PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25975684-12 2015 Among Rho GTPases, only Rac activation was different between ovarian cancer cell lines with different metastatic capability after LPA stimulation: Cdc42 could not be activated in both the invasive and non-invasive cell lines. lysophosphatidic acid 130-133 cell division cycle 42 Homo sapiens 147-152 34110567-3 2021 Among the Rho GTPases, RhoA, Rac1, and Cdc42 are best characterized and LPA-induced activation of the GTPases RhoA, Rac1, and Cdc42 influences a wide range of cellular processes and functions such as cell differentiation, contractile movements, cellular migration, or infiltration. lysophosphatidic acid 72-75 cell division cycle 42 Homo sapiens 39-44 34110567-3 2021 Among the Rho GTPases, RhoA, Rac1, and Cdc42 are best characterized and LPA-induced activation of the GTPases RhoA, Rac1, and Cdc42 influences a wide range of cellular processes and functions such as cell differentiation, contractile movements, cellular migration, or infiltration. lysophosphatidic acid 72-75 cell division cycle 42 Homo sapiens 126-131 25376707-11 2015 LPA-induced PKC phosphorylation is also involved in Rac1 and CDC42 activation, and Rac1 and CDC42 knockdown abolished LPA-induced F-actin reorganization. lysophosphatidic acid 0-3 cell division cycle 42 Homo sapiens 61-66 25376707-11 2015 LPA-induced PKC phosphorylation is also involved in Rac1 and CDC42 activation, and Rac1 and CDC42 knockdown abolished LPA-induced F-actin reorganization. lysophosphatidic acid 0-3 cell division cycle 42 Homo sapiens 92-97 25376707-11 2015 LPA-induced PKC phosphorylation is also involved in Rac1 and CDC42 activation, and Rac1 and CDC42 knockdown abolished LPA-induced F-actin reorganization. lysophosphatidic acid 118-121 cell division cycle 42 Homo sapiens 92-97 23618389-7 2013 We demonstrated that G13, but not or to a lesser extent G12, Gi or Gq, was necessary for LPA-induced dpYAP and its nuclear translocation and that RhoA-ROCK, but not RhoB, RhoC, Rac1, cdc42, PI3K, ERK, or AKT, were required for the LPA-dpYAP effect. lysophosphatidic acid 89-92 cell division cycle 42 Homo sapiens 183-188 9032247-7 1997 Lysophosphatidic acid (LPA)-induced neurite retraction, which is mediated by RhoA, was inhibited by ACh, while C3 exoenzyme-mediated neurite outgrowth was inhibited by injection with Cdc42Hs(T17N) or Rac1(T17N). lysophosphatidic acid 0-21 cell division cycle 42 Homo sapiens 183-190 17902023-9 2007 Rho GTPase binding proteins (Cdc42s) associated with lysophosphatidic acid signaling were also overexpressed in cancer patients. lysophosphatidic acid 53-74 cell division cycle 42 Homo sapiens 29-34 16007180-4 2005 The LPA-induced action was also suppressed, although incompletely, by several specific inhibitors for intracellular signaling pathways including Rac1, Cdc42, p38 mitogen-activated protein kinase (p38MAPK) and c-Jun terminal kinase (JNK), but not extracellular signal-regulated kinase. lysophosphatidic acid 4-7 cell division cycle 42 Homo sapiens 151-156 11591323-4 2001 We show that serum and the serum lipid, lysophosphatidic acid (LPA), increased Cdc42 GTP levels and triggered MTOC reorientation in serum-starved wounded monolayers of 3T3 fibroblasts. lysophosphatidic acid 40-61 cell division cycle 42 Homo sapiens 79-84 11591323-5 2001 Cdc42, but not Rho or Rac, was both sufficient and necessary for LPA-stimulated MTOC reorientation. lysophosphatidic acid 65-68 cell division cycle 42 Homo sapiens 0-5 15755723-2 2005 LPA-induced cytoskeletal changes are mediated by Rho family small GTPases, such as RhoA, Rac1, and Cdc42. lysophosphatidic acid 0-3 cell division cycle 42 Homo sapiens 99-104 15066181-4 2004 In addition, we demonstrated that Rac1/Cdc42 signals acted as upstream effector molecules of LPA-induced PAK activation. lysophosphatidic acid 93-96 cell division cycle 42 Homo sapiens 39-44 15066181-7 2004 Taken together, these findings strongly indicated that PAK1 activation was necessary for LPA-induced cell motility and FAK phosphorylation that might be mediated by sequential activation of Gi protein, PI3Kgamma and Rac1/Cdc42. lysophosphatidic acid 89-92 cell division cycle 42 Homo sapiens 221-226 11099498-0 2001 Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreading. lysophosphatidic acid 52-73 cell division cycle 42 Homo sapiens 22-27 11099498-8 2001 These findings indicate that both G alpha(i) and G beta gamma stimulate Rac and Cdc42 pathways with lysophosphatidic acid-induced cell spreading on fibronectin. lysophosphatidic acid 100-121 cell division cycle 42 Homo sapiens 80-85 9032247-7 1997 Lysophosphatidic acid (LPA)-induced neurite retraction, which is mediated by RhoA, was inhibited by ACh, while C3 exoenzyme-mediated neurite outgrowth was inhibited by injection with Cdc42Hs(T17N) or Rac1(T17N). lysophosphatidic acid 23-26 cell division cycle 42 Homo sapiens 183-190 9032247-8 1997 Together these results suggest that there is competition between the ACh- and LPA-induced morphological pathways mediated by Cdc42Hs and/or Rac1 and by RhoA, leading to either neurite development or collapse. lysophosphatidic acid 78-81 cell division cycle 42 Homo sapiens 125-132 8955154-5 1996 LPA also induced translocation of CDC42Hs to the membranes but had no effect on the distribution of Rac1, RhoB, or Rho-GDI. lysophosphatidic acid 0-3 cell division cycle 42 Homo sapiens 34-41