PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24859059-9	2014	Thalidomide analogs 1 and 2 demonstrated more potent activity to suppress expression levels of IL-6, IL-8, TNF-alpha, VEGF165, and MMP-2 than thalidomide.	Thalidomide	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	101-105	
22239529-5	2012	Results revealed that while thalidomide reduced IL-8 and nuclear factor kappa B (NF-kappaB) activity by 95% and 46% in Huh-7 cells, increasing concentrations of thalidomide correlated with a linear rise in HCV replication (17-fold at 200 mum).	Thalidomide	28-39	C-X-C motif chemokine ligand 8	Homo sapiens	48-52	
16837501-8	2006	In conclusion, thalidomide has the potential to improve the therapeutic regimens for sarcoidosis, hypersensitivity pneumonitis and idiopathic pulmonary fibrosis by reducing tumour necrosis factor-alpha, interleukin-12p40, interleukin-18 and interleukin-8 production.	Thalidomide	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	241-254	
17964516-11	2007	Using the area under the dose response curve (AUC(0 to 24) h), thalidomide reduced the AUC for IL-6 by 56%, for IL-8 by 30%, and TNF-alpha by 32%.	Thalidomide	63-74	C-X-C motif chemokine ligand 8	Homo sapiens	112-116	
16837501-0	2006	Thalidomide reduces IL-18, IL-8 and TNF-alpha release from alveolar macrophages in interstitial lung disease.	Thalidomide	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	27-31	
16837501-6	2006	At the highest thalidomide concentration (0.1 mM), LPS-stimulated IL-8 production was also suppressed.	Thalidomide	15-26	C-X-C motif chemokine ligand 8	Homo sapiens	66-70	
16837501-7	2006	In IPF patients, although spontaneous production of TNF-alpha, IL-12p40, IL-18 and IL-8 was lower than in sarcoidosis and HP patients, with LPS stimulation the cytokines were significantly elevated and also partially inhibited by thalidomide.	Thalidomide	230-241	C-X-C motif chemokine ligand 8	Homo sapiens	83-87	
15687330-0	2005	Thalidomide inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-kappaB activation.	Thalidomide	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	57-70	
10950803-4	2000	Thalidomide treatment was found to cause potent and selective inhibition of IL-8 production in a dose-responsive manner.	Thalidomide	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	76-80	
10950803-6	2000	In addition, thalidomide treatment of lipopolysaccharide-stimulated microglia inhibited the activation of protein NF-kappaB, a transcription factor known to be important for IL-8 production.	Thalidomide	13-24	C-X-C motif chemokine ligand 8	Homo sapiens	174-178	
10950803-7	2000	These results suggest thalidomide could have a therapeutic role in acute bacterial meningitis through inhibition of IL-8-mediated neutrophil chemotaxis.	Thalidomide	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	116-120	
10437657-0	1999	Inducer-specific bidirectional regulation of endothelial interleukin-8 production by thalidomide.	Thalidomide	85-96	C-X-C motif chemokine ligand 8	Homo sapiens	57-70	
17013434-5	2006	It has been demonstrated that thalidomide inhibits TNFalpha, IL-5, IL-6, IL-8, IL-12 production and increases production of IL-2, IL-10 and INFgamma.	Thalidomide	30-41	C-X-C motif chemokine ligand 8	Homo sapiens	73-77	
14558594-2	2003	The results show that thalidomide inhibits endotelial cell proliferation induced by bFGF and VEGF, more so if the cells are grown on vitronectin; moreover, treatment with thalidomide reduces the release of MMP-2 and IL-8 by endothelial cells, suggesting a further pathway for the antiangiogenic activity of drug.	Thalidomide	22-33	C-X-C motif chemokine ligand 8	Homo sapiens	216-220	
14558594-2	2003	The results show that thalidomide inhibits endotelial cell proliferation induced by bFGF and VEGF, more so if the cells are grown on vitronectin; moreover, treatment with thalidomide reduces the release of MMP-2 and IL-8 by endothelial cells, suggesting a further pathway for the antiangiogenic activity of drug.	Thalidomide	171-182	C-X-C motif chemokine ligand 8	Homo sapiens	216-220	
12485902-4	2002	Thalidomide inhibited interleukin (IL) 1beta-induced NFkappaB transcriptional activation and IL-8 production in Caco-2 colon cancer cells.	Thalidomide	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	93-97	
11297551-7	2001	Consistent with the observed inhibition of NF-kappaB, thalidomide blocked the cytokine-induced expression of NF-kappaB-regulated genes such as those encoding interleukin-8, TRAF1, and c-IAP2.	Thalidomide	54-65	C-X-C motif chemokine ligand 8	Homo sapiens	158-171	
10571725-9	1999	Thalidomide did, however, induce a 2-4-fold increase in keratinocyte-derived interleukin-8, a pro-migratory cellular autocrine factor.	Thalidomide	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	77-90