PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26400171-3	2015	Benzo[a]pyrene,diol epoxide (BPDE) is a potent cigarette smoke carcinogen that forms guanine adducts at TP53 CpG mutation hotspot sites including codons 157, 158, 245, 248 and 273.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	29-33	tumor protein p53	Homo sapiens	104-108	
33566220-0	2021	Novel lnc-HZ03 and miR-hz03 promote BPDE-induced human trophoblastic cell apoptosis and induce miscarriage by upregulating p53/SAT1 pathway.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	36-40	tumor protein p53	Homo sapiens	123-126	
33566220-11	2021	All together, the p53/SAT1 pathway upregulated by lnc-HZ03 and miR-hz03 could promote BPDE-induced human trophoblastic cell apoptosis and the occurrence of miscarriage, shedding novel light on the causes of miscarriage.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	86-90	tumor protein p53	Homo sapiens	18-21	
33566220-17	2021	After exposure to BPDE, lnc-HZ03/miR-hz03 and p53/SAT1 pathways are upregulated and finally induce miscarriage.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	18-22	tumor protein p53	Homo sapiens	46-49	
29144987-6	2018	In the mechanism, BPDE significantly increased pro-apoptosis protein (P53 and Bak1) and decreased anti-apoptosis protein (Bcl-2).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	18-22	tumor protein p53	Homo sapiens	70-73	
28593498-10	2018	As expected, BPDE activated DNA damage signaling, p53 and AP-1 dependent signaling, oxidative stress response, and apoptosis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	13-17	tumor protein p53	Homo sapiens	50-53	
28102315-3	2017	Here we describe the first restriction-enzyme-assisted LC-MS/MS sequencing study of the influence of methyl cytosines (MeC) on kinetics of p53 gene adduction by model metabolite benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), using methodology applicable to correlate gene damage sites for drug and pollutant metabolites with mutation sites.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	178-221	tumor protein p53	Homo sapiens	139-142	
28102315-3	2017	Here we describe the first restriction-enzyme-assisted LC-MS/MS sequencing study of the influence of methyl cytosines (MeC) on kinetics of p53 gene adduction by model metabolite benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE), using methodology applicable to correlate gene damage sites for drug and pollutant metabolites with mutation sites.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	223-227	tumor protein p53	Homo sapiens	139-142	
28102315-8	2017	Conformational and hydrophobicity changes in the MeC-p53 exon 7 fragment revealed by CD spectra and molecular modeling increase the BPDE binding constant to G in codon 248 consistent with a pathway in which preceding reactant binding greatly facilitates the rate of covalent SN2 coupling.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	132-136	tumor protein p53	Homo sapiens	53-56	
26400171-4	2015	We performed molecular modelling of BPDE-adducted TP53 duplex sequences to determine the degree of local distortion caused by adducts which could influence the ability of nucleotide excision repair.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	36-40	tumor protein p53	Homo sapiens	50-54	
21983885-0	2012	Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	89-115	tumor protein p53	Homo sapiens	24-27	
25847421-0	2015	TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	26-30	tumor protein p53	Homo sapiens	0-4	
25847421-0	2015	TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	26-30	tumor protein p53	Homo sapiens	60-64	
23692869-6	2013	BPDE-induced cdc2 down-regulation is p53 dependent, although there is no correspondence between p53 accumulation and cdc2 down-regulation.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-4	tumor protein p53	Homo sapiens	37-40	
23692869-7	2013	BPDE-induced cdc2 down-regulation corresponded with accumulation of the cell cycle inhibitor protein p21 (transactivation product of p53).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-4	tumor protein p53	Homo sapiens	133-136	
23244159-0	2013	Electrochemical study on the effects of epigenetic cytosine methylation on anti-benzo[a]pyrene diol epoxide damage at TP53 oligomers.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	80-107	tumor protein p53	Homo sapiens	118-122	
22746287-8	2012	Treatment with CuB induced the differentiation of DCs cocultured with tumor cells 16HBE/BPDE and enhanced the sensitivity of 16HBE/BPDE cells to p53-specific CTL by inhibiting the JAK2/STAT3 activation, but also enhancing the interferon-gamma-related STAT1 activation in 16HBE/BPDE cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	131-135	tumor protein p53	Homo sapiens	145-148	
22746287-8	2012	Treatment with CuB induced the differentiation of DCs cocultured with tumor cells 16HBE/BPDE and enhanced the sensitivity of 16HBE/BPDE cells to p53-specific CTL by inhibiting the JAK2/STAT3 activation, but also enhancing the interferon-gamma-related STAT1 activation in 16HBE/BPDE cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	131-135	tumor protein p53	Homo sapiens	145-148	
22565279-8	2012	Furthermore, our data also indicate that the formation of reactive oxygen species (ROS), decline of mitochondrial membrane potential (DeltaPsi(m)), increasing p53 and decreasing c-Myc levels play important roles in response to BPDE toxicity.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	227-231	tumor protein p53	Homo sapiens	159-162	
22565279-9	2012	In conclusion, these results suggest that BPDE-mediated apoptosis occurs via caspase-9 dependent mitochondria pathway associated with ROS formation, loss of DeltaPsi(m), up-regulation of p53 and down-regulation of c-Myc, but independent of the opening of mPTP in 16HBE cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	42-46	tumor protein p53	Homo sapiens	187-190	
21983885-11	2012	As reported previously, we could reconfirm a critical role of p53 in BPDE-induced apoptosis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	69-73	tumor protein p53	Homo sapiens	62-65	
21983885-12	2012	Furthermore, induced levels of total p53 and its transcriptional target p21 declined at higher BPDE concentrations correlating with reduced rates of apoptosis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	95-99	tumor protein p53	Homo sapiens	37-40	
21983885-13	2012	Interestingly, increased phosphorylation of p53 at serine 15 remained elevated at higher BPDE concentrations thus disconnecting p53 phosphorylation from downstream apoptosis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	89-93	tumor protein p53	Homo sapiens	44-47	
21983885-13	2012	Interestingly, increased phosphorylation of p53 at serine 15 remained elevated at higher BPDE concentrations thus disconnecting p53 phosphorylation from downstream apoptosis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	89-93	tumor protein p53	Homo sapiens	128-131	
21983885-14	2012	Hence, phosphorylation of p53 seems not only to be a more sensitive biomarker of BPDE exposure but might serve other functions unrelated to apoptosis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	81-85	tumor protein p53	Homo sapiens	26-29	
21480602-0	2011	Phenolic fraction of tobacco smoke inhibits BPDE-induced apoptosis response and potentiates cell transformation: role of attenuation of p53 response.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	44-48	tumor protein p53	Homo sapiens	136-139	
22053912-9	2012	In addition, both anti-BPDE and B[a]P-7,8-trans-dihydrodiol induced p53 expression ~6 h post-treatment at concentrations as low as 1 muM consistent with extensive DNA damage.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	23-27	tumor protein p53	Homo sapiens	68-71	
21480602-6	2011	Increased cell transformation and decreased apoptosis by TSCPhFr were associated with attenuation of BPDE-induced p53 accumulation.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	101-105	tumor protein p53	Homo sapiens	114-117	
21480602-7	2011	JB6 cells transfected with p53 siRNA showed significantly less apoptosis induction by BPDE as compared to control cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	86-90	tumor protein p53	Homo sapiens	27-30	
21480602-9	2011	Also, in p53 null HCT116 p53(-/-) cells, BPDE-induced apoptosis is unresponsive to TSCPhFr.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	41-45	tumor protein p53	Homo sapiens	9-12	
21480602-9	2011	Also, in p53 null HCT116 p53(-/-) cells, BPDE-induced apoptosis is unresponsive to TSCPhFr.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	41-45	tumor protein p53	Homo sapiens	25-28	
21480602-12	2011	Our observations indicate that attenuation of BPDE-induced p53 response has a role in apoptosis inhibition and increased cell transformation by TSCPhFr.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	46-50	tumor protein p53	Homo sapiens	59-62	
20596254-2	2010	BaP 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo(a)pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 gene mutations.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	27-31	tumor protein p53	Homo sapiens	146-149	
21428456-0	2011	Electrochemical detection of anti-benzo[a]pyrene diol epoxide DNA damage on TP53 codon 273 oligomers.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	34-61	tumor protein p53	Homo sapiens	76-80	
21428456-1	2011	DNA damage from (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) at a hotspot TP53 gene sequence was electrochemically detected.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	72-76	tumor protein p53	Homo sapiens	91-95	
20700368-1	2010	PURPOSE: Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo[a]pyrene, attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 mutations.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	47-51	tumor protein p53	Homo sapiens	160-163	
20382639-0	2010	Benzo[a]pyrene diol epoxide stimulates an inflammatory response in normal human lung fibroblasts through a p53 and JNK mediated pathway.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-27	tumor protein p53	Homo sapiens	107-110	
18085531-6	2008	However, it led to a marked impairment of p53 induction in response to BPDE treatment.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	71-75	tumor protein p53	Homo sapiens	42-45	
19470404-5	2009	These results suggest that arsenite potentiates the BPDE-induced supF mutation via a p53-independent mechanism.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	52-56	tumor protein p53	Homo sapiens	85-88	
19139065-3	2009	We show that base adducts caused by a potent carcinogen, benzo[a]pyrene diol epoxide (BPDE), constitute a strong signal for TopBP1-dependent ATR kinase activity on Chk1 and p53.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	57-84	tumor protein p53	Homo sapiens	173-176	
19139065-3	2009	We show that base adducts caused by a potent carcinogen, benzo[a]pyrene diol epoxide (BPDE), constitute a strong signal for TopBP1-dependent ATR kinase activity on Chk1 and p53.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	86-90	tumor protein p53	Homo sapiens	173-176	
18788085-1	2008	Benzo[a]pyrene diol epoxide (B[a]PDE), the ultimate carcinogenic metabolite of benzo[a] pyrene, has been implicated in the mutagenesis of the p53 gene involved in smoking-associated lung cancer.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-27	tumor protein p53	Homo sapiens	142-145	
19397966-1	2009	Benzo(a)pyrene (BP) forms benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE)-DNA adducts in human breast adenocarcinoma MCF-7 cells, leading to p53 protein induction and phosphorylation.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	26-69	tumor protein p53	Homo sapiens	144-147	
19397966-1	2009	Benzo(a)pyrene (BP) forms benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE)-DNA adducts in human breast adenocarcinoma MCF-7 cells, leading to p53 protein induction and phosphorylation.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	71-75	tumor protein p53	Homo sapiens	144-147	
18489080-10	2008	By contrast, micromolar concentrations of (+/-)- anti-BPDE generated (+)- trans- anti-BPDE-N (2)-dGuo adducts (detected by stable-isotope dilution LC/MS methodology) in p53 cDNA that correlated in a linear fashion with mutagenic frequency, but no 8-oxo-dGuo was detected.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	54-58	tumor protein p53	Homo sapiens	169-172	
17942461-9	2008	Taken together, these results give further insight into the role of p53 in the response of human cells to BaP and BPDE and suggest that loss of this tumour suppressor can influence the metabolic activation of BaP.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	114-118	tumor protein p53	Homo sapiens	68-71	
17932951-4	2008	In this study, we have characterized the effect of the ultimate carcinogenic DEs, (+)-anti-BPDE and (-)-anti-DBPDE following short exposure times, on Mdm2 and p53 pathway in A549 human lung epithelial carcinoma cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	91-95	tumor protein p53	Homo sapiens	159-162	
17932951-6	2008	(+)-anti-BPDE-induced effects on Mdm2 were transient and correlated with transient p53 Ser15 phosphorylation.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	9-13	tumor protein p53	Homo sapiens	83-86	
17942461-2	2008	Exposure of cells to BPDE for up to 24 h resulted in gene expression profiles more distinguishable by duration of exposure than by p53 status, although a subset of genes were identified that had significantly different expression in p53 wild-type (WT) cells relative to p53-null cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	21-25	tumor protein p53	Homo sapiens	131-134	
17630511-0	2007	p53 regulates cellular responses to environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide in human lung cancer cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	61-97	tumor protein p53	Homo sapiens	0-3	
20445773-3	2008	We found that among these 14 SNPs, R72P, intron 3 16-bp del/ins, and intron 6 G>A in p53, -938C>A in Bcl-2, and I522L in CASP10 were significant predictors of the BPDE-induced lymphocytic AC in single-locus analysis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	169-173	tumor protein p53	Homo sapiens	88-91	
17986867-1	2007	We have shown previously that wild-type p53 renders H460 human lung cancer cells more sensitive to apoptosis induction by environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), but the mechanism of cell death is not fully understood.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	147-183	tumor protein p53	Homo sapiens	40-43	
17986867-1	2007	We have shown previously that wild-type p53 renders H460 human lung cancer cells more sensitive to apoptosis induction by environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), but the mechanism of cell death is not fully understood.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	185-189	tumor protein p53	Homo sapiens	40-43	
17630511-1	2007	The p53 tumor suppressor is a mutational target of environmental carcinogen anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	81-117	tumor protein p53	Homo sapiens	4-7	
17630511-1	2007	The p53 tumor suppressor is a mutational target of environmental carcinogen anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	119-123	tumor protein p53	Homo sapiens	4-7	
17630511-2	2007	We now demonstrate that p53 plays an important role in regulation of cellular responses to BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	91-95	tumor protein p53	Homo sapiens	24-27	
17630511-6	2007	The H460 human lung cancer cell line (wild-type p53) was relatively more sensitive to BPDE-mediated growth inhibition and enrichment of sub-diploid apoptotic fraction compared with H1299 cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	86-90	tumor protein p53	Homo sapiens	48-51	
17630511-8	2007	Instead, the BPDE-treated H460 cells exhibited a nearly 8-fold increase in sub-diploid apoptotic cells that was accompanied by phosphorylation of p53 at multiple sites.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	13-17	tumor protein p53	Homo sapiens	146-149	
17630511-9	2007	Knockdown of p53 protein level in H460 cells attenuated BPDE-induced apoptosis but enforced activation of S and G(2) phase checkpoints.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	56-60	tumor protein p53	Homo sapiens	13-16	
17630511-10	2007	In conclusion, the present study points towards an important role of p53 in regulation of cellular responses to BPDE in human lung cancer cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	112-116	tumor protein p53	Homo sapiens	69-72	
17213797-3	2006	BaP 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of BaP, attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 mutations.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	27-31	tumor protein p53	Homo sapiens	129-132	
17218071-3	2007	DNA binding of benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) was analyzed by synchronous fluorescence spectrophotometry and p53 protein by immunoblotting.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	15-51	tumor protein p53	Homo sapiens	122-125	
17213797-0	2006	An association between BPDE-like DNA adduct levels and P53 gene mutation in pterygium.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	23-27	tumor protein p53	Homo sapiens	55-58	
17213797-4	2006	The relationship between BPDE-like DNA adduct levels and abnormal p53 has not been clear in pterygium.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	25-29	tumor protein p53	Homo sapiens	66-69	
15854413-1	2005	OBJECTIVE: To study the role of mutant p53 gene induced by anti-7,8-dihydrodiol-9,10-epoxide benzo(a)pyrene (BPDE) in the development of lung cancer and the effects of wild-type p53 substitution on malignant phenotype and resistance to drugs.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	109-113	tumor protein p53	Homo sapiens	178-181	
16774943-9	2006	In addition, we found that BPDE increased p53 activity and apoptosis in MCF-10A; however, transient transfection of constitutively active Akt attenuated both BPDE-dependent apoptosis and p53 activity.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	27-31	tumor protein p53	Homo sapiens	42-45	
15854413-1	2005	OBJECTIVE: To study the role of mutant p53 gene induced by anti-7,8-dihydrodiol-9,10-epoxide benzo(a)pyrene (BPDE) in the development of lung cancer and the effects of wild-type p53 substitution on malignant phenotype and resistance to drugs.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	109-113	tumor protein p53	Homo sapiens	39-42	
15854413-2	2005	METHODS: BPDE-induced human lung cancer cells (16HBE, a human bronchial epithelial cell line, treated by BPDE) with mutant p53 gene were transfected with pShuttle-cmv-wild p53, followed by soft-agar colony formation assay and cell growth assay.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	9-13	tumor protein p53	Homo sapiens	123-126	
15854413-2	2005	METHODS: BPDE-induced human lung cancer cells (16HBE, a human bronchial epithelial cell line, treated by BPDE) with mutant p53 gene were transfected with pShuttle-cmv-wild p53, followed by soft-agar colony formation assay and cell growth assay.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	9-13	tumor protein p53	Homo sapiens	172-175	
14729588-6	2004	We applied LwPy53 to exons 5, 7 and 8 of p53 using benzo[a]pyrene diol epoxide (BPDE)-induced mutation data for supF to obtain a predicted BPDE G-->T transversion spectrum after hypothetical treatment with BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	51-78	tumor protein p53	Homo sapiens	41-44	
15595848-2	2004	We incorporated a single (+)- or (-)-trans-anti-benzo[a]pyrene diol epoxide (BPDE) DNA adduct at the second position of codon 273 of the human P53 gene and explored the mutagenic potential of this lesion in mammalian cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	77-81	tumor protein p53	Homo sapiens	143-146	
15595848-9	2004	Thus, the mutational "hot spot" at codon 273 in P53 may reflect either sequence-specific reactivity of BPDE and/or inefficient repair of BPDE-DNA adducts positioned at this site.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	103-107	tumor protein p53	Homo sapiens	48-51	
15595848-9	2004	Thus, the mutational "hot spot" at codon 273 in P53 may reflect either sequence-specific reactivity of BPDE and/or inefficient repair of BPDE-DNA adducts positioned at this site.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	137-141	tumor protein p53	Homo sapiens	48-51	
15288541-4	2004	The FACIM assay was used to evaluate the mutagenesis of the flounder TP53 exposed in vitro to benzo[a]pyrene diol epoxide (BPDE).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	94-121	tumor protein p53	Homo sapiens	69-73	
15288541-4	2004	The FACIM assay was used to evaluate the mutagenesis of the flounder TP53 exposed in vitro to benzo[a]pyrene diol epoxide (BPDE).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	123-127	tumor protein p53	Homo sapiens	69-73	
14729588-6	2004	We applied LwPy53 to exons 5, 7 and 8 of p53 using benzo[a]pyrene diol epoxide (BPDE)-induced mutation data for supF to obtain a predicted BPDE G-->T transversion spectrum after hypothetical treatment with BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	80-84	tumor protein p53	Homo sapiens	41-44	
14729588-6	2004	We applied LwPy53 to exons 5, 7 and 8 of p53 using benzo[a]pyrene diol epoxide (BPDE)-induced mutation data for supF to obtain a predicted BPDE G-->T transversion spectrum after hypothetical treatment with BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	139-143	tumor protein p53	Homo sapiens	41-44	
15072824-8	2004	The high formation of BPDE-N(2)-dG adducts in bronchial epithelial cells and investigations showing that the profile of mutations induced by BPDE in these cells is similar to that seen in the p53 gene isolated from human lung tumors implicates benzo[a]pyrene as important carcinogen in tobacco-induced lung cancer in human beings.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	22-26	tumor protein p53	Homo sapiens	192-195	
15025498-3	2004	Our studies of the effects of noncytotoxic concentrations of Cd2+ on the levels of p53 and p21 in (+/-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE)-treated human fibroblasts showed that Cd2+ decreased BPDE-induced p21 levels in a dose-dependent manner whereas p53 accumulation is attenuated only at higher noncytotoxic concentrations of cadmium.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	147-151	tumor protein p53	Homo sapiens	83-86	
15025498-3	2004	Our studies of the effects of noncytotoxic concentrations of Cd2+ on the levels of p53 and p21 in (+/-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE)-treated human fibroblasts showed that Cd2+ decreased BPDE-induced p21 levels in a dose-dependent manner whereas p53 accumulation is attenuated only at higher noncytotoxic concentrations of cadmium.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	206-210	tumor protein p53	Homo sapiens	83-86	
15025498-4	2004	These findings suggest that both the activity and the accumulation of p53 in response of BPDE treatment are inhibited by Cd2+ although the possibility of p53-independent p21 transactivation cannot be ruled out.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	89-93	tumor protein p53	Homo sapiens	70-73	
12538356-0	2003	Simulated sunlight and benzo[a]pyrene diol epoxide induced mutagenesis in the human p53 gene evaluated by the yeast functional assay: lack of correspondence to tumor mutation spectra.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	23-50	tumor protein p53	Homo sapiens	84-87	
12175902-3	2002	The results show that the removal of anti-BPDE DNA adducts from the genome overall and NTS by GGR was significantly reduced in HPV-16E6 protein expressing cells as compared to that in normal and HPV-16E7 protein expressing cells, indicating the role of p53 and not pRb in nucleotide excision repair (NER).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	42-46	tumor protein p53	Homo sapiens	253-256	
12407735-6	2003	Tobacco-specific carcinogens, in particular BPDE, cause a unique spectrum of p53 mutations, quite distinct from those found in cancers that are not associated with smoking.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	44-48	tumor protein p53	Homo sapiens	77-80	
12507920-1	2002	Benzo[a]pyrene diol epoxide (BPDE)-DNA adducts are involved in the induction of p53 mutations and probably in the causation of human lung cancer associated with cigarette smoking.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-27	tumor protein p53	Homo sapiens	80-83	
12507920-1	2002	Benzo[a]pyrene diol epoxide (BPDE)-DNA adducts are involved in the induction of p53 mutations and probably in the causation of human lung cancer associated with cigarette smoking.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	29-33	tumor protein p53	Homo sapiens	80-83	
11505223-4	2001	In cultured lymphocytes treated with 2.5 microM BPDE for 18 h, increased levels of p53 were found, which were positively related to BPDE-DNA adduct levels assessed by ICC (rs = 0.66, P < 0.001) and 32P-postlabelling (rs = 0.56, P < 0.001) and appeared to be higher in GSTM1(-/-) than in GSTM1(+) subjects (P = 0.003).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	48-52	tumor protein p53	Homo sapiens	83-86	
12067251-8	2002	Treatment of p53 cDNA with micromolar concentrations of (+/-)-anti-7,8-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydro-benzo[a]pyrene, (anti-BPDE, an ultimate carcinogen) or sub-micromolar concentrations of BP-7,8-dione in the presence of redox-cycling conditions (NADPH and CuCl(2)) also caused p53 mutations in a dose-dependent manner.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	144-148	tumor protein p53	Homo sapiens	13-16	
11864911-1	2002	We have investigated the mechanism of S-phase arrest elicited by the carcinogen benzo(a)pyrene dihydrodiol epoxide (BPDE) in p53-deficient cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	116-120	tumor protein p53	Homo sapiens	125-128	
11585742-0	2001	Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	103-130	tumor protein p53	Homo sapiens	173-176	
11585742-3	2001	p53 codons containing methylated CpG sequences are preferential targets for formation of adducts by (+/-) anti-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	190-194	tumor protein p53	Homo sapiens	0-3	
11522624-0	2001	Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	36-63	tumor protein p53	Homo sapiens	14-17	
11522624-0	2001	Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	65-69	tumor protein p53	Homo sapiens	14-17	
11522624-3	2001	In the present study, we have used a highly sensitive mutation assay to determine the p53 mutation load in nontumorous human lung and to study the mutability of p53 codons 157, 248, 249, and 250 to benzo(a)pyrene-diol-epoxide (BPDE), an active metabolite of BP in human bronchial epithelial BEAS-2B cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	227-231	tumor protein p53	Homo sapiens	161-164	
11782367-7	2002	Transient expression of dominant-negative p53 ((175)Arg-->His) counteracted the detrimental effects of BPDE on BRCA-1 promoter activity and protein levels.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	106-110	tumor protein p53	Homo sapiens	42-45	
11782367-9	2002	We conclude that activation of the aromatic hydrocarbon receptor is not sufficient for down-regulation of BRCA-1 transcription, which is, however, inhibited by the B[a]P metabolite BPDE through a p53-dependent pathway.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	181-185	tumor protein p53	Homo sapiens	196-199	
11505223-4	2001	In cultured lymphocytes treated with 2.5 microM BPDE for 18 h, increased levels of p53 were found, which were positively related to BPDE-DNA adduct levels assessed by ICC (rs = 0.66, P < 0.001) and 32P-postlabelling (rs = 0.56, P < 0.001) and appeared to be higher in GSTM1(-/-) than in GSTM1(+) subjects (P = 0.003).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	132-136	tumor protein p53	Homo sapiens	83-86	
10786695-4	2000	In this study, we have investigated the role of p53 protein in modulating nucleotide excision repair of anti-benzo-(a)pyrene-diol-epoxide (BPDE)-DNA adducts and related effects using human fibroblasts with normal (p53-WT) and altered p53 protein (p53Mut and p53-Null).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	139-143	tumor protein p53	Homo sapiens	48-51	
11191113-7	2000	These findings suggest that the AhR mediated the inverse expression patterns of BRCA-1 and p53 upon exposure to B[a]P. The treatment with BPDE induced S-phase arrest and reduced BRCA-1 mRNA levels.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	138-142	tumor protein p53	Homo sapiens	91-94	
10786695-9	2000	Furthermore, p53-Mut and p53-Null cells were more sensitive than p53-WT cells and displayed increased levels of anti-BPDE-induced apoptosis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	117-121	tumor protein p53	Homo sapiens	13-16	
10786695-9	2000	Furthermore, p53-Mut and p53-Null cells were more sensitive than p53-WT cells and displayed increased levels of anti-BPDE-induced apoptosis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	117-121	tumor protein p53	Homo sapiens	25-28	
10786695-9	2000	Furthermore, p53-Mut and p53-Null cells were more sensitive than p53-WT cells and displayed increased levels of anti-BPDE-induced apoptosis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	117-121	tumor protein p53	Homo sapiens	25-28	
10786695-10	2000	Thus, wild-type p53 is required for the efficient global genomic repair of anti-BPDE-induced DNA adducts from the overall genome, but not for transcription-coupled repair of actively transcribed genes.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	80-84	tumor protein p53	Homo sapiens	16-19	
10676627-0	2000	p53-dependent global genomic repair of benzo[a]pyrene-7,8-diol-9,10-epoxide adducts in human cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	39-75	tumor protein p53	Homo sapiens	0-3	
10676627-2	2000	At low BPDE adduct levels (10-50 adducts/10(8) nucleotides), repair was rapid and essentially complete within 24 h in p53+ cells, whereas no repair was detected within 72 h in similarly treated p53- cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7-11	tumor protein p53	Homo sapiens	118-121	
10676627-2	2000	At low BPDE adduct levels (10-50 adducts/10(8) nucleotides), repair was rapid and essentially complete within 24 h in p53+ cells, whereas no repair was detected within 72 h in similarly treated p53- cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7-11	tumor protein p53	Homo sapiens	194-197	
10676627-3	2000	At 10-fold higher BPDE adduct levels, repair under both conditions was rapid up to 8 h, after which a low level of adducts persisted only in p53- cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	18-22	tumor protein p53	Homo sapiens	141-144	
10676627-4	2000	These results demonstrate a dependence on p53 for the efficient repair of BPDE adducts at levels that are relevant to human environmental exposure and, thus, have significant implications for human carcinogenesis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	74-78	tumor protein p53	Homo sapiens	42-45	
10446162-2	1999	It has recently been shown that BPDE preferentially modifies the guanine in methylated 5"-CpG-3" sequences in the human p53 gene, providing one explanation for why these sites are mutational hot spots.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	32-36	tumor protein p53	Homo sapiens	120-123	
10381403-11	1999	The results explain the enhanced reaction of BPDE at m5CpG in DNA and the origin of G-T mutational hotspots in the p53 gene in cancer.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	45-49	tumor protein p53	Homo sapiens	115-118	
9108075-5	1997	To investigate other possible mechanisms underlying the selectivity of BPDE binding, we have mapped the adducts in plasmid DNA containing genomic P53 sequences.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	71-75	tumor protein p53	Homo sapiens	146-149	
9605744-3	1998	Using a UvrABC incision method, we have found that cytosine methylation greatly enhances guanine alkylation at all CpG sites in the p53 gene by a variety of carcinogens, including benzo(a)pyrene diol epoxide, benzo(g)chrysene diol epoxide, aflatoxin B1 8,9-epoxide, and N-acetoxy-2-acetylaminofluorene.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	180-207	tumor protein p53	Homo sapiens	132-135	
9546425-1	1998	Using UvrABC incision in combination with ligation-mediated PCR (LMPCR) we have previously shown that benzo(a)pyrene diol epoxide (BPDE) adduct formation along the nontranscribed strand of the human p53 gene is highly selective; the preferential binding sites coincide with the major mutation hotspots found in human lung cancers.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	102-129	tumor protein p53	Homo sapiens	199-202	
9546425-1	1998	Using UvrABC incision in combination with ligation-mediated PCR (LMPCR) we have previously shown that benzo(a)pyrene diol epoxide (BPDE) adduct formation along the nontranscribed strand of the human p53 gene is highly selective; the preferential binding sites coincide with the major mutation hotspots found in human lung cancers.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	131-135	tumor protein p53	Homo sapiens	199-202	
10357792-0	1999	Use of UvrABC nuclease to quantify benzo[a]pyrene diol epoxide-DNA adduct formation at methylated versus unmethylated CpG sites in the p53 gene.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	35-62	tumor protein p53	Homo sapiens	135-138	
9047387-0	1997	Modulation of (+/-)-anti-BPDE mediated p53 accumulation by inhibitors of protein kinase C and poly(ADP-ribose) polymerase.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	25-29	tumor protein p53	Homo sapiens	39-42	
9047387-8	1997	On the contrary, inhibition of protein kinase C (PKC) by calphostin-C led to an abrogation of (+/-)-anti-BPDE mediated p53 induction.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	105-109	tumor protein p53	Homo sapiens	119-122	
9047387-5	1997	The poly(ADP-ribose) polymerase inhibitor, 3-aminobenzamide (3-AB), diminished the p53 induction response by concomitantly decreasing the extent of (+/-)-anti-BPDE induced DNA damage in cells pretreated with the inhibitor.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	159-163	tumor protein p53	Homo sapiens	83-86	
7586197-3	1995	Both immunocytochemical and immunoblot analysis indicated that treatment of PBLs with (+/-)-anti-BPDE results in p53 accumulation.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	97-101	tumor protein p53	Homo sapiens	113-116	
8832894-2	1996	The distribution of benzo[a]pyrene diol epoxide (BPDE) adducts along exons of the P53 gene in BPDE-treated HeLa cells and bronchial epithelial cells was mapped at nucleotide resolution.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	20-47	tumor protein p53	Homo sapiens	82-85	
8832894-2	1996	The distribution of benzo[a]pyrene diol epoxide (BPDE) adducts along exons of the P53 gene in BPDE-treated HeLa cells and bronchial epithelial cells was mapped at nucleotide resolution.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	49-53	tumor protein p53	Homo sapiens	82-85	
8832894-2	1996	The distribution of benzo[a]pyrene diol epoxide (BPDE) adducts along exons of the P53 gene in BPDE-treated HeLa cells and bronchial epithelial cells was mapped at nucleotide resolution.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	94-98	tumor protein p53	Homo sapiens	82-85	
7586197-8	1995	These findings suggest that (+/-)-anti-BPDE-induced DNA strand break formation is responsible for the observed p53 accumulation.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	39-43	tumor protein p53	Homo sapiens	111-114	
8634092-7	1996	The lesion frequencies in the p53 and beta-globin genes in purified DNA treated with BPDE in vitro were the same, indicating that there was no sequence-specific basis for preferential lesion formation in the p53 gene in treated cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	85-89	tumor protein p53	Homo sapiens	30-33	
7586197-5	1995	Further, (+/-)-anti-BPDE-induced p53 accumulation in PBLs was found to be time-dependent with accumulation up to 24 h after the onset of treatment.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	20-24	tumor protein p53	Homo sapiens	33-36	
7586197-6	1995	Treatment of PBLs with 2.5 microM of (+/-)-anti-BPDE and 1 mM of 3-aminobenzamide, an inhibitor of the DNA strand break-dependent enzyme poly(ADP-ribose) polymerase, resulted in increased p53 levels, in comparison to cells treated with (+/-)-anti-BPDE alone.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	48-52	tumor protein p53	Homo sapiens	188-191	
34610339-5	2021	Interestingly, we found that the mRNA and protein level of TP53 and PPP1R13L fluctuated as a wave in BPDE-induced malignant transformation under wild-type TP53 genetic background.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	101-105	tumor protein p53	Homo sapiens	59-63	
34610339-5	2021	Interestingly, we found that the mRNA and protein level of TP53 and PPP1R13L fluctuated as a wave in BPDE-induced malignant transformation under wild-type TP53 genetic background.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	101-105	tumor protein p53	Homo sapiens	155-159	
34383983-8	2021	After exposure to BPDE or in RM tissues, p53 was upregulated, which might promote p53-mediated lnc-HZ04 transcription.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	18-22	tumor protein p53	Homo sapiens	41-44	
34383983-8	2021	After exposure to BPDE or in RM tissues, p53 was upregulated, which might promote p53-mediated lnc-HZ04 transcription.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	18-22	tumor protein p53	Homo sapiens	82-85	
35483139-0	2022	Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	14-18	tumor protein p53	Homo sapiens	86-89	
35483139-10	2022	Upon BPDE exposure, BPDE up-regulated the expression levels of lnc-HZ01 and p53, triggered this positive feedback loop, activated the p53/caspase-3 apoptosis pathway, and then induced miscarriage.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	5-9	tumor protein p53	Homo sapiens	76-79	
35483139-10	2022	Upon BPDE exposure, BPDE up-regulated the expression levels of lnc-HZ01 and p53, triggered this positive feedback loop, activated the p53/caspase-3 apoptosis pathway, and then induced miscarriage.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	5-9	tumor protein p53	Homo sapiens	134-137	
35483139-10	2022	Upon BPDE exposure, BPDE up-regulated the expression levels of lnc-HZ01 and p53, triggered this positive feedback loop, activated the p53/caspase-3 apoptosis pathway, and then induced miscarriage.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	20-24	tumor protein p53	Homo sapiens	76-79	
35483139-10	2022	Upon BPDE exposure, BPDE up-regulated the expression levels of lnc-HZ01 and p53, triggered this positive feedback loop, activated the p53/caspase-3 apoptosis pathway, and then induced miscarriage.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	20-24	tumor protein p53	Homo sapiens	134-137