PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10353435-3 1999 OBJECTIVE: We have investigated the role of the 5-HT2C receptor in mediating the effect of d-fenfluramine on mouse food intake and the behavioural satiety sequence. Dexfenfluramine 91-105 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 48-63 10353435-10 1999 Hence, this dose of d-fenfluramine had a reduced effect on both food consumption and the behavioural satiety sequence in the 5-HT2C mutant mice. Dexfenfluramine 20-34 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 125-131 10353435-12 1999 CONCLUSION: These data demonstrate a role for the 5-HT2C receptor in mediating d-fenfluramine-induced satiety. Dexfenfluramine 79-93 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 50-65 16430857-2 2006 5-HT2C receptors and 5-HT1B receptors have been shown to mediate anorexic effects of 5-HT drugs such as d-fenfluramine, which stimulates 5-HT release and inhibits 5-HT reuptake, and m-chlorophenylpiperazine (mCPP), a 5-HT2C receptor agonist. Dexfenfluramine 104-118 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 0-15 15138762-1 2004 RATIONALE: The possible role of compensatory changes in 5-HT2C receptors in the reduced hypophagic action of d-fenfluramine in 5-HT1B knockout (KO) mice was assessed by comparing their response to d-fenfluramine and the 5-HT2C receptor agonist mCPP. Dexfenfluramine 109-123 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 56-62 15138762-1 2004 RATIONALE: The possible role of compensatory changes in 5-HT2C receptors in the reduced hypophagic action of d-fenfluramine in 5-HT1B knockout (KO) mice was assessed by comparing their response to d-fenfluramine and the 5-HT2C receptor agonist mCPP. Dexfenfluramine 109-123 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 56-71 15138762-10 2004 Instead, the evidence suggests that an adaptive change in 5-HT2C receptor function occurs in 5-HT1B receptor KO mice and contributes to their reduced response to d-fenfluramine. Dexfenfluramine 162-176 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 58-73