PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19954599-0 2009 [Effects of thalidomide on Annexin II gene regulation]. Thalidomide 12-23 annexin A2 Homo sapiens 27-37 19954599-1 2009 OBJECTIVE: To investigate the effect of thalidomide on Annexin II (AnxA2) gene regulation in multiple myeloma cell line RPMI8226 and human microvascular endothelial cell line HMEC-1 cells in vitro, and explore the potential mechanism of thrombosis induced by thalidomide. Thalidomide 40-51 annexin A2 Homo sapiens 55-65 19954599-1 2009 OBJECTIVE: To investigate the effect of thalidomide on Annexin II (AnxA2) gene regulation in multiple myeloma cell line RPMI8226 and human microvascular endothelial cell line HMEC-1 cells in vitro, and explore the potential mechanism of thrombosis induced by thalidomide. Thalidomide 40-51 annexin A2 Homo sapiens 67-72 19954599-3 2009 Real time quantitative PCR (RQ-PCR) was used to detect the influence of thalidomide at different concentration on the expression of AnxA2 mRNA, flow cytometry (FCM) and confocal microscopy were used to detect the cell surface protein level after the samples were stimulated with different concentrations of thalidomide. Thalidomide 72-83 annexin A2 Homo sapiens 132-137 19954599-6 2009 CONCLUSIONS: Thalidomide can inhibit the expression of AnxA2 mRNA and protein in RPMI8226 and HMEC-1 cells, which may be one of the mechanisms for the development of thrombosis induced by thalidomide in multiple myeloma patients. Thalidomide 13-24 annexin A2 Homo sapiens 55-60 19954599-6 2009 CONCLUSIONS: Thalidomide can inhibit the expression of AnxA2 mRNA and protein in RPMI8226 and HMEC-1 cells, which may be one of the mechanisms for the development of thrombosis induced by thalidomide in multiple myeloma patients. Thalidomide 188-199 annexin A2 Homo sapiens 55-60