PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20176620-1 2010 The current study was aimed at examining the role of cytochrome P450 (CYP450) activation and the electrophile-sensitive transient receptor potential ankyrin 1 receptor (TRPA1) in mediating the sensory irritation response to styrene and naphthalene. Styrene 224-231 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 53-68 20176620-1 2010 The current study was aimed at examining the role of cytochrome P450 (CYP450) activation and the electrophile-sensitive transient receptor potential ankyrin 1 receptor (TRPA1) in mediating the sensory irritation response to styrene and naphthalene. Styrene 224-231 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 70-76 20176620-3 2010 The sensory irritation response to 75 ppm styrene and 7 ppm naphthalene was diminished threefold or more in animals pretreated with the CYP450 inhibitor metyrapone, providing evidence of the role of metabolic activation in the response to these vapors. Styrene 42-49 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 136-142 20176620-5 2010 Thus, these results support the hypothesis that styrene and naphthalene vapors initiate the sensory irritation response through TRPA1 detection of their CYP450 metabolites. Styrene 48-55 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 153-159 11551533-4 2001 Comparisons of the cytochrome P-450 mediated metabolism of styrene to its oxide, and subsequent metabolism of the oxide by epoxide hydrolases and glutathione S-transferases in nasal tissues in vitro, have provided an explanation for the increased sensitivity of the mouse to styrene. Styrene 59-66 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 19-35 11551533-4 2001 Comparisons of the cytochrome P-450 mediated metabolism of styrene to its oxide, and subsequent metabolism of the oxide by epoxide hydrolases and glutathione S-transferases in nasal tissues in vitro, have provided an explanation for the increased sensitivity of the mouse to styrene. Styrene 275-282 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 19-35 7712112-2 1994 Treatment with inhibitors of hepatic cytochrome P-450-dependent monooxygenases such as carbon disulfide, methoxsalen, piperonyl butoxide, and SKF-525A prevented or tended to reduce the hepatotoxic effect of styrene given in combination with BSO. Styrene 207-214 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 37-53