PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23500539-8	2013	In addition, thalidomide pretreatment inhibited the TGF-beta-induced DNA binding activity of AP-1 and Smad3/4, caused fibronectin degradation by increasing the activity of matrix metalloproteinase 9, and decreased production of TGF-beta1 and fibronectin and the number of fibroblasts in an in vivo keloid model.	Thalidomide	13-24	fibronectin 1	Homo sapiens	118-129	
12548578-4	2003	For example, immunomodulatory derivatives of thalidomide (IMiDs) and the proteasome inhibitor PS-341 both induce apoptosis of MM cell lines and patient cells refractory to melphalan, doxorubicin, and dexamethasone; abrogate MM cell binding to fibronectin and BMSCs and related protection against immune- and drug-induced apoptosis; block production of cytokines which promote MM cell growth, survival, drug resistance, and migration; inhibit angiogenesis; and stimulate host anti-tumor immunity.	Thalidomide	45-56	fibronectin 1	Homo sapiens	243-254	
23500539-0	2013	Thalidomide inhibits fibronectin production in TGF-beta1-treated normal and keloid fibroblasts via inhibition of the p38/Smad3 pathway.	Thalidomide	0-11	fibronectin 1	Homo sapiens	21-32	
23500539-3	2013	The aims were to examine possible therapeutic effects of thalidomide on fibronectin expression in transforming growth factor-beta1 (TGF-beta1)-treated normal fibroblasts (NFs) and keloid-derived fibroblasts (KFs) and the underlying mechanism of action, especially the involvement of mitogen-activated protein kinase (MAPKs) and Sma- and Mad-related family (Smads) pathways.	Thalidomide	57-68	fibronectin 1	Homo sapiens	72-83	
23500539-5	2013	TGF-beta1 induced significant fibronectin expression in NFs and KFs and the effect was inhibited by pretreatment with thalidomide.	Thalidomide	118-129	fibronectin 1	Homo sapiens	30-41	
23500539-8	2013	In addition, thalidomide pretreatment inhibited the TGF-beta-induced DNA binding activity of AP-1 and Smad3/4, caused fibronectin degradation by increasing the activity of matrix metalloproteinase 9, and decreased production of TGF-beta1 and fibronectin and the number of fibroblasts in an in vivo keloid model.	Thalidomide	13-24	fibronectin 1	Homo sapiens	242-253	
19815837-5	2010	RESULTS: Thalidomide strongly inhibited gelatinase production by B-cell lines and primary myeloma cells in response to fibronectin, the most efficient gelatinase inducer identified in lymphoid cells.	Thalidomide	9-20	fibronectin 1	Homo sapiens	119-130	
19815837-7	2010	Unexpectedly, treatment with thalidomide elicited an increase in fibronectin-induced Akt phosphorylation through phosphoinositide 3-kinase-independent pathways since thalidomide decreased fibronectin-induced phosphoinositide 3-kinase phosphorylation and reversed the inhibition of Akt phosphorylation achieved by the phosphoinositide 3-kinase inhibitors wortmannin and LY294002.	Thalidomide	29-40	fibronectin 1	Homo sapiens	65-76	
19815837-7	2010	Unexpectedly, treatment with thalidomide elicited an increase in fibronectin-induced Akt phosphorylation through phosphoinositide 3-kinase-independent pathways since thalidomide decreased fibronectin-induced phosphoinositide 3-kinase phosphorylation and reversed the inhibition of Akt phosphorylation achieved by the phosphoinositide 3-kinase inhibitors wortmannin and LY294002.	Thalidomide	29-40	fibronectin 1	Homo sapiens	188-199	
19815837-7	2010	Unexpectedly, treatment with thalidomide elicited an increase in fibronectin-induced Akt phosphorylation through phosphoinositide 3-kinase-independent pathways since thalidomide decreased fibronectin-induced phosphoinositide 3-kinase phosphorylation and reversed the inhibition of Akt phosphorylation achieved by the phosphoinositide 3-kinase inhibitors wortmannin and LY294002.	Thalidomide	166-177	fibronectin 1	Homo sapiens	65-76	
19815837-7	2010	Unexpectedly, treatment with thalidomide elicited an increase in fibronectin-induced Akt phosphorylation through phosphoinositide 3-kinase-independent pathways since thalidomide decreased fibronectin-induced phosphoinositide 3-kinase phosphorylation and reversed the inhibition of Akt phosphorylation achieved by the phosphoinositide 3-kinase inhibitors wortmannin and LY294002.	Thalidomide	166-177	fibronectin 1	Homo sapiens	188-199