PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12016165-9 2002 Our results suggest that the concurrent lack of the GSTM1 and GSTT1 genes increases the genotoxic effects of styrene in human cells. Styrene 109-116 glutathione S-transferase theta 1 Homo sapiens 62-67 12016165-0 2002 Influence of GSTM1 and GSTT1 genotypes on sister chromatid exchange induction by styrene in cultured human lymphocytes. Styrene 81-88 glutathione S-transferase theta 1 Homo sapiens 23-28 12016165-2 2002 We previously observed that GSTT1 null genotype was associated with increased induction of sister chromatid exchanges (SCEs) by a metabolite of styrene, styrene-7,8-oxide, in human lymphocyte cultures, while GSTM1 genotype had no effect. Styrene 144-151 glutathione S-transferase theta 1 Homo sapiens 28-33 12016165-6 2002 In two separate experiments, the mean number of SCEs/cell induced by 1.5 mM styrene was 1.55 times (P = 0.011) or 1.34 times (P = 0.015) higher in subjects lacking both GSTM1 and GSTT1 than in subjects having both genes. Styrene 76-83 glutathione S-transferase theta 1 Homo sapiens 179-184 12717779-10 2003 The field survey confirms that styrene exposure is associated with increased DNA damage and indicates a modulating role for GSTM1 and GSTT1 genotypes. Styrene 31-38 glutathione S-transferase theta 1 Homo sapiens 134-139 9654239-8 1998 Although glutathione conjugation is considered a minor metabolic pathway for SO in vivo, the high GSTT1 activity in erythrocytes may be important locally and might affect the level of genotoxic damage observed in peripheral lymphocytes of styrene-exposed reinforced plastics workers. Styrene 239-246 glutathione S-transferase theta 1 Homo sapiens 98-103 23886278-1 2001 The objective of this study was to test the infiuence of genetic polymorphisms for metabolic enzymes (CYP2E1, mEH, GSTM1 and GSTT1) implicated in the biotransformation of styrene in humans on the interpretation of urinary biomarkers of exposure. Styrene 171-178 glutathione S-transferase theta 1 Homo sapiens 125-130 16125881-4 2005 The subjects" genetic polymorphisms in the genes that encode the styrene-metabolizing enzymes CYP2E1, CYP2B6, EPHX1, GSTM1, GSTT1 and GSTP1 were determined. Styrene 65-72 glutathione S-transferase theta 1 Homo sapiens 124-129 26877838-1 2015 The aim of this study was to investigate whether genetic polymorphisms of CYP2E1, GSTM1, and GSTT1 and lifestyle habits (smoking, drinking, and exercise) modulate the levels of urinary styrene metabolites such as mandelic acid (MA) and phenylglyoxylic acid (PGA) after occupational exposure to styrene. Styrene 185-192 glutathione S-transferase theta 1 Homo sapiens 93-98 26877838-1 2015 The aim of this study was to investigate whether genetic polymorphisms of CYP2E1, GSTM1, and GSTT1 and lifestyle habits (smoking, drinking, and exercise) modulate the levels of urinary styrene metabolites such as mandelic acid (MA) and phenylglyoxylic acid (PGA) after occupational exposure to styrene. Styrene 294-301 glutathione S-transferase theta 1 Homo sapiens 93-98 25562543-2 2015 The aim of this work was to investigate the effects of polymorphic genes CYP2E1, EPHX1, GSTT1, and GSTM1 on the urinary concentrations of the styrene metabolites mandelic acid (MA), phenylglyoxylic acid (PGA) and on the concentration ratios between (MA+PGA) and urinary styrene (U-Sty) and airborne styrene (A-Sty), in 30 workers from two fiberglass-reinforced plastic manufacturing plants and 26 unexposed controls. Styrene 142-149 glutathione S-transferase theta 1 Homo sapiens 88-93 16424821-5 2006 The possible influence of genetic polymorphisms of xenobiotic-metabolizing enzymes involved in styrene biotransformation (EPHX1, GSTT1, GSTM1, GSTP1) and NAT2 on the cytogenetic endpoints was investigated. Styrene 95-102 glutathione S-transferase theta 1 Homo sapiens 129-134 16424821-12 2006 Our results suggest that occupational exposure to styrene has genotoxic effects that are potentiated by the GSTT1 gene deletion. Styrene 50-57 glutathione S-transferase theta 1 Homo sapiens 108-113 24370292-1 2013 OBJECTIVE: To investigate the relationship between genetic polymorphisms of glutathione S-transferase P1 (GSTP1), glutathione S-transferase M1 (GSTM1), and glutathione S-transferase T1 (GSTT1) and urinary level of mercapturic acids of styrene (PHEMAs) in workers exposed to styrene. Styrene 235-242 glutathione S-transferase theta 1 Homo sapiens 156-184 24370292-1 2013 OBJECTIVE: To investigate the relationship between genetic polymorphisms of glutathione S-transferase P1 (GSTP1), glutathione S-transferase M1 (GSTM1), and glutathione S-transferase T1 (GSTT1) and urinary level of mercapturic acids of styrene (PHEMAs) in workers exposed to styrene. Styrene 274-281 glutathione S-transferase theta 1 Homo sapiens 156-184 14751678-0 2004 Occupational exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1. Styrene 25-32 glutathione S-transferase theta 1 Homo sapiens 160-165 15093278-10 2004 For instance, in vitro SCE induction by styrene and by epoxide metabolites of 1,3-butadiene is modified by GSTM1 and GSTT1 genotypes--which also influence the excretion of specific mercapturic acids in humans exposed to butadiene and styrene. Styrene 40-47 glutathione S-transferase theta 1 Homo sapiens 117-122 15093278-10 2004 For instance, in vitro SCE induction by styrene and by epoxide metabolites of 1,3-butadiene is modified by GSTM1 and GSTT1 genotypes--which also influence the excretion of specific mercapturic acids in humans exposed to butadiene and styrene. Styrene 234-241 glutathione S-transferase theta 1 Homo sapiens 117-122