PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20176620-1	2010	The current study was aimed at examining the role of cytochrome P450 (CYP450) activation and the electrophile-sensitive transient receptor potential ankyrin 1 receptor (TRPA1) in mediating the sensory irritation response to styrene and naphthalene.	Styrene	224-231	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	53-68	
20176620-1	2010	The current study was aimed at examining the role of cytochrome P450 (CYP450) activation and the electrophile-sensitive transient receptor potential ankyrin 1 receptor (TRPA1) in mediating the sensory irritation response to styrene and naphthalene.	Styrene	224-231	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	70-76	
20176620-3	2010	The sensory irritation response to 75 ppm styrene and 7 ppm naphthalene was diminished threefold or more in animals pretreated with the CYP450 inhibitor metyrapone, providing evidence of the role of metabolic activation in the response to these vapors.	Styrene	42-49	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	136-142	
20176620-5	2010	Thus, these results support the hypothesis that styrene and naphthalene vapors initiate the sensory irritation response through TRPA1 detection of their CYP450 metabolites.	Styrene	48-55	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	153-159	
11551533-4	2001	Comparisons of the cytochrome P-450 mediated metabolism of styrene to its oxide, and subsequent metabolism of the oxide by epoxide hydrolases and glutathione S-transferases in nasal tissues in vitro, have provided an explanation for the increased sensitivity of the mouse to styrene.	Styrene	59-66	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	19-35	
11551533-4	2001	Comparisons of the cytochrome P-450 mediated metabolism of styrene to its oxide, and subsequent metabolism of the oxide by epoxide hydrolases and glutathione S-transferases in nasal tissues in vitro, have provided an explanation for the increased sensitivity of the mouse to styrene.	Styrene	275-282	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	19-35	
7712112-2	1994	Treatment with inhibitors of hepatic cytochrome P-450-dependent monooxygenases such as carbon disulfide, methoxsalen, piperonyl butoxide, and SKF-525A prevented or tended to reduce the hepatotoxic effect of styrene given in combination with BSO.	Styrene	207-214	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	37-53