PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28335434-4	2017	FKA induces G2M arrest in cell cycle progression of HER2-overexpressing breast cancer cell lines through inhibition of Cdc2 and Cdc25C phosphorylation and downregulation of expression of Myt1 and Wee1 leading to increased Cdc2 kinase activities.	flavokawain A	0-3	cyclin dependent kinase 1	Homo sapiens	119-123	
28335434-4	2017	FKA induces G2M arrest in cell cycle progression of HER2-overexpressing breast cancer cell lines through inhibition of Cdc2 and Cdc25C phosphorylation and downregulation of expression of Myt1 and Wee1 leading to increased Cdc2 kinase activities.	flavokawain A	0-3	cyclin dependent kinase 1	Homo sapiens	128-132	
19138991-7	2008	Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.	flavokawain A	0-13	cyclin dependent kinase 1	Homo sapiens	54-58	
19138991-7	2008	Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.	flavokawain A	0-13	cyclin dependent kinase 1	Homo sapiens	147-151	
19138991-9	2008	Consistently, flavokawain A also caused a pronounced CDK1 activation and G(2)-M arrest in p53 knockout but not in p53 wild-type HCT116 cells.	flavokawain A	14-27	cyclin dependent kinase 1	Homo sapiens	53-57