PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28628909-5	2017	A transient activation of CYP4F2 gene followed by a repression response was observed in HepG2 cells during the exposure to increasing levels of the lipogenic and cytotoxic agent palmitic acid; such gene repression effect was further exacerbated by the co-treatment with oleic acid and alpha-tocopherol and was also observed for PPAR-gamma and the SREBP isoforms 1 and 2.	alpha-Tocopherol	285-301	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	26-32	
35040869-0	2022	Change in plasma alpha-tocopherol associations with attenuated pulmonary function decline and with CYP4F2 missense variation.	alpha-Tocopherol	17-33	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	99-105	
28628909-3	2017	CYP4F2 protein, a cytochrome P-450 isoform with proposed alpha-tocopherol omega-hydroxylase activity, decreased in HFD and even more in HFD+F mice liver; this finding was associated with increased hepatic levels of alpha-tocopherol and decreased formation of the corresponding long-chain metabolites alpha-13-hydroxy and alpha-13-carboxy chromanols.	alpha-Tocopherol	57-73	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	0-6	
28628909-3	2017	CYP4F2 protein, a cytochrome P-450 isoform with proposed alpha-tocopherol omega-hydroxylase activity, decreased in HFD and even more in HFD+F mice liver; this finding was associated with increased hepatic levels of alpha-tocopherol and decreased formation of the corresponding long-chain metabolites alpha-13-hydroxy and alpha-13-carboxy chromanols.	alpha-Tocopherol	215-231	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	0-6	
28628909-6	2017	Such gene response was associated with increased uptake and omega-hydroxylation of alpha-tocopherol, which suggests a minor role of CYP4F2 in the enzymatic metabolism of vitamin E in HepG2 cells.	alpha-Tocopherol	83-99	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	132-138	
18656365-6	2008	We report here the design and synthesis of N-heterocycle-containing analogues of alpha-tocopherol that act as inhibitors of Cyp4F2, the key monooxygenase responsible for omega-hydroxylation of the side chain of tocols.	alpha-Tocopherol	81-97	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	124-130	
28062356-1	2017	The expression of CYP4F2, a form of cytochrome P-450 with proposed role in alpha-tocopherol and long-chain fatty acid metabolism, was explored in HepG2 and HepaRG human hepatocytes during ethanol toxicity.	alpha-Tocopherol	75-91	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	18-24	
28062356-3	2017	alpha-Tocopherol antagonized the cytotoxicity and CYP4F2 gene repression effect of ethanol in HepG2 cells.	alpha-Tocopherol	0-16	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	50-56	
28062356-5	2017	PPAR-gamma and SREBP-1c followed the same expression pattern of CYP4F2 in response to ethanol and alpha-tocopherol treatments.	alpha-Tocopherol	98-114	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	64-70	
24759732-7	2014	Among those receiving Vit E treatment, CYP4F2 V433M genotype was associated with significantly decreased plasma alpha-tocopherol levels at w48 (p = 0.003 for PIVENS and p = 0.026 for TONIC) but not at w96.	alpha-Tocopherol	112-128	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	39-45