PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7962101-0 1994 Modulation of cell surface fibronectin assembly sites by lysophosphatidic acid. lysophosphatidic acid 57-78 fibronectin 1 Homo sapiens 27-38 7962101-2 1994 We have characterized the effect of lysophosphatidic acid on cell-mediated binding and assembly of fibronectin, an extracellular matrix protein. lysophosphatidic acid 36-57 fibronectin 1 Homo sapiens 99-110 7962101-5 1994 These results indicate that lysophosphatidic acid derived from platelets is the principal component in whole blood serum that is active in the fibronectin binding assay. lysophosphatidic acid 28-49 fibronectin 1 Homo sapiens 143-154 7962101-7 1994 The stimulatory effect of lysophosphatidic acid on the binding of fibronectin or the amino-terminal 70-kD fragment of fibronectin was rapid, sustained, and lost upon removal of lysophosphatidic acid. lysophosphatidic acid 26-47 fibronectin 1 Homo sapiens 66-77 7962101-7 1994 The stimulatory effect of lysophosphatidic acid on the binding of fibronectin or the amino-terminal 70-kD fragment of fibronectin was rapid, sustained, and lost upon removal of lysophosphatidic acid. lysophosphatidic acid 26-47 fibronectin 1 Homo sapiens 118-129 7962101-7 1994 The stimulatory effect of lysophosphatidic acid on the binding of fibronectin or the amino-terminal 70-kD fragment of fibronectin was rapid, sustained, and lost upon removal of lysophosphatidic acid. lysophosphatidic acid 177-198 fibronectin 1 Homo sapiens 66-77 7962101-7 1994 The stimulatory effect of lysophosphatidic acid on the binding of fibronectin or the amino-terminal 70-kD fragment of fibronectin was rapid, sustained, and lost upon removal of lysophosphatidic acid. lysophosphatidic acid 177-198 fibronectin 1 Homo sapiens 118-129 7962101-11 1994 The binding sites for fibronectin on lysophosphatidic acid-stimulated cells, as assessed by fluorescence, video, and scanning electron microscopy, were on areas of cell membrane containing numerous filopodia that extended between cells or between cells and substratum. lysophosphatidic acid 37-58 fibronectin 1 Homo sapiens 22-33 16689739-2 2006 Fibronectin is a plasma protein that is insolubilized into fibrils in a regulated fashion by, for example, lysophosphatidic acid (LPA)-stimulated fibroblasts or platelets spread on supportive adhesive ligands. lysophosphatidic acid 107-128 fibronectin 1 Homo sapiens 0-11 25309328-7 2014 In the present work, we aimed to answer whether LPA affects astrocytic production and rearrangement of fibronectin, and to investigate the mechanisms involved in neuronal differentiation and maturation of cortical neurons induced by LPA-primed astrocytes. lysophosphatidic acid 48-51 fibronectin 1 Homo sapiens 103-114 19940066-5 2010 RhoAV14, lysophosphatidic acid, and TGF-beta(2) stimulated significant increases in Erk1/2 phosphorylation, paralleled by profound increases in fibronectin, serum response factor (SRF), and alpha-SMA expression. lysophosphatidic acid 9-30 fibronectin 1 Homo sapiens 144-155 17984096-8 2008 The fibronectin deposition could be restored by treatment with lysophosphatidic acid, a Rho stimulator. lysophosphatidic acid 63-84 fibronectin 1 Homo sapiens 4-15 8218108-0 1993 Lysophosphatidic acid enhances fibronectin binding to adherent cells. lysophosphatidic acid 0-21 fibronectin 1 Homo sapiens 31-42 8218108-1 1993 1-Oleoyl lysophosphatidic acid (LPA) enhanced binding of 125I-labeled fibronectin by cultured MG-63 osteosarcoma cells and human fibroblasts in monolayer cultures up to threefold over control levels. lysophosphatidic acid 0-30 fibronectin 1 Homo sapiens 70-81 8218108-1 1993 1-Oleoyl lysophosphatidic acid (LPA) enhanced binding of 125I-labeled fibronectin by cultured MG-63 osteosarcoma cells and human fibroblasts in monolayer cultures up to threefold over control levels. lysophosphatidic acid 32-35 fibronectin 1 Homo sapiens 70-81 8218108-3 1993 Increased binding was evident within 10 minutes of treatment of cycloheximide-treated cells with LPA and was due to an increase in the number of fibronectin binding sites. lysophosphatidic acid 97-100 fibronectin 1 Homo sapiens 145-156 8218108-5 1993 Removal of LPA resulted in prompt return of fibronectin binding to baseline levels. lysophosphatidic acid 11-14 fibronectin 1 Homo sapiens 44-55 22561288-3 2013 Early studies, identified in this review, gave a reliable indication that LPA, via binding to one of several transmembrane receptors, stimulated multiple intracellular signalling networks coupled to changes in cell growth, fibronectin binding, maturation and survival. lysophosphatidic acid 74-77 fibronectin 1 Homo sapiens 223-234 16503403-2 2006 The soluble factor lysophosphatidic acid (LPA) acts through Rho GTPase and its effector Rho kinase (ROCK) to enhance alpha5beta1 integrin-mediated cell spreading on the Arg-Gly-Asp (RGD) cell-binding domain of FN. lysophosphatidic acid 19-40 fibronectin 1 Homo sapiens 210-212 16503403-2 2006 The soluble factor lysophosphatidic acid (LPA) acts through Rho GTPase and its effector Rho kinase (ROCK) to enhance alpha5beta1 integrin-mediated cell spreading on the Arg-Gly-Asp (RGD) cell-binding domain of FN. lysophosphatidic acid 42-45 fibronectin 1 Homo sapiens 210-212 16689739-2 2006 Fibronectin is a plasma protein that is insolubilized into fibrils in a regulated fashion by, for example, lysophosphatidic acid (LPA)-stimulated fibroblasts or platelets spread on supportive adhesive ligands. lysophosphatidic acid 130-133 fibronectin 1 Homo sapiens 0-11 9693360-11 1998 The neuropeptide bombesin, the bioactive lipid lysophosphatidic acid (LPA), and the cytokine tumor necrosis factor alpha, which signal through diverse mechanisms, were all able to activate MAPK to a much greater degree in fibronectin-adherent cells than in suspended cells. lysophosphatidic acid 47-68 fibronectin 1 Homo sapiens 222-233 12937145-10 2003 Lysophosphatidic acid, which activates RhoA and stimulates fibronectin assembly, stimulated collagen fibril formation, establishing for the first time that collagen polymerization can be regulated by soluble agonists of cell function. lysophosphatidic acid 0-21 fibronectin 1 Homo sapiens 59-70 11099498-2 2001 In the present study, we found that pertussis toxin blocks lysophosphatidic acid-induced cell spreading of NIH 3T3 fibroblasts on fibronectin. lysophosphatidic acid 59-80 fibronectin 1 Homo sapiens 130-141 11099498-8 2001 These findings indicate that both G alpha(i) and G beta gamma stimulate Rac and Cdc42 pathways with lysophosphatidic acid-induced cell spreading on fibronectin. lysophosphatidic acid 100-121 fibronectin 1 Homo sapiens 148-159 11418470-0 2001 Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists. lysophosphatidic acid 69-90 fibronectin 1 Homo sapiens 14-25 11418470-5 2001 LPA enhanced deposition of FITC-FN into linear arrays overlying platelet surfaces and on edges of platelets adherent to FN or vitronectin (VN). lysophosphatidic acid 0-3 fibronectin 1 Homo sapiens 27-34 11418470-5 2001 LPA enhanced deposition of FITC-FN into linear arrays overlying platelet surfaces and on edges of platelets adherent to FN or vitronectin (VN). lysophosphatidic acid 0-3 fibronectin 1 Homo sapiens 32-34 11418470-11 2001 RGDS (Arg-Gly-Asp-Ser) or antibodies to alpha5beta1 or alphaIIbbeta3 integrins caused a partial decrease in LPA-induced deposition of FITC-FN. lysophosphatidic acid 108-111 fibronectin 1 Homo sapiens 134-141 10216094-2 1999 We have shown that Rho-dependent cytoskeleton reorganization induced by lysophosphatidic acid (LPA) or the microtubule-disrupting agent nocodazole increases fibronectin binding (Zhang et al, Mol Biol Cell 8:1415, 1997). lysophosphatidic acid 72-93 fibronectin 1 Homo sapiens 157-168 10216094-2 1999 We have shown that Rho-dependent cytoskeleton reorganization induced by lysophosphatidic acid (LPA) or the microtubule-disrupting agent nocodazole increases fibronectin binding (Zhang et al, Mol Biol Cell 8:1415, 1997). lysophosphatidic acid 95-98 fibronectin 1 Homo sapiens 157-168 9693360-11 1998 The neuropeptide bombesin, the bioactive lipid lysophosphatidic acid (LPA), and the cytokine tumor necrosis factor alpha, which signal through diverse mechanisms, were all able to activate MAPK to a much greater degree in fibronectin-adherent cells than in suspended cells. lysophosphatidic acid 70-73 fibronectin 1 Homo sapiens 222-233 8578520-4 1995 Lysophosphatidic acid (LPA) an intermediate for de novo lipid biosynthesis and a product of platelet activation, is a powerful serum modulator of fibronectin assembly. lysophosphatidic acid 0-21 fibronectin 1 Homo sapiens 146-157 9285815-0 1997 Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contraction. lysophosphatidic acid 0-21 fibronectin 1 Homo sapiens 69-80 8969187-1 1996 Characterization of fibronectin assembly sites induced by the treatment of fibroblasts with lysophosphatidic acid. lysophosphatidic acid 92-113 fibronectin 1 Homo sapiens 20-31 8969187-3 1996 Such cross-linking caused the 70-kDa fragment to become associated irreversibly to cell layers and was greater in cells treated with lysophosphatidic acid, an enhancer of fibronectin assembly and strong modulator of cell shape. lysophosphatidic acid 133-154 fibronectin 1 Homo sapiens 171-182 8578520-4 1995 Lysophosphatidic acid (LPA) an intermediate for de novo lipid biosynthesis and a product of platelet activation, is a powerful serum modulator of fibronectin assembly. lysophosphatidic acid 23-26 fibronectin 1 Homo sapiens 146-157