent neurones, augmented the mucosal damage induced by ET-1, as assessed by both macroscopic and histological examination. Capsaicin 0-9 endothelin 1 Rattus norvegicus 147-151 1855123-8 1991 The damage induced by threshold doses of ET-1 alone or in capsaicin-pretreated rats was further enhanced by administration of indomethacin (5 mg kg-1, i.v. Capsaicin 58-67 endothelin 1 Rattus norvegicus 41-45 9932722-3 1999 We have investigated the neuromodulatory effects of endothelin-1 on capsaicin-induced release of neurotransmitters from rat vas deferens. Capsaicin 68-77 endothelin 1 Rattus norvegicus 52-64 9932722-0 1999 Endothelin-1 affects capsaicin-evoked release of neuropeptides from rat vas deferens. Capsaicin 21-30 endothelin 1 Rattus norvegicus 0-12 9932722-2 1999 Endothelin-1 was thought to potentiate the capsaicin-evoked release of neuropeptides from sensory neurones of the rat. Capsaicin 43-52 endothelin 1 Rattus norvegicus 0-12 9932722-10 1999 These results suggest that endothelin-1 selectively inhibits the capsaicin-induced release of neurotransmitters from rat vas deferens and these effects are mediated via endothelin ET(A) receptors but not by tachykinin release. Capsaicin 65-74 endothelin 1 Rattus norvegicus 27-39 1378693-7 1992 Similarly, stimulation of afferent sensory neurons by intragastric capsaicin (0.5 mg/kg) protected against damage caused by endothelin-1 and 20% ethanol. Capsaicin 67-76 endothelin 1 Rattus norvegicus 124-136 35228812-15 2022 Conclusion: The activation of ET-1 receptors could enhance chronic stress-induced bladder hypersensitization and hyperalgesia through capsaicin-sensitive C-fiber afferents. Capsaicin 134-143 endothelin 1 Rattus norvegicus 30-34