PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28659806-0 2017 Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages. erythrodiol 0-11 ATP binding cassette subfamily A member 1 Homo sapiens 66-71 28659806-5 2017 We identified erythrodiol (Olean-12-ene-3beta,28-diol) as an ABCA1 stabilizer and revealed its positive influence on ChE in THP-1-derived human macrophages. erythrodiol 14-25 ATP binding cassette subfamily A member 1 Homo sapiens 61-66 28659806-6 2017 Among the nine tested compounds from olive oil, erythrodiol was the sole compound raising ABCA1 protein level (at 10 muM). erythrodiol 48-59 ATP binding cassette subfamily A member 1 Homo sapiens 90-95 28659806-9 2017 Besides, erythrodiol (10 muM) did not influence the mRNA level of ABCA1, ABCG1, and SR-B1, as determined by quantitative reverse transcription PCR, but significantly inhibited the degradation of ABCA1 as evident by an increased half-life of the protein in the presence of cycloheximide, an inhibitor of de novo protein synthesis. erythrodiol 9-20 ATP binding cassette subfamily A member 1 Homo sapiens 195-200 28659806-10 2017 Therefore, erythrodiol promotes ChE from THP-1-derived human macrophages by stabilizing the ABCA1 protein. erythrodiol 11-22 ATP binding cassette subfamily A member 1 Homo sapiens 92-97