PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15829484-2 2005 Previously, we showed that Scd1 deficiency reduces liver triglyceride accumulation and considerably decreases synthesis of very low density lipoprotein and its secretion in both lean and obese mice. Triglycerides 57-69 stearoyl-Coenzyme A desaturase 1 Mus musculus 27-31 16537646-9 2006 Furthermore, CREB knockdown with siRNA also downregulates the expression of several genes that contain cAMP-response element (CRE) sites in their promoter, among them one that is potentially involved in synthesis of triglycerides such as SCD1. Triglycerides 216-229 stearoyl-Coenzyme A desaturase 1 Mus musculus 238-242 15494611-1 2005 Stearoyl-CoA desaturase (SCD) catalyzes the synthesis of oleate (C18:1) and palmitoleate (C16:1), which are the main monounsaturated fatty acids of membrane phospholipids, triglycerides, wax esters, and cholesterol esters. Triglycerides 172-185 stearoyl-Coenzyme A desaturase 1 Mus musculus 25-28 15761499-2 2005 Stearoyl-CoA desaturase-1 (SCD1) is the rate-limiting enzyme catalyzing the conversion of saturated long-chain fatty acids into monounsaturated fatty acids, which are major components of triglycerides. Triglycerides 187-200 stearoyl-Coenzyme A desaturase 1 Mus musculus 0-25 15761499-2 2005 Stearoyl-CoA desaturase-1 (SCD1) is the rate-limiting enzyme catalyzing the conversion of saturated long-chain fatty acids into monounsaturated fatty acids, which are major components of triglycerides. Triglycerides 187-200 stearoyl-Coenzyme A desaturase 1 Mus musculus 27-31 12401889-3 2002 Mice with a targeted disruption of the SCD1 gene have very low levels of VLDL and impaired triglyceride and cholesterol ester biosynthesis. Triglycerides 91-103 stearoyl-Coenzyme A desaturase 1 Mus musculus 39-43 15657555-3 2004 Scd1 is required for the biosynthesis of monounsaturated fatty acids and plays a key role in the hepatic synthesis of triglycerides and of very-low-density lipoproteins. Triglycerides 118-131 stearoyl-Coenzyme A desaturase 1 Mus musculus 0-4 15066988-1 2004 Stearoyl-CoA desaturase (SCD) synthesizes oleate necessary for the biosynthesis of triglycerides and other lipids. Triglycerides 83-96 stearoyl-Coenzyme A desaturase 1 Mus musculus 25-28 12364560-1 2002 Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the cellular synthesis of monounsaturated fatty acids, mainly oleate (18:1) and palmitoleate (16:1), which are the major monounsaturated fatty acids of membrane phospholipids, cholesteryl esters, waxes, and triglycerides. Triglycerides 273-286 stearoyl-Coenzyme A desaturase 1 Mus musculus 25-28 12177411-1 2002 Stearoyl-CoA desaturase (SCD) is a central lipogenic enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly oleate (C18:1) and palmitoleate (C16:1), which are components of membrane phospholipids, triglycerides, wax esters, and cholesterol esters. Triglycerides 213-226 stearoyl-Coenzyme A desaturase 1 Mus musculus 25-28 11533264-1 2001 Stearoyl-CoA desaturase (SCD) is a microsomal rate-limiting enzyme in the cellular synthesis of monounsaturated fatty acids (MUFA), mainly oleate (18:1) and palmitoleate (16:1), which are the major MUFA of membrane phospholipids, cholesterol esters and triglycerides. Triglycerides 253-266 stearoyl-Coenzyme A desaturase 1 Mus musculus 25-28 12114623-6 2002 ob/ob mice with mutations in SCD-1 had histologically normal livers with significantly reduced triglyceride storage and VLDL (very low density lipoprotein) production. Triglycerides 95-107 stearoyl-Coenzyme A desaturase 1 Mus musculus 29-34 11533264-8 2001 These results reveal a physiologic role of SCD in cholesterol homeostasis as well as in the de novo biosynthesis of cholesterol esters, triglycerides and wax esters required for normal skin and eyelid function. Triglycerides 136-149 stearoyl-Coenzyme A desaturase 1 Mus musculus 43-46 11533264-4 2001 The skin and eyelid of SCD1-/- mice are deficient in triglycerides and cholesterol esters, and the eyelid also is deficient in wax esters. Triglycerides 53-66 stearoyl-Coenzyme A desaturase 1 Mus musculus 23-27 11441127-0 2001 A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. Triglycerides 159-171 stearoyl-Coenzyme A desaturase 1 Mus musculus 50-75 11441127-1 2001 Stearoyl-CoA desaturase (SCD) catalyzes the de novo biosynthesis of oleate and palmitoleate, which are the major fatty acids found in triglycerides, cholesteryl esters, and phospholipids. Triglycerides 134-147 stearoyl-Coenzyme A desaturase 1 Mus musculus 25-28 11441127-6 2001 Triglyceride synthesis, as measured by the incorporation of [(3)H]glycerol, was dramatically reduced in the liver of SCD-/- mouse fed a lipogenic diet compared with the normal mouse. Triglycerides 0-12 stearoyl-Coenzyme A desaturase 1 Mus musculus 117-123 11441127-7 2001 These observations demonstrate that induction of triglyceride synthesis is highly dependent on SCD1 gene expression. Triglycerides 49-61 stearoyl-Coenzyme A desaturase 1 Mus musculus 95-99 10899171-0 2000 The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. Triglycerides 51-64 stearoyl-Coenzyme A desaturase 1 Mus musculus 119-144 10899171-1 2000 Stearoyl-CoA desaturase (SCD) is a microsomal enzyme required for the biosynthesis of oleate and palmitoleate, which are the major monounsaturated fatty acids of membrane phospholipids, triglycerides, and cholesterol esters. Triglycerides 186-199 stearoyl-Coenzyme A desaturase 1 Mus musculus 25-28 10899171-4 2000 We found that asebia mice homozygous for a natural mutation of the gene for SCD1 (SCD-/-) are deficient in hepatic cholesterol esters and triglycerides despite the presence of normal activities of acyl-CoA:cholesterol acyltransferase and glycerol phosphate acyltransferase, the enzymes responsible for cholesterol ester and triglyceride synthesis, respectively, in the liver of these mice. Triglycerides 138-151 stearoyl-Coenzyme A desaturase 1 Mus musculus 76-80 10899171-4 2000 We found that asebia mice homozygous for a natural mutation of the gene for SCD1 (SCD-/-) are deficient in hepatic cholesterol esters and triglycerides despite the presence of normal activities of acyl-CoA:cholesterol acyltransferase and glycerol phosphate acyltransferase, the enzymes responsible for cholesterol ester and triglyceride synthesis, respectively, in the liver of these mice. Triglycerides 138-151 stearoyl-Coenzyme A desaturase 1 Mus musculus 82-89 10899171-6 2000 The SCD-/- mouse had very low levels of triglycerides in the VLDL and LDL lipoprotein fractions compared with the normal animal. Triglycerides 40-53 stearoyl-Coenzyme A desaturase 1 Mus musculus 4-7 10899171-8 2000 Taken together, our observations demonstrate that the oleoyl-CoA and palmitoleyl-CoA produced by SCD1 are necessary to synthesize enough cholesterol esters and triglycerides in the liver and suggest that regulation of SCD1 activity plays an important role in mechanisms of cellular cholesterol homeostasis. Triglycerides 160-173 stearoyl-Coenzyme A desaturase 1 Mus musculus 97-101 10899171-8 2000 Taken together, our observations demonstrate that the oleoyl-CoA and palmitoleyl-CoA produced by SCD1 are necessary to synthesize enough cholesterol esters and triglycerides in the liver and suggest that regulation of SCD1 activity plays an important role in mechanisms of cellular cholesterol homeostasis. Triglycerides 160-173 stearoyl-Coenzyme A desaturase 1 Mus musculus 218-222 33374300-8 2020 Interestingly, hypothyroidism increased body adiposity and triglyceride and diacylglycerol levels in the heart in SCD1-/- mice. Triglycerides 59-71 stearoyl-Coenzyme A desaturase 1 Mus musculus 114-118 33374300-9 2020 The accumulation of triglycerides in cardiomyocytes in SCD1-/- hypothyroid mice was caused by the activation of lipogenesis, which likely exceeded the upregulation of lipolysis and fatty acid oxidation. Triglycerides 20-33 stearoyl-Coenzyme A desaturase 1 Mus musculus 55-59 33374300-11 2020 We also found that simultaneous SCD1 and deiodinase inhibition increased triglyceride content in HL-1 cardiomyocytes, and this process was related to the downregulation of lipolysis. Triglycerides 73-85 stearoyl-Coenzyme A desaturase 1 Mus musculus 32-36 32978274-3 2020 In this study, we demonstrate that stearoyl-CoA desaturase 1 (SCD1) in subcutaneous white adipose tissue (scWAT) responded to cold stimulation and was able to promote mobilization of triglyceride. Triglycerides 183-195 stearoyl-Coenzyme A desaturase 1 Mus musculus 35-60 32978274-3 2020 In this study, we demonstrate that stearoyl-CoA desaturase 1 (SCD1) in subcutaneous white adipose tissue (scWAT) responded to cold stimulation and was able to promote mobilization of triglyceride. Triglycerides 183-195 stearoyl-Coenzyme A desaturase 1 Mus musculus 62-66 31226399-13 2019 Knockdown of SCD1 expression mimicked the effect of BBR decreasing TG level in steatotic hepatocytes, whereas overexpression of SCD1 attenuated the effect of BBR. Triglycerides 67-69 stearoyl-Coenzyme A desaturase 1 Mus musculus 13-17 32982112-1 2020 BACKGROUND: Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. Triglycerides 162-175 stearoyl-Coenzyme A desaturase 1 Mus musculus 91-116 32982112-1 2020 BACKGROUND: Arachidyl amido cholanoic acid (Aramchol) is a potent downregulator of hepatic stearoyl-CoA desaturase 1 (SCD1) protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis. Triglycerides 162-175 stearoyl-Coenzyme A desaturase 1 Mus musculus 118-122 31729980-12 2019 Analysis of the transcripts established the increased expression of genes related to TG synthesis, including SREBP1c, SCD1, FAS, ACC1, GPAM and DGAT2 in mouse liver. Triglycerides 85-87 stearoyl-Coenzyme A desaturase 1 Mus musculus 118-122 28789977-5 2017 Sirt1Y/Y mice showed significantly higher level of hepatic triglyceride which was accompanied with higher levels of SREBP-1 and SCD1and decreased phosphorylation of LKB1 and AMPK in the liver. Triglycerides 59-71 stearoyl-Coenzyme A desaturase 1 Mus musculus 128-132 28982014-6 2018 Compared with wild-type mice on the control diet, Scd1-/- mice were leaner, had higher EE, lower hepatic and serum triglycerides, and lower serum leptin and insulin. Triglycerides 115-128 stearoyl-Coenzyme A desaturase 1 Mus musculus 50-54 29759071-0 2018 Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression. Triglycerides 21-33 stearoyl-Coenzyme A desaturase 1 Mus musculus 81-112 29759071-3 2018 Stearyl-coenzyme A desaturase 1 (SCD1) knockout mice also show decreased liver TG accumulation; however, whether SCD1 plays a role in the effect of metformin on TG accumulation is unknown. Triglycerides 79-81 stearoyl-Coenzyme A desaturase 1 Mus musculus 0-31 29759071-3 2018 Stearyl-coenzyme A desaturase 1 (SCD1) knockout mice also show decreased liver TG accumulation; however, whether SCD1 plays a role in the effect of metformin on TG accumulation is unknown. Triglycerides 79-81 stearoyl-Coenzyme A desaturase 1 Mus musculus 33-37 29759071-12 2018 Knockdown of SCD1 mimicked the effect of metformin on decreasing TG levels in AML12 cells, and the overexpression of SCD1 attenuated the effect of metformin on decreasing TG accumulation in HepG2 cells. Triglycerides 65-67 stearoyl-Coenzyme A desaturase 1 Mus musculus 13-17 29759071-12 2018 Knockdown of SCD1 mimicked the effect of metformin on decreasing TG levels in AML12 cells, and the overexpression of SCD1 attenuated the effect of metformin on decreasing TG accumulation in HepG2 cells. Triglycerides 171-173 stearoyl-Coenzyme A desaturase 1 Mus musculus 117-121 27846372-2 2017 SCD1 (stearoyl-coenzyme A desaturase 1) converts SFAs to mono-unsaturated fatty acids (MUFAs) that are incorporated into triglycerides and stored in lipid droplets. Triglycerides 121-134 stearoyl-Coenzyme A desaturase 1 Mus musculus 0-4 28190475-14 2017 Further, calycosin inhibited the expression of SREBP-1c, FASN, ACC and SCD1 involved in triglyceride synthesis, promoted the expression of PPARa, CPT1, Syndecan-1 and LPL involved in free fatty acid beta-oxidation. Triglycerides 88-100 stearoyl-Coenzyme A desaturase 1 Mus musculus 71-75 29159325-9 2017 Aramchol downregulated stearoyl-CoA desaturase 1 (SCD1), a key enzyme involved in triglyceride biosynthesis whose loss enhances fatty acid beta-oxidation. Triglycerides 82-94 stearoyl-Coenzyme A desaturase 1 Mus musculus 23-48 29159325-9 2017 Aramchol downregulated stearoyl-CoA desaturase 1 (SCD1), a key enzyme involved in triglyceride biosynthesis whose loss enhances fatty acid beta-oxidation. Triglycerides 82-94 stearoyl-Coenzyme A desaturase 1 Mus musculus 50-54 27846372-2 2017 SCD1 (stearoyl-coenzyme A desaturase 1) converts SFAs to mono-unsaturated fatty acids (MUFAs) that are incorporated into triglycerides and stored in lipid droplets. Triglycerides 121-134 stearoyl-Coenzyme A desaturase 1 Mus musculus 6-38 26219821-12 2015 Additionally, Liv-Ikk2ca mice had moderate increase in triglycerides in liver, which was associated with higher lipogenic factors Ppargamma, Lxr, Fasn, Scd1, and CD36. Triglycerides 55-68 stearoyl-Coenzyme A desaturase 1 Mus musculus 152-156 27751891-4 2016 SCD1 deficiency decreased the intracellular content of free fatty acids, triglycerides, and ceramide in the heart of SCD1-/- and SCD1-/-/PPARalpha-/- mice. Triglycerides 73-86 stearoyl-Coenzyme A desaturase 1 Mus musculus 0-4 27627966-4 2016 Hepatic Fas, Acc, Scd-1 and Dgat-2, the key genes for fatty acid and TG synthesis, were up-regulated in alcohol-treated Tlr4-wild-type mice but not in Tlr4-mutant mice. Triglycerides 69-71 stearoyl-Coenzyme A desaturase 1 Mus musculus 18-23 26690553-11 2015 In analyzing hepatic gene expression pattern it was found that TG synthesis related genes, such as carbohydrate response element binding protein (ChREBP), stearoyl-CoA desaturase 1 (SCD1) and fatty acid synthase (Fas) were upregulated in SKO mice compared to WT mice but were significantly decreased in SKO mice on DHA/EPA diet. Triglycerides 63-65 stearoyl-Coenzyme A desaturase 1 Mus musculus 155-180 26690553-11 2015 In analyzing hepatic gene expression pattern it was found that TG synthesis related genes, such as carbohydrate response element binding protein (ChREBP), stearoyl-CoA desaturase 1 (SCD1) and fatty acid synthase (Fas) were upregulated in SKO mice compared to WT mice but were significantly decreased in SKO mice on DHA/EPA diet. Triglycerides 63-65 stearoyl-Coenzyme A desaturase 1 Mus musculus 182-186 26687933-10 2016 Leucine supplementation also increased the expression of Srebf1, Scd1 and Pgc1b (that were involved in hepatic triglyceride metabolism) by 3.73-, 1.35- and 1.71-fold, respectively. Triglycerides 111-123 stearoyl-Coenzyme A desaturase 1 Mus musculus 65-69 23918045-0 2013 SCD1 activity in muscle increases triglyceride PUFA content, exercise capacity, and PPARdelta expression in mice. Triglycerides 34-46 stearoyl-Coenzyme A desaturase 1 Mus musculus 0-4 23941875-4 2013 We now know that SCD1 expression is important in regulating lipid bilayer fluidity, increasing triglyceride formation, and enabling lipogenesis and may protect against SFA-induced lipotoxicity. Triglycerides 95-107 stearoyl-Coenzyme A desaturase 1 Mus musculus 17-21 23941875-5 2013 Exercise has been shown to increase SCD1 expression, which may contribute to an increase in intramyocellular triglyceride at the expense of free fatty acids and diacylglycerol. Triglycerides 109-121 stearoyl-Coenzyme A desaturase 1 Mus musculus 36-40 25959085-0 2015 SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition. Triglycerides 65-80 stearoyl-Coenzyme A desaturase 1 Mus musculus 0-4 24566853-0 2014 Inhibition of stearoyl-CoA desaturase-1 in differentiating 3T3-L1 preadipocytes upregulates elongase 6 and downregulates genes affecting triacylglycerol synthesis. Triglycerides 137-152 stearoyl-Coenzyme A desaturase 1 Mus musculus 14-39 24566853-3 2014 During adipogenesis, SCD1 levels increase concomitantly with the accumulation of triacylglycerol (TG); however, the extent to which reduced SCD1 activity can influence TG synthesis and metabolic pathways in differentiating adipocytes remains relatively unexplored. Triglycerides 168-170 stearoyl-Coenzyme A desaturase 1 Mus musculus 140-144 24566853-12 2014 CONCLUSION: These results provide new mechanistic insight into the role of SCD1 as a regulator of fatty acid profiles and TG synthesis in adipocytes, and reinforce that modulating SCD1 activity may help reduce the risk of obesity-related complications. Triglycerides 122-124 stearoyl-Coenzyme A desaturase 1 Mus musculus 75-79 24773344-7 2014 Ezetimibe decreased hepatic oxysterols, which are endogenous agonists of liver X receptor (LXR), to decrease hepatic lipogenic gene expressions, especially in stearoyl-CoA desaturase-1 (SCD1), leading to a remarkable reduction of hepatic oleate content that would contribute to the improvement of steatosis by reducing triglycerides and cholesterol esters. Triglycerides 319-332 stearoyl-Coenzyme A desaturase 1 Mus musculus 186-190 23918045-4 2013 SCD1 overexpression was associated with increased triglyceride (TG) content. Triglycerides 50-62 stearoyl-Coenzyme A desaturase 1 Mus musculus 0-4 23918045-4 2013 SCD1 overexpression was associated with increased triglyceride (TG) content. Triglycerides 64-66 stearoyl-Coenzyme A desaturase 1 Mus musculus 0-4 21609322-7 2011 Starvation-induced down-regulation of SCD1 expression was opposed by antecedent LXR activation in wild-type mice, an effect enhanced further by PPARalpha deficiency, which may elicit increased channelling of FA into triacylglycerol to limit lipotoxicity. Triglycerides 216-231 stearoyl-Coenzyme A desaturase 1 Mus musculus 38-42 21890736-11 2011 Although Scd1 deficiency attenuated TCDD-induced TRG accumulation, overall FA levels remained unchanged compared with Scd1(+/+) mice. Triglycerides 49-52 stearoyl-Coenzyme A desaturase 1 Mus musculus 9-13 20029635-2 2009 Adipogenesis observed in the low n-3 fatty acid mice was accompanied by a 6-fold upregulation of stearyl-coenzyme A desaturase 1 (Scd1), whose activity is correlated to plasma triglyceride levels. Triglycerides 176-188 stearoyl-Coenzyme A desaturase 1 Mus musculus 97-128 20363835-3 2010 We show that disruption of the SCD1 gene improves cardiac function in ob/ob mice by correcting systolic and diastolic dysfunction without affecting levels of plasma TG and FFA. Triglycerides 165-167 stearoyl-Coenzyme A desaturase 1 Mus musculus 31-35 19095997-1 2009 OBJECTIVE: Absence of stearoyl-CoA desaturase-1 (SCD1) in mice reduces plasma triglycerides and provides protection from obesity and insulin resistance, which would be predicted to be associated with reduced susceptibility to atherosclerosis. Triglycerides 78-91 stearoyl-Coenzyme A desaturase 1 Mus musculus 22-47 19095997-1 2009 OBJECTIVE: Absence of stearoyl-CoA desaturase-1 (SCD1) in mice reduces plasma triglycerides and provides protection from obesity and insulin resistance, which would be predicted to be associated with reduced susceptibility to atherosclerosis. Triglycerides 78-91 stearoyl-Coenzyme A desaturase 1 Mus musculus 49-53 20029635-2 2009 Adipogenesis observed in the low n-3 fatty acid mice was accompanied by a 6-fold upregulation of stearyl-coenzyme A desaturase 1 (Scd1), whose activity is correlated to plasma triglyceride levels. Triglycerides 176-188 stearoyl-Coenzyme A desaturase 1 Mus musculus 130-134 18340007-1 2008 OBJECTIVE: Stearoyl-CoA desaturase 1 (SCD1) is the rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, and in mice SCD1 activity is associated with plasma triglyceride levels. Triglycerides 182-194 stearoyl-Coenzyme A desaturase 1 Mus musculus 11-36 18794388-6 2008 Further analyses revealed that SCD1 inhibition promoted accumulation of saturated fatty acids in plasma and tissues and reduced plasma triglyceride, yet had little impact on low-density lipoprotein cholesterol. Triglycerides 135-147 stearoyl-Coenzyme A desaturase 1 Mus musculus 31-35 18340007-1 2008 OBJECTIVE: Stearoyl-CoA desaturase 1 (SCD1) is the rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, and in mice SCD1 activity is associated with plasma triglyceride levels. Triglycerides 182-194 stearoyl-Coenzyme A desaturase 1 Mus musculus 38-42 18340007-1 2008 OBJECTIVE: Stearoyl-CoA desaturase 1 (SCD1) is the rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, and in mice SCD1 activity is associated with plasma triglyceride levels. Triglycerides 182-194 stearoyl-Coenzyme A desaturase 1 Mus musculus 142-146 17605312-1 2007 Previous studies showed that mice deficient in Scd1 had a reduced level of liver triglyceride and an improvement in insulin sensitivity. Triglycerides 81-93 stearoyl-Coenzyme A desaturase 1 Mus musculus 47-51 17960025-3 2008 Here, we show that absence of the Scd1 gene product reduces plasma triglycerides and reduces weight gain in severely hyperlipidemic low density lipoprotein receptor (LDLR)-deficient mice challenged with a Western diet. Triglycerides 67-80 stearoyl-Coenzyme A desaturase 1 Mus musculus 34-38 18269173-1 2007 Previous studies have shown that mice deficient in Scd1 have a dramatically reduced level of liver triglyceride and an improvement in insulin sensitivity. Triglycerides 99-111 stearoyl-Coenzyme A desaturase 1 Mus musculus 51-55 18269173-3 2007 These results predicted that Scd1(-/-) mice would be protected from the increased serum triglyceride levels that result from a lipogenic diet and might also might protect a diabetes-susceptible obese mouse strain from diabetes. Triglycerides 88-100 stearoyl-Coenzyme A desaturase 1 Mus musculus 29-33 16751624-0 2006 Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. Triglycerides 100-112 stearoyl-Coenzyme A desaturase 1 Mus musculus 18-22 16751624-2 2006 Mice with targeted disruption in SCD1 (Scd1(-/-)) have significant reduction in the tissue content of triglycerides, suggesting that monounsaturated fatty acids endogenously synthesized by SCD1 are important for triglyceride synthesis. Triglycerides 102-115 stearoyl-Coenzyme A desaturase 1 Mus musculus 33-37 16751624-2 2006 Mice with targeted disruption in SCD1 (Scd1(-/-)) have significant reduction in the tissue content of triglycerides, suggesting that monounsaturated fatty acids endogenously synthesized by SCD1 are important for triglyceride synthesis. Triglycerides 102-115 stearoyl-Coenzyme A desaturase 1 Mus musculus 39-43 16751624-2 2006 Mice with targeted disruption in SCD1 (Scd1(-/-)) have significant reduction in the tissue content of triglycerides, suggesting that monounsaturated fatty acids endogenously synthesized by SCD1 are important for triglyceride synthesis. Triglycerides 102-115 stearoyl-Coenzyme A desaturase 1 Mus musculus 189-193 16751624-2 2006 Mice with targeted disruption in SCD1 (Scd1(-/-)) have significant reduction in the tissue content of triglycerides, suggesting that monounsaturated fatty acids endogenously synthesized by SCD1 are important for triglyceride synthesis. Triglycerides 102-114 stearoyl-Coenzyme A desaturase 1 Mus musculus 33-37 16751624-2 2006 Mice with targeted disruption in SCD1 (Scd1(-/-)) have significant reduction in the tissue content of triglycerides, suggesting that monounsaturated fatty acids endogenously synthesized by SCD1 are important for triglyceride synthesis. Triglycerides 102-114 stearoyl-Coenzyme A desaturase 1 Mus musculus 39-43 16751624-2 2006 Mice with targeted disruption in SCD1 (Scd1(-/-)) have significant reduction in the tissue content of triglycerides, suggesting that monounsaturated fatty acids endogenously synthesized by SCD1 are important for triglyceride synthesis. Triglycerides 102-114 stearoyl-Coenzyme A desaturase 1 Mus musculus 189-193 16751624-5 2006 We hypothesize that SCD1 participates in triglyceride synthesis by providing a more accessible pool of monounsaturated fatty acids through substrate channeling. Triglycerides 41-53 stearoyl-Coenzyme A desaturase 1 Mus musculus 20-24 16943421-7 2006 Together, these findings suggest that SCD1 plays a pivotal role in the regulation of hepatic and plasma triglyceride accumulation, possibly by modulating the MUFA-to-SFA ratio. Triglycerides 104-116 stearoyl-Coenzyme A desaturase 1 Mus musculus 38-42