PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25683353-12 2015 Lysophosphatidic acid (LPA), an agonist of RhoA, binds to the G-protein-coupled receptor (GPCR) leading to activation of RhoA through Galpha12/13 and RhoGEF. lysophosphatidic acid 0-21 ras homolog family member A Mus musculus 43-47 26662305-0 2016 Lysophosphatidic acid activates the RhoA and NF-kappaB through Akt/IkappaBalpha signaling and promotes prostate cancer invasion and progression by enhancing functional invadopodia formation. lysophosphatidic acid 0-21 ras homolog family member A Mus musculus 36-40 26662305-1 2016 We have demonstrated previously that increased RhoA and nuclear factor (NF)-kappaB activities are associated with increased PC-3 prostate cancer cell invasion and that lysophosphatidic acid (LPA) significantly increases cancer invasion through RhoA and NF-kappaB activation. lysophosphatidic acid 168-189 ras homolog family member A Mus musculus 244-248 26662305-1 2016 We have demonstrated previously that increased RhoA and nuclear factor (NF)-kappaB activities are associated with increased PC-3 prostate cancer cell invasion and that lysophosphatidic acid (LPA) significantly increases cancer invasion through RhoA and NF-kappaB activation. lysophosphatidic acid 191-194 ras homolog family member A Mus musculus 244-248 26662305-3 2016 LPA-induced Akt and IkappaBalpha signaling pathways were necessary for RhoA and NF-kappaB activation, and these LPA effects were abolished by RhoA inhibition. lysophosphatidic acid 0-3 ras homolog family member A Mus musculus 71-75 26662305-3 2016 LPA-induced Akt and IkappaBalpha signaling pathways were necessary for RhoA and NF-kappaB activation, and these LPA effects were abolished by RhoA inhibition. lysophosphatidic acid 0-3 ras homolog family member A Mus musculus 142-146 26662305-3 2016 LPA-induced Akt and IkappaBalpha signaling pathways were necessary for RhoA and NF-kappaB activation, and these LPA effects were abolished by RhoA inhibition. lysophosphatidic acid 112-115 ras homolog family member A Mus musculus 71-75 26662305-3 2016 LPA-induced Akt and IkappaBalpha signaling pathways were necessary for RhoA and NF-kappaB activation, and these LPA effects were abolished by RhoA inhibition. lysophosphatidic acid 112-115 ras homolog family member A Mus musculus 142-146 26662305-6 2016 Activation of RhoA and NF-kappaB through the Akt and IkappaBalpha signaling pathway was required for LPA-stimulated gelatin degradation activity. lysophosphatidic acid 101-104 ras homolog family member A Mus musculus 14-18 27188168-8 2016 Our data further indicated that the downregulation of GTP-RhoA, which was mediated by increased cAMP release, was involved in CMSP-induced changes in MAPK, while LPA (Lysophosphatidic acid) partially reversed CMSP-induced B16 cell differentiation. lysophosphatidic acid 162-165 ras homolog family member A Mus musculus 58-62 27188168-8 2016 Our data further indicated that the downregulation of GTP-RhoA, which was mediated by increased cAMP release, was involved in CMSP-induced changes in MAPK, while LPA (Lysophosphatidic acid) partially reversed CMSP-induced B16 cell differentiation. lysophosphatidic acid 167-188 ras homolog family member A Mus musculus 58-62 25683353-12 2015 Lysophosphatidic acid (LPA), an agonist of RhoA, binds to the G-protein-coupled receptor (GPCR) leading to activation of RhoA through Galpha12/13 and RhoGEF. lysophosphatidic acid 0-21 ras homolog family member A Mus musculus 121-125 25683353-12 2015 Lysophosphatidic acid (LPA), an agonist of RhoA, binds to the G-protein-coupled receptor (GPCR) leading to activation of RhoA through Galpha12/13 and RhoGEF. lysophosphatidic acid 23-26 ras homolog family member A Mus musculus 43-47 25683353-12 2015 Lysophosphatidic acid (LPA), an agonist of RhoA, binds to the G-protein-coupled receptor (GPCR) leading to activation of RhoA through Galpha12/13 and RhoGEF. lysophosphatidic acid 23-26 ras homolog family member A Mus musculus 121-125 16122906-0 2006 Role of heterotrimeric G-proteins in lysophosphatidic acid-mediated neurite retraction by RhoA-dependent and -independent mechanisms in N1E-115 cells. lysophosphatidic acid 37-58 ras homolog family member A Mus musculus 90-94 23401561-6 2013 Thrombin, lysophosphatidic acid, and S1P increase COX-2 protein expression through a mechanism involving RhoA, catalytically active PLCepsilon, sustained activation of protein kinase D (PKD), and nuclear translocation of NF-kappaB. lysophosphatidic acid 10-31 ras homolog family member A Mus musculus 105-109 18596233-5 2008 Transfection of dominant-active RhoA or Rho-kinase (ROCK), as well as administration of lysophosphatidic acid or Y27632, which activates RhoA or inhibits ROCK, respectively, suggested that RhoA regulated the junctional integration of myosin-2 into ZA in a manner such that ROCK played a necessary but not-sufficient role. lysophosphatidic acid 88-109 ras homolog family member A Mus musculus 137-141 17307336-4 2007 LPA stimulates protrusion of pseudopodia that are enriched in RhoA compared to cell bodies. lysophosphatidic acid 0-3 ras homolog family member A Mus musculus 62-66 17307336-5 2007 Removal of LPA results in slow retraction with loss of vinculin-rich adhesion complexes and prolonged activation of RhoA. lysophosphatidic acid 11-14 ras homolog family member A Mus musculus 116-120 22330068-10 2012 8CPT-2Me-cAMP rescued sh-RhoA-induced reduction of the interaction between Rac1 and p22(phox), and enhanced lysophosphatidic acid (LPA)-induced increase of their interaction. lysophosphatidic acid 131-134 ras homolog family member A Mus musculus 25-29 18596233-5 2008 Transfection of dominant-active RhoA or Rho-kinase (ROCK), as well as administration of lysophosphatidic acid or Y27632, which activates RhoA or inhibits ROCK, respectively, suggested that RhoA regulated the junctional integration of myosin-2 into ZA in a manner such that ROCK played a necessary but not-sufficient role. lysophosphatidic acid 88-109 ras homolog family member A Mus musculus 137-141 10601309-10 1999 Using this antibody it was shown that stimulation of serum-starved Swiss 3T3 cells by lysophosphatidic acid, thought to activate RhoA pathways, induced an increase in Thr(695) phosphorylation on MYPT1 and this effect was blocked by a Rho-kinase inhibitor, Y-27632. lysophosphatidic acid 86-107 ras homolog family member A Mus musculus 129-133 16024133-10 2005 In lysophosphatidic acid-treated N1E-115 cells, well-developed neurites with growth cones showed RhoA activation, but sustained their extended morphology until they were drawn toward the contracting somata. lysophosphatidic acid 3-24 ras homolog family member A Mus musculus 97-101 11877391-6 2002 These results, taken together, suggest that PIP-5kin-alpha functions as a downstream effector for RhoA/ROCK to couple lysophosphatidic acid signaling to neurite retraction presumably through its product phosphatidylinositol 4,5-bisphosphate. lysophosphatidic acid 118-139 ras homolog family member A Mus musculus 98-102 11839279-2 2002 Neuronal N1E-115 cells show dramatic neurite retraction and cell rounding in response to serum factors such as lysophosphatidic acid (LPA), sphingosine-1 phosphate (S1P), and thrombin, due to activation of the RhoA-Rho kinase pathway. lysophosphatidic acid 111-132 ras homolog family member A Mus musculus 210-214 10359601-0 1999 Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction. lysophosphatidic acid 22-43 ras homolog family member A Mus musculus 14-18 10359601-11 1999 We conclude that in neuronal cells, LPA activates RhoA to induce growth cone collapse and neurite retraction through a G12/13-initiated pathway that involves protein-tyrosine kinase activity. lysophosphatidic acid 36-39 ras homolog family member A Mus musculus 50-54 10359601-7 1999 Using GST-ROK, we show that in N1E-115 neuronal cells LPA activates endogenous RhoA within 30 s, concomitant with growth cone collapse. lysophosphatidic acid 54-57 ras homolog family member A Mus musculus 79-83 10359601-9 1999 LPA-induced RhoA activation is completely inhibited by tyrosine kinase inhibitors (tyrphostin 47 and genistein). lysophosphatidic acid 0-3 ras homolog family member A Mus musculus 12-16 10359601-10 1999 Activated Galpha12 and Galpha13 subunits mimic LPA both in activating RhoA and in inducing RhoA-mediated cytoskeletal contraction, thereby preventing neurite outgrowth. lysophosphatidic acid 47-50 ras homolog family member A Mus musculus 70-74 10359601-10 1999 Activated Galpha12 and Galpha13 subunits mimic LPA both in activating RhoA and in inducing RhoA-mediated cytoskeletal contraction, thereby preventing neurite outgrowth. lysophosphatidic acid 47-50 ras homolog family member A Mus musculus 91-95 9410880-0 1997 Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA. lysophosphatidic acid 16-19 ras homolog family member A Mus musculus 113-117 9410880-5 1997 We find that LPA-induced shape changes are preceded by translocation of RhoA from the cytosol to the cell periphery. lysophosphatidic acid 13-16 ras homolog family member A Mus musculus 72-76 9410880-10 1997 We conclude that: (1) LPA-induced cytoskeletal contraction, but not stress fiber formation, requires translocation of RhoA from the cytosol to the plasma membrane; (2) translocation of RhoA occurs independently of its activation; and (3), a non-Src tyrosine kinase is involved in RhoA-stimulated contractility. lysophosphatidic acid 22-25 ras homolog family member A Mus musculus 118-122 9410880-10 1997 We conclude that: (1) LPA-induced cytoskeletal contraction, but not stress fiber formation, requires translocation of RhoA from the cytosol to the plasma membrane; (2) translocation of RhoA occurs independently of its activation; and (3), a non-Src tyrosine kinase is involved in RhoA-stimulated contractility. lysophosphatidic acid 22-25 ras homolog family member A Mus musculus 185-189 9410880-10 1997 We conclude that: (1) LPA-induced cytoskeletal contraction, but not stress fiber formation, requires translocation of RhoA from the cytosol to the plasma membrane; (2) translocation of RhoA occurs independently of its activation; and (3), a non-Src tyrosine kinase is involved in RhoA-stimulated contractility. lysophosphatidic acid 22-25 ras homolog family member A Mus musculus 185-189 7527052-1 1994 Mouse Swiss 3T3 fibroblasts cultured in serum-free medium lose their actin stress fibres and vinculin-containing focal adhesions, a process that can be reversed by the addition of serum, lysophosphatidic acid (LPA) or bombesin, and is mediated by rhoA (A. J. Ridley and A. lysophosphatidic acid 187-208 ras homolog family member A Mus musculus 247-251 7527052-1 1994 Mouse Swiss 3T3 fibroblasts cultured in serum-free medium lose their actin stress fibres and vinculin-containing focal adhesions, a process that can be reversed by the addition of serum, lysophosphatidic acid (LPA) or bombesin, and is mediated by rhoA (A. J. Ridley and A. lysophosphatidic acid 210-213 ras homolog family member A Mus musculus 247-251 31778241-16 2020 Lysophosphatidic acid (LPA) receptor 4 (LPAR4), one of the receptors of LPA, blocks the activation of RhoA/ROCK1/beta-catenin signaling pathway, and thereby reciprocally regulates osteogenic and adipogenic differentiation of mesenchymal progenitor cells in vitro and in vivo. lysophosphatidic acid 23-26 ras homolog family member A Mus musculus 102-106 29455446-6 2018 Simultaneous overexpression of BIG2 and ARF1 activated RhoA, and treatment with the RhoA activator lysophosphatidic acid in neurons lacking BIG2 or ARF1 increased the number of cells with dendritic Golgi, suggesting that BIG2 and ARF1 activate RhoA to promote dendritic Golgi polarization. lysophosphatidic acid 99-120 ras homolog family member A Mus musculus 84-88 29455446-6 2018 Simultaneous overexpression of BIG2 and ARF1 activated RhoA, and treatment with the RhoA activator lysophosphatidic acid in neurons lacking BIG2 or ARF1 increased the number of cells with dendritic Golgi, suggesting that BIG2 and ARF1 activate RhoA to promote dendritic Golgi polarization. lysophosphatidic acid 99-120 ras homolog family member A Mus musculus 84-88