PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34942919-1 2021 Clobenpropit (CLO), an antagonist on histamine H3 receptors (HH3R), has been shown to protect NMDA-induced neuronal necrosis in cortical neuronal cell culture from rats. clobenpropit 0-12 histamine receptor H3 Rattus norvegicus 37-59 34942919-1 2021 Clobenpropit (CLO), an antagonist on histamine H3 receptors (HH3R), has been shown to protect NMDA-induced neuronal necrosis in cortical neuronal cell culture from rats. clobenpropit 0-12 histamine receptor H3 Rattus norvegicus 61-65 34942919-1 2021 Clobenpropit (CLO), an antagonist on histamine H3 receptors (HH3R), has been shown to protect NMDA-induced neuronal necrosis in cortical neuronal cell culture from rats. clobenpropit 14-17 histamine receptor H3 Rattus norvegicus 37-59 34942919-1 2021 Clobenpropit (CLO), an antagonist on histamine H3 receptors (HH3R), has been shown to protect NMDA-induced neuronal necrosis in cortical neuronal cell culture from rats. clobenpropit 14-17 histamine receptor H3 Rattus norvegicus 61-65 12787830-7 2003 Clobenpropit (1 nM, a potent histamine H(3) receptor antagonist) "antagonised" the suppressive effect of SKF 91488 and histamine-evoked relaxation was restored. clobenpropit 0-12 histamine receptor H3 Rattus norvegicus 29-52 21272571-6 2011 Clobenpropit (histamine H(3) receptor antagonist, 1muM) canceled the alpha-methylhistamine-induced decrease in the periarterial nerve stimulation-induced vasoconstriction and noradrenaline release and periarterial nerve stimulation-induced vasodilation. clobenpropit 0-12 histamine receptor H3 Rattus norvegicus 14-37 15082882-7 2004 Pretreatment with histamine H(3) receptor antagonist clobenpropit (4 micromol/kg i.a.) clobenpropit 53-65 histamine receptor H3 Rattus norvegicus 18-41 15082882-13 2004 Pretreatment with histamine H(3) receptor antagonist clobenpropit (0,4 micromol i.c.v.) clobenpropit 53-65 histamine receptor H3 Rattus norvegicus 18-41 30536350-0 2018 Histamine H3 receptor antagonist Clobenpropit protects propofol-induced apoptosis of hippocampal neurons through PI3K/AKT pathway. clobenpropit 33-45 histamine receptor H3 Rattus norvegicus 0-21 30536350-1 2018 OBJECTIVE: The aim of the study was to explore whether histamine H3 receptor antagonist Clobenpropit could protect propofol-induced neurotoxicity in hippocampal neurons. clobenpropit 88-100 histamine receptor H3 Rattus norvegicus 55-76 17350613-0 2007 The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. clobenpropit 37-49 histamine receptor H3 Rattus norvegicus 4-25 17350613-2 2007 Clobenpropit reversed the neurotoxicity in a concentration-dependent manner, and showed peak protection at a concentration of 10(-7) M. This protection was antagonized by the histamine H3 receptor agonist (R)-alpha-methylhistamine, but not by the histamine H1 receptor antagonist pyrilamine or the histamine H2 receptor antagonist cimetidine. clobenpropit 0-12 histamine receptor H3 Rattus norvegicus 175-196 14735131-4 2004 The aim of the present study was to evaluate the effects of two histamine H3 receptor antagonists, clobenpropit and thioperamide, on rewarding and neurochemical effects of methamphetamine utilizing three in vivo methodologies, drug self-administration, drug discrimination, and microdialysis in Sprague-Dawley rats. clobenpropit 99-111 histamine receptor H3 Rattus norvegicus 64-85 9874165-9 1998 In conclusion, intrahypothalamic perfusion of the histamine H3 receptor agonist, immepip and the histamine H3 receptor antagonist, clobenpropit, potently and oppositely modulated in vivo histamine release from the anterior hypothalamic area. clobenpropit 131-143 histamine receptor H3 Rattus norvegicus 97-118 9017245-0 1996 Brain penetration of the histamine H3 receptor antagonists thioperamide and clobenpropit in rat and mouse, determined with ex vivo [125I]iodophenpropit binding. clobenpropit 76-88 histamine receptor H3 Rattus norvegicus 25-46 9017245-1 1996 We investigated the brain penetration of the histamine H3 receptor antagonists thioperamide and clobenpropit using ex vivo [125I]iodophenpropit binding. clobenpropit 96-108 histamine receptor H3 Rattus norvegicus 45-66 8982515-9 1996 The inhibitory effect of 100 microM histamine was completely prevented by the highly selective histamine H3 receptor antagonist, clobenpropit but was resistant to antagonism by triprolidine and cimetidine, antagonists at histamine H1 and H2 but not H3 receptors. clobenpropit 129-141 histamine receptor H3 Rattus norvegicus 95-116 8119312-0 1993 Pharmacological activity of VUF 9153, an isothiourea histamine H3 receptor antagonist. clobenpropit 28-36 histamine receptor H3 Rattus norvegicus 53-74 8119312-1 1993 The pharmacological activity of the histamine H3 receptor antagonist VUF 9153 (S-[3-(4(5)-imidazolyl)]propyl-N-(4-chlorobenzyl)isothiourea) has been investigated in vitro and in vivo. clobenpropit 69-77 histamine receptor H3 Rattus norvegicus 36-57 8119312-1 1993 The pharmacological activity of the histamine H3 receptor antagonist VUF 9153 (S-[3-(4(5)-imidazolyl)]propyl-N-(4-chlorobenzyl)isothiourea) has been investigated in vitro and in vivo. clobenpropit 79-138 histamine receptor H3 Rattus norvegicus 36-57