PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19028507-4 2009 We observed that BPDE treatment also activates all three MAP kinases e.g. ERK1/2, p38 and JNK in HL-60 cells, and inhibition of BPDE-induced apoptosis by cadmium is associated with down-regulation of pro-apoptotic bax induction/caspase-9 activation and up-regulation of ERK phosphorylation, whereas p38 MAP kinase and c-Jun phosphorylation (indicative of JNK activation) remain unaffected. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17-21 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 318-323 19028507-4 2009 We observed that BPDE treatment also activates all three MAP kinases e.g. ERK1/2, p38 and JNK in HL-60 cells, and inhibition of BPDE-induced apoptosis by cadmium is associated with down-regulation of pro-apoptotic bax induction/caspase-9 activation and up-regulation of ERK phosphorylation, whereas p38 MAP kinase and c-Jun phosphorylation (indicative of JNK activation) remain unaffected. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 128-132 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 318-323 8824521-4 1996 In this study we have specifically modified the binding site of the transcription factor AP-1 with the (+)-anti- or (-)-syn-enantiomers of BPDE, and have studied how this affects the binding of the Fos-Jun proteins. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 139-143 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 89-93 8824521-5 1996 Both (-)-syn- and (+)-anti-BPDE, giving rise to a cis- and a trans-adduct, respectively, have been used and, in both cases, the binding of AP-1 like proteins from HeLa cell nuclear extracts to the modified binding site decreased by approximately 50% as compared to controls. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 27-31 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 139-143 28593498-10 2018 As expected, BPDE activated DNA damage signaling, p53 and AP-1 dependent signaling, oxidative stress response, and apoptosis. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 13-17 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 58-62