PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31830726-6 2020 The promotion effects of atorvastatin on NEXN-AS1 and NEXN expression could be significantly abolished by knockdown of lncRNA NEXN-AS1 or NEXN, and its inhibitory effects on pyroptosis were also markedly offset by knock-down of lncRNA NEXN-AS1 or interference of NEXN. atorvastatin 25-37 NEXN antisense RNA 1 Homo sapiens 126-134 31830726-0 2020 Atorvastatin inhibits pyroptosis through the lncRNA NEXN-AS1/NEXN pathway in human vascular endothelial cells. atorvastatin 0-12 NEXN antisense RNA 1 Homo sapiens 52-60 31830726-4 2020 RESULTS: Atorvastatin upregulated long non-coding RNA (lncRNA) NEXN-AS1 and the expression of NEXN at both the mRNA and protein levels in a concentration- and time-dependent manner. atorvastatin 9-21 NEXN antisense RNA 1 Homo sapiens 63-71 31830726-6 2020 The promotion effects of atorvastatin on NEXN-AS1 and NEXN expression could be significantly abolished by knockdown of lncRNA NEXN-AS1 or NEXN, and its inhibitory effects on pyroptosis were also markedly offset by knock-down of lncRNA NEXN-AS1 or interference of NEXN. atorvastatin 25-37 NEXN antisense RNA 1 Homo sapiens 41-49 31830726-6 2020 The promotion effects of atorvastatin on NEXN-AS1 and NEXN expression could be significantly abolished by knockdown of lncRNA NEXN-AS1 or NEXN, and its inhibitory effects on pyroptosis were also markedly offset by knock-down of lncRNA NEXN-AS1 or interference of NEXN. atorvastatin 25-37 NEXN antisense RNA 1 Homo sapiens 126-134 31830726-7 2020 CONCLUSIONS: These results demonstrated that atorvastatin regulated pyroptosis via the lncRNA NEXN-AS1-NEXN pathway, which provides a new insight into the mechanism of how atorvastatin promotes non-lipid-lower effects against the development of atherosclerosis and gives new directions on how to reverse atherosclerosis. atorvastatin 45-57 NEXN antisense RNA 1 Homo sapiens 94-102 31830726-7 2020 CONCLUSIONS: These results demonstrated that atorvastatin regulated pyroptosis via the lncRNA NEXN-AS1-NEXN pathway, which provides a new insight into the mechanism of how atorvastatin promotes non-lipid-lower effects against the development of atherosclerosis and gives new directions on how to reverse atherosclerosis. atorvastatin 172-184 NEXN antisense RNA 1 Homo sapiens 94-102