PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32848052-1 2020 Thalidomide exerts its teratogenic and immunomodulatory effects by binding to cereblon (CRBN) and thereby inhibiting/modifying the CRBN-mediated ubiquitination pathway consisting of the Cullin4-DDB1-ROC1 E3 ligase complex. Thalidomide 0-11 damage specific DNA binding protein 1 Mus musculus 194-198 29449372-1 2018 Upon binding to thalidomide and other immunomodulatory drugs, the E3 ligase substrate receptor cereblon (CRBN) promotes proteosomal destruction by engaging the DDB1-CUL4A-Roc1-RBX1 E3 ubiquitin ligase in human cells but not in mouse cells, suggesting that sequence variations in CRBN may cause its inactivation. Thalidomide 16-27 damage specific DNA binding protein 1 Mus musculus 160-164