PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32851734-0 2020 Lysophosphatidic acid induces tumor necrosis factor-alpha to regulate a pro-inflammatory cytokine network in ovarian cancer. lysophosphatidic acid 0-21 tumor necrosis factor Homo sapiens 30-57 32851734-7 2020 Like many other biological responses to LPA, induction of TNF-alpha by LPA also depended on the transactivation of the epidermal growth factor receptor (EGFR). lysophosphatidic acid 40-43 tumor necrosis factor Homo sapiens 58-67 32851734-7 2020 Like many other biological responses to LPA, induction of TNF-alpha by LPA also depended on the transactivation of the epidermal growth factor receptor (EGFR). lysophosphatidic acid 71-74 tumor necrosis factor Homo sapiens 58-67 11861673-6 2002 LPA was found to increase attachment of the monocytic cell line THP-1 to vascular endothelial cells pre-stimulated with tumor necrosis factor-alpha. lysophosphatidic acid 0-3 tumor necrosis factor Homo sapiens 120-147 35365723-6 2022 IL-8, IL-6 and TNF-alpha secretion was induced by LPA in MDA-MB-468 cells. lysophosphatidic acid 50-53 tumor necrosis factor Homo sapiens 15-24 32851734-3 2020 In the current study, we demonstrated that lysophosphatidic acid (LPA), a lipid mediator present in ascites of ovarian cancer patients, induced expression of TNF-alpha mRNA and release of TNF-alpha protein in ovarian cancer cells. lysophosphatidic acid 43-64 tumor necrosis factor Homo sapiens 158-167 32851734-9 2020 To explore the biological outcomes of LPA-induced TNF-alpha, we examined the effects of a TNF-alpha neutralizing antibody and recombinant TNF-alpha soluble receptor on LPA-stimulated expression of pro-tumorigenic cytokines and chemokines overexpressed in ovarian cancer. lysophosphatidic acid 38-41 tumor necrosis factor Homo sapiens 50-59 32851734-9 2020 To explore the biological outcomes of LPA-induced TNF-alpha, we examined the effects of a TNF-alpha neutralizing antibody and recombinant TNF-alpha soluble receptor on LPA-stimulated expression of pro-tumorigenic cytokines and chemokines overexpressed in ovarian cancer. lysophosphatidic acid 168-171 tumor necrosis factor Homo sapiens 90-99 32851734-3 2020 In the current study, we demonstrated that lysophosphatidic acid (LPA), a lipid mediator present in ascites of ovarian cancer patients, induced expression of TNF-alpha mRNA and release of TNF-alpha protein in ovarian cancer cells. lysophosphatidic acid 66-69 tumor necrosis factor Homo sapiens 158-167 32851734-12 2020 Taken together, our results establish that the bioactive lipid LPA drives the expression of TNF-alpha to regulate an inflammatory network in ovarian cancer. lysophosphatidic acid 63-66 tumor necrosis factor Homo sapiens 92-101 32851734-6 2020 Inactivation of ADAM17, a disintegrin and metalloproteinase, with a specific inhibitor TMI-1 or by shRNA knockdown prevented ovarian cancer cells from releasing TNF-alpha protein in response to LPA, indicating that LPA-mediated TNF-alpha production relies on both transcriptional upregulations of the TNF-alpha gene and the activity of ADAM17, the membrane-associated TNF-alpha-converting enzyme. lysophosphatidic acid 194-197 tumor necrosis factor Homo sapiens 161-170 29209219-0 2017 Differential Effects of Inhibitor Combinations on Lysophosphatidic Acid-Mediated Chemokine Secretion in Unprimed and Tumor Necrosis Factor-alpha-Primed Synovial Fibroblasts. lysophosphatidic acid 50-71 tumor necrosis factor Homo sapiens 117-144 29209219-4 2017 RAFLS pretreated or not with TNFalpha were stimulated with LPA. lysophosphatidic acid 59-62 tumor necrosis factor Homo sapiens 29-37 29209219-8 2017 Priming with TNFalpha enhanced LPA-mediated MSK phosphorylation and cytokine/chemokine production. lysophosphatidic acid 31-34 tumor necrosis factor Homo sapiens 13-21 29128569-10 2018 Treatment of Caco-2 cells with tumor necrosis factor-alpha and interferon-gamma significantly increased paracellular permeability, which was blocked by cotreatment with LPA, but not LPA1 knockdown cells. lysophosphatidic acid 169-172 tumor necrosis factor Homo sapiens 31-58 27053111-5 2016 In human colon epithelial Caco2 cells, TNF-alpha induces sustained expression of proinflammatory molecules and sustained activation of nuclear factor-kappaB (NF-kappaB) and PKD, the late phases of which are suppressed by not only siRNA-mediated PLCepsilon knockdown but also treatment with a lysophosphatidic acid (LPA) receptor antagonist. lysophosphatidic acid 292-313 tumor necrosis factor Homo sapiens 39-48 28765952-7 2017 Reverse transcription-quantitative polymerase chain reaction and western blot analyses additionally revealed decreased expression of SIRT1, LXRalpha and CCR7 and increased expression of NF-kappaB and its downstream factor tumor necrosis factor-alpha (TNF-alpha) in an atherogenetic condition induced by lysophosphatidic acid (LPA). lysophosphatidic acid 303-324 tumor necrosis factor Homo sapiens 222-249 28765952-7 2017 Reverse transcription-quantitative polymerase chain reaction and western blot analyses additionally revealed decreased expression of SIRT1, LXRalpha and CCR7 and increased expression of NF-kappaB and its downstream factor tumor necrosis factor-alpha (TNF-alpha) in an atherogenetic condition induced by lysophosphatidic acid (LPA). lysophosphatidic acid 303-324 tumor necrosis factor Homo sapiens 251-260 28765952-7 2017 Reverse transcription-quantitative polymerase chain reaction and western blot analyses additionally revealed decreased expression of SIRT1, LXRalpha and CCR7 and increased expression of NF-kappaB and its downstream factor tumor necrosis factor-alpha (TNF-alpha) in an atherogenetic condition induced by lysophosphatidic acid (LPA). lysophosphatidic acid 326-329 tumor necrosis factor Homo sapiens 222-249 28765952-7 2017 Reverse transcription-quantitative polymerase chain reaction and western blot analyses additionally revealed decreased expression of SIRT1, LXRalpha and CCR7 and increased expression of NF-kappaB and its downstream factor tumor necrosis factor-alpha (TNF-alpha) in an atherogenetic condition induced by lysophosphatidic acid (LPA). lysophosphatidic acid 326-329 tumor necrosis factor Homo sapiens 251-260 29209219-12 2017 In TNFalpha-primed RAFLS the super-production of IL-8 and IL-6 induced by LPA occurs mainly via MSK-independent pathways, and simultaneous inhibition of at least two MAPK signaling pathways was required to block their synthesis. lysophosphatidic acid 74-77 tumor necrosis factor Homo sapiens 3-11 29209219-13 2017 Since simultaneous inhibition of both the p38MAPK and ERK-MSK-CREB pathways are required to significantly reduce LPA-mediated IL-8 and IL-6 production in TNFalpha-preconditioned RAFLS, drug combinations targeting these two pathways are potential new strategies to treat rheumatoid arthritis. lysophosphatidic acid 113-116 tumor necrosis factor Homo sapiens 154-162 27053111-6 2016 Also, LPA stimulation induces these events in an early time course, suggesting that LPA mediates TNF-alpha signaling in an autocrine manner. lysophosphatidic acid 6-9 tumor necrosis factor Homo sapiens 97-106 27053111-6 2016 Also, LPA stimulation induces these events in an early time course, suggesting that LPA mediates TNF-alpha signaling in an autocrine manner. lysophosphatidic acid 84-87 tumor necrosis factor Homo sapiens 97-106 24980231-9 2014 Sinus mucosa explant stimulated with LPA increasingly produced IL-4, IL-5, interferon gamma, and TNF-alpha, and in cultured epithelial cells stimulated with CRS-relevant cytokines, ATX, and LPA1-3 were differentially induced. lysophosphatidic acid 37-40 tumor necrosis factor Homo sapiens 97-106 25502757-6 2014 In addition, based on data suggesting that tumor necrosis factor (TNF)-alpha induces cell apoptosis, LPA upregulates TNF-induced caspase-3 and cleaved Poly(ADP-ribose)polymerase (PARP). lysophosphatidic acid 101-104 tumor necrosis factor Homo sapiens 66-69 21765444-9 2011 CT could inhibit TNF-alpha-induced expression and secretion of ATX that led to decreased activity of lysophospholipase D, thus decreasing the conversion of LPC to LPA. lysophosphatidic acid 163-166 tumor necrosis factor Homo sapiens 17-26 21292998-0 2011 TNF-alpha potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts. lysophosphatidic acid 22-43 tumor necrosis factor Homo sapiens 0-9 21292998-5 2011 TNF-alpha, while having no detectable effect on the activation of PKD when added alone, augmented PKD activation stimulated by LPA, as measured by PKD autophosphorylation at Ser(910). lysophosphatidic acid 127-130 tumor necrosis factor Homo sapiens 0-9 23688423-3 2013 We recently reported that TNF-alpha and the G protein-coupled receptor (GPCR) agonist lysophosphatidic acid (LPA) lead to synergistic cyclo-oxygenase-2 (COX-2) expression, an enzyme strongly associated with the development of colitis-associated cancer. lysophosphatidic acid 109-112 tumor necrosis factor Homo sapiens 26-35 23688423-9 2013 However, chronic exposure to TNF-alpha led to upregulation of EGFR in association with sustained LPA-mediated EGFR phosphorylation at Y1068. lysophosphatidic acid 97-100 tumor necrosis factor Homo sapiens 29-38 16760261-3 2006 In this study, LPA production and response were characterized in a human corneal epithelial cell line, 2.040 pRSV-T. LPA levels in cells and medium are increased by exogenous 18:1 LPA (oleoyl-LPA), LPS, IL-1beta, and TNF-alpha. lysophosphatidic acid 15-18 tumor necrosis factor Homo sapiens 217-226 16760261-3 2006 In this study, LPA production and response were characterized in a human corneal epithelial cell line, 2.040 pRSV-T. LPA levels in cells and medium are increased by exogenous 18:1 LPA (oleoyl-LPA), LPS, IL-1beta, and TNF-alpha. lysophosphatidic acid 117-120 tumor necrosis factor Homo sapiens 217-226 16760261-3 2006 In this study, LPA production and response were characterized in a human corneal epithelial cell line, 2.040 pRSV-T. LPA levels in cells and medium are increased by exogenous 18:1 LPA (oleoyl-LPA), LPS, IL-1beta, and TNF-alpha. lysophosphatidic acid 117-120 tumor necrosis factor Homo sapiens 217-226