PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33811845-2 2021 Aquaporin-3 (AQP3) is a water, glycerol and H2O2 transporting channel expressed in colonic epithelia. Glycerol 31-39 aquaporin 3 (Gill blood group) Homo sapiens 0-11 33811845-2 2021 Aquaporin-3 (AQP3) is a water, glycerol and H2O2 transporting channel expressed in colonic epithelia. Glycerol 31-39 aquaporin 3 (Gill blood group) Homo sapiens 13-17 34627746-2 2022 The aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) represent key glycerol channels, enabling glycerol flux across the membranes of cells. Glycerol 65-73 aquaporin 3 (Gill blood group) Homo sapiens 23-27 34627746-2 2022 The aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) represent key glycerol channels, enabling glycerol flux across the membranes of cells. Glycerol 93-101 aquaporin 3 (Gill blood group) Homo sapiens 23-27 35470510-2 2022 Aquaporin 3 (AQP3) is a glycerol/ water channel involved in several physiological functions. Glycerol 24-32 aquaporin 3 (Gill blood group) Homo sapiens 0-11 35470510-2 2022 Aquaporin 3 (AQP3) is a glycerol/ water channel involved in several physiological functions. Glycerol 24-32 aquaporin 3 (Gill blood group) Homo sapiens 13-17 34021497-9 2021 We showed that the attenuated AQP3 level may contribute to low sperm motility via reducing glycerol for energy production in sperm tails of asthenozoospermia. Glycerol 91-99 aquaporin 3 (Gill blood group) Homo sapiens 30-34 33933702-3 2021 One of them is aquaporin-3 (AQP3), which is a small, hydrophobic, integral membrane protein with a predominant role in water and glycerol transport. Glycerol 129-137 aquaporin 3 (Gill blood group) Homo sapiens 15-26 33933702-3 2021 One of them is aquaporin-3 (AQP3), which is a small, hydrophobic, integral membrane protein with a predominant role in water and glycerol transport. Glycerol 129-137 aquaporin 3 (Gill blood group) Homo sapiens 28-32 33465153-7 2021 Conversely, Cys enriched diet upregulated AQP3 enhancing basolateral membranes glycerol permeability and downregulating glycerol kinase (GK) of intestinal cells. Glycerol 79-87 aquaporin 3 (Gill blood group) Homo sapiens 42-46 33077138-3 2020 AQP3 is also known to aid in glycerol transport. Glycerol 29-37 aquaporin 3 (Gill blood group) Homo sapiens 0-4 32267715-5 2020 Accumulating evidence in the literature indicates that the water-, glycerol-, and hydrogen peroxide-transporting channel aquaporin-3 (AQP3) plays a key role in various processes involved in keratinocyte function, and abnormalities in this channel have been observed in several human skin diseases. Glycerol 67-75 aquaporin 3 (Gill blood group) Homo sapiens 121-132 32267715-5 2020 Accumulating evidence in the literature indicates that the water-, glycerol-, and hydrogen peroxide-transporting channel aquaporin-3 (AQP3) plays a key role in various processes involved in keratinocyte function, and abnormalities in this channel have been observed in several human skin diseases. Glycerol 67-75 aquaporin 3 (Gill blood group) Homo sapiens 134-138 32003033-1 2020 The water and glycerol channel, aquaporin-3 (AQP3), plays an important role in the skin epidermis, with effects on hydration, permeability barrier repair and wound healing; therefore, information about the mechanisms regulating its expression is important for a complete understanding of skin function physiologically and in disease conditions. Glycerol 14-22 aquaporin 3 (Gill blood group) Homo sapiens 32-43 32003033-1 2020 The water and glycerol channel, aquaporin-3 (AQP3), plays an important role in the skin epidermis, with effects on hydration, permeability barrier repair and wound healing; therefore, information about the mechanisms regulating its expression is important for a complete understanding of skin function physiologically and in disease conditions. Glycerol 14-22 aquaporin 3 (Gill blood group) Homo sapiens 45-49 31889130-5 2019 Our studies show that single amino acid substitutions in the selectivity filters of AQP1, AQP4 and AQP3 differentially affect glycerol and urea permeability in an AQP-specific manner. Glycerol 126-134 aquaporin 3 (Gill blood group) Homo sapiens 99-103 31081563-1 2019 Water and glycerol permeation through human AQP3 are described by exploiting advanced metadynamics approaches, which enabled both to explore the free energies involved in pore permeation and to achieve a description of the mechanisms with an atomistic level of detail. Glycerol 10-18 aquaporin 3 (Gill blood group) Homo sapiens 44-48 30862673-8 2019 Stopped-flow light scattering measurements confirmed that DFP00173 and Z433927330 inhibit AQP3 glycerol permeability in human erythrocytes. Glycerol 95-103 aquaporin 3 (Gill blood group) Homo sapiens 90-94 30659792-0 2019 Single-channel permeability and glycerol affinity of human aquaglyceroporin AQP3. Glycerol 32-40 aquaporin 3 (Gill blood group) Homo sapiens 76-80 30659792-2 2019 AQP1 is abundantly expressed in the human erythrocyte for maintaining its hydrohomeostasis where AQP3 is also expressed (at a level ~30-folds lower than AQP1) facilitating glycerol transport. Glycerol 172-180 aquaporin 3 (Gill blood group) Homo sapiens 97-101 30659792-4 2019 What is the glycerol-AQP3 affinity under near-physiological conditions? Glycerol 12-20 aquaporin 3 (Gill blood group) Homo sapiens 21-25 30659792-5 2019 Through atomistic modelling and large-scale simulations, we found that AQP3 is two to three times more permeable to water than AQP1 and that the glycerol-AQP3 affinity is approximately 500/M. Glycerol 145-153 aquaporin 3 (Gill blood group) Homo sapiens 71-75 30659792-5 2019 Through atomistic modelling and large-scale simulations, we found that AQP3 is two to three times more permeable to water than AQP1 and that the glycerol-AQP3 affinity is approximately 500/M. Glycerol 145-153 aquaporin 3 (Gill blood group) Homo sapiens 154-158 30659792-9 2019 We observed close agreement between the experimentally measured and the computationally predicted time courses of erythrocytes, which corroborated our computational conclusions on the AQP3 water-permeability and the glycerol-AQP3 affinity. Glycerol 216-224 aquaporin 3 (Gill blood group) Homo sapiens 225-229 30645101-5 2019 Stopped-flow spectroscopy showed that these complexes potently inhibit glycerol permeation in human red blood cells (hRBC) through AQP3 blockage. Glycerol 71-79 aquaporin 3 (Gill blood group) Homo sapiens 131-135 30090948-7 2018 IFNgamma decreased AQP3 mRNA expression in HT-29 cells in a time- and concentration-dependent manner and reduced functional AQP3 protein expression (decreased 3H-labelled glycerol uptake). Glycerol 171-179 aquaporin 3 (Gill blood group) Homo sapiens 124-128 29963136-6 2018 Analysis of cell permeability to water and glycerol revealed that MDA-MB-231 cells with knocked down AQP3 demonstrated a modest decrease in water permeability (17%; P<0.05) but a more marked decrease in glycerol permeability (77%; P<0.001). Glycerol 43-51 aquaporin 3 (Gill blood group) Homo sapiens 101-105 29963136-6 2018 Analysis of cell permeability to water and glycerol revealed that MDA-MB-231 cells with knocked down AQP3 demonstrated a modest decrease in water permeability (17%; P<0.05) but a more marked decrease in glycerol permeability (77%; P<0.001). Glycerol 206-214 aquaporin 3 (Gill blood group) Homo sapiens 101-105 29301341-7 2018 Subsequently, we found AQP1 and AQP3 to be the most predominant AQPs accounting for water and glycerol fluxes, respectively, in the healthy endothelium. Glycerol 94-102 aquaporin 3 (Gill blood group) Homo sapiens 32-36 29203835-6 2017 We furthermore performed functional characterization and found that AQP 2, 6 and 8 allowed flux of water whereas AQP3, 7, 9, 10, 11 and 12 also facilitated a glycerol flux. Glycerol 158-166 aquaporin 3 (Gill blood group) Homo sapiens 113-117 29038361-4 2017 AQP3 expression was assessed by real-time PCR and radiolabeled glycerol uptake, with select inhibitors and a luciferase reporter construct used to further elucidate intracellular signaling. Glycerol 63-71 aquaporin 3 (Gill blood group) Homo sapiens 0-4 28894278-3 2017 This study was conducted to investigate the effect of A. houstonianum ethanolnolic extract (AHE) on the expression of aquaporin-3 (AQP3), an integral membrane protein for water and glycerol transport in keratinocytes, and to identify the structure of the A. houstonianum bioactive compound. Glycerol 181-189 aquaporin 3 (Gill blood group) Homo sapiens 131-135 28656282-2 2017 AQP3 transports glycerol to PLD2 for the synthesis of lipid second messenger, which can mediate the effect of the AQP3/PLD2 signaling module in the regulation of keratinocyte proliferation and differentiation. Glycerol 16-24 aquaporin 3 (Gill blood group) Homo sapiens 0-4 28656282-2 2017 AQP3 transports glycerol to PLD2 for the synthesis of lipid second messenger, which can mediate the effect of the AQP3/PLD2 signaling module in the regulation of keratinocyte proliferation and differentiation. Glycerol 16-24 aquaporin 3 (Gill blood group) Homo sapiens 114-118 28732436-11 2017 AQP3, which involves in skin hydration and wound healing through water and glycerol transmission, is downregulated in SSc fibroblasts. Glycerol 75-83 aquaporin 3 (Gill blood group) Homo sapiens 0-4 28620264-0 2017 Silencing of AQP3 induces apoptosis of gastric cancer cells via downregulation of glycerol intake and downstream inhibition of lipogenesis and autophagy. Glycerol 82-90 aquaporin 3 (Gill blood group) Homo sapiens 13-17 28620264-3 2017 AQP3 is capable of transporting glycerol across the cytomembrane. Glycerol 32-40 aquaporin 3 (Gill blood group) Homo sapiens 0-4 28620264-4 2017 Previous studies have shown that AQP3 is involved in proliferation, invasion and migration by regulating glycerol and lipid metabolism in diverse cancer cell types. Glycerol 105-113 aquaporin 3 (Gill blood group) Homo sapiens 33-37 28620264-6 2017 In this study, we observed that AQP3 expression was upregulated in tumor tissues, and positively correlated with tumor size, lymph node metastasis and glycerol concentration in human GC samples. Glycerol 151-159 aquaporin 3 (Gill blood group) Homo sapiens 32-36 28620264-7 2017 Silencing of AQP3 resulted in decreased glycerol intake and impaired lipid synthesis, which contributed to increased cell apoptosis. Glycerol 40-48 aquaporin 3 (Gill blood group) Homo sapiens 13-17 28620264-9 2017 Administration of either glycerol or rapamycin restored cell viability, and overexpression of AQP3 increased cell viability by upregulating cellular glycerol metabolism and autophagy. Glycerol 149-157 aquaporin 3 (Gill blood group) Homo sapiens 94-98 28620264-10 2017 Our study demonstrates that the increase in cell apoptosis of AQP3-deficient GC cells is a consequence of reduced glycerol uptake and lipogenesis and is associated with autophagy inhibition induced by AQP3 deficiency. Glycerol 114-122 aquaporin 3 (Gill blood group) Homo sapiens 62-66 28304043-1 2017 The inhibition of water and glycerol permeation via human aquaglyceroporin-3 (AQP3) by gold(iii) complexes has been studied by stopped-flow spectroscopy and, for the first time, its mechanism has been described using molecular dynamics (MD), combined with density functional theory (DFT) and electrochemical studies. Glycerol 28-36 aquaporin 3 (Gill blood group) Homo sapiens 58-76 28304043-1 2017 The inhibition of water and glycerol permeation via human aquaglyceroporin-3 (AQP3) by gold(iii) complexes has been studied by stopped-flow spectroscopy and, for the first time, its mechanism has been described using molecular dynamics (MD), combined with density functional theory (DFT) and electrochemical studies. Glycerol 28-36 aquaporin 3 (Gill blood group) Homo sapiens 78-82 28304043-2 2017 The obtained MD results showed that the most effective gold-based inhibitor, anchored to Cys40 in AQP3, is able to induce shrinkage of pores preventing glycerol and water permeation. Glycerol 152-160 aquaporin 3 (Gill blood group) Homo sapiens 98-102 28258570-4 2017 AQP3 is involved in the diarrhea and inflammatory bowel disease; AQP5 is relevant to gastric carcinoma cell proliferation and migration; AQP9 plays considerable role in glycerol metabolism , urea transport and hepatocellular carcinoma. Glycerol 169-177 aquaporin 3 (Gill blood group) Homo sapiens 0-4 26766001-0 2016 The inhibition of glycerol permeation through aquaglyceroporin-3 induced by mercury(II): A molecular dynamics study. Glycerol 18-26 aquaporin 3 (Gill blood group) Homo sapiens 46-64 26768614-3 2016 Aquaporin 3 (AQP3) belongs to a family of transmembrane channels that are important in transporting water, glycerol, and other small molecules across the cell membrane. Glycerol 107-115 aquaporin 3 (Gill blood group) Homo sapiens 0-11 26768614-3 2016 Aquaporin 3 (AQP3) belongs to a family of transmembrane channels that are important in transporting water, glycerol, and other small molecules across the cell membrane. Glycerol 107-115 aquaporin 3 (Gill blood group) Homo sapiens 13-17 26768614-4 2016 Glycerol that is transported by AQP3 is necessary for cell energy generation and lipid synthesis which fulfill the cell biological processes. Glycerol 0-8 aquaporin 3 (Gill blood group) Homo sapiens 32-36 26768614-6 2016 However, whether AQP3-regulated glycerol uptake and metabolism were involved in cancer progression remains to be further studied. Glycerol 32-40 aquaporin 3 (Gill blood group) Homo sapiens 17-21 26768614-7 2016 Our study demonstrated that the expression of AQP3 was positively correlated with glycerol level in human gastric cancer tissues. Glycerol 82-90 aquaporin 3 (Gill blood group) Homo sapiens 46-50 26768614-9 2016 AQP3 inhibition that induced glycerol uptake reduction and glycerol administration would rehabilitate the cell proliferation. Glycerol 29-37 aquaporin 3 (Gill blood group) Homo sapiens 0-4 26768614-9 2016 AQP3 inhibition that induced glycerol uptake reduction and glycerol administration would rehabilitate the cell proliferation. Glycerol 59-67 aquaporin 3 (Gill blood group) Homo sapiens 0-4 26768614-10 2016 The energy and lipid production decreased when AQP3 was knocked down since the cellular glycerol level and several lipogenesis enzymes were downregulated. Glycerol 88-96 aquaporin 3 (Gill blood group) Homo sapiens 47-51 26768614-12 2016 Our study indicated that the energy and lipid production inhibition, which were responsible for gastric cancer cell proliferation impairment, were induced by glycerol uptake reduction after AQP3 knockdown. Glycerol 158-166 aquaporin 3 (Gill blood group) Homo sapiens 190-194 26960817-1 2016 The pH gating of human AQP3 and its effects on both water and glycerol permeabilities have been fully characterized for the first time using a human red blood cell model (hRBC). Glycerol 62-70 aquaporin 3 (Gill blood group) Homo sapiens 23-27 26794461-0 2016 The AQP-3 water channel is a pivotal modulator of glycerol-induced chloride channel activation in nasopharyngeal carcinoma cells. Glycerol 50-58 aquaporin 3 (Gill blood group) Homo sapiens 4-9 26794461-4 2016 Glycerol entered the cells via AQP-3 and induced two different Cl(-) currents through cell swelling-dependent or -independent pathways. Glycerol 0-8 aquaporin 3 (Gill blood group) Homo sapiens 31-36 26794461-6 2016 After siRNA-induced AQP-3 knock-down, the 140 mM glycerol isoosmotic solution swelled cells by 22% (45% in AQP-3-intact cells) and induced a smaller Cl(-) current; this current was smaller than that activated by 8% cell volume swelling, which induced by the 140 mM glycerol hyperosmotic solution in AQP-3-intact cells. Glycerol 49-57 aquaporin 3 (Gill blood group) Homo sapiens 20-25 26794461-6 2016 After siRNA-induced AQP-3 knock-down, the 140 mM glycerol isoosmotic solution swelled cells by 22% (45% in AQP-3-intact cells) and induced a smaller Cl(-) current; this current was smaller than that activated by 8% cell volume swelling, which induced by the 140 mM glycerol hyperosmotic solution in AQP-3-intact cells. Glycerol 49-57 aquaporin 3 (Gill blood group) Homo sapiens 107-112 26794461-6 2016 After siRNA-induced AQP-3 knock-down, the 140 mM glycerol isoosmotic solution swelled cells by 22% (45% in AQP-3-intact cells) and induced a smaller Cl(-) current; this current was smaller than that activated by 8% cell volume swelling, which induced by the 140 mM glycerol hyperosmotic solution in AQP-3-intact cells. Glycerol 49-57 aquaporin 3 (Gill blood group) Homo sapiens 107-112 26794461-8 2016 The swelling-independent Cl(-) current, which was activated by extracellular glycerol, was reduced by CuCl2 and AQP-3-siRNA pretreatment. Glycerol 77-85 aquaporin 3 (Gill blood group) Homo sapiens 112-117 26794461-9 2016 Dialyzing glycerol into cells via the pipette directly induced the swelling-independent Cl(-) current; however this current was blocked by AQP-3 down-regulation, suggesting AQP-3 is essential for the opening of chloride channels. Glycerol 10-18 aquaporin 3 (Gill blood group) Homo sapiens 139-144 26794461-9 2016 Dialyzing glycerol into cells via the pipette directly induced the swelling-independent Cl(-) current; however this current was blocked by AQP-3 down-regulation, suggesting AQP-3 is essential for the opening of chloride channels. Glycerol 10-18 aquaporin 3 (Gill blood group) Homo sapiens 173-178 26794461-10 2016 In conclusion, AQP-3 is the pathway for water, glycerol and other small solutes to enter cells, and it may be an essential modulator for the gating of chloride channels. Glycerol 47-55 aquaporin 3 (Gill blood group) Homo sapiens 15-20 26820815-1 2016 Previous studies have demonstrated that the expression of aquaporin 3 (AQP3), a water channel which promotes glycerol permeability and water transport across cell membranes, is reduced in degenerative lumbar intervertebral disc (IVD) tissues. Glycerol 109-117 aquaporin 3 (Gill blood group) Homo sapiens 58-69 26820815-1 2016 Previous studies have demonstrated that the expression of aquaporin 3 (AQP3), a water channel which promotes glycerol permeability and water transport across cell membranes, is reduced in degenerative lumbar intervertebral disc (IVD) tissues. Glycerol 109-117 aquaporin 3 (Gill blood group) Homo sapiens 71-75 26045060-10 2015 This transactivation of the AQP3 coding gene was functionally related to an increase of AQP3 permeability tests by a glycerol uptake assay. Glycerol 117-125 aquaporin 3 (Gill blood group) Homo sapiens 28-32 26045060-10 2015 This transactivation of the AQP3 coding gene was functionally related to an increase of AQP3 permeability tests by a glycerol uptake assay. Glycerol 117-125 aquaporin 3 (Gill blood group) Homo sapiens 88-92 25359234-6 2015 Recently, AQP3, AQP9, AQP10 and AQP11 were additionally identified in human adipocytes and proposed as additional glycerol pathways in these cells. Glycerol 114-122 aquaporin 3 (Gill blood group) Homo sapiens 10-14 24676973-1 2014 AQP3 has been correlated with higher transport of glycerol, increment of ATP content, and larger proliferation capacity. Glycerol 50-58 aquaporin 3 (Gill blood group) Homo sapiens 0-4 24676973-2 2014 Recently, we described the gold(III) complex Auphen as a very selective and potent inhibitor of AQP3"s glycerol permeability (Pgly ). Glycerol 103-111 aquaporin 3 (Gill blood group) Homo sapiens 96-100 25008241-2 2014 Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) encompass a subfamily of aquaporins that allow the movement of water, but also of small solutes, such as glycerol, across cell membranes. Glycerol 152-160 aquaporin 3 (Gill blood group) Homo sapiens 19-23 24803527-8 2014 Aquaporin 3 knockdown reduced cellular glycerol content and suppressed mitochondrial ATP formation. Glycerol 39-47 aquaporin 3 (Gill blood group) Homo sapiens 0-11 24685565-6 2014 In this sense, leptin modulates via PI3K/Akt/mTOR the expression of aquaglyceroporins such as AQP3 and AQP7 that facilitate glycerol efflux from adipocytes in response to the lipolytic stimuli via its translocation from the cytosolic fraction (AQP3) or lipid droplets (AQP7) to the plasma membrane. Glycerol 124-132 aquaporin 3 (Gill blood group) Homo sapiens 94-98 24685565-6 2014 In this sense, leptin modulates via PI3K/Akt/mTOR the expression of aquaglyceroporins such as AQP3 and AQP7 that facilitate glycerol efflux from adipocytes in response to the lipolytic stimuli via its translocation from the cytosolic fraction (AQP3) or lipid droplets (AQP7) to the plasma membrane. Glycerol 124-132 aquaporin 3 (Gill blood group) Homo sapiens 244-248 23677388-3 2013 AQP3 and AQP10 are aqua-glyceroporins, known to transport glycerol as well as water. Glycerol 58-66 aquaporin 3 (Gill blood group) Homo sapiens 0-4 23463292-1 2013 Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2. Glycerol 28-36 aquaporin 3 (Gill blood group) Homo sapiens 0-11 23463292-1 2013 Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2. Glycerol 28-36 aquaporin 3 (Gill blood group) Homo sapiens 13-17 23463292-1 2013 Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2. Glycerol 92-100 aquaporin 3 (Gill blood group) Homo sapiens 0-11 23463292-1 2013 Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2. Glycerol 92-100 aquaporin 3 (Gill blood group) Homo sapiens 13-17 23541697-3 2013 Here, we establish a convenient method to synthesize large amounts of functional human aquaglyceroporin 3 protein (AQP3), an AQP of physiological relevance conducting glycerol and some small neutral solutes besides water. Glycerol 167-175 aquaporin 3 (Gill blood group) Homo sapiens 87-113 23541697-3 2013 Here, we establish a convenient method to synthesize large amounts of functional human aquaglyceroporin 3 protein (AQP3), an AQP of physiological relevance conducting glycerol and some small neutral solutes besides water. Glycerol 167-175 aquaporin 3 (Gill blood group) Homo sapiens 115-119 23541697-7 2013 Functionality of hAQP3-6His was further confirmed by the strong inhibition of the glycerol and water permeability by phloretin and HgCl2, respectively, two blockers of AQP3. Glycerol 82-90 aquaporin 3 (Gill blood group) Homo sapiens 17-24 23541697-7 2013 Functionality of hAQP3-6His was further confirmed by the strong inhibition of the glycerol and water permeability by phloretin and HgCl2, respectively, two blockers of AQP3. Glycerol 82-90 aquaporin 3 (Gill blood group) Homo sapiens 18-22 22425521-3 2012 AQP3, 7, 9, and 10 are subcategorized as aquaglyceroporins which permeabilize glycerol as well as water. Glycerol 78-86 aquaporin 3 (Gill blood group) Homo sapiens 0-4 22584263-2 2012 In this study, the potential of glyceryl glucoside [GG; alpha-D-glucopyranosyl-alpha-(1->2)-glycerol], an enhanced glycerol derivative, to increase the expression of AQP3 in vitro and ex vivo was evaluated. Glycerol 95-103 aquaporin 3 (Gill blood group) Homo sapiens 169-173 21401652-2 2011 Aquaporin-3 (AQP3) facilitates water and glycerol transport across cell membranes and therefore regulates osmotic balance in different situations of stress. Glycerol 41-49 aquaporin 3 (Gill blood group) Homo sapiens 0-11 21401652-2 2011 Aquaporin-3 (AQP3) facilitates water and glycerol transport across cell membranes and therefore regulates osmotic balance in different situations of stress. Glycerol 41-49 aquaporin 3 (Gill blood group) Homo sapiens 13-17 21457357-1 2011 Aquaporin 3 (AQP3), a member of the aquaglyceroporin family, which transports water and glycerol, is robustly expressed in epidermis and plays an important role in stratum corneum hydration, permeability barrier function and wound healing. Glycerol 88-96 aquaporin 3 (Gill blood group) Homo sapiens 0-11 21457357-1 2011 Aquaporin 3 (AQP3), a member of the aquaglyceroporin family, which transports water and glycerol, is robustly expressed in epidermis and plays an important role in stratum corneum hydration, permeability barrier function and wound healing. Glycerol 88-96 aquaporin 3 (Gill blood group) Homo sapiens 13-17 21457357-5 2011 Increased AQP3 mRNA levels are accompanied by an increase in AQP3 protein in undifferentiated keratinocytes and a significant increase in glycerol uptake. Glycerol 138-146 aquaporin 3 (Gill blood group) Homo sapiens 10-14 21502813-5 2011 AQP3 and AQP7 appear to facilitate glycerol efflux from adipose tissue while reducing the glycerol influx into hepatocytes via AQP9 to prevent the excessive lipid accumulation and the subsequent aggravation of hyperglycemia in human obesity. Glycerol 35-43 aquaporin 3 (Gill blood group) Homo sapiens 0-4 21502813-5 2011 AQP3 and AQP7 appear to facilitate glycerol efflux from adipose tissue while reducing the glycerol influx into hepatocytes via AQP9 to prevent the excessive lipid accumulation and the subsequent aggravation of hyperglycemia in human obesity. Glycerol 90-98 aquaporin 3 (Gill blood group) Homo sapiens 0-4 21276418-1 2011 Aquaporin 3 (AQP3) is an aquaglyceroporin that transports water and glycerol and is expressed in the epidermis, among other epithelial tissues. Glycerol 68-76 aquaporin 3 (Gill blood group) Homo sapiens 0-11 21276418-1 2011 Aquaporin 3 (AQP3) is an aquaglyceroporin that transports water and glycerol and is expressed in the epidermis, among other epithelial tissues. Glycerol 68-76 aquaporin 3 (Gill blood group) Homo sapiens 13-17 21276418-4 2011 We have proposed that AQP3 associated with PLD2 provides the physiological primary alcohol glycerol to PLD2 for use in the transphosphatidylation reaction to generate phosphatidylglycerol (PG). Glycerol 91-99 aquaporin 3 (Gill blood group) Homo sapiens 22-26 21289260-12 2011 AQP3 and AQP7 may facilitate glycerol efflux from adipose tissue while reducing the glycerol influx into hepatocytes via AQP9 to prevent the excessive lipid accumulation and the subsequent aggravation of hyperglycemia in human obesity. Glycerol 29-37 aquaporin 3 (Gill blood group) Homo sapiens 0-4 21289260-12 2011 AQP3 and AQP7 may facilitate glycerol efflux from adipose tissue while reducing the glycerol influx into hepatocytes via AQP9 to prevent the excessive lipid accumulation and the subsequent aggravation of hyperglycemia in human obesity. Glycerol 84-92 aquaporin 3 (Gill blood group) Homo sapiens 0-4 21191421-2 2011 We previously showed that AQP3-mediated transport of water and glycerol is involved in keratinocyte migration and proliferation, respectively. Glycerol 63-71 aquaporin 3 (Gill blood group) Homo sapiens 26-30 21191421-5 2011 The upregulation of AQP3 expression in human keratinocytes by transfection with human AQP3 DNA plasmid was associated with increased cellular glycerol and ATP, as well as increased cell proliferation. Glycerol 142-150 aquaporin 3 (Gill blood group) Homo sapiens 20-24 21191421-5 2011 The upregulation of AQP3 expression in human keratinocytes by transfection with human AQP3 DNA plasmid was associated with increased cellular glycerol and ATP, as well as increased cell proliferation. Glycerol 142-150 aquaporin 3 (Gill blood group) Homo sapiens 86-90 19619514-1 2009 Aquaporin-3 (AQP3) is a water/glycerol-transporting protein that is strongly expressed at the plasma membranes of keratinocytes in skin. Glycerol 30-38 aquaporin 3 (Gill blood group) Homo sapiens 0-11 19619514-1 2009 Aquaporin-3 (AQP3) is a water/glycerol-transporting protein that is strongly expressed at the plasma membranes of keratinocytes in skin. Glycerol 30-38 aquaporin 3 (Gill blood group) Homo sapiens 13-17 19684221-6 2009 Eel AQP3 and AQPe also transport urea and glycerol, making them aquaglyceroporins. Glycerol 42-50 aquaporin 3 (Gill blood group) Homo sapiens 4-8 19684221-7 2009 Eel AQP3 is dramatically inhibited by extracellular acidity (91% and 69% inhibition of water and glycerol transport respectively at pH 6.5) consistent with channel gating by protons. Glycerol 97-105 aquaporin 3 (Gill blood group) Homo sapiens 4-8 19258345-5 2009 RESULTS: At 6 and 24 h, a significant increase in Aqp 3 and 9 mRNA was observed in the sucrose hyperosmotic treatment compared with standard medium and glycerol controls. Glycerol 152-160 aquaporin 3 (Gill blood group) Homo sapiens 50-61 19096779-5 2009 Both water and glycerol transport by AQP3 appear to play an important role in hydration of mammalian skin epidermis. Glycerol 15-23 aquaporin 3 (Gill blood group) Homo sapiens 37-41 19096779-6 2009 In addition, recent data suggest that glycerol transport by AQP3 is involved in the metabolism of lipids in skin as well as in the regulation of proliferation and differentiation of keratinocytes. Glycerol 38-46 aquaporin 3 (Gill blood group) Homo sapiens 60-64 19096781-3 2009 AQP3, 7, 9, and 10 are subcategorized as aquaglyceroporins which permeabilize glycerol as well as water. Glycerol 78-86 aquaporin 3 (Gill blood group) Homo sapiens 0-4 18601899-1 2008 We investigated the membrane trafficking of AQP3 induced by epinephrine in Caco-2 cells to clarify the digestive absorption of glycerol permeated by AQP3. Glycerol 127-135 aquaporin 3 (Gill blood group) Homo sapiens 44-48 18601899-1 2008 We investigated the membrane trafficking of AQP3 induced by epinephrine in Caco-2 cells to clarify the digestive absorption of glycerol permeated by AQP3. Glycerol 127-135 aquaporin 3 (Gill blood group) Homo sapiens 149-153 18495115-1 2008 For understanding the actions of magnesium formulations, magnesium oxide and magnesium sulfate as a constituent of antacid, in the gastrointestinal tract, the effect of magnesium ion on the water channel aquaporin 3 (AQP3) known to be permeable mainly to water and glycerol was investigated in Caco-2 cells. Glycerol 265-273 aquaporin 3 (Gill blood group) Homo sapiens 217-221 18435676-1 2008 BACKGROUND: The human GIL blood group is encoded by the aquaporin 3 (AQP3), a water-glycerol channel present in human red cell (RBC) membranes. Glycerol 84-92 aquaporin 3 (Gill blood group) Homo sapiens 56-67 18435676-1 2008 BACKGROUND: The human GIL blood group is encoded by the aquaporin 3 (AQP3), a water-glycerol channel present in human red cell (RBC) membranes. Glycerol 84-92 aquaporin 3 (Gill blood group) Homo sapiens 69-73 17943189-6 2008 Incubation of NHEK in ATRA for 24, 48, and 72 hours stimulated glycerol influx, suggesting that the increase in AQP3 gene and protein expression was followed by an enhancement of biological activity. Glycerol 63-71 aquaporin 3 (Gill blood group) Homo sapiens 112-116 17597824-3 2007 As PLD2 can utilize the physiological alcohol glycerol to form phosphatidylglycerol (PG), we hypothesized that AQP3 provides glycerol to PLD2 for PG synthesis, which then modulates keratinocyte function. Glycerol 46-54 aquaporin 3 (Gill blood group) Homo sapiens 111-115 17597824-3 2007 As PLD2 can utilize the physiological alcohol glycerol to form phosphatidylglycerol (PG), we hypothesized that AQP3 provides glycerol to PLD2 for PG synthesis, which then modulates keratinocyte function. Glycerol 75-83 aquaporin 3 (Gill blood group) Homo sapiens 111-115 17597824-4 2007 Acidic medium inhibits AQP3 transport activity; both glycerol uptake and PG synthesis were inhibited by low versus physiological pH. Glycerol 53-61 aquaporin 3 (Gill blood group) Homo sapiens 23-27 17597824-9 2007 Thus, our results support the idea that AQP3 supplies PLD2 with glycerol for synthesizing PG, a lipid signal that promotes early keratinocyte differentiation. Glycerol 64-72 aquaporin 3 (Gill blood group) Homo sapiens 40-44 16848764-1 2006 AQP3 (aquaporin-3), known as an integral membrane channel in epidermal keratinocytes, facilitates water and glycerol movement into and out of the skin. Glycerol 108-116 aquaporin 3 (Gill blood group) Homo sapiens 0-4 16848764-1 2006 AQP3 (aquaporin-3), known as an integral membrane channel in epidermal keratinocytes, facilitates water and glycerol movement into and out of the skin. Glycerol 108-116 aquaporin 3 (Gill blood group) Homo sapiens 6-17 16487477-4 2006 AQP3, 7, 9, and 10 are subcategorized as aquaglyceroporins which permeabilize glycerol as well as water. Glycerol 78-86 aquaporin 3 (Gill blood group) Homo sapiens 0-4 16651733-1 2006 Aquaporin 3 (AQP3), a membrane protein, is known to permeabilize water and other small molecules such as glycerol and urea and is localized in the bowel, skin, kidney, and erythrocytes. Glycerol 105-113 aquaporin 3 (Gill blood group) Homo sapiens 0-11 16651733-1 2006 Aquaporin 3 (AQP3), a membrane protein, is known to permeabilize water and other small molecules such as glycerol and urea and is localized in the bowel, skin, kidney, and erythrocytes. Glycerol 105-113 aquaporin 3 (Gill blood group) Homo sapiens 13-17 16651733-3 2006 Therefore we first investigated whether insulin regulating the glycolytic pathway took part in glycerol transport through AQP3 in the gastrointestinal tract and found that insulin significantly suppressed mRNA and protein expressions of AQP3 in Caco-2 cells. Glycerol 95-103 aquaporin 3 (Gill blood group) Homo sapiens 122-126 16651733-3 2006 Therefore we first investigated whether insulin regulating the glycolytic pathway took part in glycerol transport through AQP3 in the gastrointestinal tract and found that insulin significantly suppressed mRNA and protein expressions of AQP3 in Caco-2 cells. Glycerol 95-103 aquaporin 3 (Gill blood group) Homo sapiens 237-241 16638588-10 2006 As AQP3 is permeable to water, urea, and glycerol, modulation of its expression in fetal membranes may contribute to AF homeostasis. Glycerol 41-49 aquaporin 3 (Gill blood group) Homo sapiens 3-7 15966863-6 2005 Mechanistic analysis of the altered skin phenotype in AQP3 deficiency suggested that the glycerol rather than the water transporting function of AQP3 is important in skin physiology. Glycerol 89-97 aquaporin 3 (Gill blood group) Homo sapiens 54-58 15456785-0 2004 Copper inhibits the water and glycerol permeability of aquaporin-3. Glycerol 30-38 aquaporin 3 (Gill blood group) Homo sapiens 55-66 15456785-3 2004 Here we report that both water and glycerol permeability of human AQP3 is inhibited by copper. Glycerol 35-43 aquaporin 3 (Gill blood group) Homo sapiens 66-70 15456785-10 2004 When AQP3 was co-expressed with another AQP, only glycerol but not water permeability was inhibited by copper. Glycerol 50-58 aquaporin 3 (Gill blood group) Homo sapiens 5-9 12239222-1 2002 AQP3 is a water and glycerol channel present on human erythrocytes and in various tissues. Glycerol 20-28 aquaporin 3 (Gill blood group) Homo sapiens 0-4 12234316-1 2002 BACKGROUND: Aquaporin-3 (AQP3) is a member of the water channel family that is selective for the passage of not only water, but also glycerol and urea. Glycerol 133-141 aquaporin 3 (Gill blood group) Homo sapiens 12-23 12234316-1 2002 BACKGROUND: Aquaporin-3 (AQP3) is a member of the water channel family that is selective for the passage of not only water, but also glycerol and urea. Glycerol 133-141 aquaporin 3 (Gill blood group) Homo sapiens 25-29 12234316-11 2002 CONCLUSION: Our novel observation demonstrated the AQP3 expression and biosynthesis in HPMC and in vitro studies revealed that glycerol permeability in HPMC was up-regulated by glucose. Glycerol 127-135 aquaporin 3 (Gill blood group) Homo sapiens 51-55 11751877-2 2002 Here, we analyzed the oligomerization of the AQP3 aquaglyceroporin, which presents a mixed selectivity for water, glycerol, and urea. Glycerol 114-122 aquaporin 3 (Gill blood group) Homo sapiens 45-49 11597198-5 2001 Since AQP3 is not only a water channels, but also permits the rapid passage of both urea and glycerol, while AQP9 also mediates the passage of carbamides, polyols, purines, and pyrimidines, we have speculated that these proteins could be involved in the transport of water and solutes from mother to fetus. Glycerol 93-101 aquaporin 3 (Gill blood group) Homo sapiens 6-10 10206998-5 1999 Glycerol uptake and antisense studies suggest CFTR-dependent regulation of aquaporin 3 (AQP3) water channels in airway epithelial cells. Glycerol 0-8 aquaporin 3 (Gill blood group) Homo sapiens 75-86 10206998-5 1999 Glycerol uptake and antisense studies suggest CFTR-dependent regulation of aquaporin 3 (AQP3) water channels in airway epithelial cells. Glycerol 0-8 aquaporin 3 (Gill blood group) Homo sapiens 88-92 10872456-8 1999 Multifunctional aquaglyceroporins AQP3, AQP7, and AQP9 are permeated by water, glycerol, and some other solutes. Glycerol 79-87 aquaporin 3 (Gill blood group) Homo sapiens 34-38 9824541-2 1998 Aquaporins are a family of intrinsic membrane proteins that function as water-selective channels (except aquaporin-3 and aquaporin-7, which are permeable to urea and glycerol as well) in the plasma membranes of many cells. Glycerol 166-174 aquaporin 3 (Gill blood group) Homo sapiens 105-116 9858131-4 1998 Most of the AQPs are only permeable to water and impermeable to small organic and inorganic molecules, except for AQP 3, 7 and 9 which are also permeable to urea and glycerol. Glycerol 166-174 aquaporin 3 (Gill blood group) Homo sapiens 114-119 9525951-8 1998 Furthermore, pharmacological studies showed that Colton-null red cells remain sensitive to water and glycerol flux inhibitors, supporting the idea that another proteinaceous path, probably AQP3, mediates most of the glycerol movements across red cell membranes and represents part of the residual water transport activity found in AQP1-deficient red cells. Glycerol 216-224 aquaporin 3 (Gill blood group) Homo sapiens 189-193 9369468-13 1997 Expression of AQP3 increased glycerol permeability (Pgly) 3.1-fold, whereas Pgly of Y212W-expressing oocytes was similar to Pgly of control oocytes. Glycerol 29-37 aquaporin 3 (Gill blood group) Homo sapiens 14-18 8810261-4 1996 Although both aquaporins permit water flow across the cell membrane, only AQP3 was permeable to glycerol and urea (Pgly > Pur). Glycerol 96-104 aquaporin 3 (Gill blood group) Homo sapiens 74-78 8810261-5 1996 The uptake of glycerol into oocytes expressing AQP3 was linear up to 165 mM. Glycerol 14-22 aquaporin 3 (Gill blood group) Homo sapiens 47-51 7540850-4 1995 Aquaporin 1 (AQP1), aquaporin 2 (AQP2) and the mercury-insensitive water channel (MIWC) are water-selective channel proteins, whereas the fourth, referred to as aquaporin 3 (AQP3), permits transport of urea and glycerol as well. Glycerol 211-219 aquaporin 3 (Gill blood group) Homo sapiens 161-172