PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30727793-11	2019	CONCLUSION: SiNPs combined with BPDE promote EMT of BEAS-2B cells via the AKT pathway by inducing release of SDF-1alpha from THP-1 cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	32-36	AKT serine/threonine kinase 1	Homo sapiens	74-77	
33851497-0	2021	Upregulated lnc-HZ02 and miR-hz02 inhibited migration and invasion by downregulating the FAK/SRC/PI3K/AKT pathway in BPDE-treated trophoblast cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	117-121	AKT serine/threonine kinase 1	Homo sapiens	102-105	
33851497-5	2021	If trophoblast cells are exposed to BPDE, both miR-hz02 and lnc-HZ02 are upregulated, which reduce the level of HuR, weaken the interactions of HuR with FAK mRNA, downregulate FAK level and the FAK/SRC/PI3K/AKT pathway, and finally inhibit cell migration and invasion.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	36-40	AKT serine/threonine kinase 1	Homo sapiens	207-210	
22457794-5	2012	Suppression of MUC1 expression resulted in EGFR destabilization and inhibition of the BPDE-induced activation of Akt and ERK and increase of cytotoxicity.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	86-90	AKT serine/threonine kinase 1	Homo sapiens	113-116	
30011042-0	2018	Benzo[a]Pyrene-7, 8-Diol-9, 10-Epoxide Suppresses the Migration and Invasion of Human Extravillous Trophoblast Swan 71 Cells Due to the Inhibited Filopodia Formation and Down-Regulated PI3K/AKT/CDC42/PAK1 Pathway Mediated by the Increased miR-194-3p.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-38	AKT serine/threonine kinase 1	Homo sapiens	190-193	
30011042-5	2018	BPDE up-regulated the level of miR-194-3p, which further inhibited the phosphoinositide 3-kinase (PI3K)/AKT/ cell division cycle 42/ p21 (RAC1) activated kinase 1 signaling pathway and depressed the filophdia formation of Swan71 cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-4	AKT serine/threonine kinase 1	Homo sapiens	104-107	
28529061-0	2017	Benzo[a]pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast HTR-8/SVneo cells by down-regulating MMP2 through inhibition of FAK/SRC/PI3K/AKT pathway.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-36	AKT serine/threonine kinase 1	Homo sapiens	186-189	
28529061-7	2017	The presence of SC79, activator of AKT, partially attenuates the inhibition effect of BPDE on migration and invasion, confirming the involvement of AKT pathway.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	86-90	AKT serine/threonine kinase 1	Homo sapiens	35-38	
28529061-7	2017	The presence of SC79, activator of AKT, partially attenuates the inhibition effect of BPDE on migration and invasion, confirming the involvement of AKT pathway.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	86-90	AKT serine/threonine kinase 1	Homo sapiens	148-151	
28529061-8	2017	Thus, BPDE suppresses migration and invasion of human trophoblast HTR-8/SVneo cells by inhibiting the expression of FAK, SRC and PI3K, consequently down-regulating PI3K/AKT signaling pathway.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	6-10	AKT serine/threonine kinase 1	Homo sapiens	169-172	
24431215-8	2014	Both BaP and BPDE inhibited the muscle-specific protein expressions (myogenin and myosin heavy chain) and phosphorylation of Akt (a known modulator in myogenesis), which could be significantly reversed by the inhibitors for aryl hydrocarbon receptor (AhR), estrogen receptor (ER), and nuclear factor (NF)-kappaB.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	13-17	AKT serine/threonine kinase 1	Homo sapiens	125-128	
24431215-11	2014	These results suggest that both BaP and BPDE are capable of inhibiting myogenesis via an AhR- or/and ER-regulated NF-kappaB/Akt signaling pathway.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	40-44	AKT serine/threonine kinase 1	Homo sapiens	124-127	
16774943-9	2006	In addition, we found that BPDE increased p53 activity and apoptosis in MCF-10A; however, transient transfection of constitutively active Akt attenuated both BPDE-dependent apoptosis and p53 activity.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	27-31	AKT serine/threonine kinase 1	Homo sapiens	138-141	
19801633-0	2009	Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pathway promotes cell transformation and tumorigenesis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	23-59	AKT serine/threonine kinase 1	Homo sapiens	98-101	
16774943-0	2006	PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	58-85	AKT serine/threonine kinase 1	Homo sapiens	29-32	
16774943-9	2006	In addition, we found that BPDE increased p53 activity and apoptosis in MCF-10A; however, transient transfection of constitutively active Akt attenuated both BPDE-dependent apoptosis and p53 activity.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	158-162	AKT serine/threonine kinase 1	Homo sapiens	138-141	
16774943-4	2006	Previous studies have demonstrated that BPDE enhanced anti-apoptotic signaling through Akt; however, mechanisms for Akt activation by BPDE are not well defined.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	40-44	AKT serine/threonine kinase 1	Homo sapiens	87-90	
16774943-4	2006	Previous studies have demonstrated that BPDE enhanced anti-apoptotic signaling through Akt; however, mechanisms for Akt activation by BPDE are not well defined.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	134-138	AKT serine/threonine kinase 1	Homo sapiens	116-119	
16774943-7	2006	Consistent with activation of the EGFR, Akt and ERK1/2 phosphorylation was detected in MCF-10A cells treated with BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	114-118	AKT serine/threonine kinase 1	Homo sapiens	40-43	
16774943-11	2006	This work demonstrates a novel mechanism for Akt activation by BPDE that occurs through increased Ca2+ concentration, and implicates Ca2+, Pyk2, EGFR and Akt as a potential pathway by which BPDE can inhibit apoptosis and act as a promoter of carcinogenesis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	63-67	AKT serine/threonine kinase 1	Homo sapiens	45-48	
16774943-8	2006	Pharmacological methods to prevent Ca2+ elevation and EGFR activity, and small-interfering RNA against Pyk2, prevented Akt phosphorylation by BPDE, which suggested that Ca2+, Pyk2 and EGFR activation lay upstream of Akt.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	142-146	AKT serine/threonine kinase 1	Homo sapiens	119-122	
16774943-11	2006	This work demonstrates a novel mechanism for Akt activation by BPDE that occurs through increased Ca2+ concentration, and implicates Ca2+, Pyk2, EGFR and Akt as a potential pathway by which BPDE can inhibit apoptosis and act as a promoter of carcinogenesis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	190-194	AKT serine/threonine kinase 1	Homo sapiens	45-48	
16774943-11	2006	This work demonstrates a novel mechanism for Akt activation by BPDE that occurs through increased Ca2+ concentration, and implicates Ca2+, Pyk2, EGFR and Akt as a potential pathway by which BPDE can inhibit apoptosis and act as a promoter of carcinogenesis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	190-194	AKT serine/threonine kinase 1	Homo sapiens	154-157