PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35597178-6 2022 Therefore, in this study, we demonstrated that serum soluble Klotho (sKL) could exert its cardioprotective and anti-inflammatory effects by regulating the phenotype of macrophages by inhibiting TLR4/MyD88/NF-kappaB. skl 69-72 myeloid differentiation primary response gene 88 Mus musculus 199-204 35597178-9 2022 Therefore, supplementation of sKL can improve aging cardiac function, reduce cardiac oxidative stress, inflammation and apoptosis by promoting M2a/M2c polarized macrophages via inhibiting the TLR4/Myd88/NF-kappaB pathway. skl 30-33 myeloid differentiation primary response gene 88 Mus musculus 197-202