PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20718731-8 2010 TRPC1-/- exhibited enhanced EDHF-type vasodilatations in resistance-sized arterioles in vivo associated with reduced spontaneous tone. edhf 28-32 transient receptor potential cation channel, subfamily C, member 1 Mus musculus 0-5 20718731-12 2010 CONCLUSIONS AND IMPLICATIONS: Our data demonstrate that TRPC1 acts as a negative regulator of endothelial K(Ca) channel-dependent EDHF-type vasodilatations and thereby contributes to blood pressure regulation. edhf 130-134 transient receptor potential cation channel, subfamily C, member 1 Mus musculus 56-61 20718731-13 2010 Thus, we propose a specific role of TRPC1 in the EDHF-K(Ca) signalling complex and suggest that pharmacological inhibition of TRPC1, by enhancing EDHF vasodilatations, may be a novel strategy for lowering blood pressure. edhf 49-53 transient receptor potential cation channel, subfamily C, member 1 Mus musculus 36-41 20718731-13 2010 Thus, we propose a specific role of TRPC1 in the EDHF-K(Ca) signalling complex and suggest that pharmacological inhibition of TRPC1, by enhancing EDHF vasodilatations, may be a novel strategy for lowering blood pressure. edhf 49-53 transient receptor potential cation channel, subfamily C, member 1 Mus musculus 126-131