PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19028507-4	2009	We observed that BPDE treatment also activates all three MAP kinases e.g. ERK1/2, p38 and JNK in HL-60 cells, and inhibition of BPDE-induced apoptosis by cadmium is associated with down-regulation of pro-apoptotic bax induction/caspase-9 activation and up-regulation of ERK phosphorylation, whereas p38 MAP kinase and c-Jun phosphorylation (indicative of JNK activation) remain unaffected.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	17-21	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	318-323	
19028507-4	2009	We observed that BPDE treatment also activates all three MAP kinases e.g. ERK1/2, p38 and JNK in HL-60 cells, and inhibition of BPDE-induced apoptosis by cadmium is associated with down-regulation of pro-apoptotic bax induction/caspase-9 activation and up-regulation of ERK phosphorylation, whereas p38 MAP kinase and c-Jun phosphorylation (indicative of JNK activation) remain unaffected.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	128-132	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	318-323	
8824521-4	1996	In this study we have specifically modified the binding site of the transcription factor AP-1 with the (+)-anti- or (-)-syn-enantiomers of BPDE, and have studied how this affects the binding of the Fos-Jun proteins.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	139-143	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-93	
8824521-5	1996	Both (-)-syn- and (+)-anti-BPDE, giving rise to a cis- and a trans-adduct, respectively, have been used and, in both cases, the binding of AP-1 like proteins from HeLa cell nuclear extracts to the modified binding site decreased by approximately 50% as compared to controls.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	27-31	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	139-143	
28593498-10	2018	As expected, BPDE activated DNA damage signaling, p53 and AP-1 dependent signaling, oxidative stress response, and apoptosis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	13-17	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-62