PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26987986-3 2016 Yet, in previous studies we identified mutations in the yeast MAPK high osmolarity glycerol (Hog1) that render it capable of spontaneous autophosphorylation and consequently intrinsically active (MKK-independent). Glycerol 83-91 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 93-97 30682143-2 2019 Hog1 is activated through the high-osmolarity glycerol (HOG) pathway, which consists of a core MAPK cascade and two independent upstream branches (SHO1 and SLN1 branches) containing distinct osmosensing machineries. Glycerol 46-54 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 0-4 29846136-4 2018 We demonstrate that, to activate Hog1, As(III) must enter the cell through the glycerol channel Fps1 and must be metabolized to methyl arsenite [MAs(III)] by the dimeric methyltransferase Mtq2:Trm112. Glycerol 79-87 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 33-37 29341399-1 2018 Yeast cells respond to hyperosmotic stress by activating the high-osmolarity glycerol (HOG) pathway, which consists of two branches, Hkr1/Msb2-Sho1 and Sln1, which trigger phosphorylation and nuclear internalization of the Hog1 mitogen-activated protein kinase. Glycerol 77-85 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 223-227 29289724-8 2018 Transcriptional profiling of ecm33 during fermentation demonstrated the up-regulation of SLT2 and HOG1, encoding mitogen activated protein kinases involved in the cell wall integrity (CWI) and high osmolarity glycerol (HOG) pathways, respectively. Glycerol 210-218 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 99-103 27596631-4 2017 The OLE1-mediated enhanced stress tolerance was considerably diminished upon deletion of HOG1, which encodes the mitogen-activated protein kinase (MAPK) Hog1 of the high osmolarity glycerol (HOG) pathway. Glycerol 181-189 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 89-93 27596631-4 2017 The OLE1-mediated enhanced stress tolerance was considerably diminished upon deletion of HOG1, which encodes the mitogen-activated protein kinase (MAPK) Hog1 of the high osmolarity glycerol (HOG) pathway. Glycerol 181-189 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 153-157 31009461-7 2019 Here, we show the osmostress-responsive MAP kinase Hog1 regulates Cyc8 SUMOylation and inclusion formation via its role in the transcriptional activation of glycerol biosynthesis genes. Glycerol 157-165 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 51-55 28076898-1 2017 High-osmolarity glycerol (HOG) pathway required for yeast osmoregulation relies upon the mitogen-activated protein kinase (MAPK) Hog1 cascade that comprise the MAPKKKs Ssk2/Ssk22 and Ste11 converging on the MAPKK Pbs2. Glycerol 16-24 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 129-133 27730338-3 2017 The enhanced stress tolerance was dependent on the mitogen-activated protein kinase (MAPK) Hog1 of the high osmolarity glycerol (HOG) pathway, but not the MAPK Slt2 of the cell wall integrity (CWI) pathway; however, a PMA1 overexpression constitutively activated both Hog1 and Slt2. Glycerol 119-127 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 91-95 26718472-1 2016 The mitogen-activated protein kinase HOG1 (high-osmolarity glycerol response pathway) plays a crucial role in the response of yeast to hyperosmotic shock. Glycerol 59-67 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 37-41 26718472-5 2016 Interestingly, compared with the wild-type strains, the results of shake-flask culture showed that To-HOG1 null mutation increased erythritol production by 1.44-fold while decreasing glycerol production by 71.23%. Glycerol 183-191 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 102-106 26274562-3 2015 To prevent glycerol efflux, Hog1 action impedes the function of the aquaglyceroporin Fps1, in part, by displacing channel co-activators (Rgc1/2). Glycerol 11-19 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 28-32 26598606-2 2016 Hog1 is activated through the high-osmolarity glycerol (HOG) pathway, which consists of independent upstream signaling routes termed the SLN1 branch and the SHO1 branch. Glycerol 46-54 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 0-4 26274562-4 2015 However, Fps1 closes upon hyperosmotic shock even in hog1 cells, indicating another mechanism to prevent Fps1-mediated glycerol efflux. Glycerol 120-128 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 53-57 25663258-6 2015 Cross-talk between the MAPK pathways has recently been used to re-wire osmostress-controlled expression of glycerol biosynthesis genes from Hog1 to Kss1-Fus3. Glycerol 107-115 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 140-144 25898136-1 2015 The yeast high osmolarity glycerol (HOG) pathway activates the Hog1 MAP kinase, which coordinates adaptation to high osmolarity conditions. Glycerol 26-34 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 63-67 26140985-3 2015 Plasma membrane-anchored Hog1p is still able to induce increased expression of GPD1 and glycerol accumulation. Glycerol 88-96 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 25-30 25130972-7 2015 Western blot analysis showed that BcSkn7 positively regulated the phosphorylation of BcSak1 (the orthologue of S. cerevisiae Hog1) under osmotic stress, indicating that BcSkn7 is associated with the high-osmolarity glycerol pathway in B. cinerea. Glycerol 215-223 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 125-129 26845706-5 2015 Our results show how Slt2p and Hog1p could coordinate the interplay among protein kinase A (PKA), protein kinase C and high-osmolarity glycerol pathways. Glycerol 135-143 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 31-36 25213170-4 2014 By examining the genetic interactions of known spindle disassembly genes, we identified three genes in the environmental stress-sensing HOG (high-osmolarity glycerol response) pathway, SHO1, PBS2, and HOG1, and found they are necessary for proper localization of She1 to the anaphase spindle and for proper spindle disassembly. Glycerol 157-165 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 201-205 25218923-5 2014 Consequently, the last 25 years have witnessed the discovery of many signal transduction pathways in S. cerevisiae, including the high osmotic glycerol (Hog1), Stl2/Mpk1 and Smk1 mitogen-activated protein (MAP) kinase pathways, the TOR, AMPK/Snf1, SPS, PLC1 and Pkr/Gcn2 cascades, and systems that sense and respond to various types of stress. Glycerol 143-151 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 153-157 24797784-9 2014 Our results also reveal that membrane-bound sensor proteins of high osmolarity glycerol (HOG) pathway are crucial for Hog1 phosphorylation in response to KP1019-induced stress. Glycerol 79-87 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 118-122 25022582-6 2014 CQ-activated Hog1p is translocated to the nucleus and facilitates the expression of GPD1 (glycerol-3-phosphate dehydrogenase), which is required for the synthesis of glycerol (one of the major osmolytes). Glycerol 90-98 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 13-18 24799959-2 2014 Hog1PP (dually phosphorylated Hog1), a final effector in the signalling pathway of the hyper osmotic stress, regulates the glycerol synthesis both at transcriptional and non-transcriptional stages. Glycerol 123-131 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 0-4 24278344-2 2013 Yeast Hog1, the effector protein kinase of the High Osmolarity Glycerol pathway, translocates transiently from the cytosol to the nucleus during adaptation to high external osmolarity. Glycerol 63-71 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 6-10 24732094-5 2014 This approach revealed that osmotic up-regulation of only two Hog1-dependent glycerol biosynthesis genes, GPD1 and GPP2, is sufficient for successful osmoadaptation. Glycerol 77-85 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 62-66 23063696-4 2013 Functional analyses of chimeric Hog1 proteins constructed from ScHog1 and TmHog1 sequences indicated that the C-terminal region of TmHog1 is more effective for glycerol biosynthesis than ScHog1 under osmotic stress. Glycerol 160-168 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 32-36 23709042-4 2013 The strains displayed constitutive and sustained activation of Hog1, a central kinase in the high osmolarity glycerol (HOG) signal transduction pathway of S. cerevisiae. Glycerol 109-117 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 63-67 23028184-4 2012 These adaptive responses are mostly governed by the high osmolarity glycerol (HOG) pathway, which is composed of membrane-associated osmosensors, an intracellular signaling pathway whose core is the Hog1 MAP kinase (MAPK) cascade, and cytoplasmic and nuclear effector functions. Glycerol 68-76 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 199-203 23762021-4 2013 The Hog1 kinase stimulates transcription of genes encoding enzymes required for glycerol production (Gpd1, Gpp2) and glycerol import (Stl1) and activates a regulatory enzyme in glycolysis (Pfk26/27). Glycerol 80-88 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 4-8 23762021-4 2013 The Hog1 kinase stimulates transcription of genes encoding enzymes required for glycerol production (Gpd1, Gpp2) and glycerol import (Stl1) and activates a regulatory enzyme in glycolysis (Pfk26/27). Glycerol 117-125 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 4-8 23762021-13 2013 In addition, our observations suggest a role for trehalose accumulation in osmoadaptation and that Hog1 probably directly contributes to the regulation of the Fps1 glycerol facilitator. Glycerol 164-172 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 99-103 20430884-7 2010 Northern blot analysis demonstrated that Hog1p controls the tunicamycin-induced transcriptional change of GPD1 and that wild-type cells exposed to the drug accumulated glycerol in a Hog1p-dependent manner. Glycerol 168-176 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 182-187 23149687-4 2012 The model suggested that (i) the main mechanism for osmo-adaptation is a fast and transient non-transcriptional Hog1-mediated activation of glycerol production, (ii) the transcriptional response serves to maintain an increased steady-state glycerol production with low steady-state Hog1 activity, and (iii) fast negative feedbacks of activated Hog1 on upstream signalling branches serves to stabilise adaptation response. Glycerol 140-148 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 112-116 23149687-4 2012 The model suggested that (i) the main mechanism for osmo-adaptation is a fast and transient non-transcriptional Hog1-mediated activation of glycerol production, (ii) the transcriptional response serves to maintain an increased steady-state glycerol production with low steady-state Hog1 activity, and (iii) fast negative feedbacks of activated Hog1 on upstream signalling branches serves to stabilise adaptation response. Glycerol 140-148 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 282-286 23149687-4 2012 The model suggested that (i) the main mechanism for osmo-adaptation is a fast and transient non-transcriptional Hog1-mediated activation of glycerol production, (ii) the transcriptional response serves to maintain an increased steady-state glycerol production with low steady-state Hog1 activity, and (iii) fast negative feedbacks of activated Hog1 on upstream signalling branches serves to stabilise adaptation response. Glycerol 140-148 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 282-286 23149687-4 2012 The model suggested that (i) the main mechanism for osmo-adaptation is a fast and transient non-transcriptional Hog1-mediated activation of glycerol production, (ii) the transcriptional response serves to maintain an increased steady-state glycerol production with low steady-state Hog1 activity, and (iii) fast negative feedbacks of activated Hog1 on upstream signalling branches serves to stabilise adaptation response. Glycerol 240-248 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 112-116 23149687-4 2012 The model suggested that (i) the main mechanism for osmo-adaptation is a fast and transient non-transcriptional Hog1-mediated activation of glycerol production, (ii) the transcriptional response serves to maintain an increased steady-state glycerol production with low steady-state Hog1 activity, and (iii) fast negative feedbacks of activated Hog1 on upstream signalling branches serves to stabilise adaptation response. Glycerol 240-248 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 282-286 23149687-4 2012 The model suggested that (i) the main mechanism for osmo-adaptation is a fast and transient non-transcriptional Hog1-mediated activation of glycerol production, (ii) the transcriptional response serves to maintain an increased steady-state glycerol production with low steady-state Hog1 activity, and (iii) fast negative feedbacks of activated Hog1 on upstream signalling branches serves to stabilise adaptation response. Glycerol 240-248 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 282-286 21205016-7 2011 The results suggest that the high osmolarity glycerol (Hog1) mitogen-activated protein kinase (MAPK) pathway is activated by both wild type and mutant ATPases. Glycerol 45-53 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 55-59 20803478-10 2011 A deletion mutant of osmoregulatory mitogen-activated protein kinase Hog1p was more sensitive to HM-1, suggesting that high-osmolarity glycerol pathways plays an important role in the compensatory response to HM-1 action. Glycerol 135-143 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 69-74 22631601-2 2012 The integral control mechanism by which Hog1 modulates glycerol production remains uncharacterized. Glycerol 55-63 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 40-44 22631601-3 2012 An additional Hog1-independent mechanism retains intracellular glycerol for adaptation. Glycerol 63-71 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 14-18 22631601-5 2012 However, it remains unknown whether Hog1 exerts integral or proportional control over glycerol production in C. albicans. Glycerol 86-94 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 36-40 22631601-7 2012 We propose a simple ordinary differential equation (ODE) model that highlights the integral control that Hog1 exerts over glycerol biosynthesis in these species. Glycerol 122-130 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 105-109 22445853-3 2012 Here, we show that both ceramide and loss of Isc1p lead to the activation of Hog1p, the MAPK of the high osmolarity glycerol (HOG) pathway that is functionally related to mammalian p38 and JNK. Glycerol 116-124 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 77-82 20959523-2 2010 In Saccharomyces cerevisiae, the MAPK Fus3 is activated by pheromone-binding heterotrimeric guanosine triphosphate-binding protein (G protein)-coupled receptors to promote mating, whereas the MAPK Hog1 is activated by hyperosmotic stress to elicit the high-osmolarity glycerol (HOG) response. Glycerol 268-276 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 197-201 19365545-2 2009 In Saccharomyces cerevisiae most of the cellular responses to hyper-osmotic stress is regulated by two interconnected pathways involving high osmolarity glycerol mitogen-activated protein kinase (Hog1p) and Calcineurin (CAN), a Ca(2+)/calmodulin-regulated protein phosphatase 2B. Glycerol 153-161 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 196-201 19633059-2 2009 We reported previously that S. cerevisiae responds to low-pH stress by transiently depolarizing its actin cytoskeleton, and that this step requires a mitogen-activated protein kinase, high osmolarity glycerol 1 (Hog1p). Glycerol 200-208 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 212-217 18596410-4 2008 In the budding yeast Saccharomyces cerevisiae, the Hog1 MAPK mediates the high-osmolarity glycerol (HOG) signaling pathway. Glycerol 90-98 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 51-55 19061190-1 2008 In yeast, external signals such as high osmolarity or oxidant conditions activate the high osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) cascade pathway, which consists of two upstream branches, i.e. Sho1p and Sln1p and common downstream elements, including the Pbs2p MAPK kinase and the Hog1p MAPK. Glycerol 102-110 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 308-313 18719124-2 2008 The yeast high-osmolarity glycerol (HOG) pathway activates Hog1 MAPK (mammalian ortholog p38alpha/SAPKalpha), which enters the nucleus and induces expression of >50 genes, implying that transcriptional up-regulation is necessary to cope with hyperosmotic stress. Glycerol 26-34 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 59-63 18719124-6 2008 Thus, control of intracellular glycerol formation by Hog1 is critical for maintenance of osmotic balance but not transcriptional induction of any gene. Glycerol 31-39 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 53-57 16980399-2 2006 Yeast accumulates glycerol in response to osmotic stress, activated primarily by MAP kinase Hog1 signaling. Glycerol 18-26 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 92-96 18160327-8 2008 Hog1 and Fps1 control the response to osmotic stress in yeast by regulating glycerol production and plasma membrane flux, respectively. Glycerol 76-84 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 0-4 17627274-1 2007 To cope with life-threatening high osmolarity, yeast activates the high-osmolarity glycerol (HOG) signaling pathway, whose core element is the Hog1 MAP kinase cascade. Glycerol 83-91 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 143-147 17156024-5 2006 Acetate activation of Hog1p is absent in the ssk1Delta and pbs2Delta mutants, but is present in sho1Delta and ste11Delta, showing that it involves the Sln1p branch of the high-osmolarity glycerol (HOG) pathway signaling to Pbs2p. Glycerol 187-195 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 22-27 14685261-1 2004 The yeast high osmolarity glycerol (HOG) pathway signals via the Pbs2 MEK and the Hog1 MAPK, whose activity requires phosphorylation of Thr and Tyr in the activation loop. Glycerol 26-34 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 82-86 16765917-5 2006 In yeast external high osmolarity activates HOG (high osmolarity glycerol) MAPK pathway that consists of MAPKKK (Ste11p or Ssk2p/Ssk22p), MAPKK (Pbs2p), and MAPK (Hog1p). Glycerol 65-73 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 163-168 16371351-3 2006 Phosphorylation of Hog1p was dependent on Pbs2p, the MAPK kinase (MAPKK) of the high osmolarity glycerol (HOG) pathway, and Ssk1p, the response regulator of the two-component system Sln1p-Ypd1p. Glycerol 96-104 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 19-24 16371351-9 2006 Indeed, the absence of Hog1p impaired the cold-instigated expression of genes for trehalose- and glycerol-synthesizing enzymes and small chaperones. Glycerol 97-105 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 23-28 16371351-10 2006 Moreover, a downward transfer to 12 or 4 degrees C stimulated the overproduction of glycerol in a Hog1p-dependent manner. Glycerol 84-92 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 98-103 16371351-12 2006 On the contrary, deletion of HOG1 or GPD1 decreased tolerance to freezing of wild-type cells preincubated at a low temperature, whereas no differences could be detected in cells shifted directly from 30 to -20 degrees C. Thus, exposure to low temperatures triggered a Hog1p-dependent accumulation of glycerol, which is essential for freeze protection. Glycerol 300-308 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 29-33 15707964-2 2005 In baker"s yeast external high osmolarity activates high osmolarity glycerol (HOG) MAPK pathway which consists of two upstream branches (SHO1 and SLN1) and common downstream elements Pbs2p MAPKK and Hog1p MAPK. Glycerol 68-76 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 199-204 14595107-1 2004 The Saccharomyces cerevisiae high osmolarity glycerol (HOG) mitogen-activated protein kinase pathway is required for osmoadaptation and contains two branches that activate a mitogen-activated protein kinase (Hog1) via a mitogen-activated protein kinase kinase (Pbs2). Glycerol 45-53 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 208-212 14618562-3 2003 We investigated the roles of GPD1, GPD2 and HOG1-the kinase involved in the response to osmotic stress-in glycerol production during wine fermentation. Glycerol 106-114 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 44-48 14618562-6 2003 The deletion of HOG1 resulted in a slight decrease in growth rate and a 20% decrease in glycerol production, indicating that the HOG pathway operates under wine fermentation conditions. Glycerol 88-96 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 16-20 12853477-3 2003 In yeast, external high osmolarity activates the HOG (high osmolarity glycerol) MAPK pathway, which consists of two upstream branches (SHO1 and SLN1) and common downstream elements including the Pbs2 MAPKK and the Hog1 MAPK. Glycerol 70-78 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 214-218 10762242-1 2000 We have isolated several Saccharomyces cerevisiae mutants resistant to calcofluor that contain mutations in the PBS2 or HOG1 genes, which encode the mitogen-activated protein kinase (MAPK) and MAP kinases, respectively, of the high-osmolarity glycerol response (HOG) pathway. Glycerol 243-251 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 120-124 10970855-1 2000 The adaptive response to hyperosmotic stress in yeast, termed the high osmolarity glycerol (HOG) response, is mediated by two independent upstream pathways that converge on the Pbs2 MAP kinase kinase (MAPKK), leading to the activation of the Hog1 MAP kinase. Glycerol 82-90 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 242-246 12391171-4 2002 Genetic and microarray analysis indicates that high osmolarity extends the life span by activating Hog1p, leading to an increase in the biosynthesis of glycerol from glycolytic intermediates. Glycerol 152-160 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 99-104 10931288-5 2000 A hog1 deletion strain was previously found to contain lower internal glycerol and therefore displays an osmosensitive phenotype. Glycerol 70-78 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 2-6 10931288-6 2000 Here, we show that the osmosensitivity of hog1 is suppressed by growth at 37 degrees C. We reasoned that this temperature-remedial osmoresistance might be caused by a higher intracellular glycerol level at the elevated temperature. Glycerol 188-196 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 42-46 10931288-7 2000 This hypothesis was confirmed by measurement of the glycerol concentration, which was shown to be similar for wild type and hog1 cells only at elevated growth temperatures. Glycerol 52-60 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 124-128 10931288-8 2000 In agreement with this finding, hog1 cells containing an fps1 allele, encoding a constitutively open glycerol channel, have lost their temperature-remedial osmoresistance. Glycerol 101-109 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 32-36 34576788-2 2021 Of special significance, the activity of the transcriptional complex Rtg1/3 has been shown to be modulated by Hog1, the master regulator of the high osmolarity glycerol pathway, in response to osmotic stress. Glycerol 160-168 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 110-114 9148932-2 1997 In yeast glycerol-3-phosphate dehydrogenase 1 is essential for synthesis of the osmoprotectant glycerol and is osmotically regulated via the high osmolarity glycerol (HOG1) kinase pathway. Glycerol 9-17 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 167-171 9148932-2 1997 In yeast glycerol-3-phosphate dehydrogenase 1 is essential for synthesis of the osmoprotectant glycerol and is osmotically regulated via the high osmolarity glycerol (HOG1) kinase pathway. Glycerol 95-103 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 167-171 10217506-6 1999 Deletion of HOG1, which encodes the terminal protein kinase of the high osmolarity glycerol (HOG) response pathway, led to an even longer lag phase and drastically lower basal and induced GPD1 mRNA levels. Glycerol 83-91 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 12-16 8824643-0 1996 The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans. Glycerol 64-72 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 45-49 8196651-5 1994 hog1 delta mutants lacking a protein kinase involved in osmostress-induced signal transduction (the high-osmolarity glycerol response [HOG] pathway) failed to increase glycerol-3-phosphate dehydrogenase activity and mRNA levels when osmotic stress was imposed. Glycerol 116-124 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 0-4 8196651-7 1994 However, there may be Hog1-independent mechanisms mediating osmostress-induced glycerol accumulation, since a hog1 delta strain could still enhance its glycerol content, although less than the wild type. Glycerol 79-87 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 110-114 8196651-7 1994 However, there may be Hog1-independent mechanisms mediating osmostress-induced glycerol accumulation, since a hog1 delta strain could still enhance its glycerol content, although less than the wild type. Glycerol 152-160 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 110-114 35254447-4 2022 Activation of the Hog1 stress-activated protein kinase (SAPK) induces a complex program required for cellular adaptation that includes temporary arrest of cell cycle progression, adjustment of transcription and translation patterns, the regulation of metabolism including the synthesis and retention of the compatible osmolyte glycerol. Glycerol 327-335 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 18-22 31141459-5 2019 We found that As(III) treatment did not induce glycerol accumulation and, in fact, blocked the accumulation of glycerol induced by constitutive Hog1 activity. Glycerol 111-119 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 144-148 32389298-0 2020 Crosstalk between Saccharomycescerevisiae SAPKs Hog1 and Mpk1 is mediated by glycerol accumulation. Glycerol 77-85 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 48-52 32389298-6 2020 In this study, we show that hyperactivation of Mpk1 in a ptp2 ptp3 null mutant is an indirect consequence of Hog1 hyperactivation, which induces accumulation of intracellular glycerol and an attendant hypo-osmotic stress. Glycerol 175-183 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 109-113 32389298-8 2020 We found similarly that activation of Mpk1 in response to zymolyase treatment is partly a consequence of Hog1-driven glycerol accumulation. Glycerol 117-125 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 105-109 31141459-1 2019 The yeast high-osmolarity glycerol (HOG) stress-activated protein kinase Hog1 is activated in response to hyperosmotic stress, inducing the production and retention of glycerol to restore osmotic balance. Glycerol 26-34 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 73-77 31141459-1 2019 The yeast high-osmolarity glycerol (HOG) stress-activated protein kinase Hog1 is activated in response to hyperosmotic stress, inducing the production and retention of glycerol to restore osmotic balance. Glycerol 168-176 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 73-77 31141459-2 2019 Hog1 promotes retention of glycerol through closure of the plasma-membrane glycerol channel Fps1. Glycerol 27-35 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 0-4 31372715-8 2020 Furthermore, disruption of the HOG1 gene suppressed their growth deficiency on glycerol medium. Glycerol 79-87 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 31-35 31372715-9 2020 These findings suggest that altered activation of Hog1 in the gsp1-1894 cells resulted in the loss of mitochondria and inhibition of glycerol metabolism. Glycerol 133-141 mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae S288C 50-54